ライフサイエンスコーパス: OA

1 OA synovial fluid impacted U3 snoRNA expression by affec

2 OAs were used nightly for 4 wk (T2) followed by a 1-wk w

3 communis L.) coated by CNCP-CH containing 1% OA showed significantly reduced ethylene production than

4 Therefore, CNCP-CH coating with 1% OA, 0.1% CNC, and 2% CH was suggested for delaying ripen

5 t surgery with and without DDH (9 DDH-OA, 12 OA-only, one femoral fracture).

6 dictability and efficacy comparison of the 2 OAs were secondary outcomes.

7 CP-CH with 3% OA, but not that with 1% or 2% OA.

8 NO(2)-OA also significantly reduced RyR2-phosphorylation by in

9 Thus, NO(2)-OA might be a novel pharmacological option for the preve

10 NO(2)-OA treatment of isolated cardiomyocytes lowered the numb

11 ctadec-9-enoic acid (nitro-oleic acid, NO(2)-OA) significantly reduced the susceptibility to develop

12 e production than that coated with 2% and 3% OA at 1-month of accelerated cold storage at 1.7 degrees

13 observed on fruit coated by CNCP-CH with 3% OA, but not that with 1% or 2% OA.

14 ve structural outcomes including accelerated OA progression, subchondral insufficiency fracture, comp

15 e studies evaluating the risk of accelerated OA or joint destruction after IACS injections are needed

16 GC5A-12C) and negatively charged oleic acid (OA), a well-known cell membrane antioxidant, prevents th

17 ace coatings (stearic acid (SA), oleic acid (OA), poly(maleic anhydride-alt-1-octadecene) (PMAO), lin

18 dicted ocean warming (OW) and acidification (OA) affect key ecological behaviours (locomotion speed a

19 redicting the impact of ocean acidification (OA) on marine ecosystems.

20 Ocean acidification (OA) poses a major threat to marine ecosystems and shellf

21 Ocean acidification (OA), a consequence of anthropogenic carbon dioxide (CO(2

22 extended our studies to other organic acids (OAs) present in the water-soluble fraction of secondary

23 y, in which the critical oxidative addition (OA) mechanism has been replaced by a halogen abstraction

24 The evolution of organic aerosol (OA) and brown carbon (BrC) in wildfire plumes, including

25 r the online measurement of organic aerosol (OA) composition are subjected to either thermal/ionizati

26 Reducing the amount of organic aerosol (OA) is crucial to mitigation of particulate pollution in

27 dy demonstrates that osteoporosis aggravates OA symptoms.

28 t period, then 4 wk (T4) using the alternate OA.

29 For instance, the MS(2) analysis of ambient OA samples and lab-generated biogenic SOAs points to spe

30 tion with the preexisting oxygenated ambient OA.

31 st in the application of organic amendments (OAs) for soilborne plant pathogen and plant-parasitic ne

32 tes the importance of including both age and OA as factors when evaluating nanoparticles for intra-ar

33 Using this particle, the effects of age and OA pathogenesis on particle clearance and distribution w

34 or evaluating the early changes in aging and OA-affected murine subchondral bone.

35 basis of radiographic readings: KL grade and OA Research Society International (OARSI) grade.

36 There was no difference between the LA and OA for 90-day mortality (7.2% vs 8.5%, OR 0.80, 95% CI 0

37 in healthy adults, and observed that MA and OA increased in biological fluids in a dose-dependent ma

38 We assessed MA and OA pharmacokinetics after ingestion of olive oils (OOs)

39 Articular cartilage from young, old and OA knees was used in a microarray study to identify alte

40 cological consequences under unabated OW and OA, namely in regulating toxic cyanobacteria blooms on c

41 between hand injury and ipsilateral pain and OA in cricketers.

42 elated to an increased odds of hand pain and OA.

43 redictability of 2 different oral appliance (OA) designs to reduce the respiratory event index (REI)

44 type (occlusive into the ophthalmic artery [OA] vs. nonocclusive; P < 0.001) were included in multiv

45 quantitative and objective metrics to assess OA meniscal cell phenotypes.

