ライフサイエンスコーパス: Ogen

1 of beta-amyloid (Abeta) peptide with fibrin(ogen).

2 nts of CD44 binding to hyaluronan and fibrin(ogen).

3 oprotein that binds to hyaluronan and fibrin(ogen).

4 due-extended C-terminus, which binds plasmin(ogen).

5 orresponding to the alphaC regions of fibrin(ogen).

6 synthetic B-knobs that bind to human fibrin(ogen).

7 rophils to fibrin gel and immobilized fibrin(ogen).

8 -383 sequence in the gammaC-domain of fibrin(ogen).

9 ne expression in Plg(o) mice required fibrin(ogen).

10 viously to be a surface receptor for plasmin(ogen).

11 of bacteria to human fibronectin and fibrin(ogen).

12 a clot composed of both platelets and fibrin(ogen).

13 2 (FGF-2) binds with high affinity to fibrin(ogen).

14 gated the possible binding of IL-1 to fibrin(ogen).

15 action is enhanced by the presence of fibrin(ogen).

16 I, thrombin activity, and cleavage of fibrin(ogen).

17 ammation requires cell surface-bound plasmin(ogen).

18 roduction and macrophage adhesion via fibrin(ogen).

19 entified by Western blot analysis as plasmin(ogen).

20 )-binding motif on the gamma chain of fibrin(ogen).

21 assessed and related to the extent of fibrin(ogen).

22 sdrC), all with binding affinity for fibrin(ogen).

23 amma'-fibrin(ogen) than gammaA/gammaA-fibrin(ogen).

24 cruitment of host proteases, such as plasmin(ogen).

25 el glutathione conjugate of harderoporphyrin(ogen) (2,7,12,18-tetramethyl-3-vinylporphyrin-8,13,17-tr

26 IIIa, can covalently incorporate into fibrin(ogen) a physiologically active peptide, thymosin beta(4)

27 of both of these serine proteases is fibrin(ogen), a logical extension of this hypothesis is that lo

28 ccipital cortex showed an increase of fibrin(ogen)/Abeta codeposition, as well as fibrin deposits in

29 PAI-1 expression also correlated with fibrin(ogen) accumulation (R=0.77, P<0.001), and fibrin(ogen) a

30 ociate elevated PAI-1 expression with fibrin(ogen) accumulation and increased cell proliferation.

31 ) accumulation (R=0.77, P<0.001), and fibrin(ogen) accumulation correlated strongly with proliferatio

32 CD69-deficiency increased fibrin(ogen) accumulation in the ischemic tissue, and plasma VW

33 Moreover, platelet recruitment and fibrin(ogen) accumulation were significantly higher in F8-/-/PN

34 define the biological significance of fibrin(ogen)-alpha(M)beta(2) interaction in vivo, gene-targeted

35 dies suggest that therapies targeting fibrin(ogen)-alpha(M)beta(2) interactions may be useful in prev

36 ndent apo(a)-binding sites within the fibrin(ogen) alphaC domains which contribute to an alternative

37 fibronectin binds exclusively to the fibrin(ogen) alphaC domains.

38 Because the fibrin(ogen) alphaC-domains bind plasminogen and tissue-type pl

39 * following chemical cross-linking of fibrin(ogen) alphaC389-402 peptides to FXIII-A(2)*; and (3) car

40 the hypothesis that disruption of the fibrin(ogen)-alphaMbeta2 interaction in Fibgamma(390-396A) mice

41 Fibrin(ogen)-alphaMbeta2 interaction inhibited iNOS induction i

42 tissue can proceed in the absence of fibrin(ogen) and all of its proteolytic derivatives.

43 These findings indicate that host fibrin(ogen) and bacterial ClfA are dual determinants of virule

44 IL-1beta binds with high affinity to fibrin(ogen) and demonstrates increased activity in the bound f

45 s, even though these peptides bind to fibrin(ogen) and enhance turbidity, the delay in lysis is mainl

46 on at physiological concentrations of fibrin(ogen) and factor XIII was significant with molar incorpo

47 tory role for the hemostatic factors plasmin(ogen) and fibrin(ogen) in cellular plasticity within adu

48 osition of radiolabeled platelets and fibrin(ogen) and immunohistochemical analysis of perfused arter

49 bind to the lysine binding sites of plasmin(ogen) and is only a kinetically slow plasmin inhibitor.

