ライフサイエンスコーパス: ORF

1 ORF CT588 has a strong sequence similarity to RsbU cytop

2 ORF translation rate is strongly correlated with its mRN

3 iation and elongation rates for over a 1,000 ORFs in exponentially growing wild-type yeast cells.

4 aining 2,692 synonymous mutations in 9 of 11 ORFs did not lose temperature sensitivity, remained gene

5 e recognized, with at least eight SARS-CoV-2 ORFs targeted.

6 e data set involving 10,635 nsSNPs from 2154 ORFs in the human genome and recognized disease-associat

7 We annotated 31 novel ORFs of which 24 ORFs are GPI-CWPs.

8 identify a total of 201 transcripts and 284 ORFs including all known and 46 novel large ORFs.

9 dependent secreted proteins among the 35,286 ORFs of the P. helianthi transcriptome.

10 the RNAPII CTD at Ser2 residues in the cat-3 ORF region during transcription elongation and deletion

11 R34 (medium-reiteration-frequency-family-34) ORF], with unprecedented characteristics, because it is

12 mRNAs encoding E', GP2, or ORF5a as their 5' ORF as well as sg mRNAs encoding six previously unreport

13 ur results indicate that selection of HHV-6B ORFs for immunotherapy should consider this expanded pan

14 908 ORFs (accounting for 2.6% of the total proteins) were id

15 nits of secondary structure that vary across ORF boundaries such that adjacent ORFs on the same mRNA

16 ipts contain multiple translationally active ORFs, and also that most isoforms contain unique combina

17 ary across ORF boundaries such that adjacent ORFs on the same mRNA molecule are structurally distinct

18 map to exons 2 and 3 of POLG but also affect ORF-Y provides potential clinical significance to this f

19 ntly higher rates than genotype 1 across all ORFs.

20 with CPO of L), and Max FLC (with CPO of all ORFs except M2-1 and M2-2).

21 s reported being expressed from an alternate ORF in the mitochondrial genome and inhibiting apoptosis

22 uss progress in the detection of alternative ORFs as well as in the understanding of functions and th

23 Here, we identified an ORF of unknown function, YcbK (renamed MepK), as an mDAP

24 With only the sequence information of an ORF, MiPepid is able to predict whether it encodes a mic

25 Using an ORF kinome screen in MCF-7 cells treated with the CDK4/6

26 ription vector used in the RG system with an ORF encoding NSP3 fused to a fluorescent reporter protei

27 ; dsRNA2 dsRNA is 1,524 bp in length with an ORF that encodes 434 amino acids (molecular mass of 46.9

28 in the CdSe core peak UV-vis absorption and ORF wavelengths, and increases their peak cross-sections

29 nsity of the CdSe core UV-vis absorption and ORF, but it reduces the QD fluorescence depolarization.

30 le CRISPR/Cas9-mediated loss of function and ORF/cDNA driven rescue screens, and cell-based models of

31 encoded upstream and downstream of annotated ORFs, from alternative start sites nested within annotat

32 ernative start sites nested within annotated ORFs and from RNAs previously considered noncoding, it i

33 exons 2 and 3 of POLG, herein referred to as ORF-Y that arose de novo in placental mammals.

34 tional conserved uORF, herein referred to as ORF-Z, was also found in exon 2 of POLG.

35 ur distinct tailspike proteins, annotated as ORFs 210 through 213.

36 In total, 223 dockerin-bearing ORFs potentially involved in cellulosome assembly and a

37 ient protein expression from an intact BHLF1 ORF required the EBV posttranscriptional regulator prote

38 Both are plasmid-borne ORFs, carried by pBCA072 for B. cenocepacia J2315 and pE

39 ivity, but the concurrent expression of both ORFs is needed for exclusion.

40 region of the POLG ORF that is overlapped by ORF-Y.

41 highly methylated regions located in the C1 ORF and around the intergenic region (IR).

42 Some integron GCs, called ORF-less GCs, contain no identifiable ORF with a small n

43 ) often repress translation of the canonical ORF within the same mRNA.

44 ion can promote translation of the canonical ORF.

45 n the 5' mRNA leaders, and amongst canonical ORFs during the activation of the zygotic translatome at

46 ional regulation of both small and canonical ORFs from mRNAs across embryogenesis.

47 uffer the translation of canonical canonical ORFs; and show that, in general, small ORFs in mRNAs dis

48 translation of their corresponding canonical ORFs.