46 s of crystallization by oriented attachment (OA), yet a quantitative understanding is lacking.

47 pite accounting for just 4 +/- 2% of average OA mass.

48 ltaMQST and DeltaTQST) were compared between OA and control dogs.

49 ants, and 16 (44.4%) participants using both OAs had significant REI reductions.

50 .6%) MR OA-using participants, 25 (69.4%) BP OA-using participants, and 16 (44.4%) participants using

51 Thirty-six participants had used MR and BP OAs during both 4-wk study legs.

52 versus secondary sources of biomass-burning OA (BBPOA versus BBSOA) and BrC in wildfire plumes.

53 ven oxidation on the fate of biomass-burning OA and BrC in daytime wildfire plumes and point to the n

54 a common injury in dogs often accompanied by OA.

55 hat EPM impairment is associated with canine OA pain.

56 agonist able to reduce pain in rats carrying OA induced by injection of monoiodoacetic acid (MIA).

57 rocytes (OAC) and mesenchymal stromal cells (OA-MSC).

58 in one of the largest and best characterised OA cohort (NIH Osteoarthritis Initiative).

59 r, BMI, race, depression symptoms, composite OA score, use of pain medications, and knee injections.

60 e immunostaining revealed changes in damaged OA-only cartilage that was also found in undamaged DDH-O

61 lacement surgery with and without DDH (9 DDH-OA, 12 OA-only, one femoral fracture).

62 rtilage that was also found in undamaged DDH-OA cartilage.

63 al thrust with opening permitted (BP) design OAs.

64 utility of molecular markers for discerning OA pollution sources in the offshore marine atmosphere,

65 Twenty-four client-owned dogs (OA, n = 11; controls, n = 13) were recruited.

66 lage occur as degeneration progresses during OA.

67 their combinations to chondrocytes, enabling OA treatment with a single injection of low drug doses a

68 uch less than for translation, thus enabling OA to dominate.

69 of Gdf5 regulatory sequences in experimental OA following destabilisation of the medial meniscus (DMM

70 d history of physician-diagnosed hand/finger OA.

71 Currently no reliable method exists for OA detection at a reversible stage.

72 rotopic ossification, may be re-purposed for OA treatment.

73 fe, best-evidence treatments recommended for OA care.

74 iation for physiological traits relevant for OA survival.

75 rkers before an IACS injection to screen for OA-related imaging abnormalities.

76 well as potential drug delivery systems for OA and IVDD therapy.

77 ay represent a future therapeutic target for OA and other bone-associated pathologies.

78 s LDHA as a potential therapeutic target for OA treatment.

79 obesity-linked OA and could be targeted for OA therapeutics.

80 ciated with epigenome-based therapeutics for OA.

81 and symptoms but no effective treatment for OA.

82 w discusses the core priority treatments for OA, including exercise and physical activity, weight-los

83 hether cellular changes in chondrocytes from OA cartilage can be detected in chondrocytes from DDH ca

84 e 25-kDa fragment was present in the SF from OA patients, and the amount was increased after incubati

85 suggests particles cleared more slowly from OA knees than from the contralateral control, with parti

86 hand injury also had increased odds of hand OA (3.1, 2.1 to 4.7).

87 ates it in subchondral bone sclerosis in hip OA.

88 al supplementation of patients with knee/hip OA may lead to an improvement in pain intensity and phys

89 physical function in patients with knee/hip OA.

90 Dogs with stifle/hip OA and demographically-matched controls were recruited.

91 arly life play a role in predisposing to hip OA in later life remains to be determined.

92 tatarsophalangeal articular tissue and human OA tibial plateau tissues measured with or without treat

93 rtilage post-DMM, and was increased in human OA cartilage as determined by immunohistochemistry and m

94 steogenically-committed BMSC subset in human OA trabecular bone.

95 In OA chondrocytes, there is diminished mitochondrial produ

96 Inhibiting TGF-betaR1 suppressed MMP-13 in OA-MSC but stimulated it in OAC.

97 d hypertrophy, mineralization, and MMP-13 in OA-MSC.

