ライフサイエンスコーパス: ODN

1 ODNs shorter than 21 nt and with the adenosine adjacent

2 ODNs targeting the lagging-strand template blocked the t

3 nd intrathecal injection of the TLR9 agonist ODN 1826 induced mechanical allodynia in both sexes of W

4 ice with a CpG oligonucleotide TLR9 agonist (ODN 1585) enhances expansion of IL-22-producing CD3-NK1.

5 central glucoprivation was suppressed by an ODN agonist.

6 of glucose was blunted by coinjection of an ODN antagonist.

7 Finally, in rats treated with an ODN to prevent high salt-induced up-regulation of brain

8 P-LDN compared with HA-LDN (OR 3 [1,10]) and ODN (OR 5 [2, 15]).

9 endozepines, are secreted by astroglia, and ODN is a potent anorexigenic factor.

10 with proopiomelanocortin (POMC) neurons and ODN selectively activated POMC neurons through the ODN-G

11 TLR9-antagonist ODNs likewise promoted T cell activation, which has impo

12 nals via Toll-like receptor 4 (TLR4), and AS-ODN for TLR4 mRNA administered intrathecally, attenuated

13 ion of an oligodeoxynucleotide antisense (AS-ODN) to mRNA for cluster of differentiation 44 (CD44), t

14 Protein kinase C epsilon (PKCepsilon) AS-ODN also prevented LDM-induced hyperalgesia and priming,

15 xynucleotide antisense to TLR4 mRNA (TLR4 AS-ODN) prevented OIH and prolongation of prostaglandin E(2

16 , neither of which was attenuated by TLR4 AS-ODN.

17 al (Imiquimod, a TLR7 agonist) or bacterial (ODN 2395, a TLR9 agonist) surrogates.

18 patient spleens, suggest that collaborative ODN and IL-15 signaling may promote in vivo B-CLL growth

19 tion of negative controls (non-complementary ODN) were clearly discriminated by the sensor.

20 free alginate strands carrying complementary ODNs.

21 nds led to specific binding to complementary-ODN-carrying alginate gels in vitro and to injected gels

22 Induction of IDO by a GpC-containing ODN could also be demonstrated in human dendritic cells,

23 Control-ODN or iCpG-ODN did not alter CLP-induced cardiac dysfun

24 eated with CpG-ODN, control CpG-ODN (control-ODN), or inhibitory CpG-ODN (iCpG-ODN) 1 hour prior to c

25 Coupling ODNs to alginate strands led to specific binding to comp

26 CpG ODN was also co-encapsulated with p-Trp2 as an adjuvant.

27 able hapten analogue and a Th1 adjuvant (CpG ODN).

28 e a normal response to both anti-IgM and CpG ODN 1826.

29 The controlled release of anti-PD1 and CpG ODN by CpG DNA-based "nano-cocoons" can induce considera

30 given PspA plus a combination of pFL and CpG ODN showed protective immunity against nasal S. pneumoni

31 serving as a DC enhancement factor, and CpG ODN, serving as a DC activating factor, into sponge-like

32 veal that DEC-205 directly binds class B CpG ODN and enhances their uptake.

33 entify an important receptor for class B CpG ODN and reveal a unique function for DEC-205.

34 preferentially binds a specific class B CpG ODN that has been selected for human clinical trials.

35 Topical or s.c. CpG ODN adjuvant administration at the time of a s.c.

36 pH-sensitive liposomes co-encapsulating CpG ODN and cGAMP induced synergistic innate immune response

37 nstitutively active ARF6 mutant enhanced CpG ODN-induced cytokine production.

38 by a variety of cells, is a receptor for CpG ODN.

39 How CpG ODN are captured and delivered to the intracellular rece

40 6 by dominant mutants and siRNA impaired CpG ODN-mediated responses, whereas cells expressing the con

41 receptor 1 (MRC1; CD206) is involved in CpG ODN uptake and trafficking in wild-derived MOLF/Ei perit

42 presence of various adjuvants, including CpG ODN 2006, a synthetic oligonucleotide TLR9 ligand (TLR9L

43 th CpG ODN but not GpC ODN had increased CpG ODN uptake due to CpG ODN-induced ARF6 activity.

