ライフサイエンスコーパス: Native American

1 l populations (European, Asian, African, and Native American).

2 black, Asian/Pacific Islander, Hispanic, and Native American.

3 were Hispanic; 13, African; 8, white; and 2, Native American.

4 ncidence was highest in blacks and lowest in Native Americans.

5 landers than to any present-day Eurasians or Native Americans.

6 he Ainu and Polynesians than he is to modern Native Americans.

7 ia and were directly related to contemporary Native Americans.

8 tion directly ancestral to many contemporary Native Americans.

9 he primary sources of health problems facing Native Americans.

10 tics in the risk for substance dependence in Native Americans.

11 3.3 for Asian/Pacific Islanders and 3.1 for native Americans.

12 iberia and a possible homeland for ancestral Native Americans.

13 pe-specific invasive disease potential among Native Americans.

14 substantially lower for blacks, Asians, and Native Americans.

15 precise time estimates for the emergence of Native Americans.

16 amined in skeletal muscle of 153 nondiabetic Native Americans.

17 ssociation both in Finns and in Southwestern Native Americans.

18 ultimorbidity network followed by Whites and Native Americans.

19 scent populations but not among Europeans or Native Americans.

20 equency in modern Asians, Australasians, and Native Americans.

21 1 [0.021-0.022]; Asian: 0.037 [0.036-0.039]; Native American: 0.010 [0.0076-0.013]), lower quartile h

22 ents were black, 2% were Hispanic, 0.3% were Native American, 1% were Asian, and 90% were white, resp

23 Black (20.9% [95% CI, 20.8%-21.1%]), Native American (14.5% [14.2%-14.9%]), and Hispanic (13.

24 ), white (14.0% and 32.6%, respectively) and Native American (19.2% and 43.4%, respectively), respond

25 P < .001; Asian: 3.16 [2.68-3.73], P < .001; Native American: 2.11 [1.45-3.08], P < .001), lower hous

26 1%) and among non-Hispanic blacks (170%) and Native Americans (241%) compared to non-Hispanic whites

27 anics differed significantly from that among Native Americans (3.1% vs. 8.9%, P=0.01).

28 mong 27 705 past-year alcohol or drug users, Native Americans (31.5%), adolescents of multiple race/e

29 spanic whites, blacks (-30%), Asians (-19%), Native Americans (-42%), and Hispanics (-29%) all had lo

30 y, whereas the United States' population was Native American 500 years ago but is overwhelmingly Old

31 comparatively prevalent among adolescents of Native American (9.7%) and multiple race/ethnicity (8.8%

32 for blacks (95% CI, 50% to 62%), and 37% for Native American (95% CI, 17% to 58%).

33 ed Rapanui, we found statistical support for Native American admixture dating to AD 1280-1495 and Eur

34 t studies have reported genetic evidence for Native American admixture in present-day indigenous inha

35 ere we directly test the hypothesis that the Native American admixture of the current Rapa Nui popula

36 s from islands across Polynesia for signs of Native American admixture, analysing 807 individuals fro

37 errepresented minority (Black, Hispanic, and Native American) adolescents.

38 ed odds of substance-related disorders among Native Americans, adolescents of multiple race/ethnicity

39 A major factor for the population decline of Native Americans after European contact has been attribu

40 Zea mays ssp. mays) was the primary grain of Native American agricultural systems in the centuries pr

41 Second, this moderating pattern flips for Native Americans, Alaska Natives, Asians, and Hispanics,

42 anics, non-Hispanic blacks, and non-Hispanic Native American/Alaska Natives.

43 y, defined as self-reported black, Hispanic, Native American, Alaskan Native, Native Hawaiian, or Pac

44 Gene flow from the MA-1 lineage into Native American ancestors could explain why several cran

45 ely to have occurred after the divergence of Native American ancestors from east Asian ancestors, but

46 al DNA analyses have dated the separation of Native American ancestors from the Asian gene pool to 23

47 an Upper Palaeolithic Mal'ta population into Native American ancestors is also shared by the Anzick-1

48 e-way admixed between European, African, and Native American ancestries and provide an opportunity to

49 the recent mixing of African, European, and Native American ancestries, has resulted in different et

50 admixed population of African, European, and Native American ancestries, have the highest asthma prev

51 aving large proportions of both European and Native American ancestries.

