ライフサイエンスコーパス: NTP

1 NTP binding to this site could promote high-fidelity pro

2 NTP hydrolysis by ABCE1 is stimulated by post-TCs and is

3 NTP induced deactivation of NF-kappaB in SCCQLL1 cells,

4 NTP's research was key to the nation's first-ever drinki

5 NTP-assisted methane (CH4 ) oxidation over Pd/Al2 O3 was

6 including downstream promoter opening, +1+2 NTPs binding, and the rate of 2-mer synthesis.

7 E. coli QueD catalyzes the conversion of H(2)NTP to 6-carboxy-5,6,7,8-tetrahydropterin (CPH(4)).

8 nvert 7,8-dihydroneopterin triphosphate (H(2)NTP) to 6-pyruvoyltetrahydropterin (PPH(4)) in biopterin

9 Ps at frequencies of around one error per 30 NTPs polymerized, making it one of the least accurate po

10 -assembled monolayer of 4-nitrothiophenol (4-NTP) and further converting it to form a hydroxylaminoth

11 k hydrogen bonds to efficiently polymerize a NTP.

12 Our data indicate that a NTP specific for the i + 2 template position can bind to

13 In addition, NTP increased the expression level of E-cadherin, and de

14 n CTP and efficiently polymerizes additional NTPs onto the tC.

15 oductive TL conformations that persist after NTP binding but can be reversed by the elongation factor

16 her, our metabolic analyses unveil the AICAR/NTP balance as a major factor of AICAR antiproliferative

17 on, metabolite profiling points to the AICAR/NTP balance as crucial for optimal utilization of glucos

18 of corona applied, CF(2)Br(2) reacts in air NTP via a common intermediate, the CF(2)Br radical.

19 Ozone, an important product of air NTP, was never detected in experiments with CF(2)Br(2) a

20 ugh both channels have enough space to allow NTP loading, the percentage of MD conformations containi

21 y Nun in a posttranslocated register allowed NTP binding and nucleotidyl transfer but inhibited pyrop

22 highly similar to enzymes from the all-alpha NTP phosphohydrolase superfamily.

23 en an "unfolded"/"open" state that allows an NTP substrate to enter the active center and a "folded"/

24 w in nucleotide addition, as suggested by an NTP soaking experiment.

25 lyzes reversible phosphoryl transfer from an NTP donor to a 5'-OH polynucleotide acceptor.

26 and bottom DNA strands, respectively, in an NTP-hydrolysis dependent reaction.

27 Estimates of annual tuberculosis burden and NTP performance indicators and control variables during

28 to investigate the influence of cannabis and NTP co-use on maturation.

29 maging outcomes associated with cannabis and NTP co-use.

30 studies, nonadult subjects; 3) cannabis and NTP group jointly considered; and 4) neurocognitive, str

31 and separation, translocation along DNA, and NTP loading to Pol II during elongation.

32 allosteric interactions between the DNA- and NTP-binding site prior to the cofactor hydrolysis step a

33 Allosteric interactions between the DNA- and NTP-binding sites of the Escherichia coli DnaB helicase

34 asons for the observed asymmetry in dNTP and NTP pools in WT hearts.

35 We observed that the dNTP and NTP pools in WT postnatal hearts are unexpectedly asymme

36 riboswitches can integrate both effector and NTP concentrations to generate a regulatory response app

37 s of the NIEHS's intramural, extramural, and NTP programs and establishing productive partnerships wi

38 ementarity, NTP ribo/deoxyribo identity, and NTP tri/di/monophosphate identity, and serves as a targe

39 rain phosphocreatine/inorganic phosphate and NTP/exchangeable phosphate were higher at 48 h in HT+M v

40 expanded 7-mer bubble positions the RNA and NTP analog UTPalphaS, while NT scrunches into an NT loop

41 ies by enhancing the turnover of the RNA and NTP substrates.

42 ndertaken using existing national survey and NTP data.

