ライフサイエンスコーパス: NTD

1 NTDs are associated with hyperglycemia-induced protein m

2 NTDs are the most common birth anomaly of the CNS.

3 NTDs have been included within the Sustainable Developme

4 NTDs have been reported among infants born from women ta

5 e variants of the 3 enzymes in liver from 14 NTD and 16 non-NTD fetuses.

6 n; North America, 1998-2015), mothers of 164 NTD cases and 2,831 nonmalformed controls completed food

7 indings in cord blood from pregnancies of 41 NTD fetuses compared with 21 fetuses with polymalformati

8 ural and biological properties of the TDP-43 NTD, indicating that the NTD must be stably folded for T

9 temperature conditions, we show that TDP-43(NTD) is thermodynamically stable, well-folded and underg

10 s to target the elimination and control of 5 NTDs-lymphatic filariasis, trachoma, onchocerciasis, sch

11 the subsequent negative feedback by AcrIIA1(NTD) is required for optimal phage replication, even in

12 Finally, we identify AcrIIA1(NTD) homologs in other Firmicutes and demonstrate that t

13 Here, we report that the AcrIIA1(NTD) is a critical transcriptional repressor of the stro

14 Although NTD risks may be higher with dolutegravir than efavirenz

15 evealed by a point mutation identified in an NTD-affected individual that results in functionally imp

16 etaine had approximately half the risk of an NTD-affected pregnancy (odds ratio = 0.49, 95% confidenc

17 X-ray structure determination revealed an NTD consisting of two jelly-roll domains interacting acr

18 alog from the same organism, we show that an NTD-CTD heterodimer forms when the domains are expressed

19 rganelle stress and apoptosis, leading to an NTD reduction.

20 ders and strengthen the link between PCP and NTD.

21 The AR NTD is the primary site for coactivator recruitment.

22 en of major global health conditions such as NTDs.

23 dded with EFV unless dolutegravir-associated NTD risk was 1.5% or greater.

24 eracts directly with the membrane-associated NTD, which serves as both a membrane anchor and an allos

25 ach is a causative factor for the associated NTD.

26 By 2017, more than 2.3 billion NTD treatments had been delivered to at-risk populations

27 S1 protein kinase, which phosphorylated both NTD and CTD.

28 and the assessment of receptor occupancy by NTD modulators.

29 ns support the conclusion that the HTLV-1 CA NTD can functionally replace the HIV-1 CA CTD, but the H

30 y replace the HIV-1 CA CTD, but the HIV-1 CA NTD cannot replace the HTLV-1 CA CTD, indicating that th

31 highlighting the importance of the HTLV-1 CA NTD in HTLV-1 immature particle morphology.

32 re, chimeric Gag proteins with the HTLV-1 CA NTD produced particles phenotypically similar to HTLV-1

33 d that Gag proteins with a chimeric HIV-1 CA NTD/HTLV-1 CA CTD did not result in Gag oligomerization

34 The N-terminal and C-terminal domains of CA (NTD and CTD, respectively) engage in both homotypic and

35 ults demonstrate that GPR161 mutations cause NTDs via dysregulation of Shh and Wnt signaling in mice,

36 CDC73-NTD contains an extended hydrophobic groove on its surfa

37 ome are located in the region encoding CDC73-NTD.

38 of some of the most stigmatising and chronic NTDs, with subsequent under-representation within NTD pr

39 d to deliver a sterol to a tunnel connecting NTD to the luminal membrane leaflet 50 angstrom away.

40 g, but amino acid substitutions of conserved NTD residues compromised drug resistance.

41 se embryos display a fully-penetrant cranial NTD.

42 rminal and C-terminal catalytic domains (Cre(NTD) and Cre(Cat)) to be structurally independent.

