ライフサイエンスコーパス: NPI

1 NPI domain scores after the initial open-treatment phase

2 NPI mean difference favoured memantine at weeks 6 (-6.9;

3 NPI-0052 also induces DNA fragmentation in leukemia line

4 NPI-0052 inhibited YY1 promoter activity as well as both

5 NPI-0052 plus bortezomib-induced synergistic apoptosis i

6 NPI-0052 plus lenalidomide-induced apoptosis is associat

7 NPI-0052 up-regulated DR5 reporter activity and both sur

8 NPI-0052-induced apoptosis was further probed using casp

9 NPI-0052-induced inhibition of NF-kappaB activity was in

10 NPIs cocultured with MSCs had greater cellular insulin c

11 NPIs were cotransplanted with or without MSCs in diabeti

12 ssociated with worsening DR (NPA, P = 0.001; NPI, P = 0.0003).

13 participants (n = 139) exhibited at least 1 NPI symptom from the onset of cognitive symptoms.

14 Salinosporamide A ( 1 (NPI-0052)) is a potent, monochlorinated 20S proteasome i

15 Salinosporamide A (1, NPI-0052) is a potent proteasome inhibitor in developmen

16 e we consider the implications of SARS-CoV-2 NPIs for two endemic infections circulating in the Unite

17 e nonmetastatic LNCaP cells induced EMT, (2) NPI-0052-induced repression of Snail via inhibition of N

18 In stage 2, NPI Agitation/Aggression scores were reduced from 5.8 to

19 with visual acuity (NPA, r = 0.14, P = 0.23; NPI, r = 0.24, P = 0.05).

20 g in a county that did not have any of the 3 NPIs, 1.6 (95% CI: 1.5-1.7) times higher for people livi

21 mobility data during 2020 and 2021, and (3) NPI stringency data in 2020 and 2021.

22 ly significant macular edema (NPA, P = 0.99; NPI, P = 0.67), nor correlated with visual acuity (NPA,

23 Salinosporamide A (NPI-0052, marizomib) is a naturally occurring proteasome

24 nd geographically resolved information about NPI adoption, access to SARS-CoV-2 testing, and examine

25 ination of at least two (three) of the above NPIs.

26 e of BIM using siRNA significantly abrogates NPI-0052 plus lenalidomide-induced apoptosis.

27 In addition, NPI-0052 blocked rapid disease progression and death in

28 xternal datasets recording 42,151 additional NPIs from 226 countries.

29 After NPI implementation, IPD incidence decreased by 63% (95%

30 After NPI implementation, the estimated number of influenza ca

31 and deaths also decrease 2 to 4 weeks after NPI implementation, as measured by anonymized, phone-der

32 eine (NAC) also conferred protection against NPI-0052-induced apoptosis, indicating a role for oxidat

33 a/importin-alpha and hSrp1/karyopherin alpha/NPI-1, respectively, and show considerable sequence dive

34 Implementing an NPI program in a large school system to mitigate the eff

35 191.8 mm(2) vs. 306.1 mm(2); P = 0.0019) and NPI (0.25 vs. 0.43; P = 0.0003).

36 which are required for binding to NPI-1 and NPI-3, respectively.

37 Two cellular proteins, NPI-1 and NPI-3, were previously identified through their interact

38 ygen-functionalized molecules NPI-PTZ2,3 and NPI-PTZ5; on the other hand, a twisted intramolecular ch

39 ansmission between patient skin bacteria and NPI contamination, and a third did not find any cross-tr

40 or the proteasome inhibitors bortezomib and NPI-0052, as well as with the conventional anti-MM agent

41 NN) classifiers that predicted ER, Grade and NPI status in the test set with an average misclassifica

42 iated with estrogen receptor (ER), Grade and NPI were used to build k-nearest neighbor (KNN) classifi

43 C) score and compared it to CDR, IQCODE, and NPI scores.

44 otocol, the evaluation of UWF FA for NPA and NPI is reproducible.