98 emains unclear to what extent differences in OA prevalence are attributed to sex differences in hip s

99 r treatment of localized chondral disease in OA.

100 Our aim was to assess EPM impairment in OA dogs compared to controls using CPM.

101 testing would demonstrate EPM impairment in OA dogs compared to controls.

102 etic regulators that have been implicated in OA, their individual roles, and potential crosstalk.

103 table target for therapeutic intervention in OA.

104 esis that A2AR ligation is mitoprotective in OA.

105 crosslinking of surface-active molecules in OA and provide novel insights into OA molecular patholog

106 reviews the current understanding of pain in OA, summarizes current international guidelines regardin

107 hat attenuates pro-inflammatory signaling in OA cartilage of the TMJ and knee joint, induces chondrop

108 activated BMP signaling-associated SMAD1 in OA-MSC.

109 cells only localised on the bone surface, in OA bone they were additionally present in the areas of n

110 n a strong historical research foundation in OAs and the physical, chemical, and biological character

111 been implicated in many diseases, including OA.

112 Increasing OA from 1 to 3% reduced emulsion stability ~43%, indicat

113 int damage in monosodium iodoacetate-induced OA.

114 In an obesity-induced OA mouse model, there was a marked increase in mitochond

115 damage in a murine model of obesity-induced OA.

116 ting as it provides mechanistic insight into OA susceptibility.

117 ecules in OA and provide novel insights into OA molecular pathology.

118 Octanol-air partition coefficients (K(OA)) and vapor pressures (P(L)) of the OPEs were also me

119 igh octanol-air partitioning coefficients (K(OA)) are likely to have a greater potential to undergo l

120 ios, which were converted to estimates for K(OA) (octanol-air) and K(dust-air).

121 -air) (m(3) g(-1)) of <5.5 or unitless log K(OA) of <11.5.

122 also examined via four widely used models (K(OA), Soot, Steady-State, and pp-LFER).

123 dy suggested that the basic assumptions of K(OA)-based models (i.e., xi(OCT)/xi(OM) and MW(OCT)/MW(OM

124 gnificantly and positively correlated with K(OA), but declined with increasing relative humidity.

125 Hip and knee OA alone are major contributors to global disability, ha

126 ten used for pain management of hip and knee OA in patients who have not responded to oral or topical

127 In patients with hip and knee OA, an explicit improvement in function is seen within t

128 9), and grouped into subjects with both knee OA and DM (n = 148) or knee OA only without DM (n = 1171

129 ilable guidelines for the management of knee OA, those from OARSI and ESCEO were updated in 2019.

130 plexities of non-surgical management of knee OA.

131 s with both knee OA and DM (n = 148) or knee OA only without DM (n = 1171).

132 participants were patients with hip or knee OA; intervention was different nutritional supplements;

133 egression showed that participants with knee OA and DM had 2.45 (95% CI 1.07-5.61) to 2.55 (95% CI 1.

134 Data of participants with knee OA were used for this analysis (n = 1319), and grouped i

135 in SF was confirmed in 16 patients with knee OA.

136 ateral versus no pain) in subjects with knee OA.

137 However, those of larger OAs and many other OAs in alpha-pinene SOA are affected

138 uld play an important role in obesity-linked OA and could be targeted for OA therapeutics.

139 the light absorption properties of the major OA components in Singapore, a well-developed city in the

140 se two complementary approaches is that many OA genetic risk signals interact with, map to or correla

141 meniscal cells and chondrocytes from medial OA knee joints (n = 10).

142 derived from the lateral meniscus in medial OA patients have chondrogenic capacity in vitro and henc

143 amily may play an important role in meniscus OA pathology.

144 Currently, there are over 500 million OA cases worldwide, and there is an urgent need to ident

145 as been shown that knee loading can mitigate OA symptoms.

