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1 ga target, the organic cation transporter 2 (OCT2).
2 n efficacy maximally in cells overexpressing OCT2.
3 d not significantly change the properties of OCT2.
4 D) values for binding to the model of rabbit OCT2.
5 f threonine 223 in the DNA-binding domain of OCT2.
6 t OBF1 extensively colocalizes with OCT1 and OCT2.
7 he POU family transcription factors OCT1 and OCT2.
8 fic enhancer, where the risk allele disrupts OCT2/4 binding, allowing increased interaction with the
9                                      Catfish Oct2 a and beta are tissue restricted, bind both consens
10 s dependent on organic cation transporter 2 (OCT2), a dopamine transporter, providing an explanation
11  attenuated by saracatinib via inhibition of OCT2, a potential consideration for the clinical develop
12                           In contrast, mouse Oct2 activated transcription in mouse but not catfish ce
13           Yes1 inhibition in vivo diminished OCT2 activity, significantly mitigating oxaliplatin-indu
14                                      Catfish Oct2 alpha and beta isoforms are derived by alternative
15 a more potent transcriptional activator than Oct2 alpha.
16                                        Mouse Oct2 also showed increased activity with the variant oct
17 one genes HIST1H1 B-E (27%) and mutations in OCT2 (also known as POU2F2; 8%), IRF8 (6%), and ARID1A (
18 a ternary complex with the lymphoid-enriched OCT2 and GC-specific MEF2B transcription factors and tha
19          Here, we show that cellular factors OCT2 and HCF1 bind OriP in association with EBNA1 to mai
20 cell lines are addicted to the expression of OCT2 and its coactivator OCA-B.
21       Finally, the transcriptional activator Oct2 and its cofactor OBF-1 were identified as regulator
22 nding motifs that became heavily loaded with OCT2 and its GC-specific coactivator OCAB in GC B cells
23 and metformin, which is a probe for OCT1 and OCT2 and MATE1 and MATE2K (multidrug and toxin extrusion
24 c decreases in the kidney mRNA expression of Oct2 and Mate1, whereas Oct1 mRNA expression was only de
25 olocalization of IkappaBzeta with the POU TF OCT2 and NF-kappaB:p50 at hundreds of DNA elements harbo
26 ochic acid, which are diminished upon adding OCT2 and OAT1/3 transport inhibitors.
27                                              OCT2 and OCT3 showed highly stereoselective cell uptake
28 es of exogenous organic cation transporters (OCT2 and OCT3), organic anion transporter (OAT1), and mo
29 scriptase-polymerase chain reaction detected OCT2 and OCT3, but not OCT1, mRNA expression in CP.
30 redominantly B-cell-restricted expression of OCT2 and the absence of a systemic phenotype in our knoc
31 hylsulfonate, reduced transport by wild-type OCT2 and the mutant with cysteine 474 restored.
32 pitating and reducing transport by wild-type OCT2 and the mutant with cysteine 474 restored.
33  significant upregulation of organic cation (OCT2) and organic anion (OAT1/3) transporters, which lea
34 y through active secretion mediated by Oct1, Oct2, and Mate1.
35 nockdown experiments demonstrated that OCT1, OCT2, and OBF1 regulate each other and are essential for
36            Furthermore, we showed that OBF1, OCT2, and OCT1 bind widely to the promoters or enhancers
37  in cells overexpressing mouse Oct2 or human OCT2, and this process was associated with increased DNA
38                                     OBF1 and OCT2 are B cell-specific and indispensable for germinal
39 nd in vivo data indicate that mouse Oct1 and Oct2 are essential for facilitating the exit step of fre
40                                     OCT1 and OCT2 are involved in renal secretion of cationic drugs.
41 d in OCT1 orthologs as one amino acid and in OCT2 as a different one, influence homolog-specific sele
42 ues on the activity of the human ortholog of OCT2, as expressed in Chinese hamster ovary-K1 cells.
43  hypothetical three-dimensional structure of OCT2 based on a homology model that used the Escherichia
44                                      Catfish Oct2 beta is a more potent transcriptional activator tha
45      In transient expression assays, catfish Oct2 beta showed a marked preference for the octamer var
46       The POU transcription factors Oct1 and Oct2 bind to DNA in various monomer and dimer configurat
47    SEs with high abundance of pre-positioned OCT2 binding preferentially formed long-range chromatin
48 per-enhancers (SEs) contained pre-positioned OCT2-binding sites in naive B cells (NBs).
49 is competition assays indicated that catfish Oct2 binds the consensus octamer motif with an apparentl
50  POU homeodomain transcription factors Oct1, Oct2, Brn4, SCIP, Skn1a or Skn1i, results in a strong su
51 y of OCT3 is different from that of OCT1 and OCT2 but correlates significantly with that of the extra
52         To test this hypothesis, two catfish Oct2 cDNAs (alpha and beta) were cloned by screening a c
53 es suggest that pharmacological targeting of OCT2 could be exploited to afford neuroprotection in can
54 single visit using both the Spectralis HRA + OCT2 device and the Optos California device.
55 Our data indicate that the PORE-type Oct1 or Oct2 dimer, rather than the monomer, is the primary targ
56 lustering of regulatory elements enriched in OCT2 DNA-binding motifs that became heavily loaded with
57  and reduced tetraethylammonium transport by OCT2 expressed in Chinese hamster ovary cells, effects t
58 ng force for choline uptake in rat and human OCT2-expressing oocytes and in intact CP in vitro.
