ライフサイエンスコーパス: OT

1 OT binds to its cognate G protein-coupled receptor (OTR)

2 OT COV in a stable phantom was less than 2.8% across all

3 OT-II mice expressing a transgenic T cell receptor (TCR)

4 ive blood loss decreased (-255 mL, P<0.001), OT increased (+65 min, P < 0.001), and median LOS decrea

5 .065 (0.049-0.080); OU: 0.085 (0.061-0.138); OT: 0.047 (0.031-0.054), P <= 0.053).

6 switching to the corresponding reagents CD(3)OTs or (13)CH(3)OTs.

7 corresponding reagents CD(3)OTs or (13)CH(3)OTs.

8 SAR1376, and perhaps other members of the 4-OT protein family, represent very small domains which ca

9 potency nor efficacy of Pro(8)-OT and Leu(8)-OT differed with respect to G(q) signaling.

10 , Pro(8)-OT was more efficacious than Leu(8)-OT in measures of G(q) activation, with both peptides di

11 both mOTR- and hOTR-expressing cells, Leu(8)-OT was more potent and modestly more efficacious than Pr

12 with leucine in the eighth position (Leu(8)-OT).

13 In mOTR cells, Leu(8)-OT-induced hyperpolarization was modestly inhibited by p

14 , neither the potency nor efficacy of Pro(8)-OT and Leu(8)-OT differed with respect to G(q) signaling

15 nt and modestly more efficacious than Pro(8)-OT in inducing hyperpolarization.

16 e for G(i/o) activation; however, the Pro(8)-OT response in mOTR and hOTR cells was PTX insensitive.

17 At the mOTR, Pro(8)-OT was more efficacious than Leu(8)-OT in measures of G(

18 oline in the eighth residue position (Pro(8)-OT).

19 y's own action (ST), another agent's action (OT), or both (SOT).

20 We added OT, AA, SO(2) and bentonite to botrytized must obtained

21 In addition, OT acts as an anxiolytic factor and is released during s

22 monstrate that the peripherally administered OT is entering the CSF.

23 t, depending on the dose of OT administered, OT could reduce social reward in females, while enhancin

24 tion, we tested the benefit of administering OT under simultaneously induced opioid antagonism during

25 pioid systems and suggest that administering OT under opioid antagonism may boost the therapeutic eff

26 Langmuir phospholipid monolayers and Aerosol-OT (AOT) reverse micelles.

27 We inserted high- and low-affinity OT-I epitopes into IAV and infected mice after transfer

28 uronally differentiated SH-SY5Y cells to AM, OT and PT triggered upregulation of p53 gene expression,

29 ein, we found that we were able to elicit an OT-II T cell response in an antigen-dependent manner, bu

30 the effects of systemic administration of an OT receptor (OTR) antagonist L-368,899 on social behavio

31 VH-OT neuron number and administration of an OT receptor agonist improved social deficits.

32 ese mice was rescued by administration of an OT receptor agonist.

33 One analog (OT-12) in particular was shown to be a potent full agoni

34 AVP and OT signaling predominantly occur within a circuit of int

35 Importantly, AVP and OT signaling within the SBNN has been shown to different

36 n part to age and sex differences in AVP and OT synthesis within the SBNN.

37 ever, a thorough characterization of AVP and OT-immunoreactive (ir) fibers and cell bodies across age

38 We therefore quantified AVP- and OT-ir fibers and cell bodies in 22 subregions of the for

39 e riboside may allow animals with cADPR- and OT-forming deficits to overcome these deficits and funct

40 females had more OT-immunoreactive cells and OT messenger RNA in the paraventricular nucleus of the h

41 u-opioid and kappa-opioid receptor genes and OT genes at the OT-releasing sites in the human brain.

42 GT and OT inhibition of glucose uptake was partial non-competit

43 gs at spatially aligned sites in the Imc and OT reveal that although some properties of stimulus comp

44 and Ser20, seen in cells treated with PT and OT.

45 n implicated in mediating natural reward and OT-synthesizing neurons project to the ventral tegmental

46 tested for activity against the V2, V1a and OT uterine receptors and not tested against the V1b rece

47 Data acquired with our small-animal OT system were highly repeatable and reproducible across

48 We used a commercial small-animal OT system.

49 As OT is a peptide, delivery by the intranasal (IN) route i

50 pecific, MHC class II-restricted alpha/beta (OT-II) T cells reflected CD36-dependent DC function.