50 In this paper, the role of fibrin(ogen) and its degradation products in the growth and spo

51 xplore the interactions of polyP with fibrin(ogen) and its effect on fibrin structure and fibrinolysi

52 we studied binding of alpha(2)-AP to fibrin(ogen) and its fragments by an enzyme-linked immunosorben

53 affinity-based assays, we found that fibrin(ogen) and its heparin-binding domain bind several GFs fr

54 However, fibrin(ogen) and proteases controlling its deposition and clear

55 FBA-tb bound human plasmin(ogen) and protected FBA-tb-bound plasmin from regulation

56 This accumulated Abeta can bind to fibrin(ogen) and render fibrin clots more resistant to degradat

57 the first time, a unique link between fibrin(ogen) and the development of inflammation-driven maligna

58 t physiological ionic conditions only fibrin(ogen) and the E(1) fragment bind heparin, indicating tha

59 predominant gammaA/gammaA isoform of fibrin(ogen) and the gammaA/gamma' variant with an extended gam

60 In addition, we demonstrate that plasmin(ogen) and thrombin induce a significant increase in secr

61 t." Confocal microscopy revealed that fibrin(ogen) and thrombospondin colocalized as "cap," a single

62 ase ancistron increased the amount of fibrin(ogen) and thrombospondin on the surface of the PS-positi

63 venance and putative neurotoxicity of fibrin(ogen), and its potential impact on clinical disability.

64 the mechanisms by which blood cells, fibrin(ogen), and platelet-fibrin interactions modulate clot co

65 ins include binding of host laminin, plasmin(ogen), and regulators of complement activation.

66 ly determine whether fibrin(ogen) or plasmin(ogen) are determinants of the metastatic potential of ci

67 nteractions of endothelial cells with fibrin(ogen) are implicated in inflammation, angiogenesis, and

68 A causative role for plasmin (ogen) as a "second hit" in kidney disease progression ha

69 effects on fibrin clots, implicating fibrin(ogen) as a potential critical factor in this disease.

70 of SAA increased amyloid formation of fibrin(ogen) as determined both with auto-fluorescence and with

71 identify the gamma370-381 sequence of fibrin(ogen) as the binding site for alpha(IIb)beta3 involved i

72 r cytoskeletal motility proteins) and fibrin(ogen) (as the substrate bridging platelets for contracti

73 tion by inducing amyloid formation in fibrin(ogen), as well as by propelling platelets to a more prot

74 echanistic links between the thrombin/fibrin(ogen) axis and obesity-associated pathologies are incomp

75 t one mechanism by which the platelet-fibrin(ogen) axis contributes to metastatic potential is by imp

76 We have shown previously that fibrin(ogen) binding potentiates the capacity of fibroblast gro

77 creases the tensile strength of CD44s-fibrin(ogen) binding, which is in stark contrast to CD44v-fibri

78 We have shown previously that fibrin(ogen) binds fibroblast growth factor 2 (FGF-2) and poten

79 Additionally, upon activation plasmin(ogen) bound to PGK cleaved the central complement protei

80 or downstream (71%), as was extensive fibrin(ogen) buildup (87%).

81 agments and NDSK corresponding to the fibrin(ogen) central E region, using laser tweezers-based force

82 sites involved in fibrin binding and plasmin(ogen) cleavage, respectively.

83 ain protein prior to perfusion over a fibrin(ogen)-coated surface.

84 ts were added before perfusion over a fibrin(ogen)-coated surface.

85 hesion and closeness of apposition to fibrin(ogen)-containing surfaces.

86 These studies demonstrate that plasmin(ogen) contributes to favorable arterial remodeling and a

87 liferation after PHx, indicating that fibrin(ogen) contributes to liver regeneration after PHx by pro

88 We tested the hypothesis that fibrin(ogen) contributes to liver regeneration by promoting int

89 These data show that the fibrin(ogen)-covered cap, predominantly formed as a result of f

90 ther, these results indicate that the fibrin(ogen) D region and the C-terminal subdomain of the alpha

91 aused by deficiency of hepatic uroporphyrin- ogen decarboxylase activity.