43 We solved the structure of an A55BB/Cul3-NTD complex from anisotropic crystals diffracting to 2.3

44 -affinity interaction between A55BB and Cul3-NTD suggests that, in addition to directing the Cul3-RIN

45 resemble the structures of cellular BTB/Cul3-NTD complexes, despite low sequence identity between A55

46 directly to the Cul3 N-terminal domain (Cul3-NTD), forming a 2:2 complex in solution.

47 ng motif, reduced affinity of A55BB for Cul3-NTD by at least 2 orders of magnitude.

48 structural similarity, the affinity of Cul3-NTD for A55BB was stronger than for cellular BTB protein

49 ermore, treatment with PBA in vivo decreases NTD rate in the embryos of diabetic mice, as well as Cas

50 ied separate amino acid clusters in the Ded1-NTD required for binding to eIF4A or eIF4E in vitro.

51 aine, and methionine and neural tube defect (NTD) outcomes among mothers meeting the folic acid recom

52 c acid-responsive neural tube birth defects (NTDs).

53 axial midline, neural tube closure defects (NTDs) arose and dorsal extension was compromised.

54 Neural tube defects (NTDs) are a group of severe congenital malformations cau

55 cell polarity (PCP) and neural tube defects (NTDs) are linked, with a subset of NTD patients found to

56 Neural tube defects (NTDs) are the most severe congenital malformations of th

57 kout (dKO) mice display neural tube defects (NTDs) coupled with reduced proliferation and precocious

58 Tsepamo study reported neural tube defects (NTDs) in 4 of 426 (0.94%) infants of women receiving pre

59 rly pregnancy can cause neural tube defects (NTDs) in embryos by perturbing protein activity, causing

60 morphic mutations cause neural tube defects (NTDs) in mouse models.

61 h an increased risk for neural tube defects (NTDs) in newborns if used by women at conception.

62 ls of folate-responsive neural tube defects (NTDs) indicate that impaired de novo thymidylate (dTMP)

63 The risk of neural tube defects (NTDs) is influenced by nutritional factors and genetic d

64 Neural tube defects (NTDs) represent a failure of the neural plate to complet

65 n prevents up to 70% of neural tube defects (NTDs), which result from a failure of neural tube closur

66 (NT) closure result in neural tube defects (NTDs).

67 We designed NTD-CTD hybrid proteins, and hybrid res sites containing

68 well established neglected tropical disease (NTD) programs have seen great progress towards disease c

69 ale anthelmintic neglected tropical disease (NTD) screening campaign is the result of a partnership b

70 entions against neglected tropical diseases (NTD), including lymphatic filariasis (LF), scaled up dra

71 Neglected tropical diseases (NTDs) are increasingly recognised as major drivers of ps

72 The concept of neglected tropical diseases (NTDs) emerged more than a decade ago and has been recogn

73 malaria and the neglected tropical diseases (NTDs) kill more than 800,000 people annually, while crea

74 ) established a neglected tropical diseases (NTDs) program to support the scale-up of integrated plat

75 hocerciasis are neglected tropical diseases (NTDs) targeted for elimination by mass (antifilarial) dr

76 2030 goals for neglected tropical diseases (NTDs).

77 ation (MDA) for neglected tropical diseases (NTDs).

78 In conclusion, the disordered NTD of HSPB6 helps regulate the size and stability of he

79 domains, an N- terminal DNA binding domain (NTD) and a C- terminal motor domain (CTD).

80 consisting of an N-terminal effector domain (NTD) and a C-terminal regulatory domain (CTD); a caroten

81 domain (CTD), an N-terminal effector domain (NTD) and a ketocarotenoid; the chromophore spans the two

82 , while the isolated N-terminal FinO domain (NTD) of ProQ specifically recognized RNAs with Rho-indep

83 te (NMDA) receptor GluN2B N-terminal domain (NTD) aims for the treatment of various neurologic diseas

84 nsists of a non-catalytic N-terminal domain (NTD) and a catalytic C-terminal domain (CTD) connected b