43 d; and we define effects of DNA topology and NTP concentration.

44 lable research on the co-use of cannabis and NTPs demonstrates a potential nicotine-related masking e

45 tes to the co-administration of cannabis and NTPs, despite the high prevalence rates of co-use in ado

46 is to changes in concentrations of ppGpp and NTPs.

47 y changes in the concentrations of ppGpp and NTPs.

48 bination with an ACB moiety are described as NTP delivery systems.

49 a broad and objective approach for assessing NTP's effectiveness, including methodological needs for

50 3 requires the binding and hydrolysis of ATP/NTP to translocate along and unwind double-stranded nucl

51 nd over 8000 studies including all available NTP carcinogenicity, short-term toxicity and genetic tox

52 nonorthologous replacement of the bacterial NTP:AdoCbi kinase (EC 2.7.7.62)/GTP:AdoCbi-P guanylyltra

53 ding non-native pyrimidine- and purine-based NTPs as well as non-native D- and L-sugars (both alpha-

54 ata reveals the functional interplay between NTP triphosphate moiety and base pair hydrogen bonding r

55 eraction with an amino acid sequence between NTP binding motifs A and B of 2C(ATPase).

56 in pol iota is able to discriminate between NTPs and dNTPs during DNA synthesis.

57 r 43% of the proteome can theoretically bind NTP ligands.

58 tin-labeled nucleotide triphosphates (biotin-NTPs) into the 3' end of nascent RNA.

59 ins that isomerize the triphosphate of bound NTP and two Mg(2+) ions from a preinsertion state to a r

60 oside triphosphate (NTP) binding followed by NTP incorporation/pyrophosphate release, quantitatively

61 accommodate the breadth of data produced by NTP, the CEBS data collection component is an integrated

62 ct dNTPs from a nucleotide pool dominated by NTPs.

63 The results show that with a cognate NTP, TL closing should be a spontaneous process.

64 of mismatch extension with the next cognate NTP in vitro.

65 r and is capable of binding the next cognate NTP.

66 apeutic potential of treatment that combines NTP and cetuximab in OSCC.

67 we report for the first time that combining NTP treatment with cetuximab led to inhibition of migrat

68 ovides a checkpoint for NTP complementarity, NTP ribo/deoxyribo identity, and NTP tri/di/monophosphat

69 of the NTPase domains to form two composite NTP phosphohydrolase sites.

70 e-ligand affinity chromatography, we confirm NTP binding to 47 different proteins, of which 4 are hyp

71 port the k(pol) and K(d) of all four correct NTP additions by T7 RNAP, which showed a range of values

72 On addition of the correct NTP to the T7 RNAP-DNA, 2-aminopurine fluorescence incre

73 replicative DNA helicase (DnaB) that couples NTP hydrolysis to 5' to 3' translocation.

74 tion-dependent catalytic incorporation of (d)NTP nucleotides into nucleic acids.

75 expression according to the abundance of (d)NTPs.

76 o be the most important checkpoint for deoxy-NTP discrimination.

77 esult advocates the feasibility of designing NTP/dNTP analogues by chemical substitutions to nucleoti

78 These interactions dictate NTP specificity.

79 The goal of this study is to develop dNTP/NTP analogues directly from nucleotides.

80 bind NS3h with similar affinities, but each NTP supports a different unwinding rate and processivity

81 on, the RPB9 deletion substantially enhances NTP misincorporation and increases the rate of mismatch

82 ymerases have evolved to efficiently exclude NTPs while copying long stretches of undamaged DNA.

83 A polymerase predicts that ACT also executes NTP selection thereby contributing to high transcription

84 pol iota incorporates and extends NTPs opposite damaged and undamaged template bases in a

85 with the non-template DNA strand facilitates NTP sequestration through interaction with the adjacent

86 losing and opening provides a checkpoint for NTP complementarity, NTP ribo/deoxyribo identity, and NT

87 asured by counting views of and requests for NTP's products by external stakeholders.

