ライフサイエンスコーパス: OEC

1 OEC cultures were successfully generated from a similar

2 OECs attenuated immune cell infiltration, reduced second

3 OECs demonstrate a TLR-response profile similar to that

4 OECs from T1D participants are TLR-hyper-responsive, due

5 OECs have a unique response to P. gingivalis LPS, where

6 OECs may be used for further phenotypic, genetic, and fu

7 OECs, but not FBs, intermingled with astrocytes, facilit

8 more (NS) and nvAMD 32-times more (P < 0.05) OECs on expansion of clusters than did non-AMD/low-risk

9 by ligand lability, with the Mn(IV)(3)CaO(4) OEC model being unreactive.

10 al performance of pre-optimized OEC/BiVO(4) (OEC: NiOOH, MnO(x,) and CoOOH) systems by 1.2~1.6-fold,

11 rall improvement in locomotor function after OEC transplantation, measured using the Basso, Beattie,

12 nd share many properties in common, although OECs appear to be a better candidate for transplantation

13 An OEC population was isolated and expanded from the blood

14 Site-selective deposition of an OEC, guided by the activity maps, improves the overall p

15 The lack of an OEC-specific marker, however, has limited the investigat

16 re can be applied to human studies, where an OEC can be analyzed in light of an individual's entire g

17 orescent protein-labeled fibroblast (FB) and OEC transplants acutely after a complete low-thoracic sp

18 indings provide new insights into GnRH-1 and OECs development and demonstrate that human GLI3 mutatio

19 pha1 was expressed in immature OSN axons and OECs of the nerve layer, as well as mitral and tufted ce

20 atically reduced, exhibiting fewer axons and OECs.

21 ignaling network that exists in human OM and OECs.

22 are lost from amino acid that will serve as OEC ligands as metals are bound.

23 SN axon bundles were enlarged and associated OECs increased, indicating impaired migration of OECs an

24 nstrated that immune suppression can augment OEC contact-mediated protection of axons and neurons dur

25 ively links the OER activity of the Ni-based OECs with the generation of those sites on the surface o

26 tain catalytically active phases in Ni-based OECs, in addition to the key role of the Fe impurities.

27 d to a deprotonation process of the Ni-based OECs, leading to the formation of the negatively charged

28 aracterization of two Fe-containing Ni-based OECs, namely nickel borate (Ni(Fe)-B(i)) and nickel oxyh

29 y of solar-driven devices utilizing Ni-based OECs.

30 wever, there were subtle differences between OECs and Schwann cells in their interactions with astroc

31 reduces interface recombination at the BiVO4/OEC junction while creating a more favorable Helmholtz l

32 lvaging ischemic murine limbs, whereas bolus OEC delivery was ineffective in preventing toe necrosis

33 neration of negatively charged sites in both OECs (NiOO(-)), which can be described as adsorbed "acti

34 The OER activity of both OECs is strongly pH dependent, which can be attributed t

35 sorption spectroscopy results show that both OECs are chemically similar, and that the borate anions

36 Since the ammonia-bound OEC is active, the ammonia-binding Mn site is not a subs

37 We found that, as in the case of bulbar OEC preparations, the mucosal cells also restored direct

38 osis of the primary olfactory axon debris by OECs was first detected at E14.5.

39 While the repertoire of TLRs expressed by OECs is similar to that expressed by macrophages (M), th

40 However, it is unclear when phagocytosis by OECs first commences.

41 We investigated the onset of phagocytosis by OECs in the developing mouse olfactory system by utilizi

42 modelling (reduction) of HS 6-O-sulfation by OECs, compared with SCs, to suppress boundary formation.

43 ing two different oxygen evolution catalyst (OEC) layers, FeOOH and NiOOH, which reduces interface re

44 hotoanode with an oxygen evolution catalyst (OEC) to increase the photocurrent and reduce the onset p

45 kinetic profile of the O2 evolving catalyst (OEC).