44 The capacity of prophylactic intranasal CpG ODN to enhance survival does not require adaptive immuni

45 ed cytidyl guanosyl dinucleotide motifs (CpG ODN) are TLR9 ligands with attractive immunostimulatory

46 ablish that intranasal administration of CpG ODN 1 day prior to lethal pulmonary exposure to Y. pesti

47 nt studies indicate that the delivery of CpG ODN directly into the tumor bed reduces the immunosuppre

48 , indicating that intranasal delivery of CpG ODN has systemic impacts.

49 we evaluated the therapeutic profile of CpG ODN in a triple transgenic mouse model, Tg-SwDI, with ab

50 quired for downstream ARF6 regulation of CpG ODN uptake.

51 A single dose of CpG ODN was associated with reduced biomarkers of cardiac in

52 Peripheral administration of CpG ODN, both before and after the development of CAA, negat

53 iphile-CpG, an albumin-binding analog of CpG ODN, following systemic administration 3days after tumor

54 ing by regulating the cellular uptake of CpG ODN.

55 nformation for potential clinical use of CpG ODN.

56 the potential clinical applicability of CpG ODN.

57 CpG oligodeoxynucleotide (CpG ODN) cellular uptake into endosomes, the rate-limiting s

58 and guanine rich oligodeoxynucleotides (CpG ODN) and their effects on cardiac function, injury, and

59 ants [Bordetella pertussis toxin (PT) or CpG ODN or a squalene-based oil-in-water nanoemulsion (NE)],

60 e pretreated with vehicle or stimulatory CpG ODN (beating heart control and DCD stimulated with CpG O

61 Additional studies showed that CpG ODN uptake was increased in ARF6-activated cells but imp

62 To identify the gene responsible for the CpG ODN defect, we have performed genome-wide linkage analys

63 All of these CpG ODN-mediated impacts, including the increased pulmonary

64 llele, R892W, which is hyporesponsive to CpG ODN and acts as a dominant-negative in a cellular model

65 e strain, MOLF/Ei, are hyporesponsive to CpG ODN but are fully responsive to bacterial DNA, thus impl

66 ODN had increased CpG ODN uptake due to CpG ODN-induced ARF6 activity.

67 ell memory can be generated with topical CpG ODN at the time of s.c. immunization, suggesting a new m

68 When CpG ODN are used as an adjuvant, mice deficient in DEC-205 h

69 insight into a novel mechanism by which CpG ODN contribute to tumor regression, and they support int

70 ormulation of (S)MLMH-TT adjuvanted with CpG ODN 1826 + alum successfully raised anti-METH antibodies

71 However, only mice with CpG ODN administered topically had significant numbers of CD

72 Furthermore, cells pretreated with CpG ODN but not GpC ODN had increased CpG ODN uptake due to

73 Donor pretreatment with CpG ODN doubled the number of functional DCD hearts at ESHP.

74 Indeed, intranasal prophylaxis with CpG ODN provides significant protection against subcutaneous

75 ng heart control and DCD stimulated with CpG ODN, BST and DST).

76 nding and defective co-localization with CpG ODN.

77 antibody and CpG oligodeoxynucleotides (CpG ODNs) has been demonstrated to prevent cancer relapse ut

78 -motif containing oligodeoxynucleotides (CpG ODNs) is preceded by agonist endocytosis and delivery in

79 CpG-ODN attenuation of angiogenesis, however, remains TLR9-d

80 CpG-ODN pre-treated endothelial cells enhance macrophage mig

81 CpG-ODN prevented CLP-induced cardiac dysfunction, as eviden

82 CpG-ODN prevents CLP-induced cardiac dysfunction, in part th

83 CpG-ODN significantly attenuated CLP-induced myocardial apop

84 CpG-ODN-induced intraocular inflammation was abrogated in TL

85 bition of ERK by U0126 in vivo abolished CpG-ODN attenuation of CLP-induced cardiac dysfunction.

86 Addition of the adjuvants CpG-ODN or Poly(I:C) preferentially amplified Teffs over Tre

87 By 6 hours after CpG-ODN administration, TLR9 mRNA was increased in the corne

88 synergy between accessory cytokines and CpG-ODN in NK cells.