85 ble linker connecting the N-terminal domain (NTD) and C-terminal domain (CTD) of AhpF suggests that t

86 oles of the HTLV-1 CA amino-terminal domain (NTD) and CA CTD in particle biogenesis, we generated and

87 he contributions of Nbr's N-terminal domain (NTD) and exonucleolytic domain (EXO) in miRNA 3'-end tri

88 stigate the role of Tau's N-terminal domain (NTD) and proline-rich region (PRR) in regulating interac

89 A disordered N-terminal domain (NTD) and structured C-terminal domain are essential for

90 A tunnel connecting the N-terminal domain (NTD) and the transmembrane sterol-sensing domain (SSD) w

91 TDP-43's N-terminal domain (NTD) is important for these activities and dysfunctions;

92 periments showed that the N-terminal domain (NTD) is intrinsically disordered and binds presequence n

93 n of its highly conserved N-terminal domain (NTD) is unknown.

94 on of the membrane-distal N-terminal domain (NTD) layer.

95 r(64), and Tyr(86) in the N-terminal domain (NTD) of beta-catenin.

96 wing that for WT p97, the N-terminal domain (NTD) of each subunit can exist in either a down (ADP) or

97 along an interface at the N-terminal domain (NTD) of human MCU that is a hotspot for post-translation

98 The N-terminal domain (NTD) of nsp11 was responsible for STAT2 degradation and

99 Here, we report that the N-terminal domain (NTD) of RAD52 devoid of the potential mediator function

100 crystal structure of the N-terminal domain (NTD) of the A subunit of the Bacillus megaterium GerK(3)

101 The N-terminal domain (NTD) of the GluN1 subunit (GluN1-NTD) is important for N

102 itis virus (MHV) uses its N-terminal domain (NTD) of the viral spike (S) protein to bind the host rec

103 te the impact of the PHF1 N-terminal domain (NTD) on the Tudor domain interaction with the nucleosome

104 The spidroin N-terminal domain (NTD) plays a pivotal role in this process: it polymerize

105 BILBO1's N-terminal domain (NTD) plays an essential role in T. brucei FPC biogenesis

106 NCR1 has its N-terminal domain (NTD) positioned to deliver a sterol to a tunnel connecti

107 Here, we show that Cet1's N-terminal domain (NTD) promotes the recruitment of FACT (facilitates chrom

108 ily DinF suggest that the N-terminal domain (NTD) supports substrate and ion binding.

109 o differ substantially at N-terminal domain (NTD) surfaces involved in dimerization and synapse assem

110 that AsfvLIG has a unique N-terminal domain (NTD) that plays critical roles in substrate binding and

111 Interactions of the Ded1 N-terminal domain (NTD) with eIF4A, and Ded1-CTD with eIF4G, subunits of eI

112 equilibrium involving the N-terminal domain (NTD) with implications for the binding of certain adapto

113 the role/function of the N-terminal domain (NTD) within chromatin is yet unresolved.

114 ncludes a long disordered N-terminal domain (NTD), a phosphorylation motif around Ser16, and a core a

115 ognize a region of the AR N-terminal domain (NTD), including a FQNLF motif, that interacts with the A

116 hose directed against the N-terminal domain (NTD), indicating that both of these regions at the top o

117 We pinpointed critical N-terminal domain (NTD), NTD-nucleotide-binding domain 1 (NBD1) linker, NBD

118 ge between the disordered N-terminal domain (NTD), residues 23-45, and core of the caspase-6 structur

119 Using the NFAT5 N-terminal domain (NTD), which contains AD1, as a model, we demonstrate by

120 t the extracellular AMPAR N-terminal domain (NTD), which projects midway into the synaptic cleft, pla

121 ndent AF-1 located in its N-terminal domain (NTD).

122 e, strongly ssDNA binding N-terminal domain (NTD).

123 the distant AMPA receptor N-terminal domain (NTD).