46 evelopment of oxygen evolution co-catalysts (OECs) is being actively undertaken, the tailored integra

47 Ni-based oxygen evolution catalysts (OECs) are cost-effective and very active materials that

48 Earth-abundant oxygen evolution catalysts (OECs) with extended stability in acid can be constructed

49 ection model and olfactory ensheathing cell (OEC) or fibroblast (FB; control) transplantation as a re

50 neuroprotective olfactory ensheathing cell (OEC) subset is difficult to isolate, means an allogeneic

51 Olfactory ensheathing cell (OEC) transplantation is a candidate cellular treatment a

52 eficial therapy, olfactory ensheathing cell (OEC) transplantation, results in functional improvements

53 In this study, human oral cancer cells (OEC-M1) were encapsulated in 3D agarose scaffold and cul

54 n with cultured olfactory ensheathing cells (OEC) into the lesion cavity 6 weeks after contusion inju

55 elopment of the olfactory ensheathing cells (OEC) is imperative for normal GnRH-1 neuronal migration.

56 rd migration of outgrowth endothelial cells (OECs) have been delineated, and a material incorporating

57 ure of 50% p75+ olfactory ensheathing cells (OECs) and fibroblasts derived from the outer layers of t

58 Olfactory ensheathing cells (OECs) are known to enhance axonal regeneration and to pr

59 Olfactory ensheathing cells (OECs) are often described as being present in both the p

60 Olfactory ensheathing cells (OECs) are specialized glia associated with olfactory sen

61 Olfactory ensheathing cells (OECs) are the glia of the primary olfactory nerve and ar

62 Transplants of olfactory ensheathing cells (OECs) cultured from the olfactory bulb are able to induc

63 Wnt-5a, whereas olfactory ensheathing cells (OECs) express Wnt-4.

64 Olfactory ensheathing cells (OECs) have neuro-restorative properties in animal models

65 infected human olfactory ensheathing cells (OECs) in vitro and measured bacterial invasion and the c

66 ons (OSNs), and olfactory ensheathing cells (OECs), but was excluded from mature OSNs.

67 (SCs), but not olfactory ensheathing cells (OECs), form a boundary with astrocytes, due to a SC-spec

68 al culturing of olfactory ensheathing cells (OECs), which can be used to understand how OECs interact

69 cells (SCs) and olfactory ensheathing cells (OECs).

70 bicans-infected human oral epithelial cells (OECs) and in tongue tissue from mice with OPC.

71 riodontium, including oral epithelial cells (OECs), express innate immune receptors, including TLRs.

72 atalyst found in the oxygen evolving center (OEC) in photosystem II, nanostructured manganese oxide s

73 luble model of a cobalt-phosphate/borate (Co-OEC) water splitting catalyst.

74 the growing cobaltate clusters comprising Co-OEC.

75 ) solutions in weakly basic electrolytes (Co-OEC).

76 ity is oxidized to produce the well-known Co-OEC heterogeneous cobaltate catalyst, which is an active

77 n isotopologues produced by (18)O-labeled Co-OEC in H2(16)O reveals that water splitting catalysis pr

78 Steady-state electrodeposition of Co-OEC exhibits a Tafel slope approximately equal to 2.3 x

79 The edge site chemistry of Co-OEC has been probed by using a dinuclear cobalt complex.

80 s are consistent with the OER activity of Co-OEC in Bi and Pi.

81 orce microscopy reveal that nucleation of Co-OEC is progressive and reaches a saturation surface cove

82 n oxygens bound to dicobalt edge sites of Co-OEC.

83 is also confirmed by DEMS experiments of Co-OEC.

84 These complementary studies on Co-OEC and the dicobalt edge site mimic allow for a direct

85 em and the high-valent active site of the Co-OEC, with specific emphasis on the manifestation of a do

86 oxidic cobalt oxygen-evolving catalysts (Co-OECs).

87 of anions in the self-repair mechanism of Co-OECs.

88 The Co-OECs are active when residing at two oxidation levels ab

89 e properties of the oxygen-evolving complex (OEC) and the structure of the Mn(4)Ca cluster in Photosy

90 he active site of the O(2)-evolving complex (OEC) as expected.

91 hin and outside the oxygen-evolving complex (OEC) have been examined.

92 is the case for the oxygen evolving complex (OEC) in photosystem II (PSII), where we have studied whe

93 o S(3) steps of the oxygen-evolving complex (OEC) in photosystem II (PSII).

94 The oxygen-evolving complex (OEC) in the membrane-bound protein complex photosystem I

95 sible models of the oxygen-evolving complex (OEC) in the S0-S4 states.