89 In contrast, LPS, MPLA, and CpG-ODN, but not poly(I:C), improved the host response to a

90 study, we report the development of anti-CpG-ODN antibodies in 21 of 37 patients who received CpG 790

91 These data show that topically applied CpG-ODN induces intraocular inflammation owing to TLR9 activ

92 d CpG-ODN with different CpG motifs, but CpG-ODN with GACGTT or AACGTT had better activity to this TL

93 Regulation of angiogenesis by CpG-ODN is pervasive and tissue non-specific.

94 Activation of these two TLRs by CpG-ODN occurred inside the cells and was modulated by UNC93

95 mice were treated with CpG-ODN, control CpG-ODN (control-ODN), or inhibitory CpG-ODN (iCpG-ODN) 1 ho

96 ew and alternative signaling pathway for CpG-ODN in murine NK cells.

97 Furthermore, CpG-ODN stimulation in the presence of accessory cytokines i

98 The impaired CpG-ODN-induced TNF-alpha production is GNP concentration- a

99 d with protective TLR ligands, including CpG-ODN, showed reduced plasma cytokines during P. aeruginos

100 rol CpG-ODN (control-ODN), or inhibitory CpG-ODN (iCpG-ODN) 1 hour prior to cecal ligation and punctu

101 Fluorescein isothiocyanate-CpG-ODN rapidly penetrated the cornea and ocular media to re

102 peutic compounds evaluated in the model, CpG-ODN reduced body weight loss (to <6% on days 3-7 after c

103 otide containing unmethylated CpG motif (CpG-ODN) and alanyl-glutamine in vivo and in vitro.

104 s the endocytosis and internalization of CpG-ODN by mouse bone marrow-derived macrophages and directl

105 a molecular basis for the activities of CpG-ODN in fish.

106 and TLR21 are the cellular receptors of CpG-ODN in mammals and chickens, respectively.

107 mediate the antimicrobial activities of CpG-ODN.

108 and respond to CpG oligodeoxynucleotide (CpG-ODN) by producing IFN-gamma and GM-CSF.

109 stimulation by CpG-oligodeoxynucleotide (CpG-ODN) was integrated into microbiome-gene expression asso

110 the effect of CpG oligodeoxynucleotide (CpG-ODN), the TLR9 ligand, on polymicrobial sepsis-induced c

111 nt in binding CpG oligodeoxynucleotides (CpG-ODN), the microbial DNA mimetic sensed by toll-like rece

112 osphate-guanosine oligodeoxynucleotides (CpG-ODN), to investigate the role of TLR9 in vascular pathop

113 ith CXCL13-coupled CpG oligonucleotides (CpG-ODN) can block cancer metastasis by inhibiting CD20(Low)

114 ing GM-CSF in combination with P(I:C) or CpG-ODN induced the complete regression of solid tumors (</=

115 Vaccine formulations of peptide+CpG-ODN or Poly(I:C) induced selective production of proinfl

116 zebTLR9 broadly recognized CpG-ODN with different CpG motifs, but CpG-ODN with GACGTT o

117 Further, we noted that synthetic CpG-ODN requires backbone phosphorothioate but not TLR9 acti

118 In vitro experiments demonstrated that CpG-ODN promotes an association between TLR9 and Ras, result

119 We demonstrate that CpG-ODN stimulates inflammation yet inhibits angiogenesis.

120 echanistic investigations suggested that CpG-ODN upregulates low surface levels of 4-1BBL on tBregs t

121 The CpG-ODN binding function of DEC-205 is conserved between mou

122 Consistent with cytokine inhibition, the CpG-ODN-induced phosphorylation of NF-kappaB and JNK as well

123 This CpG-ODN chaperone complex-promoted innate immunity confers i

124 afish TLRs are functional, responding to CpG-ODN but not to other TLR ligands.

125 LR signaling pathways was also linked to CpG-ODN responsive fibroblasts, OTU1341 (Prevotella), and Sh

126 dividuals with fibroblasts responsive to CpG-ODN stimulation.

127 st, zebTLR21 responded preferentially to CpG-ODN with GTCGTT motifs.

128 stored corneal inflammatory responses to CpG-ODN.