88 the secondary channel is the major route for NTP entry during Pol II transcription.

89 he "secondary channel" is the only route for NTP to reach the active site of the enzyme or if the "ma

90 MD conformations containing enough space for NTP loading through the secondary channel is twice highe

91 dNTPs in vitro, with a strong preference for NTPs, using Mn(2+) as a cofactor.

92 Such compounds formed NTPs with high selectivity by an enzyme-triggered mechan

93 nding properties and interacts with all four NTPs and both RNA and DNA.

94 A $1 per capita (general population) higher NTP budget (including domestic and external sources) was

95 e show that RppH binds and slowly hydrolyzes NTPs, NDPs and (p)ppGpp, which each resemble the 5'-end

96 on was decreased and/or when an imbalance in NTP concentration was introduced (situations that mimic

97 ith Mg(2+) and exhibits a marked increase in NTP incorporation and extension, and surprisingly, it al

98 m (NTP) began using GeneXpert instruments in NTP laboratories.

99 tive-center betaR1106 side chain involved in NTP positioning also strongly inhibited NDP-directed syn

100 ested that the terminal phosphate residue in NTP (not present in NDP) is important for positioning th

101 NS3 helicase domain plays critical roles in NTP-dependent RNA unwinding and translocation during vir

102 Increased investment in NTPs was significantly associated with improved performa

103 Crick base pair of template DNA and incoming NTP are critical for efficient incorporation, they are n

104 te upon binding of the next correct incoming NTP, which prevented further nucleotide addition.

105 ution of the base encoding the next incoming NTP and the base encoding the 3' end of the nascent RNA,

106 eotide could still bind to the next incoming NTP.

107 nt of the 3' end of the RNA and the incoming NTP in the active site is crucial for pausing.

108 het model for elongation, where the incoming NTP is able to bind in either the pre- or posttranslocat

109 ather than the interaction with the incoming NTP.

110 that are partially regulated by the incoming NTP.

111 luate the ability of pol iota to incorporate NTPs during DNA synthesis.

112 Because wild-type pol iota incorporates NTPs in a template-specific manner, certain DNA sequence

113 that T7 RNAP discriminates against incorrect NTP both at the nucleotide binding and incorporation ste

114 ion constant (K(d)) of correct and incorrect NTPs and their incorporation rate constants (k(pol)).

115 correct") and noncomplementary ("incorrect") NTPs and on the local sequence of the P/T DNA.

116 more, the compact conformation of inhibitory NTP identified in this study provides precise informatio

117 efficient +1+2 melting increases the initial NTPs Kms of the AG and AT promoters relative to AA or si

118 ndicate that the binding site for initiating NTP is located on p58C.

119 ketogenesis; (iv) depletion of intracellular NTPs; (v) accelerated purine biosynthesis and salvage; a

120 l Toxicology Program 1,408-compound library (NTP 1408, which contains 1,340 unique compounds) for the

121 alytically inactive conformer unable to load NTP substrate.

122 ed polymerase using 3'-deoxy- or 3'-O-methyl-NTPs as substrates.

123 Mismatched NTPs also lead to conformational changes in the active s

124 s, is hindered by the presence of mismatched NTPs.

125 Similarly, primase did not incorporate most NTPs containing hydrophobic bases incapable of Watson-Cr

126 However, above 400 muM [NTP], the concentration of lysine required to elicit tra

127 virus-1 primase misincorporates the natural NTPs at frequencies of around one error per 30 NTPs poly

128 orporation, it prevented binding of the next NTP and stimulated pyrophosphorolysis of the nascent tra

129 NIEHS/NTP BPA research investments made over the past 4 years

130 e workshop and discuss activities that NIEHS/NTP is undertaking to address research recommendations.