45 yes without PDR (n = 52), increasing NPA and NPI was associated with worsening DR (NPA, P = 0.001; NP

46 NPA and NPI were not associated with clinically significant macu

47 ate the association of variables with PI and NPI and with in-hospital mortality.

48 A total of 68 and 50 patients with PI and NPI, respectively were included; 6 patients had incomple

49 of the oxygen-free derivatives NPI-PTZ1 and NPI-PTZ4, with the fluorescence being thus significantly

50 portin alpha homologues hSRP1 alpha/Rch1 and NPI/ hSRP1.

51 s to quantify the impact of vaccinations and NPIs.

52 Furthermore, as NPIs are removed, higher vaccination coverage with less

53 Consistent with studies assessing NPIs relative to COVID-19 incidence and mortality, the p

54 ntigens were measured in 230 children before NPIs and 92 thereafter.

55 re measured in 252 children recruited before NPIs and 200 thereafter.

56 ntial data show a strong resemblance between NPI-inferred EC and real stimulation propagation pattern

57 Three studies explored association between NPIs contamination and patient colonization and infectio

58 ter at 24 hours compared with 1 hour in both NPI (wild-type) and AIs.

59 to adjust our estimates for the role of both NPIs and mobility patterns in reducing transmission.

60 rfilzomib, Onyx 0912, MLN 9708] and broader [NPI-0052] proteasome inhibitors; immunoproteasome inhibi

61 Caspase-3 activation by NPI-0052 was seen in wild-type Jurkat cells, but was sig

62 erall, our results suggest that crosstalk by NPI-0052 and HDACi are contributing, along with caspase-

63 , controlling for temporal phases defined by NPI intensity levels.

64 Hyperacetylation by NPI-0052 occurred to a lesser extent in caspase-8-defici

65 The direct role of Snail inhibition by NPI-0052 in sensitization was shown with Snail small int

66 s, indicating a role for oxidative stress by NPI-0052.

67 Salinosporamide A (also called NPI-0052), recently identified from the marine bacterium

68 nts in distress as measured by the caregiver NPI at 12 months; at 18 months, caregivers showed improv

69 ify the impact of 6,068 hierarchically coded NPIs implemented in 79 territories on the effective repr

70 Interestingly, combining NPI-0052 with either MS-275 or valproic acid (VPA) induc

71 Here, we demonstrate that combining NPI-0052 and bortezomb induces synergistic anti-MM activ

72 Here we demonstrate that combining NPI-0052 and lenalidomide (Revlimid) induces synergistic

73 Less disruptive and costly NPIs can be as effective as more intrusive, drastic, one

74 idents but was less impactful with declining NPI adherence.

75 otoexcitation of the oxygen-free derivatives NPI-PTZ1 and NPI-PTZ4, with the fluorescence being thus

76 and candidate pandemic viruses, we developed NPIs that simulated notions of protective isolation for

77 However, the effectiveness of different NPIs at reducing transmission is poorly understood.

78 Here, we show that compliance with each NPI measure can be highly dynamic and context-dependent

79 c perspective, we find that highly effective NPIs lead at most to partial adherence.

80 effectiveness decreases, partially effective NPIs initially lead to increases in population-level adh

81 Given their well-known side effects, NPIs should be employed only as long as necessary and la

82 orship and public transportation) where even NPIs may not be possible or sufficient.

83 rship and public transportation), where even NPIs may not be possible or sufficient.

84 employed to gauge the effectiveness of five NPIs and they are gathering restriction, restaurant capa

85 IgM and macrophages were highly specific for NPIs (alpha1,3-galactosyltransferase knockout) compared

86 Immununostaining of MM tumors from NPI-0052 plus bortezomib-treated mice showed growth inhi

87 ausal understandings of brain functionality, NPI marks a stride in decoding the brain's functional ar

88 red eleven distinct program participants had NPI numbers, with 1584 records of participation over the

89 57%) on CF images had a significantly higher NPI (P = 0.014) than eyes without PPLs.