129 s IL-15 and IL-18) was required, whereas CpG-ODN or accessory cytokines alone did not induce IFN-gamm

130 reflecting endotoxin tolerance, whereas CpG-ODN-primed mice showed augmented cytokine production.

131 of Listeria monocytogenes compared with CpG-ODN treatment alone.

132 Male C57BL/6 mice were treated with CpG-ODN, control CpG-ODN (control-ODN), or inhibitory CpG-OD

133 Additionally, CpG-ODNs induce an M1 macrophage phenotype that restricts an

134 The effects mediated by CpG-ODNs can therefore modulate both endothelial cells and m

135 CpG-oligodeoxynucleotides (CpG-ODNs) are potent immune stimuli currently under investig

136 tion of TLR9 (CpG oligodeoxynucleotides; CpG-ODNs) signal in macrophages.

137 odies cross-reacted with other synthetic CpG-ODNs but not with the DNA of mixed bacterial vaccine and

138 The CpG-ODNs that activate both zebTLR9 and zebTLR21 were more p

139 fected TLR9 translocation in response to CpG-ODNs and to phagosomes.

140 Unlike CpG-ODNs, the effects of GpC-ODN required TLR7/TRIF-mediated

141 ongoing and planned clinical trials with CpG-ODNs.

142 We performed 4286 DNs: 2759 open DN (ODNs), 1190 hand-assisted (HA) laparoscopic DNs (LDNs),

143 -(Ph)ImdC):ORN(G) was reduced only 3.8-fold, ODN(CF3-(Ph)ImdC) appears to be a DNA-selective probe.

144 These findings establish poly-G ODN as a novel type of cancer immunotherapy.

145 Mechanistically, poly-G ODN directly induced the phosphorylation of Lck (an esse

146 The antitumor activity of poly-G ODN was mediated through CD8 T cells in a TLR9-independe

147 e, cells pretreated with CpG ODN but not GpC ODN had increased CpG ODN uptake due to CpG ODN-induced

148 Unlike CpG-ODNs, the effects of GpC-ODN required TLR7/TRIF-mediated but not TLR9/MyD88-media

149 In this study, we show that a synthetic GpC-ODN conferred highly suppressive activity on mouse splen

150 NA (dsDNA) donors with central heterologies, ODNs generated short conversion tracts with Gaussian-lik

151 N (control-ODN), or inhibitory CpG-ODN (iCpG-ODN) 1 hour prior to cecal ligation and puncture (CLP)-i

152 Control-ODN or iCpG-ODN did not alter CLP-induced cardiac dysfunction.

153 since the quantum yield of ODN(CF3-(Ph)ImdC):ODN(G) was reduced 17-fold vs that of a single strand, w

154 y important for IL-15->CD122/yc signaling in ODN-primed cells expressing activated pSTAT3.

155 The high yield of Gh in ODNs underscores the importance of further study on this

156 When incorporated in ODNs, this fluorescent deoxyuridine analog exhibits rema

157 INH-ODN 2088 is a prototypic member of this class of INH-ODN

158 ODN 2088 and G-modified INH-ODNs such as INH-ODN 24888, TLR7-induced TNF-alpha release and TLR7- and

159 dendritic cells was equally inhibited by INH-ODN 2088 and G-modified INH-ODNs such as INH-ODN 24888,

160 toimmune MRL/Mp-lpr/lpr mice, G-modified INH-ODN 24888 was significantly more efficient than unmodifi

161 is a prototypic member of this class of INH-ODN and acts as a TLR7 and TLR9 antagonist.

162 nucleotides (inhibitory oligonucleotide [INH-ODN]) are characterized by a phosphorothioate backbone a

163 Surprisingly, INH-ODN 2088 stimulated B cells to proliferate when used in

164 ificantly more efficient than unmodified INH-ODN 2088.

165 inhibited by INH-ODN 2088 and G-modified INH-ODNs such as INH-ODN 24888, TLR7-induced TNF-alpha relea

166 more efficiently impaired by G-modified INH-ODNs.

167 ignificantly more impaired by G-modified INH-ODNs.