51 ches should exploit the interactions between OT and serotonin to regulate social functions.

52 However, the underlying mechanism between OT and 5-HT remains unclear.

53 there is an inverted U relationship between OT dose, social reward, and neural activity within struc

54 Finally, blocking OT receptors in the dorsal raphe nucleus during estrogen

55 tation in vivo and in vitro assessed by BMDC OT-I cocultivation assays.

56 an not only inhibit contractions elicited by OT, but also inhibit contractions and inflammation induc

57 central circuitry, are explained entirely by OT increases in systemic circulation following both intr

58 nhibitor (IC(50) : 0.077 mg/mL), followed by OT (IC(50) : 0.136 mg/mL) and BT (IC(50) : 0.56 mg/mL).

59 onal martial arts may be in part mediated by OT release and underscore the potentially therapeutic ap

60 in the identity task was also unaffected by OT.

61 fic t-cell receptor transgenic CD8+ T cells (OT-I) CXCR5 or CXCR3 CD8 T-cell subsets was also investi

62 measured correlations between single-channel OTs and CTs.

63 TRs, respectively) were used to characterize OT signaling.

64 knockout mice have low levels of circulating OT in cerebrospinal fluid, which can be corrected by the

65 ve shown increased cerebrospinal fluid (CSF) OT levels following IN administration, this does not une

66 labeled (d5-deuterated) from endogenous (d0) OT.

67 We administered d5 OT (80 IU) to six nonhuman primates via IN and IV routes

68 ) and after (t=10, 20, 30, 45 and 60 min) d5 OT dosing.

69 Peripheral administration of d5 OT did not lead to increased d0, endogenous OT in the CS

70 d, as were responses in HIF-1alpha-deficient OT-1 cells.

71 fter the intranasal administration of either OT or saline in a within-subjects design.

72 oncentrations of administered and endogenous OT before (t=0) and after (t=10, 20, 30, 45 and 60 min)

73 OT did not lead to increased d0, endogenous OT in the CSF.

74 es not lead to central release of endogenous OT.

75 could lead to central release of endogenous OT.

76 demonstrate CSF penetrance of d5, exogenous OT delivered by IN and IV administration.

77 Green tea extract (GT), oolong tea extract (OT), and black tea extract (BT) inhibited glucose uptake

78 Five OT were tested (gallotannin, ellagitannin, quebracho, gr

79 endent inverted U dose-response function for OT's effects on social reward and in the development of

80 Thus, unlike the static pattern observed for OT, AVP innervation of the forebrain SBNN appears to und

81 contrast, ovalbumin responsive T cells from OT-I mice did not exhibit this preferential homing.

82 ce, adoptive transfer with CD4(+) cells from OT-II mice restored effects of OVA on lymphocytes, eosin

83 Here, we selectively recorded from OT neurons in the paraventricular hypothalamic nucleus (

84 Furthermore, OT-12 is peripherally restricted, with very limited brai

85 ydroxysuccinimide ester polyethylene glycol (OT-58)] on clinical end points relevant to human patient

86 ity to the receptors follows the trend: V2 > OT > V1a.

87 out mice after postnatal day 3, an identical OT increase was not observed.

88 If OT has a general affect on behavior, then performance in

89 l spray, and a nebulizer expected to improve OT deposition in nasal areas putatively involved in dire

90 In OT-II CD4(+) anti-OVA TCR transgenic mice sensitized to

91 al OT supplementation may be advantageous in OT drug development.

92 PIP2 appears to influence AHPs in OT neurons by reducing Ca(2+) influx during spiking.

93 tively reduced whole cell Ca(2+) currents in OT neurons while leaving VP neurons unaffected.

94 VP, we observed no age or sex differences in OT-ir fiber fractional areas or cell bodies in any of th

95 Static LV chamber compliance was greater in OT compared to both untrained groups (median (25-75%): M

96 Analyses revealed a significant increase in OT immediately after a high-intensity training, returnin

97 cleus of the hypothalamus and an increase in OT receptor density in the dorsal raphe nucleus.