52 nts of Mexican mestizos, namely European and Native American ancestries.

53 ohort (n = 1998) and evaluated the effect of Native American ancestry (NAA) and diet on biomarkers fo

54 th pancreatitis included genetically defined Native American ancestry (P < .001), older age (P < .001

55 apMap contain modest (but nonzero) levels of Native American ancestry (~0.4%).

56 d on chromosome 5q35.1, indicating that each Native American ancestry allele was associated with a 0.

57 nome-wide SNPs for predicting and estimating Native American ancestry and admixture levels.

58 ciation between local European, African, and Native American ancestry and BDR, adjusting for genomic

59 ombia harbor substantially more European and Native American ancestry as a result of their complex ad

60 s the ancestry, we showed that the choice of Native American ancestry could affect the local ancestry

61 ilobase in segments inferred to have diploid Native American ancestry from the genomes of Mexican and

62 Our data thus suggest that the Native American ancestry in contemporary Easter Islander

63 opulations to identify 324 highly predictive Native American ancestry informative markers (AIMs).

64 Here we show that Native American ancestry is associated with reduced heig

65 We demonstrated that the Tupiniquim Native American ancestry is not related to any extant Br

66 Furthermore, we estimate that 14 to 38% of Native American ancestry may originate through gene flow

67 segments than when they overlap European or Native American ancestry segments of the genome.

68 s the first study supporting the notion that Native American ancestry significantly contributes to NM

69 age, NMO patients had a higher proportion of Native American ancestry than controls (68.1% vs 58.6%;

70 ted the proportion of African, European, and Native American ancestry using genome-wide data.

71 t 18q21 in Latinos (P = 6.8 x 10(-6)), where Native American ancestry was associated with increased r

72 st significant peak was 6p21.32-p22.1, where Native American ancestry was associated with lower IgE l

73 Native American ancestry was associated with lower odds

74 of genomic variation that co-segregated with Native American ancestry was associated with risk of rel

75 .1) at which local African, European, and/or Native American ancestry was significantly associated wi

76 a genomic region (3p24.2) in which increased Native American ancestry was significantly associated wi

77 higher exposure to asparaginase, and higher Native American ancestry were independent risk factors f

78 hat any of these individuals had substantial Native American ancestry.

79 sociations with retinopathy were present for Native American ancestry; country of origin; health insu

80 Also, the observed low Native-American ancestry (6-8%) was mostly introduced in

81 eviously possible, we assembled data from 52 Native American and 17 Siberian groups genotyped at 364,

82 highlighting that CAEBV is not restricted to native American and Asian populations.

83 etected genome-wide patterns consistent with Native American and European admixture.

84 ntributions to the Mestizo FRDA gene pool by Native American and European genes were 76-87% and 13-24

85 are the result of two-way admixture between Native American and European populations or of three-way

86 n resulted from the admixture between mainly Native American and European populations, we used genome

87 s showing high frequency differences between Native American and European populations.

88 pulse into the Americas independent of both Native American and Inuit expansions.

89 abian ancestries, 2) Kalash ancestry, and 3) Native American and Northern European ancestries.

90 of ancestry-informative markers validated in Native American and other populations.

91 a calibrated sequence-based analysis of 222 Native American and relevant Eurasian Y chromosomes (24

92 udicial decisions that Kennewick Man was not Native American and that therefore NAGPRA did not apply.

93 e-grain intake was lowest among youth of the Native American and white races and among youth of high

94 4-h EE measures in 509 healthy subjects (368 Native Americans and 141 whites) while subjects consumed

95 which were spread throughout the Americas by Native Americans and adapted to a wide range of environm

96 ojects: newborn screening for SCID in Navajo Native Americans and B-cell reconstitution in patients w

97 sians, Asian Indians, African Americans, and Native Americans and did not differ by adiponectin assay

98 populations, particularly African Americans, Native Americans and Hispanic Americans, are disproporti

99 te to type 2 diabetes susceptibility in both Native Americans and the Old Order Amish.