168 G modification allows the development of INH-ODNs with superior inhibitory potency for inflammatory d

169 ications for the study of these "inhibitory" ODNs in inflammatory diseases.

170 sufficiently stable to be incorporated into ODNs.

171 minoethyl phosphotriester modifications into ODNs.

172 esiniferatoxin failed to affect intraplantar ODN 1826-induced mechanical allodynia.

173 and WM-239A cells with fluorescently labeled ODNs shows significant cytoplasmic fluorescence when vie

174 A fluorescently labeled 16-mer ODN modified with two TP linkages shows efficient cellul

175 To demonstrate feasibility, seven 20-mer ODNs including four that contain sensitive ester and alk

176 Fluorescently labeled 23-mer ODNs modified with four cationic or hydrophobic Z phosph

177 The minimal ODNs that activate human TLR9 comprise 2 CG dinucleotide

178 a slight destabilization when a TP-modified ODN is hybridized to its complementary RNA.

179 the subcellular distribution of TP-modified ODNs is highly dependent on cell type; a significant nuc

180 ontaining cationic or hydrophobic Z modified ODNs indicate that the backbone-phosphotriester modifica

181 is to use overexpression dominant-negative (ODN) phenotypes to identify mutant proteins that disrupt

182 N) or short-incision open donor nephrectomy (ODN).

183 th open procurement (open donor nephrectomy [ODN]) for children.

184 tion of the endozepine octadecaneuropeptide (ODN) reduces feeding and improves glucose tolerance, yet

185 processing product the octadecaneuropeptide (ODN), collectively named endozepines, are secreted by as

186 A small molecule, odanacatib (ODN), which is a cathepsin K (Ctsk) inhibitor, was inves

187 dy, a small molecular inhibitor (odanacatib [ODN]) is explored to inhibit the function of CTSK in a b

188 The application of ODN decreased the number of osteoclasts, macrophages, an

189 At the end of ODN synthesis, deprotection is achieved with strong base

190 vs that of a single strand, whereas that of ODN(CF3-(Ph)ImdC):ORN(G) was reduced only 3.8-fold, ODN(

191 Furthermore, since the quantum yield of ODN(CF3-(Ph)ImdC):ODN(G) was reduced 17-fold vs that of

192 ated with the association or dissociation of ODNs were measured as change in resistance.

193 cross-links are produced upon irradiation of ODNs containing 1 at 350 nm.

194 ence, length, and dimerization properties of ODNs modulate their activation of TLR9.

195 logies are not suitable for the synthesis of ODNs containing sensitive functionalities.

196 technology is suitable for the synthesis of ODNs containing sensitive functions.

197 pression and augmented oligodeoxynucleotide (ODN) sequestration and PLT clumping upon addition of bac

198 matically characterize oligodeoxynucleotide (ODN)-mediated PGE using Cas9 and its nickase variants in

199 anide ISA 720 plus CpG oligodeoxynucleotide (ODN) and was observed in both inbred and outbred strains

200 the use of topical CpG oligodeoxynucleotide (ODN) as adjuvant to generate skin T(RM) in mice.

201 adjuvants alum and CpG oligodeoxynucleotide (ODN) generated heroin "immunoantagonism", reducing heroi

202 B-CLL exposure to CpG oligodeoxynucleotide (ODN) raised questions about a central role for TLR-9.

203 sphate-guanidine (CpG) oligodeoxynucleotide (ODN), a toll-like receptor 9 (TLR9) agonist, confers pro

204 Gh yield increased in oligodeoxynucleotide (ODN) contexts or at reduced pH.

205 preparation of labeled oligodeoxynucleotide (ODN) probes based on MS2 and cyclin D1 (a known breast c

206 rast, the TLR9 ligand [oligodeoxynucleotide (ODN)1826] stimulated sFlt-1 secretion from macrophages a

207 re SMDHs with multiple oligodeoxynucleotide (ODN) strands.

208 Selective oligodeoxynucleotide (ODN)-mediated down-regulation of brain Galphai(2) protei

209 Mammalian telomeric oligodeoxynucleotide (ODN) significantly inhibited all features of TLR ligand-

210 In traditional oligodeoxynucleotide (ODN) synthesis, phosphate groups are protected with the

211 cked by synthetic CpG oligodeoxynucleotides (ODN).