98 122 did not inhibit either ImAHP or IsAHP in OT neurons, consistent with wortmannin's effects not bei

99 t PIP2 modulates both the ImAHP and IsAHP in OT neurons, most likely by controlling Ca(2+) entry thro

100 and LV mass index (g m(-2) ) were larger in OT versus OU (~11% and ~16%, respectively, both P <= 0.0

101 d higher mobility than CD8alpha-bound Lck in OT-I T hybridoma cells.

102 Neuroplasticity in OT-producing neurons in the paraventricular nucleus of t

103 stigated whether this phenomenon occurred in OT and VP neurons of the SON.

104 c and/or actionable molecular participant in OT-dependent social behaviour.

105 We observed 3 learning curve phases in OT: accumulation (<31 cases), optimization (case 31-65),

106 e explicit reward category representation in OT is visible in the first sniff (50-100 ms) of an odor

107 yadic prosocial interaction, would result in OT response.

108 a(2+) ]i increase induced by spike trains in OT neurons, but had no effect on AHPs evoked by uncaging

109 nalogue (diC8 -PIP2 ) into neurons, which in OT neurons not only prevented wortmannin's inhibitory ef

110 Cs, whereas OVA peptide-loaded MCs increased OT-II CD4(+) T cell proliferation in vitro.

111 Estrogen withdrawal induces OT neuroplasticity in the paraventricular nucleus of the

112 A NO donor inhibited OT II T cell receptor recognition of OT II specific tetr

113 is considerable debate as to how intranasal OT influences primate behavior.

114 ssociation provides evidence that intranasal OT affects primate behavior under very particular circum

115 is study was to determine whether intranasal OT has a general anxiolytic effect on the performance of

116 on following both intranasal and intravenous OT administration.

117 Therefore, longitudinal OT studies may be performed with high confidence when ou

118 the much larger population of magnocellular OT neurons.

119 First, we tracked congenically marked OT-I cell populations in recipient mice infected with mu

120 +) release even if open probability and mean OTs and CTs are identical.

121 but potentially overlapping circuits mediate OT-dependent social approach or social avoidance.

122 activation of these inflammatory mediators, OT led to increases in the expression of cyclooxygenase-

123 leus of the hypothalamus (PVH) of male mice (OT-Ires-Cre) enhanced social investigation during a soci

124 nd that, compared with untreated I278T mice, OT-58 treatment of I278T mice fed with the REG diet resu

125 hermore, estrogen-withdrawn females had more OT-immunoreactive cells and OT messenger RNA in the para

126 Most OT neurons are magnocellular neurons, which simultaneous

127 7 cytokine profile was increased in cMy-mOVA-OT-II mice after TAC.

128 The resulting cMy-mOVA-OT-II mice did not display signs of spontaneous autoimmu

129 were induced in response to TAC in cMy-mOVA-OT-II mice, yet more CD3(+) T cells infiltrated their my

130 On background of the MRD, OT-58 performed equally well with plasma Hcy entirely no

131 This defect diminished the ability of naive OT-1 T cells to develop antitumor activity against ovalb

132 In mammals, the nonapeptide OT structure is highly conserved with leucine in the eig

133 safety and efficacy for catheter ablation of OT ventricular arrhythmias.

134 id not activate G proteins in the absence of OT.

135 into the circulation and from absorption of OT in mother's milk into the blood via intestinal permea

136 udy, we show that chemogenetic activation of OT neurons within the paraventricular nucleus of the hyp

137 tial benefit of concurrent administration of OT and naloxone (NAL) to robustly modulate social behavi

138 s suggests that peripheral administration of OT does not lead to central release of endogenous OT.

139 e dancing after intranasal administration of OT or placebo.

140 xamined whether intranasal administration of OT would modulate synchronization during a real-life dan

141 model, daily subcutaneous administration of OT-12 exhibited more potent anorexigenic and body weight

142 s should be altered by the administration of OT.

143 y of our new method in the classification of OT-II white blood cells and SW-480 epithelial cancer cel

144 t to achieving greater CSF concentrations of OT.

145 s been suggested that peripheral delivery of OT could lead to central release of endogenous OT.

146 As a result, depending on the dose of OT administered, OT could reduce social reward in female

147 e randomly assigned to one of eight doses of OT (8, 12, 24, 36, 48, 60, 72, or 84 IU).