90 st of the present North Patagonian Icefield (NPI), serve as 'dipsticks' that allow us to reconstruct

91 adopted various strategies for implementing NPIs and administering vaccinations.

92 reduce its interaction with nuclear importin NPI-1, which might be responsible for its decreased nucl

93 ety of settings confirms the need to improve NPIs decontamination practices.

94 lue in Scan2 and non-planning impulsiveness (NPI) measured at follow-up.

95 offers insights into overcoming barriers in NPI adoptions.

96 the transcription factor SP-1 is involved in NPI-0052-induced HB-EGF transcription.

97 Changes in NPIs, including the intensity of lockdowns and stay at h

98 However, these strategies often increase NPI durations, amplifying their substantial costs to liv

99 genomic instability (P = 0.019), increasing NPI score (P < 0.001), and reduced disease-free survival

100 perfusion area (NPA) and nonperfusion index (NPI; nonperfused/total gradable area).

101 American Pattern (PNA), North Pacific Index (NPI), El Nino-Southern Oscillation (ENSO)] to explain de

102 tion index (PI) and Nemerow pollution index (NPI) implied that Pb, Zn, and Cu had a moderate to high

103 rognosis group (Nottingham Prognostic Index (NPI) <or=3.4) tumors had frequent loss of 16q24-qtel.

104 .0001), and the Nottingham Prognostic Index (NPI) score (P <.0001).

105 dated estimates for how effective individual NPIs were in the first wave.

106 However, a completely ineffective NPI results in no adherence.

107 , which was defined as nonprimary infection (NPI) owing to the presence of highly elevated serum immu

108 e introduce Neural Perturbational Inference (NPI), a data-driven framework for mapping whole-brain EC

109 nd RKIP small interfering RNA that inhibited NPI-0052-mediated sensitization.

110 The proteasome inhibitor NPI-0052 also prevented disease progression and death in

111 The novel proteasome inhibitor NPI-0052 has been shown to sensitize tumor cells to apop

112 t the second-generation proteasome inhibitor NPI-0052 induced the mRNA transcription of several EGFR

113 e hypothesized that the proteasome inhibitor NPI-0052 inhibits the transcription repressor Yin Yang 1

114 monstrated that a novel proteasome inhibitor NPI-0052 is distinct from bortezomib (Velcade) and, impo

115 monstrated that a novel proteasome inhibitor NPI-0052 triggers apoptosis in multiple myeloma (MM) cel

116 G7128) is a nucleoside polymerase inhibitor (NPI), which requires intracellular uptake and phosphoryl

117 ork found that a novel proteasome inhibitor, NPI-0052, and HDACi synergistically induce apoptosis in

118 The proteasome inhibitor, NPI-0052, induces the metastasis tumor suppressor/immune

119 teasome in WM using 2 proteasome inhibitors, NPI-0052 and bortezomib.

120 s as a stable, naive-to-primed intermediate (NPI) pluripotent state.

121 a voluntary nonpharmaceutical intervention (NPI).

122 t models of non-pharmaceutical intervention (NPI) effects and their datasets covering 143 regions in

123 ced strict Non-Pharmaceutical Interventions (NPI) that restricted movement, public gatherings, nation

124 under which nonpharmaceutical interventions (NPIs) alone might prevent the introduction of a pandemic

125 entation of nonpharmaceutical interventions (NPIs) during the COVID-19 pandemic was associated with c

126 Nonpharmaceutical interventions (NPIs) have been employed to reduce the transmission of s

127 Nonpharmaceutical interventions (NPIs) intended to reduce infectious contacts between per

128 e impact of nonpharmaceutical interventions (NPIs) on this virus spread remain challenging.