92 Fibrin(ogen) deficiency (Fg-/-) was shown previously to be comp

93 demonstrate that coagulation-impaired fibrin(ogen)-deficient mice, in comparison with genetically mat

94 However, adhesion was suppressed in fibrin(ogen)-deficient mice, suggesting that fibrin formation s

95 rsiniosis with a phenotype similar to fibrin(ogen)-deficient mice, whereas factor XI-deficient mice s

96 rsiniosis with a phenotype resembling fibrin(ogen)-deficient mice.

97 Interactions between CgA and plasmin(ogen) define a previously unrecognized autocrine/paracri

98 Although surface-bound plasmin(ogen) degraded fibrin, no direct evidence for a role in

99 linking TF to metastasis is through a fibrin(ogen)-dependent and platelet-dependent restriction in na

100 ombin-generating potential underlying fibrin(ogen)-dependent bacterial clearance.

101 l accumulation of IL-6 and MCP-1 in a fibrin(ogen)-dependent manner.

102 latelets use lamellipodia to scan for fibrin(ogen) deposited on the inflamed vasculature and to direc

103 enicity, inhibiting both platelet and fibrin(ogen) deposition (580 versus 194 plateletsx10(6)/cm2; P<

104 Fibrin(ogen) deposition (x10(12) molecules/cm(2) of carotid art

105 addition, these mice showed decreased fibrin(ogen) deposition and expression of proinflammatory media

106 by coagulation-dependent intrahepatic fibrin(ogen) deposition drives platelet accumulation and liver

107 Progressive MS cases with severe fibrin(ogen) deposition have significantly reduced neuronal den

108 erved that cerebral infarct sizes and fibrin(ogen) deposition in chimeric mice with only platelet VWF

109 n was noted in Plg-/- mice and sparse fibrin(ogen) deposition in control mice on days 1 and 3 after i

110 of coagulation system activation and fibrin(ogen) deposition in models of inflammatory disease and t

111 y had focal sterile inflammation with fibrin(ogen) deposition in the liver and elevated plasma thromb

112 Fibrin(ogen) deposition is neurotoxic in animal models of MS, b

113 s activation of synovial fibroblasts, fibrin(ogen) deposition may promote the recruitment (via chemok

114 Fibrin(ogen) deposition occurs during corneal wound repair afte

115 The amount of fibrin(ogen) deposition on the collagen/vWF spots was approxima

116 We tested the hypothesis that hepatic fibrin(ogen) deposition reduces severity of APAP-induced liver

117 Intrahepatic fibrin(ogen) deposition was abolished in mice with liver-specif

118 Moreover, increased intrahepatic fibrin(ogen) deposition was evident in livers of patients after

119 Exuberant corneal fibrin(ogen) deposition was noted in Plg-/- mice and sparse fib

120 Fibrin(ogen) deposition was noted in the peritoneal cavity in r

121 Thrombin-dependent intrahepatic fibrin(ogen) deposition was recently reported after partial hep

122 Motor cortical fibrin(ogen) deposition was significantly over-represented in M

123 s platelet and (125)I-labeled porcine fibrin(ogen) deposition, and the incidence of macroscopic mural

124 ession, as well as platelet function, fibrin(ogen) deposition, and VWF (von Willebrand factor) expres

125 damage was correlated with increased fibrin(ogen) deposition, suggesting that this protein might pla

126 oagulation, evidenced by intrahepatic fibrin(ogen) deposition.

127 ion primarily by driving intrahepatic fibrin(ogen) deposition.

