ライフサイエンスコーパス: O. volvulus

1 O. volvulus blisterase expressed in insect cells has max

2 namely, a Glu(124) (C. elegans) or Asp(123) (O. volvulus) residue present in a critical position.

3 tested for (1) Loa MFD in blood samples, (2) O. volvulus presence by SST, and (3) Immunoglobulin (Ig)

4 eatment of Onchocerca volvulus infection, 40 O. volvulus-infected Ghanaians were randomized to receiv

5 In addition, O. volvulus contains the rickettsial endosymbiont Wolbac

6 The life expectancy of adult O. volvulus is reduced by approximately 50% and 70% afte

7 tonophoric activity was capable of affecting O. volvulus L3 molting and that the presence of both act

8 TLR4-mutant mice were immunized against O. volvulus with irradiated third-stage larvae, and it w

9 ding of an existing drug with impact against O. volvulus provides promise in the hunt for new therapi

10 ment of a protective immune response against O. volvulus in TLR4-mutant mice is not due to loss of Th

11 e colony-stimulating factor responses to all O. volvulus antigens unrelated to age.

12 by endosymbiotic Wolbachia in B. malayi and O. volvulus filaria are dependent on TLR2-TLR6 interacti

13 NETs and neutrophils were visualised around O. volvulus in nodules excised from untreated patients b

14 L. loa, and microscopically misidentified as O. volvulus due to their superficially similar morpholog

15 d with responses in 43 subjects with chronic O. volvulus infections.

16 ed immune response, the effect of concurrent O. volvulus infection on the immune response to tetanus

17 We describe O. volvulus genome variation in 27 isolates from the ear

18 a isolates were clustered in the O. fasciata-O. volvulus lineage and were well separated from other f

19 reduction in the percentage of adult female O. volvulus positive for Wolbachia) is 91%-94% on averag

20 s or as biomarkers of treatment efficacy for O. volvulus.

21 enzymes that are likely to be essential for O. volvulus viability.

22 negative for Mf: 16 (57%) were positive for O. volvulus DNA in the PCR-based assay.

23 xhibits high sensitivity and specificity for O. volvulus infection, and has great potential as a tool

24 aneously, and a soluble antigen extract from O. volvulus adult worms (OvAg) was injected into the cor

25 ransmitter-derived secretion metabolite from O. volvulus.

26 Importantly, the chitinase OvCHT1 from O. volvulus was recently discovered, however, its exact

27 ctive antitetanus response, although heavier O. volvulus infections are able to alter the magnitude o

28 In O. volvulus adult worms the Ov-SPI proteins are localize

29 Conversely, expression of ICAM-1 in O. volvulus-mediated keratitis was significantly reduced

30 To examine the role of IFN-gamma in O. volvulus keratitis, C57BL/6 and IFN-gamma(-/-) mice w

31 lso been found to be critical for molting in O. volvulus L3 larvae.

32 Targeting the Wolbachia in O. volvulus is effective in clearing microfilariae in th

33 esponse, and concurrent helminth infections (O. volvulus and intestinal helminths) may alter TT-speci

34 d for adaptive protective immunity to larval O. volvulus in mice.

35 o the corneal stroma, and that TLR2 mediates O. volvulus/Wolbachia-induced neutrophil activation and

36 with OV-16 improved serologic assessment of O. volvulus infection, a current unmet need toward the g

37 for a better understanding of the biology of O. volvulus as well as for the identification of novel t

38 Here, we describe the chromosomes of O. volvulus and its Wolbachia endosymbiont.

39 eatment for achieving sustained clearance of O. volvulus MF from the skin (p=0.024).

40 is of the expressed sequence tag datasets of O. volvulus and other filariae identified four other mem

41 activation, we injected a soluble extract of O. volvulus containing Wolbachia bacteria into the corne

42 While the serum levels of O. volvulus-specific immunoglobulin G (IgG), IgG subclas

43 found also to completely inhibit molting of O. volvulus infective L3 stage larvae.

44 a humped pattern with host age, patterns of O. volvulus infection vary markedly with locality.

45 O. ochengi is the closest extant relative of O. volvulus and shares several key natural history trait

46 arasite representing the closest relative of O. volvulus.

47 tive immune response to the larval stages of O. volvulus in mice immunized with irradiated larvae.

48 nses to adult and infective larval stages of O. volvulus which are age related are consistent with th

49 d the goal of elimination of transmission of O. volvulus.

50 ve, cytokine, and antibody response to TT of O. volvulus-infected subjects (n = 19) and comparable no

51 pact of each of its biological activities on O. volvulus L3 molting was investigated.

52 corneal inflammation induced by Wolbachia or O. volvulus antigens containing Wolbachia is completely

53 Other O. volvulus genes showed homology only to predicted gene

54 s (L3 and a recombinant L3-specific protein, O. volvulus ALT-1) which were significantly increased or

55 improved the specificity for cross-reactive O. volvulus patient sera (100% sensitivity and 100% spec

56 by antibodies directed against a recombinant O. volvulus L3 cysteine protease that was cloned and exp

57 Both recombinant O. volvulus and C. elegans cyclophilins were found to po

58 al ivermectin treatment in Ghana has reduced O. volvulus microfilarial intensity and prevalence, but

59 iving an intrastromal injection of a soluble O. volvulus extract.

60 tion and intracorneal injection with soluble O. volvulus Ags (OvAg), and that the inflammatory respon

61 sly and injected intrastromally with soluble O. volvulus antigens.

62 dicate that CD4(+) T cells mediate sustained O. volvulus keratitis by regulating eosinophil recruitme

63 mportant option for achieving and sustaining O. volvulus elimination.

64 e assays with fluorescent peptides show that O. volvulus blisterase requires a P4 arginine and a basi

65 undant DNA repeat families identified in the O. volvulus genome were also evaluated.

66 Stratification of the O. volvulus-infected group into two groups representing

67 To determine whether in utero exposure to O. volvulus biases a child's subsequent immune responses

68 Thus, in utero exposure to O. volvulus has a long-term effect on the child's subseq

69 with age (equivalent to years of exposure to O. volvulus).

70 ore hypothesized that protective immunity to O. volvulus would not develop in C3H/HeJ mice which have

71 s capable of inducing protective immunity to O. volvulus.

72 ased significantly with age, although not to O. volvulus ALT-1, which may have unique L3-specific epi

73 hat may render the child more susceptible to O. volvulus infection postnatally.

74 Our results demonstrate that NATOG tracks O. volvulus metabolism in both worms and humans, and thu

75 but a small number of patients infected with O. volvulus, M. perstans, or W. bancrofti showed positiv

76 inal punch' to knockout human infection with O. volvulus altogether.

77 dies indicate that concurrent infection with O. volvulus can diminish the immune response to an unrel

78 ings indicate that concurrent infection with O. volvulus does not prevent the development of a protec

79 the individual level, between infection with O. volvulus microfilariae and bilateral blindness was ex