131 ranthenes (NFLs), mw 273 nitrotriphenylenes (NTPs), nitrobenz[a]anthracenes (NBaAs), nitrochrysene (N

132 P summary and conclusion data and larger non-NTP datasets.

133 The energy density of NVPF-NTP reaches up to 486 W h kg(-1) , which is higher than

134 The prepared NVPF-NTP exhibits two high working plateaux at about 4.01 and

135 f Na3 V2 (PO4 )2 O2 F nano-tetraprisms (NVPF-NTP) is proposed to enhance the energy density of SIBs.

136 of Ragone plots further discloses that NVPF-NTP presents the best power performance among the state-

137 c voltammetry at varied scan rates, the NVPF-NTP shows long-term cycle life, superior low-temperature

138 The approach identified awareness of NTP's work on CrVI by external stakeholders (proximal ou

139 ive center that is induced by the binding of NTP, which could slow down nucleotide addition cycles an

140 eholders (proximal outcome) and citations of NTP's research in scientific publications, reports, cong

141 ese results indicate that the combination of NTP with cetuximab can decrease invasiveness in cetuxima

142 With WT RdRp, increasing concentrations of NTP pools cause a gradual decrease in termination and th

143 of adenosine-binding residues as couplers of NTP hydrolysis to motor activity.

144 ng cDNA diminished the combination effect of NTP on invasion, migration and related signals.

145 inetic studies showed that the efficiency of NTP-mediated excision was highest with ATP.

146 In addition to the hydrolysis of NTP and NDP substrates, adenylate kinase activity was de

147 mechanism in which sequential hydrolysis of NTP causes a sequential 5' to 3' movement of the subunit

148 otential drug targets, the identification of NTP binding can directly facilitate structure-based drug

149 The effect of ssDNA on the kinetics of NTP hydrolysis depends on the type of nucleotide cofacto

150 n the DnaB-DnaC complex and the mechanism of NTP hydrolysis by the complex have been examined using t

151 ld be accounted for by molecular modeling of NTP/RNAP co-crystal structures.

152 ecA2 domains confirmed the essential role of NTP hydrolysis for DHX29's function in initiation and va

153 We use a set of NTP binding sub-structural motifs derived from a previou

154 Addition of NTPs, Mg(2+), and S-adenosylmethionine, which allows act

155 that can begin RNA synthesis upon binding of NTPs (nucleoside triphosphate).

156 , propose that template-dependent binding of NTPs in the main channel regulates RNA synthesis.

157 d migration into a concentration gradient of NTPs, resembling chemotaxis.

158 that RPB9 deletion promotes sequestration of NTPs in the polymerase active center just prior to the p

159 unwinding by T7 helicase using a variety of NTPs and their analogs.

160 er with structural analysis to shed light on NTP entry pathways.

161 the effect of non-thermal plasmas (NTPs) on NTP catalytic hybrid reactions; namely, modification or

162 L mobility, suppresses the effect of Rpb9 on NTP misincorporation, consistent with a role for Rpb9 in

163 all cellular transcription occurs using only NTPs.

164 m 4 muM to 1 mM, with specificity over other NTP molecules.

165 c residue allowed the accommodation of other NTPs, resulting in the preferential use of dATP and the

166 xposure to ATP alone in the absence of other NTPs.

167 to nonhuman primates resulted in persistent NTP levels in peripheral blood mononuclear cells (half-l

168 Nucleoside tri-phosphates (NTP) form an important class of small molecule ligands t

169 idation mechanisms in air nonthermal plasma (NTP) at room temperature and atmospheric pressure were i

170 hat non-thermal atmospheric pressure plasma (NTP) induces death of various cancer cells, including or

171 In this study, non-thermal plasma (NTP) is investigated as an innovative preparative analyt

172 o explain the effect of non-thermal plasmas (NTPs) on NTP catalytic hybrid reactions; namely, modific

173 The enzyme did not efficiently polymerize NTPs incapable of forming two Watson-Crick hydrogen bond

174 meric form and has the ability to polymerize NTPs as well as dNTPs in vitro, with a strong preference