100 in a second population-based sample of 3,723 Native Americans and the published DIAGRAM study.

101 were Asian/Pacific Islander, 63 (0.8%) were Native American, and 228 (2.8%) were other.

102 were Asian/Pacific Islander, 211 (0.5%) were Native American, and 2947 (6.3%) were other.

103 os, who typically inherit a mix of European, Native American, and African ancestry.

104 arkers in at least 232 new Latino, European, Native American, and African samples, and we selected a

105 recent (within the last 500 years) African, Native American, and European ancestry.

106 2 NASH was more common in children of Asian, Native American, and Hispanic ethnicity.

107 tive traits were analyzed in 536 nondiabetic Native Americans, and ASK1 expression was examined in sk

108 en OR = 0.75, 95% CI = 0.58-0.96; Hispanics, Native Americans, and whites showed no significant assoc

109 rn Siberia (such as the Koryaks), as well as Native Americans; and a Holocene migration of other East

110 ven to extinction in a blitzkrieg fashion by Native Americans approximately 13,000 years ago.

111 the recognized maternal founding lineages of Native Americans are at least 15, indicating that the ov

112 The ratio of ENKCL to PCTL-NOS among Native Americans, Asians/Pacific Islanders, and Hispanic

113 Hispanics, Asians and Pacific Islanders, and Native Americans at a higher risk than Whites of being d

114 ferences that include substantial numbers of Native American attendees.

115 e = 74.6%, range = 45.0%-96.7%), followed by Native American (average = 18.1%, range = 2.1%-33.3%) an

116 , with Pacific Islanders, Asian Indians, and Native Americans being considerably more prone to develo

117 ng White, African American, Asian, Hispanic, Native American, Bi- or Multi-racial and Pacific Islande

118 tury socioecological fire regimes, including Native American burning, postcontact disruption and nati

119 1775 CE)-reduced the self-limiting effect of Native American burns on fire spread.

120 en, the cumulative prevalence is 1 in 5; for Native American children, 1 in 7.

121 o improve science learning, especially among Native American children.

122 ent of the isolates in MCG-2 originated from Native American clinics, and 90% belonged to two PFGE ty

123 came from patients who were treated at five Native American clinics.

124 recovered from patients who were treated at Native American clinics.

125 eta (beta), and theta (theta) EEG power in a Native American cohort of 322 individuals to take advant

126 vide a unique genetics education program for Native American college and university students.

127 ical sites spanning approximately 3,500 y of Native American, colonial, and historical occupation.

128 MCG-2 strains spread to four additional Native American communities and 20 other communities.

129 g 242 individuals aged <6 months-78 years in Native American communities between 2007 and 2009.

130 at CA-MRSA in Wisconsin likely originated in Native American communities in the early 1990s and since

131 D) (all ages; years 1994-2007) isolates from Native American communities.

132 trains recovered from outpatients treated at Native American community clinics.

133 pes associated with an outbreak of MRSA in a Native American community in 1992.

134 curring metals in abandoned mine wastes in a Native American community in northeastern Arizona were i

135 c ancestry is Polynesian, with no detectable Native American component.

136 their last sex partner (African American and Native American).Conclusions.

137 rought forward supporting the possibility of Native American contact prior to the European "discovery

138 he northeast Asian affinities of present-day Native Americans contrast with a distinctive morphology

139 ded to compare the Inuit findings with other Native American data.

140 pean admixture, but also a contribution from Native Americans dating to 1280-1495 AD, demonstrating e

141 e-climate relationships were strongest after Native American depopulation-following mission establish

142 rn Eurasian genetic signatures in modern-day Native Americans derive not only from post-Columbian adm

143 Here we show that Native Americans descend from at least three streams of

144 genome-wide data to show that some Amazonian Native Americans descend partly from a Native American f

145 ociation was greater in Hispanic children of Native American descent (beta=2.3; P=0.004) than in non-

146 ts were replicated in a population sample of Native American descent (top hit rs1611115, P = 4.1 x 10

147 Native American discourse, in contrast, tends to describ

148 ter their arrival to the Americas, ancestral Native Americans diversified into two basal genetic bran

149 e American groups in South America than with Native Americans elsewhere, providing further support fo

150 ype (Finns, empirical P = .004; Southwestern Native Americans, empirical P = .02).