148 ormation is available regarding the doses of OT that are effective for influencing social processing

149 antagonist, nolasiban, reduced the effect of OT on NF-kappaB and p38 kinase activation in both myomet

150 Molecular weight of laccases and effect of OT upon these laccases were studied by SDS-PAGE.

151 The effects of OT are context dependent, and it has been proposed that

152 for neural circuits mediating the effects of OT in appetitive and aversive social contexts.

153 ls to inhibit the proinflammatory effects of OT in human amnion; atosiban alone activates nuclear fac

154 tractions and the proinflammatory effects of OT without the biased agonist effects.

155 y critical roles in mediating the effects of OT.

156 inalis (BNST) mediates anxiogenic effects of OT.

157 gonism may boost the therapeutic efficacy of OT for enhancing social cognition.

158 however, direct neuroanatomical evidence of OT regulation of DA neurons within the VTA is sparse.

159 ceptor antagonist, reducing the frequency of OT induced contractions (EC50 = 350 nM) and increasing t

160 omic structures implicated in the genesis of OT arrhythmias, making catheter ablation for arrhythmias

161 However, further investigations of OT functions, especially over the last decade, have prov

162 e been made to increase endogenous levels of OT.

163 ECG algorithms used to guide localization of OT ventricular arrhythmias.

164 y, we show that a much smaller population of OT neurons, parvocellular neurons that do not project to

165 field continues to evaluate the potential of OT-based therapeutics.

166 hibited OT II T cell receptor recognition of OT II specific tetramers, thus serving as a direct measu

167 performed the first definitive recording of OT neurons in awake mice using two-photon calcium imagin

168 ole for the enzyme CD38 in the regulation of OT release was demonstrated.

169 e mediator for the production and release of OT and its social engagement and anti-anxiety functions.

170 ision (repeatability and reproducibility) of OT has yet to be determined.

171 ch suggests that the proinflammatory role of OT should be taken into account when developing tocolyti

172 rovide dosing guidance for future studies of OT to be used to enhance social processing in people wit

173 controlled, cross-over dose ranging study of OT.

174 into IAV and infected mice after transfer of OT-I T cells.

175 tractions and METx (100 nM) had no effect on OT induced uterine contractions.

176 ated process with RAGE and suggest that oral OT supplementation may be advantageous in OT drug develo

177 functional groups, among them, -OBn, -OTBS, -OTs, N-phthalimido- groups, are tolerated, and er's > 95

178 nate types of phenol derivatives (e.g., OTf, OTs, etc.), which have similar reactivities to the corre

179 e antagonists - amprolium (AM), oxythiamine (OT) or pyrithiamine (PT).

180 Oxytocin (OT) has been implicated in mediating natural reward and

181 Oxytocin (OT) is a critical molecule for social recognition and me

182 Oxytocin (OT) is a great facilitator of social life but, although

183 Oxytocin (OT) is a potential treatment for multiple neuropsychiatr

184 Oxytocin (OT) is critical for the expression of social behavior ac

185 Oxytocin (OT) is increasingly studied for its therapeutic potentia

186 Oxytocin (OT) is widely known for promoting social interactions, b

187 ABSTRACT: Oxytocin (OT)- and vasopressin (VP)-secreting magnocellular neuron

188 How estrogen withdrawal affects oxytocin (OT) neurocircuitry has not been examined.

189 europeptides vasopressin (AVP) and oxytocin (OT) have been implicated in the regulation of numerous s

190 te the effects of peptides such as oxytocin (OT) on brain physiology when delivered intranasally?

191 in infancy and preschool, assayed oxytocin (OT) and vasopressin (AVP), and measured coparenting and

192 research suggest that the hormone oxytocin (OT) may be important for metabolic regulation.

193 The neurohypophyseal hormone oxytocin (OT) regulates biologic functions in both peripheral tiss

194 reward, and more specifically, how oxytocin (OT) acts in the mesolimbic dopamine system (MDS) to medi

195 th medium and slow AHP currents in oxytocin (OT) neurons of the supraoptic nucleus.

196 nd reliability of using intranasal oxytocin (OT) to clinically enhance social functions remains undep

197 The neuropeptide oxytocin (OT) is a key regulator of social and emotional behaviors

198 Although the neuropeptide oxytocin (OT) is thought to regulate prosocial behavior in mammals

199 Low plasma levels of oxytocin (OT) have also been found in ASD patients; recently, a cr

200 our due to the significant role of oxytocin (OT) in the onset of both term and preterm labour.