49 ing applications using collections of cloned ORFs as probes.

50 Consequently, ORF 12 and 13 protein expression was abolished and Akt p

51 shed essential genes and 82 highly conserved ORFs that have no known gene products or assigned functi

52 alignment of mammalian sequences containing ORF-Y revealed that the CUG codon has a strong initiatio

53 on phenotype allowed us to identify two core ORFs, so far without any assigned function, as responsib

54 ngle peptide expressed from both the cryptic ORF and wild-type genomes, suggesting a potential new ge

55 ing intact only the 82 conserved but cryptic ORFs.

56 nthetic genome in which 71 conserved cryptic ORFs were simultaneously disrupted is viable but with ~5

57 ted small ORFs in the 3' UTRs (downstream (d)ORFs) is unknown.

58 ons is low, then an AUG-initiated downstream ORF prevents the generation of shorter, AUG-initiated is

59 g and enhancing expression of the downstream ORF.

60 The peptides encoded by these downstream ORFs (dORFs) are often poorly conserved across evolution

61 The dsRNA1 ORF contains motifs representative of RNA-dependent RNA

62 nt RNA polymerase (RdRp), whereas the dsRNA2 ORF sequence showed homology with the putative capsid pr

63 tome, providing evidence for the use of dual ORFs in these transcripts.

64 yces cerevisiae has isolated several dubious ORFs whose deletions mitigated the protein burden effect

65 ultimately specifies the translation of each ORF.

66 With few exceptions, ORFs for PUA-superfamily domain containing endonucleases

67 veral in-frame internal ORFs within existing ORFs, resulting in N-terminally truncated products, as w

68 n conclusion, SCD patients with the FCGR2Cnc-ORF polymorphism have over a 3-fold lower risk for RBC a

69 the second ORF is independent from the first ORF.

70 s on the 5'-untranslated region of the first ORF.

71 on scattering and on-resonance fluorescence (ORF).

72 , absorption, and on-resonance-fluorescence (ORF) activities of CdSe/CdS core/shell fluorescent QDs a

73 thematical model for calculating fluorophore ORF and scattering cross sections has been developed tha

74 e experimental separation of the fluorophore ORF and photon scattering features in the fluorophore re

75 lytical methods that exploit the fluorophore ORF and photon scattering properties.

76 Another finding is that the fluorophore ORF has a depolarization close to 1, while its Rayleigh

77 l of de novo gene birth where a fully formed ORF existed before the regulatory element to activate tr

78 expression of a conserved alternative-frame ORF, encoding the protein XP.

79 six previously unreported alternative frame ORFs or 14 previously unreported C-terminal ORFs of know

80 d products, as well as internal out-of-frame ORFs, which generate novel polypeptides.

81 d a 2,158-bp deletion in open reading frame (ORF) 12.

82 N antagonism of MERS-CoV open reading frame (ORF) 8b accessory protein.

83 nce encoded in the first open reading frame (ORF) and accumulation of the reporter gene product in to

84 otated Copenhagen strain open reading frame (ORF) as a 17.4-kDa protein.

85 pan-cancer fusion genes, open reading frame (ORF) assignment, and retention search of 39 protein feat

86 of the chloroplast psbJ open reading frame (ORF) but has no effect on psbA expression.

87 additional uninterrupted open reading frame (ORF) covering almost the entire length of the reverse co

88 assumptions, such as one open reading frame (ORF) encodes one protein and minimal lengths for transla

89 to 4.4 kb with a single open reading frame (ORF) encoding an RNA-dependent RNA polymerase.

90 e approximately 1,100 bp open reading frame (ORF) encoding the envelope proteins is fully nested with

91 (TCV) coat protein (CP) open reading frame (ORF) has been found to promote internal expression of th

92 replication, although an open reading frame (ORF) is retained among an unknown percentage of EBV isol

93 ty of the putative BWRF1 open reading frame (ORF) is retained in over 80% of strains, and deletions t

94 The open reading frame (ORF) lengths of TmELO1 and TmELO2 were 1005 bp and 972 b

95 le at least one reliable open reading frame (ORF) model has been assigned for every coding gene, the

96 is, we replaced the NSP3 open reading frame (ORF) of the segment 7 (pT7/NSP3) transcription vector us

97 of a frameshift into the open reading frame (ORF) of the target gene which truncates the coding seque

98 ad: the median number of open reading frame (ORF) products recognized was nine per person.