146 clude that small kelp patches could mitigate OA stress and serve as spatial and temporal refugia for

147 We employed two mouse models (OA and OPOA), and conducted histology, cytology, and mol

148 delivery of a broad array of small molecule OA drugs and their combinations to chondrocytes, enablin

149 e new grading system was tested in two mouse OA models, (1) senescence accelerated mouse (SAM)-prone

150 Twenty (55.6%) MR OA-using participants, 25 (69.4%) BP OA-using participan

151 re-expansion and were present in control non-OA trabecular bone.

152 However, while in non-OA bone CD56+ cells only localised on the bone surface,

153 p < 0.001) increased in control dogs but not OA dogs (DeltaMQST p = 0.65; DeltaTQST p = 0.76).

154 to the OA group, the pathological changes of OA in the OPOA group were considerably aggravated.

155 was identified as the largest contributor of OA in continental air, with contributions fluctuating fr

156 Therefore, earlier detection of OA pathology is needed for improved disease management.

157 urinary CTXII may aid in early diagnosis of OA in symptomatic patients without radiographic evidence

158 human femoral head, highlighting effects of OA in the superior subchondral cortical and trabecular b

159 We experimentally compared the effects of OA on two populations of red abalone (Haliotis rufescens

160 The etiology of OA is complex and involves a variety of factors, includi

161 n the role of dilution-driven evaporation of OA and subsequent radical-driven oxidation on the fate o

162 ic patients without radiographic evidence of OA.

163 th key radiographic and clinical features of OA (outcomes) in one of the largest and best characteris

164 hed radiographic and/or clinical features of OA.

165 ic SOA accounted for the highest fraction of OA in marine (37 +/- 4%) and mixed air (31 +/- 3%), over

166 esponse may serve as an earlier indicator of OA pathology.

167 y prior to the radiographic manifestation of OA, indicating that lubricin may be a potential biomarke

168 in the medial meniscus transection model of OA (5-, 10-, and 15-month old male Lewis rats).

169 ry human chondrocytes, and a murine model of OA by transmission electron microscopy analysis, mitocho

170 weeks in cartilage explant culture models of OA.

171 ing in cartilage that define future onset of OA.

172 sis which contributes to the pathogenesis of OA.

173 er over, and above established predictors of OA such as age, gender, BMI and race.

174 t homeostasis lost during the progression of OA, preserving the production of cytokines involved in t

175 p learning (DL) prediction model for risk of OA progression by using knee radiographs in patients who

176 urther investigations on different stages of OA would be needed to identify early changes in the bone

177 estruction than [-1A]TIMP3 at late stages of OA.

178 stent associations with clinical symptoms of OA as well as radiographic evidence of joint damage.

179 MA bioavailability was greater than that of OA, and consumption of pentacyclic triterpenes was assoc

180 prolonging intra-cartilage residence time of OA drugs.

181 therapeutic strategies for the treatment of OA.

182 present a helpful option in the treatment of OA.

183 time and air-origin dependent variations of OA markers and source contributions at a regionally urba

184 on disease suppression with the addition of OAs.

185 his review focuses on recent applications of OAs and their potential for the management of soilborne

186 ess has been made in the characterization of OAs, application of strategies for their use, and elucid

187 eal-time, near-molecular characterization of OAs.

188 macokinetics of maslinic (MA) and oleanolic (OA) acids, at normal dietary intakes in humans, have not

189 ng upwelling region were tolerant of ongoing OA, whereas a captive-raised population sourced from a r

190 We acclimated sea hares to OW and/or OA across three developmental stages (metamorphic, juven

191 ll, sea hares that developed under OW and/or OA exhibited a less severe impact, indicating beneficial

192 ed ~1.5- to 2-fold when the stressors (OW or OA) were experienced in isolation, but reduced ~3-fold w

193 The association of hand injury with pain or OA is unclear.

194 Osteoarthritic (OA) dogs are good translational models, but CPM has not

195 Osteoarthritis (OA) affects nearly 10% of the population of the United S

196 Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) as major

197 Osteoarthritis (OA) is a complex musculoskeletal disease and a leading c

198 Osteoarthritis (OA) is a degenerative disease resulting in irreversible,

199 Osteoarthritis (OA) is a highly prevalent chronic condition with marked

200 Osteoarthritis (OA) is an age-associated disease characterized by chroni

201 Osteoarthritis (OA) is the most common chronic degenerative joint diseas

202 Osteoarthritis (OA), the most common joint disorder, is characterised by

203 is (MS), arthritis (RA), and osteoarthritis (OA) both in humans and in animal models, drives pain ass

204 etween Osteoporotic (OP) and osteoarthritis (OA) is complex.