129 9 pandemic, nonpharmaceutical interventions (NPIs) reduced pathogen transmission and mortality worldw

130 impacts of nonpharmaceutical interventions (NPIs) such as household isolation cannot be practically

131 tiveness of nonpharmaceutical interventions (NPIs) was uncertain.

132 s and other nonpharmaceutical interventions (NPIs) with 0.93-day accuracy over the time span of a yea

133 COVID-19 nonpharmaceutical interventions (NPIs), including mask wearing, have proved highly effect

134 ndemic with nonpharmaceutical interventions (NPIs).

135 adoption of nonpharmaceutical interventions (NPIs).

136 -associated nonpharmaceutical interventions (NPIs).

137 herence to non-pharmaceutical interventions (NPIs) against within-facility transmission could therefo

138 mplemented non-pharmaceutical interventions (NPIs) as they did historically, the 100 Days Mission cou

139 lifting of non-pharmaceutical interventions (NPIs) as vaccination roll-out continued, with step one s

140 e or relax non-pharmaceutical interventions (NPIs) based on real-time outbreak surveillance data is a

141 nding when non-pharmaceutical interventions (NPIs) can be lifted as immunity builds up remains a key

142 doption of non-pharmaceutical interventions (NPIs) remains critical to curtail the spread of COVID-19

143 d to guide non-pharmaceutical interventions (NPIs) to combat the spread of the coronavirus disease 20

144 mplemented non-pharmaceutical interventions (NPIs) to contain its spread.

145 nments use non-pharmaceutical interventions (NPIs) to control resurging waves of COVID-19.

146 iveness of non-pharmaceutical interventions (NPIs) to mitigate the spread of SARS-CoV-2 is critical t

147 ented many non-pharmaceutical interventions (NPIs) to suppress the spread of COVID-19 with varying re

148 eract with non-pharmaceutical interventions (NPIs), compounding differences across subgroups.

149 number of non-pharmaceutical interventions (NPIs), including hand washing and use of hand sanitizer,

150 iveness of non-pharmaceutical interventions (NPIs), such as school closures and stay-at-home orders,

151 doption of non-pharmaceutical interventions (NPIs).

152 nation and non-pharmaceutical interventions (NPIs).

153 , digital non-pharmacological interventions (NPIs) represent a cost-effective, scalable means of redu

154 baseline on the Neuropsychiatric Inventory (NPI) Agitation/Aggression domain (scale range, 0 [absenc

155 m domains in the Neuropsychiatric Inventory (NPI) and relapse in the first 16-week phase after random

156 PS) based on the Neuropsychiatric Inventory (NPI) or NPI-Questionnaire (NPI-Q).

157 y (CMAI) and the Neuropsychiatric Inventory (NPI), ability to complete activities of daily living (AD

158 mination (MMSE), Neuropsychiatric Inventory (NPI), and Everyday Cognition (ECog) variables available

159 rtaken using the Neuropsychiatric Inventory (NPI).

160 luated using the Neuropsychiatric Inventory (NPI).

161 assessed by the Neuropsychiatric Inventory (NPI).

162 measured by the neuropsychiatric inventory (NPI).

163 ls completed the Neuropsychiatric Inventory (NPI); 362 were classified as having dementia, 320 as hav

164 easured with the Neuropsychiatric Inventory (NPI, 0-120 points) and the Alzheimer Disease Assessment

165 immune responses to neonatal porcine islet (NPI) xenografts compared with rhesus islet allografts at

166 Interestingly, neonatal porcine islet (NPI) xenografts uniformly survived long term (>100 days)

167 erived MSCs have on neonatal porcine islets (NPIs) in vitro and determined islet engraftment and meta

168 iant, it might not be possible to fully lift NPIs without a third wave of hospital admissions and dea

169 l [95% CrI] 69-83) over alpha, fully lifting NPIs on June 21, 2021, as originally planned might have

170 hanism by which a proteasome inhibitor, like NPI-0052, inhibits the transcription repressor YY1 invol

171 have ever been implemented and only limited NPIs have taken place for a period of time.