99 683 bp in length with an open reading frame (ORF) that encodes 539 amino acids (molecular mass of 62.

100 6 nucleotides of the NSs open reading frame (ORF) were needed to ensure the efficient termination of

101 e or by truncating the X open reading frame (ORF), had little effect on the infectious virus titer of

102 sites or shifting of the open reading frame (ORF), leading to a variety of human diseases and conside

103 triplet-long overlapping open reading frame (ORF), which we call POLGARF (POLG Alternative Reading Fr

104 ed a single read-through open reading frame (ORF).

105 lades based on the mtDNA open reading frame (ORF).

106 and only four putative open reading frames (ORF), vB_RpoMi-Mini becomes the smallest ssDNA phage amo

107 sion of canonical viral open reading frames (ORFs) and to identify 23 unannotated viral ORFs.

108 reviously annotated EBV open reading frames (ORFs) and viral promoters.

109 of ribosome flux along open reading frames (ORFs) are not fully understood.

110 can also predict novel open reading frames (ORFs) from regular ribosome profiling (rRibo-seq) data a

111 nd variable (accessory) open reading frames (ORFs) grouped at fixed regions in their genomes; however

112 alf of the 32 annotated open reading frames (ORFs) have no homologs in databases (ORFans), being puta

113 consisting of discrete open reading frames (ORFs) in a single polycistronic mRNA.

114 bundant expressed short open reading frames (ORFs) in bacteria.

115 We subjected various open reading frames (ORFs) in the genome of respiratory syncytial virus (RSV)

116 The open reading frames (ORFs) involved have functions related to host-pathogen i

117 that were localized in open reading frames (ORFs) likely associated with host cell entry and exit be

118 The predicted 80 open reading frames (ORFs) of herpes simplex virus 1 (HSV-1) have been intens

119 uption of any of the 12 open reading frames (ORFs) of the virus.

120 y to generate candidate Open Reading Frames (ORFs) resulting from Cytidine to Uridine (c->u) editing

121 he formation of altered open reading frames (ORFs) that appear to be under relaxed selection.

122 dentified 315 potential open reading frames (ORFs) within the genome, including the 11 established es

123 nscripts with competent open reading frames (ORFs), and can be found in the peripheral blood CD4(+) T

124 lly carry promoter-less open reading frames (ORFs), encoding proteins with various functions includin

125 the coding potential of open reading frames (ORFs), including many short ORFs that were previously pr

126 dentify hundreds of new open reading frames (ORFs), including upstream ORFs (uORFs) and internal ORFs

127 ng 128 unique predicted open reading frames (ORFs), many of which were most closely related to herpes

128 repeat epitopes in two open reading frames (ORFs), one translated from the 5' cap, and the other fro

129 n addition to canonical open reading frames (ORFs), thousands of translated small ORFs (containing le

130 of actively translated open reading frames (ORFs), to the quantification of translational efficiency

131 at the level of single open reading frames (ORFs), using information from Ribo-seq data.

132 (dsDNA) genome with 31 open reading frames (ORFs), whose predicted gene products show little homolog

133 s can also encode small open reading frames (ORFs).

134 RNAs lacking annotated open reading frames (ORFs).

135 ipts with nine distinct open reading frames (ORFs).

136 Each genome encodes 21 open reading frames (ORFs).

137 e remaining alleles for open reading frames (ORFs).

138 ce to the Pgd1 and Pgd2 open reading frames (ORFs).

139 onally encode two major open reading frames (ORFs): Rep and capsid protein (CP) characteristic of a t

140 that the annotation of currently functional ORFs for the oX174 genome is formally complete.

141 sequences of these genes show no functional ORFs, but include segments of different protein coding g

142 In order to validate the generated ORFs, a screening is performed by checking for sequence

143 N/35 transgenic mice expressing the full HCV ORF.

144 b locus, consisting of the hp1369 and hp1370 ORFs, encodes for a truncated and inactive MTase in H. p

145 called ORF-less GCs, contain no identifiable ORF with a small number shown to be involved in antisens

146 f these variants cause amino acid changes in ORF-Y or ORF-Z.