175 A in the presence of pyrophosphate producing NTP.

176 s and nicotine and tobacco-related products (NTPs) during the adolescent years has harmful effects on

177 Nam's National Tuberculosis Control Program (NTP) began using GeneXpert instruments in NTP laboratori

178 ven these new data, the National TB Program (NTP), operating through a decentralized health system, i

179 y (EPA) and the National Toxicology Program (NTP) are collaborating to develop a risk-based approach

180 ces (NIEHS) and National Toxicology Program (NTP) have developed an integrated, multipronged, consort

181 In 2011, the National Toxicology Program (NTP) organized a workshop to assess the literature for e

182 Division of the National Toxicology Program (NTP) organized a workshop to evaluate the current state

183 l data from the National Toxicology Program (NTP) testing program and other depositors into a single

184 onducted by the National Toxicology Program (NTP).

185 However, 2-pyridone NTP and 4-methyl-2-pyridone NTP provided striking except

186 ever, 2-pyridone NTP and 4-methyl-2-pyridone NTP provided striking exceptions to this rule.

187 fied from the authentic olive oil reference, NTP treatments of 60min (Ar/O2 0.1%) on the oil batches

188 Addition of the remaining NTPs resulted in run-off transcription, with an efficien

189 of formation of RdRp-RNA binary and RdRp-RNA-NTP ternary complexes for the poliovirus RdRp, including

190 I'/I and J'/J, and the RNA polymerase (RNAp)/NTPs machinery.

191 H(F), the templates M'/M and N'/N, the RNAp/NTPs machinery, and the cell-free ribosome t-RNA machine

192 In 2013, Viet Nam's NTP implemented an Xpert MTB/RIF external quality assura

193 assessment of National Toxicology Program's (NTP's) effectiveness across multiple sectors and demonst

194 t role in the National Toxicology Program's (NTP) efforts to advance toxicology from a predominantly

195 ations, the effects of different active site NTPs in both open and closed trigger loop (TL) structure

196 into a hexagon, driven by the binding of six NTPs (or six nonhydrolyzable GTPgammaS analogues) that a

197 xistence of a noncatalytic template-specific NTP binding site in the main channel that is involved in

198 n was necessary at position 535 to stabilize NTP for efficient unwinding.

199 rd transcription in the presence of standard NTPs.

200 For validity and reliability studies, NTP apprentices and experts were asked to submit video-r

201 oying beta,gamma-bridging atom-'substituted' NTPs, we elucidate how the methylene substitution in the

202 e 2'-hydroxyl of both template and substrate NTP.

203 , with each monomer binding to one substrate NTP.

204 Compared with the natural RNAP substrates, NTPs, the K(m) of RNAP for NDPs was increased ~4-fold, w

205 ed a dose-dependent decrease in both (99m)Tc-NTP 15-5 and (18)F-FDG uptake ratios versus saline-treat

206 l results bring data in favor of the (99m)Tc-NTP 15-5 radiotracer for assessing, in vivo, cartilage r

207 me course of cartilage remodeling by (99m)Tc-NTP 15-5 scintigraphy, bone damages by (99m)Tc-hydroxyme

208 (99m)Tc-NTP 15-5 showed specific tracer accumulation within RA j

209 iethylammonium)-3-propyl-[15]ane-N5 ((99m)Tc-NTP 15-5) targeting proteoglycans has a pathophysiologic

210 otifs A-F coordinate the viral RNA template, NTPs and magnesium ions to facilitate nucleotide condens

211 otifs A-F coordinate the viral RNA template, NTPs, and magnesium ions to facilitate nucleotide conden

212 athway and uncouples establishment of key TH-NTP contacts from complete TH formation and clamp moveme

213 It was assumed that NTP-induced oxidation triggers unique lipid oxidation me

214 The NTP is an educational initiative by the National Cancer

215 The NTP-binding pocket of the protein was examined by random

216 ddition, we show that Archease can alter the NTP specificity of RtcB such that ATP, dGTP or ITP is us