96 down turnover of the O(2)-evolving complex (OEC) is a plausible approach to gain mechanistic informa

97 water oxidation at the O2-evolving complex (OEC) of photosystem II (PSII) is a complex process invol

98 ctural model of the oxygen-evolving complex (OEC) of photosystem II (PSII) is introduced.

99 5)Ca cluster of the oxygen-evolving complex (OEC) of Photosystem II (PSII) poised in the S(2) state w

100 e Mn4Ca site in the oxygen evolving complex (OEC) of photosystem II (PSII).

101 ation catalyst, the oxygen-evolving complex (OEC) of photosystem II (PSII).

102 otif present in the oxygen-evolving complex (OEC) of photosystem II and in water-oxidizing Mn/Ca laye

103 The oxygen-evolving complex (OEC) of photosystem II contains a Mn(4)CaO(n) catalytic

104 etic organisms, the oxygen-evolving complex (OEC) of photosystem II generates dioxygen from water usi

105 ry synthesis of the oxygen-evolving complex (OEC) of photosystem II has been the objective of synthet

106 hough the {CaMn4O5} oxygen evolving complex (OEC) of photosystem II is a major paradigm for water oxi

107 lly relevant to the oxygen-evolving complex (OEC) of photosystem II were prepared and characterized.

108 d reactivity of the oxygen-evolving complex (OEC) of photosystem II, a low-symmetry Mn4CaOn cluster.

109 nd formation at the oxygen-evolving complex (OEC) of Photosystem II, and its electronic structure has

110 ional models of the oxygen evolving complex (OEC) of photosystem II, we report the synthesis of site-

111 laser pulse on the oxygen-evolving complex (OEC) of photosystem II.

112 n this process, the oxygen-evolving complex (OEC) of PSII cycles through five states, S0 to S4, in wh

113 oleracea shows that oxygen evolving complex (OEC) synthesis, and resynthesis after photodamage, requi

114 takes place in the oxygen-evolving complex (OEC) that is comprised of a tetranuclear manganese clust

115 anganese-containing oxygen evolving complex (OEC) to the oxidized primary electron-donor chlorophyll

116 s binding site in the O(2)-evolving complex (OEC) under continuous illumination.

117 er oxidation is the oxygen-evolving complex (OEC), a Mn(4)CaO(5) cluster.

118 on reactions at the oxygen-evolving complex (OEC), which is composed of four manganese ions and one c

119 equivalents at the oxygen-evolving complex (OEC).

120 equivalents at the oxygen-evolving complex (OEC).

121 anganese-containing oxygen evolving complex (OEC).

122 e manganese-containing O 2-evolving complex (OEC).

123 4)Ca cluster of the oxygen-evolving complex (OEC).

124 CaO5 cluster in the oxygen-evolving complex (OEC).

125 tosystem II (PS II) oxygen-evolving complex (OEC): a multiprotein assembly embedded in the thylakoid

126 mbrane-protruding oxygen-evolving complexes (OECs) associated with photosystem II (PSII) on spinach (

127 In conclusion, OEC transplantation exerts considerable beneficial effec

128 se structural model of the asymmetric-cubane OEC unit.

129 e used floating liquid marbles to co-culture OECs with Schwann cells and astrocytes which formed natu

130 he injured olfactory pathway and of cultured OECs identified 102 genes that were subsequently functio

131 rous simultaneous oxygen equilibrium curves (OECs) can be obtained under truly identical conditions f

132 Cx43-deleted OECs exhibited features consistent with the loss of gap

133 ate that from early in embryonic development OECs are the primary phagocytic cells of the primary olf

134 Direct injection of an EPC/OEC combination was minimally effective in improving lim

135 However, because excess OEC material can hinder light absorption and decrease ph

136 between the number of OEC clusters, expanded OECs and levels of KDR was demonstrated.

137 GFP-expressing OECs survived in the lesion and distributed longitudinal

138 servations suggest that Gli3 is critical for OEC development in the nasal mucosa and subsequent GnRH-

139 e large axon fascicles, but are negative for OEC markers.

140 tes give optimal improvement if targeted for OEC deposition, and whether sites catalysing water oxida

141 te connexin genes with temporal control from OECs and address the physiological consequences.