151 status epilepticus, older age, and Black and Native American/Eskimo race; patients admitted to a rura

152 specific ancestries (e.g. European, African, Native American, etc).

153 mixture mapping by comparing levels of local Native American, European, and African ancestry between

154 subcontinental source populations within the Native American, European, and African segments of the a

155 ean populations or of three-way admixture of Native American, European, and West African populations.

156 and potentially ancient substructure within Native American, European, and West African source popul

157 erica has been the site of ongoing mixing of Native Americans, European settlers, and Africans (broug

158 ction were both high information content for Native American/European ancestry (measured as the stand

159 We present 2 Native American families with a total of 5 affected pers

160 portionate contribution of European male and Native American female ancestry to present-day populatio

161 Native American fisheries were focused on nearshore oyst

162 ler regional freshwater bodies are important Native American fisheries.

163 onian Native Americans descend partly from a Native American founding population that carried ancestr

164 we focused our map on markers distinguishing Native American from other ancestries and restricted it

165 tes risk haplotype had a frequency of 50% in Native Americans from Mexico but was rare in Europeans a

166 Genetic Education for Native Americans (GENA) was a National Human Genome Rese

167 mixture of European mutant FRDA genes in the Native American gene pool that existed prior to contact

168 at this SNP was highly correlated with local Native American genetic ancestry (P = 1.8 x 10(-8)).

169 Although not significant, increasing Native American genetic ancestry appeared to account for

170 ven among Hispanics with stronger African or Native American genetic ancestry.

171 t across quartiles of European, African, and Native American genetic ancestry.

172 ionship and requested repatriation under the Native American Graves Protection and Repatriation Act (

173 pa Nui, between Polynesian individuals and a Native American group most closely related to the indige

174 Importantly, this Native American group showed a high degree of both HLA h

175 Among the Native American groups for whom genome-wide data are ava

176 istently indicated a single common origin of Native American groups from Central and South America.

177 uan individual shares more alleles with some Native American groups in South America than with Native

178 iously reported populations (including other Native American groups).

179 m 17 island populations and 15 Pacific coast Native American groups.

180 ad a higher incidence of AITL and ENKCL; and Native Americans had a lower incidence of PTCL-NOS (all

181 ith increased risk of ASD, as were Asian and Native American haplogroups A and M, with odds ratios ra

182 will probably increase extensively when all Native American haplogroups reach the same level of phyl

183 lience in oyster populations under long-term Native American harvest, sea-level rise, and climate cha

184 demographic impact of European contact with Native Americans has remained unclear despite recent int

185 teria for a substance-related disorder, with Native Americans having the highest prevalence of use (4

186 = 22), White (n = 23), Latino (n = 23), and Native American/Hawaiian (n = 1).

187 different selective pressures in determining Native American HLA diversity, we evaluated the relation

188 cept of unique African, European, Asian, and Native American HPV-16 variants.

189 a higher likelihood of pregnancy was seen in Native American (HR, 1.77; 95% CI, 1.33 to 2.36), Hispan

190 Water availability for Native Americans in the southwestern United States durin

191 ense variant (common only in East Asians and Native Americans) in MFSD12, a gene recently associated

192 ated with substance dependence phenotypes in Native Americans include OPRM1, CRN1, COMT, GABRA2, MAOA

193 found that the ancestors of all present-day Native Americans, including Athabascans and Amerindians,

194 t in the etiology of substance dependence in Native Americans, including studies of heritability, lin

195 ricana Medik.), once a staple food source of Native American Indians, produces protein-rich tubers, t

196 toric contact of Polynesian individuals with Native American individuals (around AD 1200) contemporan

197 r was generally greater among men, white and Native American individuals, younger and previously or n

198 ontrolled, randomised trial enrolled healthy Native American infants aged 6 months or younger who wer

199 etic relationship between Palaeo-Eskimos and Native American, Inuit, Yup'ik and Aleut populations rem

200 ewick Man, referred to as the Ancient One by Native Americans, is a male human skeleton discovered in

201 o Native American populations, although most Native Americans lack protective variants seen in other

202 oss between a wild sunflower and a primitive Native American landrace that has not been the target of

203 xposures for remaining groups (e.g., Asians, Native Americans, Latinos) are somewhat lower.