124 s to an integral-membrane N-terminal domain (NTD); however, how the NTD activates the C-terminal cata

125 motif (MIM), both N- and C-terminal domains (NTD and CTD) of MAD1 also contribute to mitotic checkpoi

126 have shown that the sHSP N-terminal domains (NTDs), which have a high degree of intrinsic disorder, a

127 involving additional amino-terminal domains (NTDs).

128 Notably, the perturbed up/down NTD equilibrium in mutant subunits is partially restored

129 sh that, in the ADP-bound state, the up/down NTD equilibrium shifts progressively toward the up confo

130 -/-);Rpl24(Bst/+) compound mutants exhibited NTDs resembling those seen in Lin28a/b dKO mice.

131 The stably folded NTD also promotes dimerization, which is pertinent to th

132 h online data availability were analyzed for NTD reports for 4 integrase inhibitors (DTG, raltegravir

133 aluation of the safety of integrated MDA for NTDs.Clinical Trials Registration.

134 tal or familial disorders" were searched for NTDs.

135 harmacovigilance databases were searched for NTDs.

136 We also show that, while the free NTD oligomerizes, binding to Hsp70 increases its solubil

137 he decreased vitamin B-12 in cord blood from NTD pregnancies.

138 nsmembrane proteins using the purified GluN1-NTD protein as a bait, we identify Protocadherin 7 (PCDH

139 nal domain (NTD) of the GluN1 subunit (GluN1-NTD) is important for NMDA receptor structure and functi

140 n, but the interacting proteins of the GluN1-NTD are not well understood.

141 nt receptor occupancy of eliprodil, a GluN2B NTD modulator.

142 In contrast, greater NTD mobility imparted by the flop cassette acts as a mas

143 lecular dynamics simulations of different H1 NTD subtypes, we demonstrate that the NTD is completely

144 e show that the helical propensity of the H1 NTD is subtype-dependent and correlates with the experim

145 dues form a globularly folded domain (hCDC73-NTD).

146 ave determined a crystal structure of hCDC73-NTD at 1.02 A resolution, which reveals a novel protein

147 he folding of the hydrophobic core of hCDC73-NTD, while others such as the K34Q mutant reduce its the

148 e, we discuss current understanding of human NTD genetics, recent advances regarding potential mechan

149 rted any association between FKBP8 and human NTDs.

150 M that are known to be associated with human NTDs.

151 rgy landscape lead to significant changes in NTD conformation and adaptor binding.

152 on of Pax3, Alx1 and Alx3 genes was found in NTD SR-BI(-/-) embryos.

153 ed inactive isoforms of MS were increased in NTD livers.

154 of the remethylation pathway are involved in NTD risk.

155 Uncertainty in NTD risks and dolutegravir efficacy in resource-limited

156 s only is necessary and sufficient to induce NTDs.

157 hagy and ameliorating hyperglycaemia-induced NTDs.

158 n by methotrexate during neurulation induces NTDs by inhibiting folate interaction with its uptake sy

159 timulated by independent interactions of its NTD with eIF4E and eIF4A, and its CTD with eIF4G.

160 ll, our data establish that Nbr requires its NTD as a substrate recruitment platform to execute exonu

161 ficiency prevalence (RBC folate <748 nmol/L; NTD risk) in women decreased from 2007-2010 (23.2%) to 2

162 MAD1(NTD) and MAD1(CTD) also interacted with each other and w

163 Our results have uncovered that the MAD1(NTD) and MAD1(CTD) directly interact with each other and

164 For river blindness, a major NTD targeted for elimination, there is a long history of

165 of the B vitamin folic acid can prevent many NTDs.

166 Vangl2, Prickle, Wnt11) rescued Gsc-mediated NTDs.

167 previous crystal structure study of the MHV NTD/mCEACAM1a complex (G.

168 Flip variants promote moderate NTD movement, which establishes slower channel desensiti

169 gth (FL) IN or deletion of the outer monomer NTDs.