142 nd accordingly suggest a reassessment in how OEC activities of different catalysts are compared and r

143 This protocol can be used to determine how OECs and other cell types associate and interact while f

144 (OECs), which can be used to understand how OECs interact with other cells in three dimensions.

145 Human OECs killed >90% of the B. pseudomallei in a CPS I-indep

146 timicrobial program to be described in human OECs and establishes the extensive transcriptional defen

147 -hyper-inflammatory phenotype, primary human OECs from individuals with T1D and diabetes-free individ

148 asal and GnRH-1ns but less severe defects in OEC development.

149 to play two ostensibly antagonistic roles in OEC activity: as a promulgator of catalyst activity by e

150 To interrogate the role of the IL-17R in OECs, we generated mice with conditional deletion of IL-

151 a network of signaling pathways activated in OECs following infection involving a novel group of 378

152 main connexin forming functional channels in OECs.

153 shed the expression of connexin 43 (Cx43) in OECs in both juvenile and adult mice.

154 tive siRNA-mediated knockdown of 16 genes in OECs (ADAMTS1, BM385941, FZD1, GFRA1, LEPRE1, NCAM1, NID

155 that endogenous expression of these genes in OECs supports neurite extension of DRG neurons.

156 Expression of VEGF receptor-2 (KDR) in OECs after expansion was determined by Western blot.

157 ice which express red fluorescent protein in OECs.

158 d with OECs, and siRNA reduction of Sulfs in OECs was, in itself, sufficient to induce boundary forma

159 perty is effective in abrogating TLR-induced OEC hyperactivity.

160 rated significantly higher number of initial OEC clusters and expansion potential of OECs in patients

161 dered unique as it consists of intermingling OECs and astrocytes.

162 ential hydrogen bond network, which involves OEC peptide CO groups.

163 The data justify OECs as a cellular substrate to develop and optimize min

164 T lesion paradigm to examine whether mucosal OEC preparations can provide a similar repair to those f

165 atalyst activity with Fe doping of oxidic Ni OEC under acid conditions, as compared to neutral or bas

166 ing by a self-assembled nickel-borate (NiBi) OEC.

167 H-1 neurogenesis, is not required for normal OEC development.

168 strocytes, we demonstrated that SCs, but not OECs, secrete a heat labile factor(s) that inhibits olig

169 The low Cl(-) affinity of OEC (re-)assembly could be a component limiting the rate

170 d conditions; and observed for appearance of OEC clusters and growth characteristics on expansion.

171 This study evaluated the effect of OEC transplantation on microsurgically repaired sciatic

172 ogic approach, (i) to assess the efficacy of OEC transplantation on locomotor recovery after traumati

173 vomeronasal progenitors and the formation of OEC in the nasal mucosa.

174 risk dry AMD had a 5.6-fold higher number of OEC clusters per 20 mL blood, and subjects with nvAMD ha

175 ignificant correlation between the number of OEC clusters, expanded OECs and levels of KDR was demons

176 The growth phase of OEC photoassembly shows an H/D solvent isotope effect of

177 ly could be a component limiting the rate of OEC (re-)assembly.

178 To date, studies of OEC behaviour in a multicellular environment have been h

179 e mucosal cell cultures contained only 5% of OECs and a conversely much larger proportion of fibrobla

180 es from mucosal samples yielded around 5% of OECs compared with the 50% obtained from samples culture

181 The ability of OECs to interact with astrocytes is one reason why OECs

182 The aberrant TLR-activation of OECs in T1D has the potential to contribute to excessive

183 functionally characterized in cocultures of OECs and primary dorsal root ganglion (DRG) neurons.

184 lly, material deployment of a combination of OECs with another cell population commonly isolated from

185 f Cx43 deletion did not alter the density of OECs.

186 increased, indicating impaired migration of OECs and OSN axons.

187 tial OEC clusters and expansion potential of OECs in patients at risk for or already affected by nvAM

188 These results suggest that presentation of OECs at the time of nerve injury enhances regeneration a

189 to the regeneration-promoting properties of OECs.

190 To delineate the TLR responses of OECs derived from T1D participants and to determine effe

191 to better understand the functional roles of OECs in vivo.

192 Immunosuppression enhanced survival of OECs and FBs, but only OEC transplantation promoted scaf

193 Notably, the "bridging" tract of OECs formed within 1 h of cell injection, raising the po

194 Transplantation of OECs is being trialled for repair of the paralysed spina

195 microsurgical repair and transplantation of OECs or injection of medium without cells.