204 western Eurasians and near the root of most Native American lineages.

205 n highlanders (>3500 m) comparing them to 16 Native American lowlanders.

206 %; black, 12%; Hispanic, 12%; Asian, 4%; and Native American, < 1%) with neuroblastoma were included.

207 Follow-up data were available for 290 Native Americans (median follow-up time: 6.6 years).

208 ectional facilities, and among sports teams, Native Americans, men who have sex with men, and militar

209 heories (epistemological orientations) among Native Americans (Menominee) and European American child

210 Being female; Native American; middle-aged; widowed, separated, or div

211 In the 15th century, ~900,000 Native Americans, mostly Tupi speakers, lived on the Bra

212 ation in human STAC3 causes the debilitating Native American myopathy (NAM), but the nature of how St

213 AC3 is the genetic basis of the debilitating Native American myopathy (NAM).

214 ase variant in STAC3 that has been linked to Native American myopathy (NAM).

215 eas expression of Stac3W280S (containing the Native American myopathy mutation) partially restored Ca

216 ontrol subjects, n = 998) and one additional Native American (n = 2,531) sample.

217 further genotyped in independent samples of Native American (n = 3,723) and Old Order Amish (n = 486

218 was asserted that Kennewick Man was neither Native American nor closely related to the claimant Plat

219 such dynamics in 19th century, post-contact Native Americans on the western Great Plains is especial

220 The mutation was not carried by the three Native Americans or 360 patients from Asia or the Pacifi

221 ), Asian or Pacific Islander (OR, 3.51), and Native American (OR, 5.22) patients with candidemia were

222 ic white people, and men and women of Asian, Native American, or unkown race/ethnicity who are referr

223 ociated alleles within the HLA region are of Native American origin.

224 ted in both Finns (P = .01) and Southwestern Native Americans (P = .03).

225 Blacks (P < .001) and Native Americans (P = .04) had a higher prevalence of hi

226 nemic-euglycemic clamp among 536 nondiabetic Native Americans (P = 0.02).

227 5898099 was replicated in a second sample of Native Americans (P = 0.04, 1.22 [1.01-1.47]), while tha

228 nic blacks, Asians or Pacific Islanders, and Native Americans (P<0.05 for all comparisons) and that t

229 th populations (Finns, P = .01; Southwestern Native Americans, P = .008), and the GABRA6 1519T allele

230 gesic (mean, 7.4; 95% CI, 4.0-10.8) than non-Native American patients (mean, 11.2; 95% CI, 7.2-15.2;

231 score (mean, 6.5; 95% CI, 3.6-9.4) than non-Native American patients (mean, 8.1; 95% CI, 6.3-9.9; t3

232 inpatient mortality benefit was observed for Native American patients (n = 185; OR, 0.38 [95% CI, 0.1

233 Native American patients also received less postsurgical

234 A retrospective chart review of 21 Native American patients and a control group who underwe

235 Native American patients had a statistically lower numer

236 Medical staff attending Native American patients should be aware that response t

237 We noted that our Native American patients were less likely than others to

238 Black and Native American patients with neuroblastoma have a highe

239 for Asian patients, 0.95 (0.52 to 1.73) for Native American patients, and 0.95 (0.60 to 1.50) for pa

240 small population size and limited number of Native American patients, PTCL subtype frequencies in th

241 ce of gene flow from European or present-day Native American peoples, and Inuit living around Hudson

242 estry is not related to any extant Brazilian Native American population already studied, and thus the

243 ical data needed to assess the links between Native American population decline and ecological change

244 trically interviewed samples, a Southwestern Native American population sample (N = 433) and a Finnis

245 d little evidence of a recent contraction in Native American population size.

246 nome-wide patterns of African, European, and Native American population structure within and among Hi

247 ht, which likely occurred in a European or a Native American population.

248 e overall high prevalence of obesity in this Native American population.