201 e toward improving the efficacy of oxytocin (OT) in treating social dysfunction, we tested the benefi

202 e of the most established roles of oxytocin (OT) is in inducing uterine contractions and labor.

203 Recent interest has focused on oxytocin (OT), a neurotransmitter that promotes social processing,

204 Plasma oxytocin (OT) originates from secretion from the pituitary gland i

205 ous studies have demonstrated that oxytocin (OT), a peptide hormone, plays an important role in regul

206 IGNIFICANCE STATEMENT Although the oxytocin (OT) system is well known to regulate a diverse array of

207 Because the oxytocinergic (OT) system has previously been linked to regulation of c

208 Thus, parvocellular OT neurons receive particular inputs to control social b

209 To phenotype OT-receptor (OTR) expressing neurons originating within

210 Compared with placebo, OT significantly reduced [(11)C]DASB binding potential i

211 In adult mice, plasma OT was also increased in a RAGE-dependent manner after o

212 Here, we report that plasma OT concentrations increased within 10 min after oral del

213 We therefore also examined possible OT system dysfunction in a mouse model of autism, Shank3

214 In line with our predictions, OT increased synchrony between partners.

215 L-368,899 prevented OT activation of G proteins and did not activate G prote

216 d CXCR5CXCR3 (and not CXCR3CXCR5) OVA-primed OT-I CD8 T cells mediated in vivo suppression of anti-OV

217 demonstrate that social stimuli activate PVH-OT neurons and that these neurons differentially encode

218 k3b KO mice showed a marked reduction in PVH-OT neuron number and administration of an OT receptor ag

219 us is sufficient to induce activation of PVH-OT neurons, we performed the first definitive recording

220 social behavior have reduced numbers of PVH-OT neurons.

221 l and nonsocial stimuli, suggesting that PVH-OT neurons may act to convey social salience of environm

222 ocial stimulus induces activation of the PVH-OT neurons to promote adaptive social behavior responses

223 Using a Q-OT-MS, 22 compounds were tentatively identified, 16 of w

224 rid quadrupole-orbitrap mass spectrometer (Q-OT-MS).

225 pathways, but beyond its role in regulating OT secretion, it is not known whether a deficit in CD38

226 he absence of HDAC3, MHC Class II-restricted OT-II thymocytes are redirected to the CD8 cytotoxic lin

227 stems from the two-state model's single-RyR OT and CT distributions being qualitatively different fr

228 Salivary OT levels were assessed at baseline, immediately followi

229 a significantly higher increase in salivary OT followed ground grappling, as compared to "punch-kick

230 DCs showed reduction in CD4(+) OVA-specific OT-II T cell proliferation.

231 ice, adoptive transfer of ovalbumin-specific OT-I CD8 T cells induced severe enteric ganglionitis.

232 brain regions have been extensively studied, OT neuron activity during actual social interactions rem

233 f concept, we applied this strategy to study OT-1 T cells, revealing that the T cell receptor (TCR) m

234 pulation, such that dominant and subdominant OT-I cells were maintained at stable frequencies over ti

235 In the central nervous system, OT influences social processes, including peer relations

236 e presence of different oenological tannins (OT) were investigated in relation to B. cinerea negative

237 cal lesions were placed in the optic tectum (OT) and in the nucleus isthmi pars parvocellularis (Ipc)

238 rtions of the space map in the optic tectum (OT), thereby mediating stimulus competition in the OT.

239 ogical levels of 5-HT modification, and that OT does not act directly on the 5-HT1AR.

240 We demonstrate that OT-induced decreases in amygdala perfusion, a key hub of

241 Mass spectrometry evaluated that OT was absorbed intact.

242 d health and adding to growing evidence that OT relates to human obesity risk.

243 We found that OT inhalation selectively reduced a selection bias again

244 These data highlight that OT is transmitted via a receptor-mediated process with R

245 TR expression by VTA neurons implicates that OT regulation of reward circuitry is more complex than a

246 Recent data indicate that OT acts in the bed nucleus of the stria terminalis to in

247 om several sources supports the premise that OT acting within the nucleus accumbens and ventral tegme

248 ext dependent, and it has been proposed that OT increases the salience of both positive and negative

249 pparently opposing actions by proposing that OT enhances the salience of both positive and negative s

250 contractions, our recent studies showed that OT can also activate proinflammatory pathways in both hu

251 s of gene and metabolic networks showed that OT triggers cell apoptosis through the p53-dependent int

252 This study shows that OT-58 is a highly efficacious novel treatment for HCU on

253 Results suggest that OT affects central measures of social information proces

254 onal synchrony during dance, suggesting that OT underlies the kinesthetic dimension of empathy.