196 enhanced survival of OECs and FBs, but only OEC transplantation promoted scaffold formation in the l

197 electrochemical performance of pre-optimized OEC/BiVO(4) (OEC: NiOOH, MnO(x,) and CoOOH) systems by 1

198 to freely associate and interact to produce OEC spheroids with uniform shapes and sizes.

199 ulting in the disordered arrangement of PSII-OEC particles.

200 3 reaction center protein (CP43) in the PSII-OEC extrinsic domains of grana membranes under condition

201 ide analysis of HS in SC-conditioned and rat OEC-conditioned media showed that SCs secrete more highl

202 ensemble of molecular pathways that regulate OEC development remains to be fully deciphered.

203 Reporter TOPGAL mice demonstrated that some OECs located in the inner olfactory nerve layer can resp

204 In kinetic studies, OEC photoassembly shows a significant lag phase in H(2)O

205 etworks, however, the connexins that support OEC connectivity in vivo have not been identified.

206 connective tissue growth factor (CTGF) than OECs.

207 hat SCs secrete more highly sulfated HS than OECs.

208 ans of the olfactory nervous system and that OECs are primarily "PNS glia."

209 We also found that OECs interact with astrocytes in a similar fashion as Sc

210 Our findings indicate that OECs survive longer than FBs post-transplantation, prese

211 Additionally, we show that OECs limit immune-cell activation and infiltration, wher

212 Collectively, these data suggest that OECs have neuroprotective and immunomodulatory mechanism

213 The OEC is a Mn4CaO5 cluster, and its sequentially oxidized

214 The OEC is successively oxidized by the absorption of 4 quan

215 e tyrosine between those of P680(*+) and the OEC.

216 sis of amino acid residues in and around the OEC has identified residue 87 in the D1 subunit as the o

217 gen bonds to water form a network around the OEC; this network is predicted to involve multiple pepti

218 d state changes from S = 1/2 to S = 3 as the OEC is oxidized from the S(2) state to the S(3) state.

219 orable Helmholtz layer potential drop at the OEC/electrolyte junction.

220 phosphorene (BP) layer, inserted between the OEC and BiVO(4) can improve the photoelectrochemical per

221 late-adherent hOMCs, thought to contain the OEC subset.

222 is study, we have used NH 2OH to destroy the OEC, which would release any tightly bound bicarbonate i

223 The relevance of these cubanes for the OEC and synthetic oxides is discussed.

224 The metals for the OEC are assembled within the PSII protein environment vi

225 the X-ray absorption data with those for the OEC reveal 1 to possess structural parameters that make

226 lectrons are sequentially extracted from the OEC in four light-driven charge-separation events.

227 essential for the relay of protons from the OEC to the lumen, are affected.

228 Under illumination, the OEC cycles through five intermediate S-states (S0 to S4)

229 ctural changes of the Mn4CaO5 cluster in the OEC during the S state transitions using x-ray absorptio

230 te-containing, internal water cluster in the OEC hydrogen-bonded network.

231 roposals that one function of calcium in the OEC is to modulate the reduction potential of the cluste

232 o the geometry of the Mn4CaO5 cluster in the OEC obtained from a polarized XAS model and the 1.9-A hi

233 Conduction velocity in the OEC transplant group was increased in comparison to the

234 rved low-spin to high-spin conversion in the OEC.

235 larities with the bound water network in the OEC.

236 t OH(-)-induced release from its site in the OEC.

237 ly observed Mn oxidation states found in the OEC.

238 gainst tightly bound bicarbonate ions in the OEC.

239 er by facilitating retention of Cl(-) in the OEC.

240 those of other Mn(IV) species, including the OEC S(2) state.

241 mber of manipulations which may increase the OEC content and the effectiveness of mucosal preparation

242 en ammonia/ammonium is incorporated into the OEC hydrogen bond network.

243 ore amino acid residues that reside near the OEC active site on the D1 and CP43 intrinsic subunits of

244 ith more structurally accurate models of the OEC ([MMn3O4]) suggest a general relationship between th

245 The sequentially oxidized forms of the OEC are referred to as the S(n) states.

246 Although the basic structures of the OEC are the same for T. elongatus PSII and spinach PSII,

247 dation of key subunits and reassembly of the OEC as frequently as every 20 to 40 min.