170 d even though it is exposed in the monomeric NTD.

171 tal pediatric deaths by 4400 because of more NTDs.

172 The mutated NTD is strongly stabilized and folds at the theoretical

173 tabilizer that exhibits both antiviral and N-NTD protein-stabilizing activities.

174 he MERS-CoV nucleocapsid protein (MERS-CoV N-NTD).

175 wed that 5-benzyloxygramine stabilizes the N-NTD dimers through simultaneous hydrophobic interactions

176 The NED, NTD, and CTD of the outer monomers are disordered in int

177 osmolytes, trehalose and sorbitol, the NFAT5 NTD undergoes a disorder-to-order shift, adopting higher

178 he 3 enzymes in liver from 14 NTD and 16 non-NTD fetuses.

179 is for cholesterol handoff from NPC2 to NPC1(NTD).

180 mbryos were detected in SR-BI(-/-) with NTD (NTD SR-BI(-/-)).

181 pinpointed critical N-terminal domain (NTD), NTD-nucleotide-binding domain 1 (NBD1) linker, NBD1, and

182 Further, the Nup133(NTD) contains a structurally conserved amphipathic lipid

183 ic CTD can bind carotenoid in the absence of NTD, and name this truncated variant the C-terminal doma

184 We thus addressed potential causality of NTD-associated Vangl1/2 mutations, from either mouse or

185 ted to the CTD catalytic site, consisting of NTD loop-1 and CTD loop-3.

186 Our results show positive cooperativity of NTD up/down equilibria between neighboring protomers, al

187 sults showed that energetics and kinetics of NTD self-assembly are highly conserved across spider spe

188 s autophagy in the forebrain and midbrain of NTD embryos.

189 utritional recommendations for prevention of NTD risk beside folate fortification or supplementation.

190 defects (NTDs) are linked, with a subset of NTD patients found to harbor mutations in PCP genes, but

191 n of the developmental and genetic causes of NTDs.

192 was implemented, yet the genetic drivers of NTDs in humans, and the mechanisms by which folic acid p

193 sively investigated, the genetic etiology of NTDs remains poorly understood.

194 ing the scope of the mental health impact of NTDs and the innovative practice emerging in this area.

195 ns, a dramatic reduction in the incidence of NTDs was observed in areas where the policy was implemen

196 nal segment of P (P N-terminal disordered [P(NTD)]) to perform polymerase activity.

197 no assigned function, binds a component of P(NTD) We further show that this interaction is a positive

198 omain of L and the N-terminal domain of P (P(NTD)) is missing.

199 eltaproteobacterium, including a periplasmic NTD fused to the conventional ligand-binding domain (LBD

200 involving Ca(2+) modulation and periplasmic NTDs.

201 posterior sites, thus leading to a posterior NTD.

202 Fkbp8-/- mouse embryos showed posterior NTDs consistent with a diagnosis of spina bifida (SB).

203 tocopherol dietary supplementation prevented NTD almost completely (from 54% to 2%, p < 0.001) in SR-

204 by folate and lead to new ways of preventing NTDs.

205 ts showed that tight RNA binding by the ProQ NTD required a terminator hairpin of at least 2 bp prece

206 In summary, these data suggest that the ProQ NTD specifically recognizes 3' intrinsic terminators of

207 RNAs to the Hfq protein, but not to the ProQ NTD.

208 PyoS2(NTD) induces unfolding by TonB1 of a force-labile portio

209 Mimicry leads to fluorescently labeled pyoS2(NTD) being imported into FpvAI-expressing P. aeruginosa

210 ure of the N-terminal domain of pyoS2 (pyoS2(NTD)) bound to FpvAI (Kd = 240 pM) reveals that the pyoc

211 We show that RAD52 NTD forms nuclear foci upon DNA damage in BRCA-deficient

212 hermore, we show that mutations in the RAD52 NTD that disrupt these activities fail to maintain viabi

213 -notably when consumed together-might reduce NTD risk.