172 In cell lines, NPI-0052 inhibits all 3 proteolytic activities associate

173 sed a Bayesian hierarchical model that links NPI implementation dates to national case and death coun

174 Longer NPIs, in general, lead to larger future outbreaks althou

175 unexpected, given that few cities maintained NPIs longer than 6 weeks in 1918.

176 inhibitor (-)-salinosporamide A (marizomib; NPI-0052; 1), using a regio- and stereoselective epoxide

177 In stage 1, mean NPI Agitation/Aggression scores were reduced from 7.1 to

178 a palliative care vs usual care groups, mean NPI-Q severity scores were 9.92 vs 9.41 at baseline and

179 r DHMEQ and (3) RKIP overexpression mimicked NPI-0052 in the inhibition of Snail and EMT.

180 he NF-kappaB inhibitor DHMEQ, which mimicked NPI-0052 in sensitization and inhibition of Snail and in

181 ed by both overexpression of RKIP (mimicking NPI-0052) and RKIP small interfering RNA that inhibited

182 In multivariate models, NPI was significantly associated with underlying psychia

183 ated for the oxygen-functionalized molecules NPI-PTZ2,3 and NPI-PTZ5; on the other hand, a twisted in

184 Monitoring NPI adoption and their association with SARS-CoV-2 infec

185 thesis that rapid implementation of multiple NPIs can significantly reduce influenza transmission, bu

186 Among proposed novel NPIs, we found plausible mechanistic pathways for photod

187 to intricate temporal switching behavior of NPI adoptions.

188 obtained data on the timing of 19 classes of NPI in 17 U.S. cities during the 1918 pandemic and teste

189 sis in WM cells, and that the combination of NPI-0052 and bortezomib induced synergistic cytotoxicity

190 raft model show that low dose combination of NPI-0052 and bortezomib is well tolerated and triggers s

191 tumor model studies, low-dose combination of NPI-0052 and lenalidomide is well tolerated, significant

192 bortezomib, a 400-fold less concentration of NPI-0052 was used.

193 namic regimes through the perceived costs of NPI measures and their effectiveness in particular regar

194 Here, we describe effects of NPI-0052, a novel proteasome inhibitor, in leukemia mode

195 These effects of NPI-0052, alone and in combination with HDACi, warrant f

196 The underlying mechanism of NPI-0052-induced inhibition of the metastatic phenotype

197 Overall, rates of NPI contamination ranged from 23% to 100%.

198 demonstrate, for the first time, the role of NPI-0052 in the regulation of EMT via inhibition of NF-k

199 The direct role of NPI-0052-induced inhibition of YY1 and up-regulation of

200 However, the success of NPI lies in sufficiently high levels of collective compl

201 Because the proximal targets of NPI-0052 and HDACi are inhibition of proteasome activity

202 oup adopters separately from non-adopters of NPIs.

203 Although the potential benefits of NPIs are supported by mathematical models, the historica

204 dUTP nick end labeling])-positive cells) of NPIs compared with AIs.

205 ults indicate that a suitable combination of NPIs is necessary to curb the spread of the virus.

206 y 2013 on studies regarding contamination of NPIs and association to infections in non-outbreak circu

207 the future impact and implementation cost of NPIs are uncertain, how these would interact with vaccin

208 Cotransplantation of NPIs and MSCs resulted in significantly earlier normogly

209 cenarios, we assess how the effectiveness of NPIs depends on the local context such as timing of thei

210 However, the effectiveness of NPIs in preventing SARS-CoV-2 transmission remains poorl

211 Accordingly, we measure the impact of NPIs on mitigating disease spread by exploiting the spat

212 epidemiological data to study the impact of NPIs on the two circulating subtypes, RSV-A and RSV-B.

