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1  organic anion transporting polypeptide 1B3 (OATP1B3).
2 AG were preferentially (>68%) transported by OATP1B3.
3 tified glibenclamide as a novel substrate of OATP1B3.
4 nced by genetic polymorphisms of OATP1B1 and OATP1B3.
5  anion transporting polypeptides OATP1B1 and OATP1B3.
6 tial drug-drug interactions with OATP1B1 and OATP1B3.
7 inhibition of 8-FcA transport by OATP1B1 and OATP1B3.
8 ly, as compared to 16.3 microM for wild-type OATP1B3.
9 ctal cancer cell lines stably overexpressing OATP1B3.
10 nides were primarily taken up by OATP1B1 and OATP1B3.
11  anion transporting polypeptides OATP1B1 and OATP1B3.
12                                              OATP1B3-1B3 (LST-3TM12) is a transporter that has yet to
13 fied a new member of the OATP1B family named OATP1B3-1B7 (LST-3TM12).
14 itor was ezetimibe, which not only inhibited OATP1B3-1B7 but is also a substrate, as its cellular con
15                        After verification of OATP1B3-1B7 expression in the small intestine, we determ
16    One aim of this study was to test whether OATP1B3-1B7 interacts with commercial drugs.
17 ransporter is encoded by SLCO1B3 and SLCO1B7 OATP1B3-1B7 is expressed in hepatocytes and is located i
18             Ezetimibe, which interacted with OATP1B3-1B7, is highly metabolized by uridine-5'-diphosp
19 ction of OATP1B substrates for inhibition of OATP1B3-1B7-mediated transport of dehydroepiandrosterone
20  is orchestrated by SER transporters such as OATP1B3-1B7.
21 SER access can be modulated by inhibitors of OATP1B3-1B7.
22 y bromsulphthalein, which is an inhibitor of OATP1B3-1B7.
23  we report that multiple drugs interact with OATP1B3-1B7; for ezetimibe, we were able to show that SE
24                                          The OATP1B3*4 polymorphism was not of functional relevance.
25 ganic anion transporting polypeptide 1B3 (Ct-OATP1B3), a splice variant of the hepatic uptake transpo
26                      This study reports that OATP1B3 activity is dependent on the Lck/Yes novel tyros
27 elimination, although much is unknown of how OATP1B3 activity is mediated, or how such regulators con
28  these metabolites as clinical biomarkers of OATP1B3 activity.
29 ructed a series of chimeric proteins between OATP1B3 and 1B1, expressed them in HEK293 cells, and det
30 ular uptake of gadoxetic acid by OATP1B1 and OATP1B3 and their frequent genetic variants was measured
31 orters, MABA uptake was efficient (NTCP>ASBT>OATP1B3) and inhibitable by TCA.
32        Gadoxetate disodium is a substrate of OATP1B3, and its uptake has been shown to correlate with
33 r efflux transporters revealed that OATP1B1, OATP1B3, and OATP1A2, either alone or in combination wit
34 xel, were transported substrates of OATP1B1, OATP1B3, and OATP1B2, and these in vitro transport proce
35 ic anion transporting polypeptides (OATP1B1, OATP1B3, and OATP2B1).
36  specific and general inhibitors of OATP1B1, OATP1B3, and OATP2B1.
37 ls revealed that OATP1A2, but not OATP1B1 or OATP1B3, and the rat ortholog Oatp1a4 were capable of si
38  anion transporting polypeptides OATP1B1 and OATP1B3 are membrane proteins that mediate uptake of dru
39       Our results show that both OATP1B1 and OATP1B3 are responsible for the hepatic uptake of major
40                   Liver-specific OATP1B1 and OATP1B3 are uptake carriers for gadoxetic acid in subjec
41       MTA predictions identified OATP1B1 and OATP1B3 as major determinants of atorvastatin uptake in
42 sent cryo-EM structures of human OATP1B1 and OATP1B3 bound to synthetic Fab fragments and in function
43 n tumors indicated tumoral overexpression of OATP1B3 by approximately 100-fold, compared with 20 norm
44 nsporting polypeptide 1B1 (OATP1B1) and 1B3 (OATP1B3) can result in clinically relevant drug-drug int
45 in glucuronide due to coexisting OATP1B1 and OATP1B3 deficiencies explains Rotor-type hyperbilirubine
46 reatment are substrates and/or inhibitors of OATP1B3 (e.g. encorafenib, vemurafenib).
47           The organic anion polypeptide 1B3 (OATP1B3, encoded by SLCO1B3) transporter has been shown
48                             Both OATP1B1 and OATP1B3 exhibited the highest transport rate toward AG a
49 variant of the liver-type uptake transporter OATP1B3 expressed in several tumor entities.
50 oci within CD19-positive tumors representing OATP1B3-expressing T cells were clearly visible and thei
51           As inter-individual variability in OATP1B3 expression and function has both predictive and
52                                 In CRC, high OATP1B3 expression has been associated with reduced prog
53  its uptake has been shown to correlate with OATP1B3 expression in other cancers.