214 The N-terminal 640 residues (NTD) of FIP200 interact with the C-terminal IDR of ATG13

215 mixtures of wild-type Tn3 and Bart resolvase NTD dimers are recombination-defective, but activity can

216 a specific "R" interface involving resolvase NTDs at all three dimer-binding sites in res.

217 expression is causative in folate-responsive NTDs.

218 Absence of Cet1's NTD decreases FACT targeting to ADH1 and consequently re

219 , our results support the notion that Cet1's NTD promotes FACT targeting to the active gene independe

220 group of highly conserved residues on ProQ's NTD as the primary face for in vivo recognition of two R

221 Six NTDs were identified for DTG across the pharmacovigilanc

222 perhaps also contributing to caudal specific NTDs.

223 resent in the hydrophobic core of a spidroin NTD from a nursery web spider's dragline silk to leucine

224 Here we analyze sequences of spidroin NTDs and find an unusually high content of the amino aci

225 rt the comparative investigation of spidroin NTDs originating from the major ampullate glands of the

226 STAT2 degradation and interacted with STAT2 NTD and the coiled-coil domain.

227 Here, we studied NTD mutations designed to destabilize its structure util

228 rom resolution crystal structure of TbBILBO1-NTD, which revealed a conserved horseshoe-like hydrophob

229 close the binding site of TbFPC4 on TbBILBO1-NTD, which may provide a basis for rational drug design

230 no terminal extension (NED), amino terminus (NTD), catalytic core (CCD), and carboxyl terminus domain

231 The NTD forms insoluble aggregates through an arginine/tyros

232 The NTD was functionally complemented by low-complexity regi

233 The NTD-core domain of Aedes aegypti Nbr adopts a HEAT-like

234 At pH 5.5, the NTD exhibits two conformations, suggesting the motion fo

235 ositions have been identified that alter the NTD equilibrium; these lie in specific regions that loca

236 esidues in the hexamer central pore, and the NTD-CTD linker region, are well defined.

237 ns, including increased contacts between the NTD and classic LBD agonist-binding sites.

238 ight be an absence of cross talk between the NTD and CTD during conformational changes of the S prote

239 d that direct interactions occur between the NTD and the CTD.

240 s that localize to the interface between the NTD and the D1 nucleotide-binding domain of the complex.

241 ubstrate-binding platform encompassed by the NTD and the 240's region (containing residues 236-246),

242 Hexameric turrets formed by the NTD decorate the majority of the capsid surface.

243 rain was blocked in vitro and in vivo by the NTD modulators Ro-25-6981 and eliprodil.

244 between the PRR and MTBR are reduced by the NTD through a conserved conformational ensemble.

245 AR anchoring mechanism that is driven by the NTD.

246 to H3K36me3, is dramatically enhanced by the NTD.

247 ns of Jak3 interacted with beta-catenin, the NTD domain of beta-catenin facilitated its interactions

248 olyte-induced more ordered conformation, the NTD interacts with several proteins, including HMGI-C, w

249 TG13:ATG101 HORMA dimer does not contact the NTD.

250 the CTD catalyzes cytosine deamination, the NTD is believed to provide additional affinity for ssDNA

251 This phosphorylation decreased the NTD:CTD interaction and also CTD's interaction with MPS1

252 mild L28A mutation severely destabilized the NTD, drastically reducing TDP-43's in vitro splicing act

253 ne N-terminal domain (NTD); however, how the NTD activates the C-terminal catalytic domain is unclear

254 rative deletion mapping to elucidate how the NTD of HSPB6 influences its preferential association wit

255 triction assays identify R24, located in the NTD loop-1, as essential to a critical interaction with

256 previously named the helical hairpin in the NTD of DnaB altered the conformation of the helical hair

257 at Ile-85 is located at the interface in the NTD of DnaB that contacts primase.