249 groups and three chlorinated pesticides in a Native American population.

250 he Medieval Climate Anomaly (950-1250 CE) as Native American populations adopted intensive maize agri

251 thogen richness for a global dataset and for Native American populations alone.

252 f uniparentally inherited genetic systems in Native American populations and the comparison of these

253 groups as well as the most likely ancestral Native American populations as the ancestry, we showed t

254 Native American populations declined between 1492 and 19

255 g contact between prehistoric Polynesian and Native American populations has long intrigued researche

256 Pre-Columbian (pre-1492 CE), maize-dependent Native American populations in the midcontinental United

257 ancestors, but before the diversification of Native American populations in the New World.

258 Analyses of this dataset that focused on Native American populations revealed very strong cluster

259 available African, European, East Asian and Native American populations reveals strong genetic ties

260 ly, we find evidence of a deep divergence in Native American populations that predates the Anzick-1 i

261 etic diversity and distance from Africa when Native American populations were considered alone.

262 e not revealed any risk variants specific to Native American populations, although most Native Americ

263 ifferentiates them from other Aboriginal and Native American populations.

264 astigmatism were higher than reported in non-Native American populations.

265 influence the phenotypic variation in extant Native American populations.

266 n American (PR 1.86; 95% CI: 1.42-2.45), and Native American (PR 1.87; 95% CI: 1.48-2.35) race were i

267 , the differences between Paleoamericans and Native Americans probably resulted from in situ evolutio

268 included younger age, male gender, Black or Native American race, a higher burden of medical comorbi

269 d with increasing age, male sex, Asian race, Native American race, and symptoms of weight loss and vo

270 r additional Upper Palaeolithic Siberian and Native American related ancestry.

271 ost prevalent mtDNA haplogroups (African and Native American, respectively).

272 dependence were generally greater among men, Native Americans, respondents aged 18 to 44 years, those

273 g in the staggered abandonment of many major Native American river valley settlements and large urban

274 ), blacks (RR, 1.17; 95% CI, 1.03-1.33), and Native Americans (RR, 1.72; 95% CI, 1.07-2.77) had incre

275 se associations replicated in an independent Native American sample (1.19, P = 0.04, for rs11003125)

276 which results in SCID in Athabascan-speaking Native Americans (SCIDA).

277 Although Native Americans seem to be genetically most closely rel

278 n the earliest American skeletons and modern Native Americans, separate origins have been postulated

279 and demonstrating that southern Altaians and Native Americans share a recent common ancestor.

280 Subsequent gene flow resulted in some Native Americans sharing ancestry with present-day East

281 dence has a substantial genetic component in Native Americans, similar in magnitude to that reported

282 he maize-based agriculture practiced by many Native American societies in eastern North America at th

283 content) in either our global dataset or the Native American subset of the dataset.

284 Our reconstruction suggests that Native Americans suffered a significant, although transi

285 find that Kennewick Man is closer to modern Native Americans than to any other population worldwide.

286 changes in socioecological systems from the Native American to the current period drove shifts in fi

287 STC-2 added race (black/Native American) to STC-1 and identified 89% of cases wh

288 hern United States, including plants used in Native American traditional medicine.

289 e cannabis use disorder were higher for men, Native Americans, unmarried individuals, those with low

290 d haplotypes in a group of 218 Lacandon Maya Native American using a high-resolution next generation

291 that Y-chromosomal diversity among the first Native Americans was greater than previously recognized.

292 rom the admixture of Europeans, Africans and Native Americans, which started over 400 years ago and h

293 tance use is widespread among adolescents of Native American, white, Hispanic, and multiple race/ethn

294 nd genetically closely related to modern-day Native Americans, with no close affinity to east Asians.

295 regions of Europe, and forced relocation of Native Americans within the US.

296 wer rates of advanced cancer among Asian and Native American women persisted when the cohort was stra

297 omen were more likely than white, Asian, and Native American women to have large, advanced-stage, hig

298 African-American, Hispanic, Asian, and Native American women were more likely than white women

299 nificantly more prevalent among men, whites, Native Americans, younger and unmarried adults, and thos

300 natal home-visiting intervention to pregnant Native American youth.