147 Features of the system include ORF selection to improve efficiency, high bacterial tran

148 These include ORF assignment of exon skipped transcript, studies of lo

149 including upstream ORFs (uORFs) and internal ORFs (iORFs), generating a complete unbiased atlas of HH

150 a regulatory role, several in-frame internal ORFs within existing ORFs, resulting in N-terminally tru

151 These data suggest that intrinsic ORF mRNA structure encodes a rough blueprint for transla

152 ence (SPHINX 1.8), with an iteron before its ORF, was evaluated here for its expression in neural cel

153 on is approximately 10-fold smaller than its ORF counterparts for all the six model fluorophores, but

154 The >3 kb ORF overlap on opposite strands, unprecedented among RNA

155 onymous mutations solely in the polymerase L ORF quickly lost substantial attenuation.

156 potentially deattenuating mutations in the L ORF as well as, surprisingly, many appearing in other OR

157 ORFs including all known and 46 novel large ORFs.

158 e of retroviral env genes with a full-length ORF.

159 One identified provirus has full-length ORFs for all genes, and thus could potentially be replic

160 repress translation of their downstream main ORFs, whereas sORFs may encode signaling peptides.

161 their genomes; however, in either case, many ORFs remain without assigned functions.

162 domain, resulting from the splicing of MCMV ORFs m131 and m129 MCK-2 is essential for full MCMV infe

163 ases were not close to DNA methyltransferase ORFs, strongly supporting modification dependent activit

164 s and large-scale DNA synthesis, one or more ORFs of a microbial pathogen can be recoded by different

165 nd L, which in common had CPO of one or more ORFs of proteins of the polymerase complex, exhibited gl

166 reading frame in the FCGR2C gene (FCGR2C.nc-ORF) was strongly associated with a decreased alloimmuni

167 grown in culture as a means to validate non-ORF associated promoters discovered through BbIVET.

168 g tools for classifying coding and noncoding ORFs were built on datasets in which "normal-sized" prot

169 We annotated 31 novel ORFs of which 24 ORFs are GPI-CWPs.

170 of Canada goose coronavirus include 6 novel ORFs, a partial duplication of the 4 gene and a presumpt

171 ng amino-acid deprivation and predicts novel ORFs in 5'UTRs, long noncoding RNAs, and introns.

172 Ps by inserting reporter genes into the NSP1 ORF of genome segment 5.

173 ying on fusing the reporter gene to the NSP3 ORF of genome segment 7.

174 Further modification of the NSP3 ORF showed that it was possible to generate recombinant

175 led us to uncover novel ribosomally occupied ORFs in both strains.

176 ration and detection of promoter activity of ORF-less GCs from Treponema bacteria and the development

177 In this study, the promoter activity of ORF-less GCs, previously recovered from the oral metagen

178 dicated that operonic mRNAs are comprised of ORF-wide units of secondary structure that vary across O

179 y(A) site utilization, with increased use of ORF-proximal poly(A) sites resulting in shorter 3' mRNA

180 most isoforms contain unique combinations of ORFs.

181 explain translation of the vast majority of ORFs as well as N-terminal extensions (NTEs) and truncat

182 e DNA bacteriophage with the least number of ORFs.

183 nding and to defective ribosomal scanning of ORFs outside periods of productive translation.

184 tion, we detected signatures of selection on ORF 5a and on a small subset of sites in the genome.

185 For most genes, one ORF represents the dominant translation product, but we

186 ariants cause amino acid changes in ORF-Y or ORF-Z.

187 ll as, surprisingly, many appearing in other ORFs.

188 e developed a new approach to classify phage ORFs into ten major classes of structural proteins or in

189 that are synonymous with respect to the POLG ORF and found that most of these variants cause amino ac

190 ound among mammals in the region of the POLG ORF that is overlapped by ORF-Y.

191 en mapped over the coding region of the POLG ORF.

192 ding sequence, ORF-Y, that overlaps the POLG ORF.

193 Here, we present ORF Capture-Seq (OCS), a flexible method that addresses

194 Nidovirales express their structural protein ORFs from a nested set of 3' subgenomic mRNAs (sg mRNAs)

195 also represents a rare example of the proto-ORF model of de novo gene birth where a fully formed ORF

196 thesis by activating translation of the psbJ ORF, that this function is conserved in Arabidopsis LPE1

197 Using an improved version of Rapid ORF Description and Evaluation Online (RODEO 2.0), a bio

198 on events encompassing the 3'-end of the Rep ORF in the unclassified CRESS DNA virus.

199 sitive NanK enzymes belong to the Repressor, ORF, Kinase (ROK) family, but many lack the canonical Zn

200 and in every case the codons in the reverse ORF and the RdRp are aligned.