258 interface between the two subdomains in the NTD of GR A subunits serves as the germinant binding sit

259 unctionally important regions, including the NTD beta-hairpin, the cyclophilin A-binding loop, residu

260 ground state and translocates fully into the NTD upon illumination.

261 pose that a concerted movement involving the NTD, C-terminal NADH, and FAD domains, and the flexible

262 Receptors lacking the NTD exhibit increased mobility in synapses, depress syna

263 hich stably associated only with C-MAD2, the NTD and CTD in MAD1 surprisingly bound both O- and C-MAD

264 Moreover, the NTD appears to negatively regulate tubulin-binding inter

265 ease mutants by shifting the position of the NTD back to its wild-type location.

266 Finally, stabilization of the NTD by G29P had almost no effect on pH-independent RIS i

267 We have solved the crystal structures of the NTD core and EXO domains of Nbr, both in the apo-state.

268 Cryo-EM of the NTD dimer revealed a structural similarity to the scaffo

269 a S2 cells confirmed a principal role of the NTD in exonucleolytic miRNA trimming, which depends on b

270 experiments revealed a potential role of the NTD in recruiting Nbr to Argonaute-bound small RNA subst

271 es predominantly from reconfiguration of the NTD-CTD and CTD trimer interfaces.

272 ting from clustering of point charges on the NTD surface required for function.

273 Stabilizing the NTD-Hsp70 interaction with small molecules reduces AR ag

274 e mutant involving an R155C substitution the NTD equilibrium can be shifted back to its wild-type pos

275 t targets the RBD, a second that targets the NTD, and a third that bridges two separate RBDs showed t

276 ent H1 NTD subtypes, we demonstrate that the NTD is completely unstructured in solution but undergoes

277 We show that the NTD is partially ordered when it is natively attached to

278 rties of the TDP-43 NTD, indicating that the NTD must be stably folded for TDP-43's physiological fun

279 demonstrate by biophysical methods that the NTD senses osmolytes and hypertonicity, resulting in sta

280 ecognition of two RNAs, and propose that the NTD structure serves as an electrostatic scaffold to rec

281 This model demonstrated that the NTD was rotated 90 degrees relative to the CTD along the

282 uggests A3G securely binds ssDNA through the NTD, while the CTD samples and potentially deaminates th

283 carotenoid-binding proteins ancestral to the NTD and CTD.

284 es to shuttle electrons from the CTD via the NTD to AhpC.

285 anchor Tim44 to the translocon, whereas the NTD is a dynamic arm, interacting with multiple componen

286 ndings support a model mechanism wherein the NTD mediates allosteric coupling to ion gradients throug

287 re-loop in NBD1, which collaborates with the NTD and NBD1 tyrosine-bearing pore-loop to drive protein

288 e ULK1 EAT domain interacts loosely with the NTD dimer, while the ATG13:ATG101 HORMA dimer does not c

289 he relationship of ligand binding within the NTD to the drug resistance mechanism of the H(+)-depende

290 substrate affinity was unperturbed in these NTD variants.

291 e display "super-activity" and resistance to NTD-mediated allosteric modulators.

292 l trials but have not been widely applied to NTDs, where their resource-saving payoffs could be highl

293 ) impairs neural tube formation and leads to NTDs.

294 We uncovered NTD residues in the loop between helices A1 and A2 that

295 To understand NTD functional dynamics in biologically relevant p97 het

296 Accordingly, SDG-associated and WASH-NTD indicators have been developed, commencing important

297 ne variant of GIF exon 3 was associated with NTD risk.

298 ylation pathway as hallmarks associated with NTD risk.

299 /-) embryos were detected in SR-BI(-/-) with NTD (NTD SR-BI(-/-)).

300 tal and physical health for individuals with NTDs.

301 with subsequent under-representation within NTD programmes.