59        These findings indicate that HCF1 and OCT2 function at OriP to regulate viral transcription, h
60  spiny neurons, and this activity depends on OCT2 function.
61  model of the three-dimensional structure of OCT2, Glu(447) was found in a putative docking region wi
62  of multiple octamer motifs suggests that an Oct2 homologue may play an important role in driving exp
63 cells are formed normally after depletion of OCT2 in a conditional knockout mouse, but their prolifer
64   This finding led us to examine the role of OCT2 in germinal center-derived lymphomas.
65                       Expression of OCT1 and OCT2 in Xenopus oocytes increased hemicholinium-3-sensit
66 al role of the organic cation transporter 2 (OCT2) in satellite glial cells in oxaliplatin-induced ne
67 istinct molecular properties of MATE1 versus OCT2 inhibitors and was used to screen the DrugBank in s
68 cal properties that differ between MATE1 and OCT2 inhibitors.
69 plicing; as determined by Southern analysis, Oct2 is a single copy gene.
70  These data demonstrate that cysteine 474 of OCT2 is exposed to the aqueous milieu of the cleft and c
71           Importantly, genetic alteration of OCT2 is not a requirement for cellular addiction in DLBC
72 found that the organic cation transporter 2 (OCT2) is expressed on dorsal root ganglia cells within t
73 comparisons with mammalian Oct2, the catfish Oct2 isoforms show high sequence conservation in their N
74  subtly alters the DNA-binding preference of OCT2, leading to the transactivation of noncanonical tar
75 T1 and additional cation transporters (renal OCT2, MATE1, and MATE2K).
76            We measured transport kinetics of OCT2-mediated uptake and demonstrated that IRIP overexpr
77                     These data indicate that OCT2 mediates choline transport across the ventricular m
78 led expression of OCT3 mRNA, but not OCT1 or OCT2 mRNA, in the medial hypothalamus.
79 ly cloned organic cation transporters (OCT1, OCT2, NKT, NLT, RST, and OCTN1).
80 ntroducing mutations designed to disrupt the OCT2-OCA-B interface, we reveal a requirement for this p
81 uirement for the B-cell transcription factor OCT2 (octamer-binding protein 2, encoded by Pou2f2) in g
82 ransferase complex, and transcription factor OCT2 (octamer-binding transcription factor 2) bound coop
83  membrane of enterocytes and hepatocytes and OCT2 on the basolateral membrane of proximal tubular cel
84                                 Depletion of OCT2 or HCF1 deregulated latency transcription and histo
85 16- to 35-fold in cells overexpressing mouse Oct2 or human OCT2, and this process was associated with
86                                   Along with OCT2, other SLC-family drug transporters are potentially
87              The organic cation transporter, OCT2, plays a role in renal secretion of a broad array o
88 ifs were examined to determine if they bound Oct2 POU domains in monomeric or dimeric (PORE and MORE)
89 ation, the two octamer motifs in Emu3' bound Oct2 POU domains only in monomeric configuration.
90                                 Mutations in OCT2 (POU2F2) affected its transcriptional and functiona
91 ermore, genetic or pharmacologic knockout of Oct2 protected mice from hypersensitivity to cold or mec
92 gy with organic cation transporters OCT1 and OCT2 remain incompletely understood.
93                         Ablation of OCT1 and OCT2 significantly reduced the distribution of metformin
94 ganic cation transporters OCT1 (SLC22A1) and OCT2 (SLC22A2) are critically involved in absorption and
95  anion transporters Slc22a1 (Oct1), Slc22a2 (Oct2), Slc22a6 (Oat1), Slc22a8 (Oat3), and Slc47a1 (Mate
96 notype in our knockout mice, suggest that an OCT2-targeted therapeutic strategy would be efficacious
97                    The unique cell-cycle and OCT2-targeting activities of palbociclib and LEE011, com
98 ransport had significantly more overlap with OCT2 than OCT1.
99 e broad transcriptional program regulated by OCT2 that includes the expression of STAT3, IL-10, ELL2,
100                In comparisons with mammalian Oct2, the catfish Oct2 isoforms show high sequence conse
101 some other multidrug transporters, including OCT2, the results suggest that substrate identity exerts
102           The N353L and R403I substitutions (OCT2 to OCT1) did not significantly change the propertie
103 OCT1/2 ranged from 7.6 +/- 3.7 mmol/L (mouse Oct2) to 13.4 +/- 8.1 mmol/L (mouse Oct1).
104 ments in HEK293 cells overexpressing OCT1 or OCT2, to identify and characterize novel endogenous subs
105 iched in motifs belonging to PU.1, TCF3, and OCT2 transcription factors and involved elevated MYD88/T
106 se Yes1, which was found to be essential for OCT2 tyrosine phosphorylation and function.
107 eurotoxicity, and demonstrate that targeting OCT2 using genetic and pharmacological approaches amelio
108  residues contained in the human ortholog of OCT2 was examined.
109                                While catfish Oct2 was shown to be capable of binding PORE and MORE mo
110 ng the humoral immune response, we show that OCT2 was the dominant transcription factor linked to dif
111 ounds plays a role in their interaction with OCT2, we examined the influence of external pH values on
112                                      Catfish Oct2, when bound in this monomeric conformation, was sho
113  inhibitors of organic cation transporter 2 (OCT2), which contributes to the cellular accumulation of

 
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