201 The RQD ORF cross-sections and quantum yields are significantly

202 t prevent translation of the downstream RTC4 ORF.

203 We then used a genome-scale ORF overexpression screen and a CRISPR knockout screen t

204 High-level GFP accumulation from the second ORF facilitates identification of transplastomic events

205 uld show that protein output from the second ORF is independent from the first ORF.

206 n tobacco chloroplasts encoded in the second ORF.

207 rovide evidence for a novel coding sequence, ORF-Y, that overlaps the POLG ORF.

208 Max A (with CPO of NS1, NS2, N, P, M, and SH ORFs), Max B (with CPO of G and F), Max L (with CPO of L

209 trast, we detected selection focused on SHFV ORFs 5a and 5, which encode putative membrane proteins.

210 tated polycysteine-encoding leaderless short ORF architectures responded to cysteine limitation, reve

211 l analysis shows that one polycysteine short ORF controls expression of the downstream genes.

212 ns were considered to be positives and short ORFs were generally considered to be noncoding.

213 ng actively translating ORFs including short ORFs on multiple published datasets across species inclu

214 Individual leaderless short ORFs confer independent operon-level control, while thei

215 that polycysteine-encoding leaderless short ORFs function as cysteine-responsive attenuators of oper

216 reading frames (ORFs), including many short ORFs that were previously presumed to be non-translating

217 0S ribosomes translate the 5'-proximal short ORFs (uORFs) of piRNA precursors.

218 l coordination by ribosomes on sensory short ORFs illustrates one utility of the many unannotated sho

219 tion of translating ORFs, specifically short ORFs, from Ribo-seq data, remains challenging due to its

220 Whether these short ORFs, or the small proteins they encode, are functional

221 derless mRNAs often encode unannotated short ORFs as the first gene of a polycistronic transcript.

222 es one utility of the many unannotated short ORFs expressed in bacterial genomes.

223 ble with the main function of upstream short ORFs being to buffer the translation of canonical canoni

224 especially prevalent amongst upstream short ORFs located in the 5' mRNA leaders, and amongst canonic

225 roteins in T. brucei, we identified a single ORF, Tb927.9.8780, as a potential candidate.

226 Small ORFs in 5' UTRs (upstream (u)ORFs) often repress transla

227 ions of annotated coding genes and 354 small ORFs (sORFs) among unannotated transcripts.

228 e EMBO Journal, Wu et al characterized small ORFs in the 3' untranslated regions (3' UTRs) of human a

229 nical ORFs; and show that, in general, small ORFs in mRNAs display markers compatible with an evoluti

230 frames (ORFs), thousands of translated small ORFs (containing less than 100 codons) have been identif

231 The prediction of translated small ORFs (sORFs) by quantitation of translation termination

232 However, the function of translated small ORFs in the 3' UTRs (downstream (d)ORFs) is unknown.

233 tend the catalog of in vivo translated small ORFs, and to reveal the translational regulation of both

234 RNA-binding proteins, encode potential Split-ORFs, some of which are expressed under specific cellula

235 nslation of two protein halves, termed Split-ORFs, from the bicistronic SRSF7-PCE transcript.

236 hich we show is essential to remove spurious ORFs and to distinguish coding from pseudogene regions.

237 h for quantification of the fluorophore SSF, ORF, and scattering depolarization and anisotropy using

238 velength region, and they all exhibit strong ORF emission in the wavelength regions where the QDs bot

239 ional regions, with accessory and structural ORFs containing the highest structural density in the vi

240 utation of the start codon of two C-terminal ORFs in an infectious clone reduced virus yield.

241 ORFs or 14 previously unreported C-terminal ORFs of known proteins were also identified.

242 gested translation of some of the C-terminal ORFs.

243 The recent discovery that ORF 72 on chromosome 9 (C9orf72), the gene most commonly

244 Ribosome profiling data revealed that ORF-Y is translated and that initiation likely occurs at

245 ofiling and mass spectrometry data show that ORF-Y is expressed.

246 PhyloCSF and synplot2 analysis show that ORF-Y is subject to strong purifying selection.

247 The ORF excluding transit peptides encoded a 64.9 kDa protei

248 The discovery of the ORF 12 deletion, revealed through targeted genome sequen

249 ap completely prevents the expression of the ORF and avoids expression of C-terminal truncated protei

250 (2017) report that ribosomes translating the ORF that encodes the copper pump frequently frameshift a

251 envelope proteins is fully nested within the ORF of the viral replicase P.