217 pes incubated with GS-5734 in vitro, and the NTP acts as an alternative substrate and RNA-chain termi

218 vored by electrostatic repulsion between the NTP and the highly negatively charged backbones of nucle

219 The divalent metal bridging the NTP to NS3h also influences observed unwinding rates, wi

220 oduct 5' phosphate group is displaced by the NTP gamma phosphate and the local architecture of the ac

221 rick hydrogen bonding groups from either the NTP or templating bases varied from almost no effect to

222 ces on opposite sides of the protein for the NTP phosphate donor and a 5'-OH single-stranded oligonuc

223 It is however removed from the NTP processed gas by passage through a water scrubber re

224 and a "folded"/"closed" state that holds the NTP substrate in the active center.

225 However, the NTP did lead to an increase in the temperature of the Pd

226 However, the NTP only identified and commenced treatment for around 1

227 Here, we seek to identify the NTP binding proteome (NTPome) in M. tuberculosis (M.tb),

228 m (competition with UTP for occupancy of the NTP addition site) that differ from those of the RNAP in

229 the Watson-Crick base-pairing region of the NTP base and the nature of the functional groups attache

230 D, a region that forms the outer edge of the NTP entry channel where it may act as a nucleotide senso

231 caused by the impaired sequestration of the NTP substrate in the active center prior to catalysis.

232 ups attached to the 2' and 3' carbons of the NTP sugar.

233 nnels has revealed that the diffusion of the NTP through the main channel is greatly disfavored by el

234 Modifications to the 2' position of the NTP, including 2',3'-ddCTP, arabinose-CTP, and 2'-O-meth

235 identify the structural requirements of the NTP, we determined the efficiency of DNA unwinding by T7

236 its RNAP through a binding site on RNAP (the NTP addition site) and mechanism (competition with UTP f

237 rease the rate of RNA synthesis and that the NTP bound to this site can be shuttled directly into the

238 r, we now demonstrate biochemically that the NTP GTP is equally capable of activating SAMHD1, but GTP

239 Results from this study suggest that the NTP must be stabilized by specific interactions within t

240 te population was further increased when the NTP concentration was decreased and/or when an imbalance

241 abilized by specific interactions within the NTP-binding site of the protein to achieve efficient hyd

242 The inhibitory effects of the NTPs were more pronounced on authentic N-RNA with the ex

243 ine Guided Search tools that allow access to NTP summary and conclusion data and larger non-NTP datas

244 ith tyrosine reduced the binding affinity to NTP and the catalysis step.

245 for template binding; Trp-97 contributes to NTP binding and the catalysis step; and Trp-147 maintain

246 its weak binding affinity to PPi relative to NTP, suggesting a mechanism in which PPi is rapidly rele

247 In response to NTP binding, the TL undergoes large conformational chang

248 iate, distal) and applied retrospectively to NTP's research on hexavalent chromium (CrVI).

249 d with sunflower oil (1-3%) and submitted to NTP treatment.

250 tive mechanism of inhibition with respect to NTPs found previously [Mukhopadhyay J, Sineva E, Knight

251 is partially noncompetitive with respect to NTPs.

252 small library of nucleotide-5'-triphosphate (NTP) analogues and use them to prepare 33 2'3'CDNs.

253 mplex RNAs using nucleoside 5'-triphosphate (NTP) substrates.

254 ift for incoming nucleoside 5'-triphosphate (NTP), thus compromising nucleotide addition.

255 disclose a study on nucleoside triphosphate (NTP) analogues in which the gamma-phosphate is covalentl

256 teps, TL folding on nucleoside triphosphate (NTP) binding followed by NTP incorporation/pyrophosphate

257 but not a Walker A nucleoside triphosphate (NTP) binding motif mutant, induced (i) MPB labeling of C

258 atases (NTPases) or nucleoside triphosphate (NTP) binding proteins.