212 Oligodeoxynucleotides (ODNs) complementary to the (CTG)(45) . (CAG)(45) lagging

213 Application of CpG oligodeoxynucleotides (ODNs) resulted in neutrophil and macrophage infiltration

214 ne-phosphate-guanine) oligodeoxynucleotides (ODNs) leads to cognitive improvements and CAA reduction,

215 ne-phosphate-guanine) oligodeoxynucleotides (ODNs), can reduce amyloid and tau pathologies without ca

216 ific incorporation in oligodeoxynucleotides (ODNs) of an emissive deoxyuridine analog electronically

217 be incorporated into oligodeoxynucleotides (ODNs) by chemical DNA synthesis and thus very little is

218 and incorporated into oligodeoxynucleotides (ODNs).

219 -assembly of modified oligodeoxynucleotides (ODNs) is described.

220 Synthetic oligodeoxynucleotides (ODNs) comprised of the immunosuppressive motif TTAGGG bl

221 Short synthetic oligodeoxynucleotides (ODNs) rich in CpG or GpG motifs have been considered as

222 Indeed, short U3 oligodeoxynucleotides (ODNs) based on these RNA sequences ably inhibited prolif

223 ls were modified with oligodeoxynucleotides (ODNs) that provide a target for drug payloads in the for

224 ts showed that CpG oligodeoxyribonucleotide (ODN) induces very low levels of anti-CPS IgM antibodies,

225 of mixed backbone oligodeoxyribonucleotides (ODNs) having 1,2,3-triazolylphosphonate (TP) as well as

226 f phosphotriester oligodeoxyribonucleotides (ODNs) that are stable to the conditions used for their p

227 Synthetic oligodeoxyribonucleotides (ODNs) containing CpG (unmethylated deoxycytidylyl-deoxyg

228 C) that undergoes an input oligonucleotide (ODN)-selective structural transformation from a stem-loo

229 Immunostimulatory CpG oligonucleotides (ODN) activate cells that express TLR9 and have been show

230 Synthetic CpG oligonucleotides (ODN) have potent immunostimulatory properties exploited

231 of polyguanosine (poly-G) oligonucleotides (ODN) has such an effect, boosting antitumor immunity and

232 onds (fNDs) to deliver CpG oligonucleotides (ODNs) for sustained immunostimulation is reported.

233 ucleases (TALENs) with DNA oligonucleotides (ODNs).

234 nic effects of centrally injected glucose or ODN agonist were suppressed by blockade of the melanocor

235 Pam2-ODN also extended survival of pneumonia in NSG mice engr

236 Pam2-ODN had no discernible effect on replication rate, total

237 Pam2-ODN prevented death due to pneumonia caused by Pseudomon

238 ceptor 2/6 (TLR 2/6) and TLR9 agonists (Pam2-ODN) induces protective mucosal defenses in mice against

239 As Pam2-ODN-induced protection persists despite depletion of sev

240 ate and amine protection for the solid phase ODN synthesis.

241 lity assays show that methylborane phosphine ODNs are highly resistant to 5' and 3' exonucleases.

242 motifs of B-class and C-class phosphodiester ODNs to identify the sequence properties that govern TLR

243 type, right LDN (OR=1.58, P<0.01) and right ODN (OR=1.38, P=0.02) demonstrated an association with i

244 ain Galphai(2) proteins, but not a scrambled ODN, abolished the renal sympathoinhibitory response and

245 In scrambled ODN-treated rats, chronic changes in dietary sodium inta

246 anic substrates and homo- or mixed-sequenced ODNs.

247 SMDHs bearing up to six ODNs were successfully prepared through the coupling of

248 The present novel molecularly imprinted ss-ODN biosensor could greatly benefit in terms of cost-eff

249 single-stranded oligodeoxyribonucleotide (ss-ODN) biosensor was fabricated and characterised in this

250 The resulting ss-ODN imprinted PoPD/ITO electrode was characterised using

251 i.e., Deltai as a function of the target ss-ODN concentration was studied.

252 near Delta current response to the target ss-ODN concentration within the range of 0.01-300 fM.