213 However, the real-world impact of NPIs versus vaccination, or a combination of both, on CO

214 We evaluated implementation of NPIs during fall 2009 in response to H1N1 pandemic influ

215 chronological data on the implementation of NPIs for several European and non-European countries bet

216 llected before and after the introduction of NPIs.

217 A comprehensive list of NPIs was developed, and a systematic review of these ite

218 2021, corresponding to the maximal period of NPIs.

219 -19 incidence and mortality, the presence of NPIs were associated with lower SARS-CoV-2 seroprevalenc

220 tion were also associated with the timing of NPIs.

221 cast scenarios for relaxing various types of NPIs.

222 ections with pathogens found concurrently on NPIs, one found cross-transmission between patient skin

223 and multiply resistant organisms present on NPIs in routine, non-outbreak conditions and in a variet

224 d on the Neuropsychiatric Inventory (NPI) or NPI-Questionnaire (NPI-Q).

225 a diagnosis of primary WNV infection (PI) or NPI during 2005-2007 at Sheba Medical Center (Tel-Hashom

226 cal items potentially shared among patients (NPIs) are part of the patient's immediate surroundings a

227 rn epidemics are of similar magnitude to pre-NPI outbreaks.

228 Two cellular proteins, NPI-1 and NPI-3, were previously identified through thei

229 he Neuropsychiatric Inventory Questionnaire (NPI-Q).

230 iatric Inventory (NPI) or NPI-Questionnaire (NPI-Q).

231 nonresponders) showed significantly reduced NPI Agitation/Aggression scores for dextromethorphan-qui

232 behavioural relaxation, potentially reducing NPIs adherence.

233 ng the resulting responses in other regions, NPI maps the directionality, strength and excitatory/inh

234 we found that COVID-19 outbreaks and related NPIs may have reduced influenza in Southern and Northern

235 They compared caregiver-reported NPI scores at week 9 in patients receiving citalopram (3

236 n inner zone arteriolar diameter and retinal NPI overall or in any retinal region.

237 rp1alpha and Srp1/karyopherin-alpha/alpha-S1/NPI-1) which function in nuclear transport as the import

238 Assuming high susceptibility, more stringent NPIs may be required to minimize outbreak risk in the wi

239 Early pandemic phases with more stringent NPIs were associated with greater reductions in disease

240 Study NPI-0052-101 Part 1 enrolled relapsed or RRMM patients i

241 gest the therapeutic application of subtoxic NPI-0052 concentrations in combination with TRAIL/agonis

242 I; 6 and 12 weeks Neuropsychiatric symptoms (NPI), Clinical Global Impression Change (CGI-C), Standar

243 e and phenothiazine-based push-pull systems (NPI-PTZ1-5), in which we structurally modulate the oxida

244 al models to explore the impact of long-term NPIs on the dynamics of endemic infections.

245 caspase-8 versus caspase-9 demonstrate that NPI-0052 plus lenalidomide-triggered apoptosis is primar

246 Moreover, we demonstrated that NPI-0052 and bortezomib inhibited migration and adhesion

247 We demonstrated that NPI-0052-induced cytotoxicity was completely abrogated i

248 We found that NPI-0052 inhibited proliferation and induced apoptosis i

249 We hypothesized that NPI-0052 may inhibit Snail expression and, consequently,

250 We hypothesized that NPI-0052-mediated sensitization may result from NF-kappa

251 These results indicate that NPI-0052 is eliciting caspase-8 and oxidative stress-dep

252 The possibility that NPI may be an emerging clinical entity with a high morta

253 We show that NPI-0052 inhibits both NF-kappaB and Snail and induces R

254 These findings show that NPI-0052 modifies the NF-kappaB-Snail-RKIP circuitry in

255 It appears unavoidable that NPI combinations effective against pandemics more severe

256 lity-driven transmission model, we show that NPIs reduced the reproduction number from >3 to 1 to 1.6

257 The NPI-0052 concentrations used for TRAIL sensitization wer

258 The NPI-0052-induced sensitization to TRAIL involved activat

259 re was a significant correlation between the NPI score and more sophisticated tests of ToM in the fvF

260 Another NLS activity not mediated by the NPI binding sites is associated with noncontiguous seque

261 pha5 and alpha6, which together comprise the NPI-1 subfamily of karyopherin alphaS.