259 A PrgJ nucleoside triphosphate (NTP) binding site mutation (K471E) slightly diminished A

260 ires only an intact nucleoside triphosphate (NTP) binding site within the Rep proteins, indicating th

261 ologically relevant nucleoside triphosphate (NTP) concentrations.

262 We developed a nucleoside triphosphate (NTP) delivery system (the TriPPPro approach), in which t

263 ryl transfer from a nucleoside triphosphate (NTP) donor to a 5'-OH polynucleotide acceptor, either DN

264 template tunnel or nucleoside triphosphate (NTP) entry tunnel and the exterior of the protein, sugge

265 e P-loop-containing nucleoside triphosphate (NTP) hydrolase superfamily.

266 r competes with the nucleoside triphosphate (NTP) in the active center.

267 acologically active nucleoside triphosphate (NTP) is efficiently formed in multiple human cell types

268 usion routes of the nucleoside triphosphate (NTP) substrate through the main channel might overlap wi

269 incorporate correct nucleoside triphosphate (NTP) substrates with high efficiency and fidelity.

270 tion of the matched nucleoside triphosphate (NTP), catalysis of transcription elongation, and translo

271 At low nucleotide triphosphate (NTP) concentrations, we observe good agreement between t

272 Elevated dNTP/nucleotide triphosphate (NTP) ratios in Deltalon cells protects them from deletio

273 n that contacts the nucleotide triphosphate (NTP) substrate to allow rapid nucleotide addition.

274 ent K(m) values for nucleotide triphosphate (NTP) use.

275 bioactive nucleoside analogue triphosphates (NTP).

276 the hydrolysis of nucleoside triphosphates (NTP).

277 polymerases for nucleoside-5'-triphosphates (NTPs) could help define the catalytic mechanisms for nuc

278 to investigate how nucleoside triphosphates (NTPs) fuel HCV helicase-catalyzed DNA unwinding.

279 Although nucleoside triphosphates (NTPs) have been seen only in the catalytic site and the

280 n of two bioactive nucleoside triphosphates (NTPs) in human hepatocytes.

281 is initiated using nucleoside triphosphates (NTPs) only.

282 nce of the cognate Nucleoside triphosphates (NTPs), Adenosine triphosphate (ATP) and Cytosine triphos

283 amydia imports ribonucleotide triphosphates (NTPs) but not deoxyribonucleotide triphosphates (dNTPs)

284 pending on the lipophilicity of the TriPPPro-NTP prodrugs against HIV-1 and HIV-2 replication in cult

285 Previous studies have uncovered NTP-mediated excision mechanisms that may be responsible

286 rgo any significant structural changes under NTP conditions.

287 nging to the AAA+ superfamily of ATPases use NTP hydrolysis to remodel their versatile substrates.

288 y, the polymerase elongation complex can use NTPs to excise the terminal nucleotide in nascent RNA.

289 that all transcription in cells occur using NTPs only (i.e., de novo).

290 y DNA-dependent RNA polymerases occurs using NTPs alone.

291 Various NTPs bind NS3h with similar affinities, but each NTP sup

292 o DNA typically followed RNApII binding, was NTP dependent, and was correlated with association of mR

293 The main benefits of WF-NTP relate to the high number of worms that can be asses

294 field-of-view nematode tracking platform (WF-NTP), which enables the simultaneous analysis of hundred

295 We compare the WF-NTP with other existing worm trackers, including those h

296 in the RNAP secondary channel, through which NTP substrates enter the RNAP active site, and stericall

297 site and does not sterically interfere with NTP binding, and we show that Cap inhibition is partiall

298 annel in a manner expected to interfere with NTP substrate binding, explaining the partial competitiv

299 energetic study based on MD simulations with NTP loaded in the channels has revealed that the diffusi

300 Studies with NTP analogs reveal that specificity is determined by the