253 The template ss-ODN was washed out of the ss-ODN/poly(o-phenylenediamine

254 The template ss-ODN was washed out of the ss-ODN/poly(o-phenylenediamine)(PoPD)/ITO electrode using s

255 Using ss-ODN as the template and o-phenylenediamine as the functi

256 The biosensor using ss-ODN imprinted PoPD/ITO as the working electrode showed a

257 is inhibition in vivo, we administered ssDNA-ODNs and poly I:C, alone or in combination, via the intr

258 immune activation can be modulated by ssDNA-ODNs and provide evidence of dampening proinflammatory c

259 atopoietic cells was also inhibited by ssDNA-ODNs.

260 o cells was reduced in the presence of ssDNA-ODNs, preventing TLR3 engagement from occurring.

261 single-stranded DNA oligonucleotides (ssDNA-ODNs) on TLR3 activation.

262 s were reduced in the groups receiving ssDNA-ODNs or both substances.

263 events were inhibited in cultures with ssDNA-ODNs.

264 study, we demonstrate that such suppressive ODN abrogate activation of cytosolic nucleic acid-sensin

265 c cells and macrophages with the suppressive ODN-A151 abrogated type I IFN, TNF-alpha, and ISG induct

266 nd unveil novel applications for suppressive ODNs in the treatment of infectious and autoimmune disea

267 ings reveal a new route by which suppressive ODNs modulate the immune system and unveil novel applica

268 turally derived pathogenic DNA and synthetic ODNs.

269 ddition of different concentration of target ODNs in presence of relevant buffer.

270 The target ODNs specific to Homo sapiens Breast and ovarian cancer

271 Host-derived telomeric ODN suppress B-cell activation and antibody production d

272 Our results demonstrated that ODN can inhibit endodontic disease development, bone ero

273 hroism spectroscopy, which demonstrates that ODN is a more sensitive assessment of protein stability

274 mal protease, we were surprised to find that ODN can suppress the bacterium-induced immune response a

275 cal and immunofluorescent staining show that ODN treatment dramatically decreased F4/80+ macrophages

276 rocomputed tomography (micro-CT) showed that ODN treatment had significant bone protection effects at

277 Collectively, our results suggest that ODN-mediated PGE utilizes synthesis-dependent strand ann

278 Finally, the ODN-GPCR agonist decreased feeding and promoted weight l

279 rs 4, 5, and 9 also largely decreased in the ODN-treated disease group.

280 and corresponding cytokine expression in the ODN-treated disease group.

281 nylenediamine as the functional monomer, the ODN biosensor was fabricated by an electropolymerisation

282 ted poly-thymidine tail at the 3' end of the ODN.

283 We conclude that the ODN(CF3-(Ph)ImdC) probe, exhibiting emission sensitivity

284 lectively activated POMC neurons through the ODN-GPCR but not GABAA, and supressed feeding while incr

285 etween the stimulatory CpG motifs within the ODN fine-tunes the activation of B cells.

286 remove base labile protecting groups and the ODNs from the solid support.

287 Moreover, the ODNs were physically incorporated into the genome only i

288 epending on the relative strandedness of the ODNs and the nick.

289 Among potentially therapeutic ODNs, this study identifies GpC-rich sequences as novel

290 After synthesis these ODNs were found to be stable to the condition required t

291 A robust response to ODN+IL-15 was positively linked to presence of chromosom

292 mal memory B cells proliferate vigorously to ODN+IL-15, a cytokine found in stromal cells of bone mar

293 esults demonstrate that triazolylphosphonate ODNs are versatile additions to the oligonucleotide chem

294 , through proof-of-concept experiments using ODN-modified nanopores, we show that functionalized nano

295 Interestingly, single-nick-induced PGE using ODN donors produced conversion tracts biased either most

296 LT clumping upon addition of bacterial/viral ODNs.

297 nce was observed for the G-matched duplex vs ODN(CF3-(Ph)ImdC), while for A-mismatched duplex, only a

298 ly conserved charged residues, combined with ODN screening to eliminate partially unfolded proteins,

299 tes of graft failure at 1 year compared with ODN (P = 0.002).

300 oupling of arylenethynylene macrocycles with ODNs, which were used to mediate the assembly of gold na