252 The ORFs display high homology between the strains, but they

253 for PUA domain containing endonucleases, the ORFs for DUF3427 fusion proteins were frequently found i

254 We demonstrate that the ORFs PA3911, PA3912, and PA3913, which are homologs of t

255 In contrast to the ORFs for PUA domain containing endonucleases, the ORFs f

256 long polyadenosine (polyA) runs within their ORFs, distinguishing the parasite from its hosts and oth

257 These ORFs include upstream ORFs that are likely to have a reg

258 ow individual RNA structures formed by these ORFs are affected by the differences in genomic and subg

259 omic mRNAs (sg mRNAs), and for most of these ORFs, a single genomic transcription regulatory sequence

260 No function has been described for this ORF, yet the absence of stops is conserved across divers

261 Of HEV's three ORFs, the function of ORF3 has remained elusive.

262 important for ribosomes to elongate through ORFs encoding multiple TMDs.

263 wo unique peptides that map unambiguously to ORF-Y.

264 the serendipitous discoveries of translated ORFs encoded upstream and downstream of annotated ORFs,

265 ion transcriptome-wide, revealing translated ORFs on multiple isoforms per gene.

266 ins, methods for predicting short translated ORFs must be trained independently from those for longer

267 ct, but we also detect genes with translated ORFs on multiple transcript isoforms, including targets

268 a method for detecting actively translating ORFs by directly leveraging the three-nucleotide periodi

269 er methods at detecting actively translating ORFs including short ORFs on multiple published datasets

270 However, the detection of translating ORFs, specifically short ORFs, from Ribo-seq data, remai

271 g frames and revealed the translation of two ORFs (ORF4b and ORF4c on sgmRNA IR), which are widely co

272 Small ORFs in 5' UTRs (upstream (u)ORFs) often repress translation of the canonical ORF wit

273 ucleotide polymorphism within the AD169 UL55 ORF, resulting in a D275Y amino acid exchange within gly

274 gh-throughput method to discover unannotated ORFs, elucidates evolutionarily conserved and unique tra

275 lysis confirmed that some of the unannotated ORFs generate stable proteins in planta.

276 This includes a so far unknown ORF in the locus deleted in the FDA-approved oncolytic v

277 SPR-Cas9 targeting of the conserved upstream ORF present in the mRNA leader derepress PRL protein syn

278 egulated mRNAs, 30% had one or more upstream ORF (uORF) that influenced the number of ribosomes on th

279 Translation of a short upstream ORF 5' of this CUG governs the ratio between POLG (the c

280 ycin (TOR) promotes reinitiation at upstream ORFs (uORFs) in genes that play important roles in stem

281 by a mechanism mediated in part by upstream ORFs situated in the 5'-leader of CDKN1A mRNA.

282 These ORFs include upstream ORFs that are likely to have a regulatory role, several

283 en reading frames (ORFs), including upstream ORFs (uORFs) and internal ORFs (iORFs), generating a com

284 also changes the inclusion of long upstream ORFs (uORFs).

285 t produce protein due to regulatory upstream ORFs in its extended 5' leader.

286 translation of specific mRNAs with upstream ORFs (uORFs) situated in their 5'-leader regions.

287 Here, various ORFs in the genome of respiratory syncytial virus (RSV)

288 lent accumulation at regions where the viral ORFs overlapped.

289 ccumulation of transcripts just at the viral ORFs, while vsRNAs spanned the entire genome, showing a

290 lished without interrupting any of the viral ORFs, yielding recombinant viruses that likely express t

291 (ORFs) and to identify 23 unannotated viral ORFs.

292 ted deletion of a significant portion of VZV ORF 12 following propagation in cultured human fibroblas

293 ts up in different colors depending on which ORF is translated.

294 e variants of poliovirus type 1 (PV1), whose ORF (6,189 nucleotides) carried up to 1,297 "Max" mutati

295 reen utilized the most extensive genome-wide ORF collection to date, covering 90% of human, nonredund

296 t by a +1 frameshifted open reading frame (X-ORF) in segment 3.

297 The X-ORF can be translated in full-length (61-amino-acid) or

298 Genetic analysis indicated that the X-ORFs of equine H3N8 and avian H3N2 influenza viruses enc

299 2 influenza viruses were full-length, with X-ORFs encoding 61 amino acids; however, those of equine-o

300 We found that deletion of the YJL175W ORF yielded an N-terminal deletion of Swi3, a subunit of