248 n reported to prevent the advancement of the OEC beyond the S(2)Yz(*) intermediate state.

249 AgO4 cluster that models the topology of the OEC by displaying both a cubane motif and a "dangler" tr

250 tions as a barrier against inhibition of the OEC by OH(-).

251 Although the structure of the OEC has remained conserved over eons of evolution, signi

252 bly inhibited the S1 to S2 transition of the OEC in PSII.

253 re elucidation of both the structures of the OEC in the different S-states and the binding of the two

254 t a range of DFT optimized structures of the OEC may all be considered consistent with experimental E

255 Molecular models of the OEC Mn3CaO4Mn catalytic cluster are constructed by expli

256 We analyzed the protonation states of the OEC protein environment using classical Multiconformer C

257 genome-wide transcriptomic profiling of the OEC response by RNA-Seq revealed a network of signaling

258 ctivity as well as the Cl(-) affinity of the OEC that decreases with an increasing pH.

259 Q-band CW ENDOR from the S(2) state of the OEC was obtained following multihour (17)O exchange, whi

260 (III)-Mn(IV) state is a protein model of the OEC's S(2) state.

261 rly useful to establish the structure of the OEC, consistently with high-resolution spectroscopic dat

262 rt recent proposals for the mechanism of the OEC, involving oxido migration between distinct position

263 acceptor side and at the Mn4CaO5 core of the OEC.

264 an oxyl radical ligand in the center of the OEC.

265 1) signals from the D1-His332 ligand of the OEC.

266 e trimanganese-calcium-cubane subsite of the OEC.

267 ase in the rate of catalytic turnover of the OEC.

268 ed in the formation and stabilization of the OEC.

269 S(1) is the dark-adapted state of the OEC.

270 1-Asp(170) in the coordination of Mn4 of the OEC.

271 bind and oxidize the first manganese of the OEC.

272 ded invaluable structural information on the OEC and show that it comprises a [Mn(3)CaO(4)] distorted

273 the absence of structural information on the OEC has hampered these efforts.

274 nce of the additional negative charge on the OEC of the mutant.

275 ukaryotic PSII play a role in protecting the OEC against OH(-) inhibition.

276 is consistent with the observation that the OEC is functional only with one of these two metals.

277 2 as the protonation sites, analogous to the OEC in PS-II of the natural water oxidation system; the

278 rbonate is bound sufficiently tightly to the OEC that it cannot readily exchange with bicarbonate in

279 te ion does not bind reversibly close to the OEC, but it remains possible that bicarbonate is bound s

280 where and when substrate water binds to the OEC.

281 ation, a key transformation pertinent to the OEC.

282 increase in hydrogen bond strength when the OEC is oxidized.

283 nd CoOOH) systems by 1.2~1.6-fold, while the OEC overlayer, in turn, can suppress BP self-oxidation t

284 a product of the reaction of NH 2OH with the OEC, is detected in good yield.

285 ) evolution of the synthesised PSII with the OEC.

286 ate water-binding sites and modes within the OEC.

287 The OECs survived and integrated into the repaired nerves as

288 Floating liquid marbles allow the OECs to freely associate and interact to produce OEC sph

289 eration of those sites on the surface of the OECs.

290 ndertaken, the tailored integration of those OECs with photoanodes is expected to be a plausible aven

291 Thus, OECs dominantly control IL-17R-dependent responses to OP

292 ive sprouting and that SCARB2 contributes to OEC-mediated neuronal repair.

293 ctivity of bridging oxidos is fundamental to OEC function.

294 ges were often present in close proximity to OECs but they contributed only a minor role to clearing

295 ed axons were myelinated by the transplanted OECs and nodes of Ranvier were formed.

296 As probes, we used OEC peptide carbonyl frequencies, the substrate-based in

297 provide evidence for the advantages of using OECs, and not mature SCs, for transplant-mediated repair

298 y the observation that the yield of in vitro OEC photoassembly is higher in deuterated water, D(2)O,

299 o interact with astrocytes is one reason why OECs are believed to be superior to Schwann cells for tr

300 gnificantly lower level by SCs compared with OECs, and siRNA reduction of Sulfs in OECs was, in itsel