128 intracerebral thrombosis [assessed by fibrin(ogen) deposition] and postischemic inflammation (phospho

129 Indeed, fibrin(ogen) deposits are a near-universal feature of tissue in

130 ectomy (PHx) in mice, but the role of fibrin(ogen) deposits in liver regeneration has not been invest

131 Fibrin(ogen) deposits resolved in control mice but persisted in

132 More abundant fibrin(ogen) deposits were also found in brain and lungs.

133 After Stx2/LPS, intraglomerular fibrin(ogen) deposits were detected earlier in TM(LeD/LeD) than

134 s is mediated through interaction of fibrin-(ogen) deposits with the apolipoprotein(a) (apo(a)) moiet

135 tiple sclerosis lesions together with fibrin(ogen) deposits.

136 e interaction of alpha(2)-AP with the fibrin(ogen)-derived D(1), D-D, and E(3) fragments, and the rec

137 The results indicate that fibrin(ogen) does not contribute to development of APAP-induced

138 Increased ICAM-1 expression was fibrin(ogen) dose-dependent and was demonstrated by ELISA, flow

139 The beta chain 15-42 sequence of the fibrin(ogen) E region was implicated in heparin binding; whethe

140 hesion, and microthrombi formation on fibrin(ogen), extracellular matrix, and collagen at high shear

141 le myosin II, red blood cells (RBCs), fibrin(ogen), factor XIIIa (FXIIIa), and thrombin on the kineti

142 ibers, and (2) through inhibition of plasmin(ogen)-fibrin binding.

143 tion why pathogenic microbes utilize plasmin(ogen) for immune evasion and tissue penetration.

144 Herein, we review aspects of fibrin(ogen) formation, structure, stability, and function, foc

145 mulations of the structural models of fibrin(ogen) fragment D complexed with synthetic peptides GPRP

146 herichia coli a number of recombinant fibrin(ogen) fragments containing the beta15-42 region or the V

147 nteraction between apo(a) and various fibrin(ogen) fragments representing the whole fibrin(ogen) mole

148 Purified plasmin(ogen) from diabetic subjects had impaired fibrinolytic a

149 Plasma-purified plasmin(ogen) functional activity was evaluated by chromogenic,

150 Thus, plasmin(ogen) functions in limiting progressive fibrosis in the

151 related conformational changes in the fibrin(ogen) gamma-modules.

152 ne levels, proteinuria, deposition of fibrin(ogen), glomerular endothelial damage, hemolysis, leukocy

153 tified a key residue on the alphaC of fibrin(ogen) (Glu396) involved in binding activated factor XIII

154 in the accumulation of the harderoporphyrin(ogen)-glutathione conjugate observed in the expression s

155 ses with high levels of extracellular fibrin(ogen) had significantly upregulated PAI-1 expression in

156 r of the normal fibrinolytic role of plasmin(ogen) has been a major research focus.

157 Hepatic fibrin(ogen) has been noted to occur after acetaminophen (APAP)

158 ntrol of blood loss following injury, fibrin(ogen) has been proposed to play an important role in tis

159 unctional features of factor XIII and fibrin(ogen) have been elucidated by protein and gene analysis,

160 ons bound both strongly and weakly to fibrin(ogen) have been localized, and some aspects of their rol

161 physiologic functions of extravasated fibrin(ogen) have led to the discovery, reported here, that fib

162 earance, including (pro)thrombin and plasmin(ogen), have powerful roles in driving acute and reparati

163 scanning via anti-GPIbalpha and anti-fibrin(ogen) immunofluorescence.

164 vascular plasma perfusion deficit and fibrin(ogen) immunoreactivity in a rat model of focal cerebral

165 Therefore, batroxobin binds fibrin(ogen) in a manner distinct from thrombin, which may cont

166 Herein, we investigate roles for fibrin(ogen) in an in vivo model of mycobacterial granuloma for

167 To determine the importance of fibrin(ogen) in arthritis, gene-targeted mice either deficient

168 Chemokine production was induced by fibrin(ogen) in cell culture supernatants >100-fold as compared

169 hemostatic factors plasmin(ogen) and fibrin(ogen) in cellular plasticity within adult tissues of the

170 ht the increasingly important role of fibrin(ogen) in health and disease.

171 urrent in-vivo studies on the role of fibrin(ogen) in hemostasis and thrombosis.