54       To determine the functional effects of OATP1B3 expression on drug-induced apoptosis, we used ca
55                                              OATP1B3 expression on IHC trended higher contrast enhanc
56                                              OATP1B3 expression was evaluated via immunohistochemistr
57                                     Finally, OATP1B3 function was determined to be sensitive to the k
58 sine kinase activity as a major regulator of OATP1B3 function which is sensitive to kinase inhibition
59 a provide evidence that the drug transporter OATP1B3 functions as a determinant of the insulinotropic
60 med that HCT116(p53+/+) cells overexpressing OATP1B3 had significantly lower apoptotic levels compare
61              The functional importance of Ct-OATP1B3 has not been elucidated so far.
62                                  OATP1B1 and OATP1B3 have been implicated in the hepatic uptake of st
63 cade, OATPs, primarily OATP1A2, OATP1B1, and OATP1B3, have emerged as potential mediators of chemothe
64 mor specimens, we detected immunostaining of OATP1B3 in 75 colon adenocarcinomas (81%) and no immunos
65  show that transient overexpression of human OATP1B3 in a murine beta-cell line (MIN6)-which exhibits
66  study, we showed frequent overexpression of OATP1B3 in colorectal adenocarcinomas.
67       In this study, we report expression of OATP1B3 in human pancreatic tissue, with the abundance o
68 ds were correctly classified for OATP1B1 and OATP1B3 inhibition, respectively.
69 ther investigated as potential biomarkers of OATP1B3 inhibition.
70    Nilotinib was assessed as the most potent OATP1B3 inhibitor among the investigated TKIs, which can
71 139 molecules were identified as OATP1B1 and OATP1B3 inhibitors, respectively (minimum 50% inhibition
72       Organic anion transporting polypeptide OATP1B3 is a membrane-bound drug transporter that facili
73                             The structure of OATP1B3 is determined in a drug-free state but reveals a
74                                              OATP1B3 is expressed de novo in primary prostate cancer
75                      This study reports that OATP1B3 is similarly regulated, as at least 50% of its a
76 c uptake transporter OATP1B3 (liver-type; Lt-OATP1B3), is expressed in several tumor entities includi
77 ells engineered to express either OATP1B1 or OATP1B3 isoforms.
78 e some substrates being recognized solely by OATP1B3, its ability to compensate for loss of OATP1B1-m
79 ssion of a point mutation (G583E) variant of OATP1B3 lacking transport activity did not confer an ant
80 ce variant of the hepatic uptake transporter OATP1B3 (liver-type; Lt-OATP1B3), is expressed in severa
81  suggesting that the antiapoptotic effect of OATP1B3 may be associated with its transport activity.
82                             The OATP1B1- and OATP1B3-mediated transport of 8-FcA was time dependent a
83 was developed for measuring the OATP1B1- and OATP1B3-mediated transport of 8-fluorescein-cAMP (8-FcA)
84 , respectively), whereas the K (m) value for OATP1B3-mediated uptake for EtioG, AG, DHTG, and TG were
85 his indicates a competitive inhibition of Ct-OATP1B3-mediated uptake into lysosomes by BSP.
86                              Metastases with oatp1b3-MRI could be observed at the single lymph node l
87                                  In summary, oatp1b3-MRI enables longitudinal tracking of cancer cell
88 stry (IHC) and a pharmacogenomic analysis of OATP1B3, NCTP and OATP1B1 was conducted.
89                        Moreover, OATP1B1 and OATP1B3 null mutations may confer substantial drug toxic
90 various cell lines transfected with OATP1B1, OATP1B3, or the rodent equivalent OATP1B2.
91  role in hepatic disposition are OATP1B1 and OATP1B3 (organic anion-transporting polypeptides 1B1 and
92                      Transport studies using OATP1B3-overexpressing MDCKII cells revealed significant
93                   The results indicated that OATP1B3 overexpression enhanced cell survival in RKO, HC
94     Taken together, our results suggest that OATP1B3 overexpression in colorectal cancer cells may pr
95 cancer DLD1 cells endogenously expressing Ct-OATP1B3 protein had poorer survival rates when the OATP1
96          Therefore, the expression of the Ct-OATP1B3 protein is associated with a better survival of
97 sed expression analysis demonstrated that Ct-OATP1B3 protein is intracellularly localized in lysosome
98            These results demonstrate that Ct-OATP1B3 protein is localized in the lysosomal membrane a
99        HEK293 cells stably overexpressing Ct-OATP1B3 protein were established and compared with contr
100 d that cells recombinantly expressing the Ct-OATP1B3 protein were more resistant against the kinase i
101                        The overexpression of OATP1B3 reduced the transcriptional activity of p53, wit
102 y regulatory agencies, little is known about OATP1B3 regulatory factors and how they are involved wit
103                     As a result, OATP1B1 and OATP1B3 represent sites for potential drug-drug interact
104    Transgenic expression of human OATP1B1 or OATP1B3 restored the function of this detoxification-enh
105  Organic anion transporting polypeptide 1B3 (OATP1B3, SLCO1B3) is normally expressed in hepatocytes.
106      Besides common substrates with OATP1B1, OATP1B3 specifically transports cholecystokinin octapept
107 3 protein had poorer survival rates when the OATP1B3 substrate bromosulfophthalein (BSP) was coincuba
108 d residues (Y537, S545, and T550) in TM10 of OATP1B3 that are important for CCK-8 transport.
109  (normalized mg) (-1) min (-1) for wild-type OATP1B3 to 13.3 and 19.0 pmol (normalized mg) (-1) min (
110           The apparent higher selectivity of OATP1B3 toward testosterone glucuronide and androsterone
111  organic anion-transporting polypeptide 1b3 (oatp1b3) was used as an MRI reporter gene, and its sensi
112 e important for the substrate selectivity of OATP1B3, we constructed a series of chimeric proteins be
113 dicted to be transported by both OATP1B1 and OATP1B3, whereas TG and AG were preferentially (>68%) tr
114                            Replacing TM10 in OATP1B3 with TM10 of OATP1B1 resulted in a dramatically
115                                              OATP1B3 works in tandem with OATP1B1, with which it shar

 
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