205 k of joint diseases, such as osteoarthritis (OA), is pain, originating from both inflammatory and neu

206 FD) become obese and develop osteoarthritis (OA)-like lesions, including chondrocyte apoptosis, in th

207 to the chronic joint disease osteoarthritis (OA) is unclear, and this lack of clarity is detrimental

208 DF5) is a key risk locus for osteoarthritis (OA).

209 tive medicine approaches for osteoarthritis (OA).

210 ing therapeutic approach for osteoarthritis (OA).

211 important determinant of hip osteoarthritis (OA), which occurs more commonly in women.

212 been observed in idiopathic osteoarthritis (OA), while the detailed mechanism still remains unknown.

213 implicated to be involved in osteoarthritis (OA) development.

214 ion plays a critical role in osteoarthritis (OA).

215 e methods for assessing knee osteoarthritis (OA) do not provide enough comprehensive information to m

216 Knee Osteoarthritis (OA) is a common musculoskeletal disorder in the United S

217 Knee osteoarthritis (OA) is a heterogeneous disease associated with substanti

218 d to the progression of knee osteoarthritis (OA).

219 The diagnosis of osteoarthritis (OA) currently depends on the presence of pain and radiog

220 to the molecular genetics of osteoarthritis (OA) has been substantially bolstered in the past few yea

221 Current management of osteoarthritis (OA) is primarily focused on symptom control.

222 tion is a central feature of osteoarthritis (OA), elicited when local regulatory macrophages (M2-like

223 (DDH) often show early-onset osteoarthritis (OA); however, the molecular mechanisms underlying this p

224 cal translation of promising osteoarthritis (OA) drugs.

225 Radiographic osteoarthritis (OA) is most prevalent in the hand.

226 Chronic disability in TMJ osteoarthritis (OA) increases with aging, and the main goal is to diagno

227 lupus arthritis (LA), using osteoarthritis (OA) and rheumatoid arthritis (RA) as comparators.

228 and knee pain in people with osteoarthritis (OA).

229 However, those of larger OAs and many other OAs in alpha-pinene SOA are affected to a much less exte

230 In the future, coupling presymptomatic OA detection with emergent clinical therapies could modi

231 The continental air contained primary OA markers indicative of source categories, such as levo

232 estimate that up to one-third of the primary OA has evaporated and subsequently reacted to form BBSOA

233 correlated with the presence of radiographic OA and were elevated in three animals sustaining RCCL in

234 2AR agonist, CGS21680, significantly reduced OA cartilage damage in a murine model of obesity-induced

235 rs), 16.9% reported hand pain, 4.3% reported OA.

236 Rspo1 and Rspo3 reversed OA-induced cholesterol synthesis, accompanying with incr

237 Secondary OA (SOA) markers derived from isoprene and monoterpenes

238 valuated with laboratory-generated secondary OAs (SOAs) and filter extracts of ambient particulate ma

239 e present an approach that enables sensitive OA detection in presymptomatic individuals.

240 Knee synovia from SLE, OA, and RA patients were analyzed for differentially exp

241 ns such as exercise and weight loss can slow OA progression, but at later stages, only an invasive op

242 hows that the atmospheric lifetimes of small OAs (e.g., FA) are highly sensitive to cloud water pH.

243 matically different between FA, the smallest OA, and those that contained more than eight carbons.

244 -axis integrated cavity output spectroscopy (OA-ICOS) technique.

245 d mouse (SAM)-prone 8 (SAMP8) as spontaneous OA model with SAM-resistant 1 (SAMR1) as control; (2) de

246 The spontaneous OA dog model may be used to test drugs that normalize EP

247 -invasive diagnostic readout for early stage OA in combination with arthroscopy devices.