172 , these findings suggest a role for plasmin (ogen) in mediating glomerular injury and as a viable tar

173 stent with the protective function of fibrin(ogen) in mice, low postoperative plasma fibrinogen level

174 tigate the extent and distribution of fibrin(ogen) in progressive MS cortex and elucidate its relatio

175 udies indicated an important role for fibrin(ogen) in sustained adhesion and survival of tumor cells

176 Here, we characterize the role of plasmin(ogen) in the complement cascade.

177 es, suggesting an additional role for fibrin(ogen) in the growth of established adenomas.

178 llate, with a significant increase in fibrin(ogen) in the plasminogen-deficient mice.

179 To further define the role of fibrin(ogen) in thrombus formation and stabilization, platelet

180 or dissemination through at least one fibrin(ogen)-independent mechanism.

181 blastic cells, no significant data on fibrin(ogen)-induced gene expression by fibroblasts have been p

182 Our study demonstrates a role for plasmin (ogen)-induced podocyte injury in the PAN nephropathy mod

183 Our data suggest that extravascular fibrin(ogen) induces macrophage chemokine expression, thereby p

184 cterize a novel mechanism whereby the fibrin(ogen)-integrin-alphaMbeta2 interaction reduces biliary f

185 -glycosylation of CD44, whereas CD44s-fibrin(ogen) interaction has an absolute requirement for N-, bu

186 nent importance of the bacterial ClfA-fibrin(ogen) interaction in determining host survival.

187 n, although it has no effect on CD44s-fibrin(ogen) interaction.

188 coagulation, but a decreased platelet/fibrin(ogen) interaction.

189 ular requirements of CD44-HA and CD44-fibrin(ogen) interactions at the single-molecule level.

190 ogen) mediated by the 5-residue FGF-2-fibrin(ogen) interactive site is required for augmented angioge

191 matory demyelination include entry of fibrin(ogen) into the central nervous system (CNS), which is no

192 The authors concluded that fibrin(ogen) is a critical determinant of the metastatic potent

193 studies definitively demonstrate that fibrin(ogen) is a physiologically relevant ligand for alpha(M)b

194 Thus, fibrin(ogen) is an important, but context-dependent, determinan

195 Fibrin(ogen) is central to hemostasis and thrombosis and also c

196 pha(M)beta(2), integrin engagement of fibrin(ogen) is critical to leukocyte function and innate immun

197 we provide unequivocal evidence that fibrin(ogen) is extensively deposited in progressive MS motor c

198 that the only heparin-binding site in fibrin(ogen) is formed by NH(2)-terminal portions of the beta c

199 However, fibrin (ogen) is important for appropriate cellular migration an

200 ally relevant heparin-binding site of fibrin(ogen) is located in its E region.

201 lpha(M)beta(2)-mediated engagement of fibrin(ogen) is mechanistically coupled to local inflammatory p

202 ent position in gamma-chains of human fibrin(ogen) is occupied by a lysine (gamma338), but in chicken

203 olecular interaction between CD44 and fibrin(ogen) is predominantly mediated by the chondroitin sulfa

204 XIII, indicating that the presence of fibrin(ogen) is required to confer sufficient stability at the

205 Although fibrin and/or fibrinogen (fibrin(ogen)) is abundantly present in inflamed tissues and joi

206 Angiostatin, a fragment of plasmin(ogen), is a ligand and an antagonist for integrin alpha(

207 In contrast, batroxobin binds both fibrin(ogen) isoforms with similar high affinity (Kd values of

208 gamma338), but in chicken and lamprey fibrin(ogen), it is an arginine, just as occurs in beta chains.

209 As such, fibrin(ogen) lies at the nexus of vascular injury and repair.

210 cules loosely bound to the surface of fibrin(ogen) matrix are not able to consolidate their grip on t

211 rculating leukocytes to the insoluble fibrin(ogen) matrix is mediated by integrins and occurs in the

212 iple ligands, but local engagement of fibrin(ogen) may be particularly important for leukocyte functi

213 of concept that targeting thrombin or fibrin(ogen) may limit pathologies in obese patients.

214 demonstrate that binding of FGF-2 to fibrin(ogen) mediated by the 5-residue FGF-2-fibrin(ogen) inter

215 o characterize possible mechanisms of fibrin(ogen)-mediated antimicrobial responses.