262 antine treatment had no effect on either the NPI (mean difference 2.2, 95% CI -3.9 to 8.3, p=0.47) or

263 For the NPI, reductions between 1.5 m w.e. (RCP2.6) and 1.9 m w.

264 dness plan were more likely to implement the NPI guidelines recommended by NYC public health official

265 e was found from baseline to 6 months in the NPI apathy score in those receiving methylphenidate comp

266 mbined with parameters currently used in the NPI.

267 lymph node stage, and Ki-67 LI, but not the NPI score.

268 20% in the United States at the start of the NPI period.

269 erase inhibitors improved 1.72 points on the NPI (95% confidence interval [CI], 0.87-2.57 points), an

270 and caregiver distress scores but not on the NPI agitation subscale, ADLs, or in less use of rescue l

271 sychiatric symptoms, based on ratings on the NPI in the previous month and from the onset of cognitiv

272 As susceptibility increases over the NPI period, we find that substantial outbreaks of RSV ma

273 specific domains on the NP that bind to the NPI proteins.

274 24 (eVP24) involves its interaction with the NPI-1 subfamily of karyopherin alpha (KPNA) nuclear tran

275 egarding schools' ability to implement these NPIs during an influenza outbreak.

276 otherwise small additional lifting of these NPIs can lead to dramatic increases in infections, hospi

277 We estimated the effectiveness of these NPIs, which range from limiting gathering sizes and clos

278 ed that each VP24 binds to each of the three NPI-1 KPNAs.

279 d RESTV VP24 (rVP24) interactions with three NPI-1 subfamily KPNAs (KPNA1, KPNA5, and KPNA6).

280 ndividuals living in a county with all three NPIs in place, the odds of having anti-N antibodies were

281 TKRSxxxM, which are required for binding to NPI-1 and NPI-3, respectively.

282 II interferon (IFN) signaling by binding to NPI-1 subfamily karyopherin alpha (KPNA) nuclear import

283 d significant improvement on the CMAI, total NPI, and caregiver distress scores but not on the NPI ag

284 Primary endpoints were the change in total NPI score and clinical global impression of change (CGIC

285 ymptoms of dementia as measured by the total NPI score at 12 months (mean difference, -5.6; P = .01)

286 l respondents (99%) implemented at least two NPIs.

287 ore accurate forecast of disease spread when NPIs are partially loosened and gives policymakers bette

288 A key public health question is whether NPIs could continue to be implemented long term to reduc

289 outbreak, provided they maintain widespread NPIs, continue testing, and take measures to protect the

290 mortality was significantly associated with NPI (aOR, 3.86; 95% CI, 1.12-13.28; P = .032) and a high

291 Treatment of PC-3 and Ramos cells with NPI-0052 (</=2.5 nM) and TRAIL sensitizes the tumor cell

292 tocols evaluating lenalidomide together with NPI-0052 to improve patient outcome in MM.

293 rotocols evaluating bortezomib together with NPI-0052 to improve patient outcome in MM.

294 in Jurkat and CLL primary cells treated with NPI-0052, alone or in combination with various HDACi (MS

295 Cell treatment with NPI-0052 induced E-cadherin and inhibited Snail expressi

296 in vitro activities, biweekly treatment with NPI-0052 lessened total white blood cell (WBC) burden ov

297 g sharp declines in 2020 that coincided with NPIs related to the coronavirus disease 2019 pandemic.

298 High vaccination coverage (90%) coupled with NPIs reduces cumulative infections to 2-54%.

299 een used to characterize viral kinetics with NPIs.

300 Cotransplantation of human MSCs with NPIs demonstrated a beneficial metabolic effect likely a