248 cin were found to be decreased in late-stage OA patients, coinciding with an increase in unsialylated

249 medial meniscus in C57BL/6 mice as surgical OA model.

250 uracy of 78% in detecting future symptomatic OA progression 3 y prior to symptoms.

251 se individuals had progressed to symptomatic OA.

252 This work demonstrates that OA detection may be possible at a potentially reversible

253 It was found that OA concentration played significant role on emulsion sta

254 RNAseq analysis indicated that OA-MSC expressed the same level of Bone Morphogenetic Pr

255 We show that OA is driven by forces and torques due to a combination

256 taTQST(p < 0.001) were different between the OA and control groups.

257 trospective analysis that used data from the OA Initiative, a DL model on knee radiographs was develo

258 After 2 h, the OA increased by 70% on average and the sulfate by 40%.

259 In the OA and OPOA groups, articular cartilage was degenerated

260 ts the function of NF-kappaB activity in the OA joint as well as a ROS promoting function for LDHA an

261 dure, placement of the catheter tip into the OA distal third versus medial and proximal thirds (P = 0

262 Catheterization of the OA should be attempted from an ostial position or an ext

263 Compared to the OA group, the pathological changes of OA in the OPOA gro

264 int cells and SASP-factors contribute to the OA phenotype.

265 Although all the OAs exhibited larger OH reactivities at pH 10, the pH de

266 y used midline-traction and bilateral-thrust OA designs differ in effectiveness to reduce the REI wit

267 Upon surgically creating TMJ OA in miniature pigs, we discovered increased vasculatur

268 resolution CBCT (radiomics) markers from TMJ OA patients and controls.

269 r, the pathological mechanisms governing TMJ OA are poorly understood.

270 ntially alter the clinical management of TMJ OA by defining new drugs that target angiogenesis or blo

271 tiation or vasculature in human-relevant TMJ OA large animal models or in human TMJ tissues and cells

272 .870, and F1-score 0.823 to diagnose the TMJ OA status.

273 employed two different models to assess TMJ-OA.

274 In one model, clinical TMJ-OA cartilage from 5 different samples in TMJ-OA cartilag

275 further study as an anabolic therapy for TMJ-OA.

276 LOXL2 has beneficial functions in human TMJ-OA cartilage implants and promotes gender-specific anabo

277 tworks and extracellular matrix in human TMJ-OA cartilage implants in vivo.

278 OA cartilage from 5 different samples in TMJ-OA cartilage plugs were implanted subcutaneously in nude

279 disorders, including TMJ osteoarthritis (TMJ-OA).

280 responses in Cho/+ mice with progressive TMJ-OA, suggesting its merit for further study as an anaboli

281 reatments declining in continued exposure to OA.

282 characterized pathological linkage of OP to OA, and evaluated the effect of knee loading on OPOA.

283 Identifying traits that convey resilience to OA is critical to the continued success of abalone and o

284 o experimentally test copepod sensitivity to OA.

285 d significant mortality and vulnerability to OA.

286 s (P = 0.04) and a mean catheter diameter-to-OA lumen ratio of 0.6 or more (P < 0.001) were correlate

287 in a rat model of established post-traumatic OA (PTOA).

288 g the A2AR is an effective approach to treat OA.

289 s a potential therapeutic agent for treating OA.

290 ly lineages, and the highest mortality under OA occurred in the fastest growing crosses.

291 ween lipid concentrations and survival under OA.

292 ed products perpetuate inflammation, whereas OA was characterized by fibroblasts and RA of lymphocyte

293 xpression, are a major conduit through which OA genetic risk polymorphisms exert their functional eff

294 th hand pain (in former cricketers) and with OA (in all cricketers), adjusted for age, seasons played

295 ich may partly underpin its association with OA risk.

296 eatment recommendations for individuals with OA and health-care providers.

297 Patients with OA receiving total hip or knee arthroplasty were recruit

298 roaches and provide relief for patients with OA.

299 roviding appropriate care to all people with OA, but despite the scale of the challenge many individu

300 43 +/- 0.057 (p < 0.05) for patients without OA.