216 Fibrin(ogen)-mediated bacterial clearance was dependent on (pro

217 AA causes atypical coagulation with a fibrin(ogen)-mediated increase in coagulation, but a decreased

218 echanisms underlying the deficits of plasmin(ogen)-mediated macrophage migration in 2 models: murine

219 d ICAM-1 may participate in multistep fibrin(ogen)-mediated melanoma cell adhesion within the circula

220 3), ICAM-1, and CD11b/CD18 (Mac-1) in fibrin(ogen)-mediated melanoma-PMN aggregations was explored.

221 ogen) to investigate whether abnormal fibrin(ogen) might contribute to the pathogenesis of CTEPH.

222 gen) fragments representing the whole fibrin(ogen) molecule except the alphaC regions.

223 l coiled-coil connectors of the human fibrin(ogen) molecule using biomolecular simulations of their f

224 ether encompass practically the whole fibrin(ogen) molecule.

225 ain that together encompass the whole fibrin(ogen) molecule.

226 Individual fluorescently labeled fibrin(ogen) molecules and their assembly to make a clot were o

227 etalloproteinase-3 and degradation of fibrin(ogen), nidogen, and perlecan in the adventitia of descen

228 and the presence of anterior chamber fibrin(ogen) occurred in plasminogen-deficient mice but not in

229 n acute lesions tPA co-localized with fibrin(ogen) on large diameter axons also stained with SMI-32,

230 we explored the hypothesis that host fibrin(ogen), on balance, supports Staphylococcus aureus infect

231 The batroxobin-binding sites on fibrin(ogen) only partially overlap with those of thrombin beca

232 To directly determine whether fibrin(ogen) or plasmin(ogen) are determinants of the metastati

233 g of alpha(IIb)beta(3) to immobilized fibrin(ogen), per se, triggers interaction of the integrin with

234 CD44 and fibrin(ogen) play critical roles in the hematogenous disseminat

235 These results suggest that plasmin(ogen) plays a role in the turnover of extracellular matr

236 Hence, our results suggest fibrin(ogen) plays an important role in spontaneous metastasis,

237 ylococcal aureus, we demonstrate that fibrin(ogen) plays little role in controlling peritoneal number

238 d in T2D, and we recently showed that fibrin(ogen) polymerisation during blood clotting can be affect

239 escence colocalized with staining for fibrin(ogen) present in the extravascular compartment of tumors

240 Rather, fibrin(ogen) primarily limits the growth of these intracellular

241 espite confirming a prior report that fibrin(ogen) promotes the peritoneal clearance of the extracell

242 ar, failure to effectively remove the fibrin(ogen) provisional matrix.

243 s was unimpeded by the absence of the fibrin(ogen) receptors, alphaMbeta2 and ICAM-1, the myeloid cel

244 rsus CD44 variant (CD44v) isoforms in fibrin(ogen) recognition have yet to be delineated.

245 d that the betaN-domains are the only fibrin(ogen) regions involved in the interaction with VE-cadher

246 nding; whether heparin binds to other fibrin(ogen) regions remains to be clarified.

247 al fragments corresponding to various fibrin(ogen) regions, and tested the interactions between them

248 To test if the other fibrin(ogen) regions/domains are involved in this interaction a

249 Thus, plasmin(ogen) regulates both complement and coagulation, the two

250 e studies suggest that one target of plasmin(ogen) relevant to tumor progression in vivo is intravasc

251 the interaction of apo(a) with intact fibrin(ogen) remained unclear.

252 In mice depleted of fibrin(ogen), remyelination of myelinated axons is accelerated

253 re of human synovial fibroblasts with fibrin(ogen) results in the up-regulation of ICAM-1 as well as

254 hat FGF-2 bound to surface-associated fibrin(ogen) retained activity.

255 Fibrin(ogen) retention was normal in Bernard-Soulier syndrome a

256 Without fibrin(ogen) retention, their ability to be incorporated in agg

257 ransglutaminases are also involved in fibrin(ogen) retention.