255 The OT has since been classified as one of several olfactory

256 resence of social conspecifics activates the OT system to generate an adaptive social response.

257 ch to date suggests caution in assigning the OT with a purely olfactory role.

258 pa-opioid receptor genes and OT genes at the OT-releasing sites in the human brain.

259 upport a regulatory relationship between the OT and opioid systems and suggest that administering OT

260 A lesion in the OT caused a severe impairment in orientation discriminat

261 sentation for reward category emerges in the OT within minutes of learning a novel odor-reward associ

262 hereby mediating stimulus competition in the OT.

263 tractions (EC50 = 350 nM) and increasing the OT EC50 from 0.081 nM to 21 nM at a concentration of 600

264 ade, have provided evidence for roles of the OT beyond olfaction, including in learning, motivated be

265 ases in amygdala perfusion, a key hub of the OT central circuitry, are explained entirely by OT incre

266 ver, the intimate and complex anatomy of the OT limits predictive value ECG criteria alone for locali

267 These data suggest that activation of the OT system is necessary to direct behavior preferentially

268 We also show that activation of the OT system is necessary to promote social behavior and th

269 us exposure indeed induces activation of the OT system.

270 unt when developing tocolytics targeting the OT/oxytocin receptor (OTR) system.

271 lus more categorically, and earlier than the OT.

272 We concluded that the OT system plays an important role in promoting interpers

273 The data support the proposal that the OT transmits a space-specific signal that is required to

274 By crossing Sting(N153S/+) to the OT-1 mouse, we fully restored CD8(+) T cells and drastic

275 functions and an "olfactory" purpose to the OT.

276 Using the OT-I RIP-mOVA model, we found that Nur77 deficiency did

277 s research to synthesize a model wherein the OT, which may be more appropriately termed the "tubular

278 xponentials to fit single-channel open time (OT) and closed time (CT) distributions, and an extension

279 Cumulative sum charts of operating time (OT) assessed institutional learning.

280 Results confirm that bentonite, contrary to OT, did not permit to reduce laccase activity.

281 collaborative coparenting and was linked to OT, whereas a stronger caudate-dACC connectivity was ass

282 Similar to OT, prostaglandins (PGs) play key roles in myometrial co

283 Optoacoustic tomography (OT) is now widely used in preclinical imaging; however,

284 ricular and left ventricular outflow tracts (OTs).

285 weekly for at least 25 years (older trained, OT), and (3) 22 middle-aged (range 35-59 years) untraine

286 CD8(+) transgenic OT-1 cells differentiated with IL-2 and IL-4 (T(C)2 cell

287 o CD4(+) T cells (T cell receptor transgenic OT-II) was measured via a [(3)H]-thymidine incorporation

288 ls from ROCK2-sufficient OVA TCR transgenic (OT-II) mice or saline i.v. 48 h before challenge with ae

289 tical catapulting (OC) and optical trapping (OT) have recently been combined with laser-induced break

290 g are not known, but the olfactory tubercle (OT) and posterior piriform cortex (pPC) are candidates f

291 is commonly known as the olfactory tubercle (OT).

292 Using optical tweezers (OT) and steered molecular dynamic simulations (SMD), we

293 force microscopy (AFM) and optical tweezers (OT) experiments to show that high mobility group B (HMGB

294 e (ST)], another agent's action [other-type (OT)], or both [self- and other-type (SOT)].

295 2D2 TCR-transgenic naive T cells, unrelated OT-II TCR-transgenic memory-like T(H)17 cells infiltrate

296 for arrhythmias beyond the right ventricular OT a feasible option for cure-indeed ablation is now a c

297 Here, we introduce Waddington-OT, an approach for studying developmental time courses

298 METx is a weak OT receptor antagonist, reducing the frequency of OT ind

299 (2+) release events become even smaller when OT/CT correlations are included.

300 of social behaviors, the mechanism in which OT acts to promote the appropriate social response is po