258 f platelet glycoprotein GPIbalpha and fibrin(ogen) revealed a critical TF concentration (EC50) of 3.6

259 Immunoblotting analysis of plasmin(ogen) revealed increased levels of lysine-plasminogen in

260 tions performed in a prior study with fibrin(ogen)'s gamma' peptide and IIa.

261 the alpha(M)beta(2)-binding motif on fibrin(ogen) severely compromised the inflammatory response in

262 Fibrin(ogen) stimulation of ICAM-1 could be suppressed by pyrro

263 ed lysis may be due to alterations in fibrin(ogen) structure affecting accessibility to plasmin cleav

264 egrins but rather associated with the fibrin(ogen) substrate.

265 ctive mechanisms, we demonstrate that fibrin(ogen) suppresses anemia, reduces hemorrhagic pathology,

266 n rapidly bound, covering >90% of the fibrin(ogen) surface area, whereas the intact tri-A domain prot

267 to rapidly bind, covering 100% of the fibrin(ogen) surface area.

268 ffin cells express components of the plasmin(ogen) system, including tissue plasminogen activator, wh

269 finity interaction with gammaA/gamma'-fibrin(ogen) than gammaA/gammaA-fibrin(ogen).

270 rminus contains the binding site for plasmin(ogen), the key component necessary for the rapid and eff

271 o mediating high affinity binding to plasmin(ogen), the streptokinase beta-domain is required for non

272 ide interaction of apo(a) with intact fibrin(ogen) through another alternative mechanism, which depen

273 by the interaction of leukocytes with fibrin(ogen) through the integrin alpha(M)beta(2) receptor.

274 the enhancement requires binding of plasmin(ogen) to cellular receptors.

275 itis, but the precise contribution of fibrin(ogen) to inflammatory events that cause debilitating joi

276 c, genomic, and functional studies on fibrin(ogen) to investigate whether abnormal fibrin(ogen) might

277 arthritis, and one mechanism linking fibrin(ogen) to joint disease is coupled to alphaMbeta2-mediate

278 tablished the overall utility of host fibrin(ogen) to S. aureus virulence.

279 moglobin (Hb) on platelet adhesion to fibrin(ogen) under conditions of different hydrodynamic forces.

280 ents, we found associations between plasmin (ogen) uria and edema status as well as eGFR.

281 entially novel relationship between plasmin (ogen) uria and estimated glomerular filtration rate (eGF

282 Additionally, association between plasmin (ogen) uria and kidney function in glomerular diseases re

283 hy was associated with increases in plasmin (ogen) uria and proteinuria.

284 iopsy albuminuria, proteinuria, and plasmin (ogen) uria for correlations with kidney outcomes.

285 Urinary plasminogen/plasmin, or plasmin (ogen) uria, has been demonstrated in proteinuric patient

286 activation, and measured changes in plasmin (ogen) uria.

287 The extent and distribution of fibrin(ogen) was assessed and related to measures of demyelinat

288 n during the observational period and fibrin(ogen) was detected immunohistochemically.

289 Increased glomerular plasmin (ogen) was found in PAN rats and focal segmental glomerul

290 Binding of VEGF to fibrin(ogen) was independent of FGF-2, indicating that there ar

291 pe (WT) A1A2A3 protein, collagen, and fibrin(ogen) was inhibited (32-75%) by anti-vimentin antibody u

292 Fibrin(ogen) was not essential for leukocyte trafficking to joi

293 In this model, fibrin(ogen) was not required for cell recruitment, cytokine re

294 Fibrin(ogen) was observed in blood vessels positive for amyloid

295 The surface fibrin(ogen) was strongly decreased in the presence of a fibrin

296 Levels of ICAM-1 induced by fibrin(ogen) were comparable to those that could be induced by

297 polymeric fibrin and surface-adsorbed fibrin(ogen), while no binding was observed with fibrinogen in

298 s revealed a significant increase in plasmin(ogen) with age.

299 2 from P1 may regulate interaction of fibrin(ogen) with leukocytes during the inflammatory response.

300 tissue transglutaminase cross-linked fibrin(ogen) with mainly alpha-gamma cross-links.