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1 ber in the developing nucleus of the ciliate Oxytricha.
2 DNA repeats from vertebrates, Tetrahymena or Oxytricha.
3 e its DNA recognition properties directly in Oxytricha.
4 Telomeric sequences investigated include the Oxytricha 3' overhang, d(T4G4)2, and the related sequenc
5 ation of thousands of eccDNA molecules makes Oxytricha a model system for studying nucleic acid topol
6 nts, but its extent had not been surveyed in Oxytricha, a ciliate with elaborate DNA elimination and
7 n organizing guide for DNA rearrangements in Oxytricha and a template that can transmit spontaneous m
8 the macronuclear telomeres from the ciliates Oxytricha and Euplotes.
9                                              Oxytricha and its close relatives have a unique genome a
10  ciliates-Paramecium, Tetrahymena, Euplotes, Oxytricha and Stylonychia-reveal considerable variation
11 crM), the MTA1-MTA9 complex from the ciliate Oxytricha, and the mammalian MettL3-MettL14 complex.
12     Recently, telomeric DNA in human, mouse, oxytricha, and trypanosome chromosomes have been found a
13 t of the telomere repeats of Tetrahymena and Oxytricha as well as that of the thrombin binding aptame
14       Here we use the single-celled ciliate, Oxytricha, as an analog to some of the genetic and genom
15 itro by reconstructing complete, full-length Oxytricha chromosomes harboring 6mA in native or ectopic
16                                           An Oxytricha family of Tc1/mariner transposons, known as te
17  This study suggests a new important role in Oxytricha for this large portion of genomic DNA that was
18                                Using a draft Oxytricha genome assembly and a custom-written protein-c
19                          Here, we report the Oxytricha germline genome and compare it to the somatic
20  non-coding nanochromosomes, suggesting that Oxytricha has few independent ncRNA genes besides homolo
21  the catalytic subunit, MTA1, in the ciliate Oxytricha leads to genome-wide loss of 6mA and abolishme
22 la, and Paramecium tetraurelia, but only the Oxytricha lineage has a massively scrambled genome, whos
23  of discontinuous and scrambled genes in the Oxytricha lineage.
24        The assembly of the highly fragmented Oxytricha macronuclear genome is the first completed gen
25                                          The Oxytricha macronuclear TERT gene has no introns, whereas
26                                 For example, Oxytricha maintains tens of millions of telomeres per ce
27 ocesses related to the genomes and nuclei of Oxytricha may exemplify primitive states of the developi
28 ed DNA molecule in the macronucleus (mac) of Oxytricha nova (On) encoding heat-shock protein 70 (Hsp7
29 its of the telomere end binding protein from Oxytricha nova (OnTEBP) combine with telomere single str
30 tructure of the germline DNA polalphagene in Oxytricha nova .
31 de Pot1 in humans and fission yeast, TEBP in Oxytricha nova and Cdc13 in budding yeast.
32 s of 1.5 units of the repeat in telomeres of Oxytricha nova and has been shown by NMR and X-ray cryst
33 ats of the telomeric DNA sequence d(T4G4) of Oxytricha nova are capable of forming unusually stable s
34 he heterodimeric telomere binding protein of Oxytricha nova have been probed by Raman spectroscopy, C
35 0 000 IESs from a haploid germline genome in Oxytricha nova requires approximately 150 000 recombinan
36 assium-containing quadruplex formed from the Oxytricha nova sequence d(GGGGTTTTGGGG) are reported, in
37 heart-shaped structure of ciliated protozoan Oxytricha nova TEBPalpha-beta complex, POT1-TPP1 adopts
38 an TPP1, Schizosaccharomyces pombe Tpz1, and Oxytricha nova TEBPbeta.
39                                          The Oxytricha nova telemere binding protein alpha subunit bi
40 ations of the alpha and beta subunits of the Oxytricha nova telomere binding protein have been invest
41      Interactions of the beta subunit of the Oxytricha nova telomere binding protein with the telomer
42 ned the crystal structure of the two-subunit Oxytricha nova telomere end binding protein (OnTEBP) com
43                                          The Oxytricha nova telomere end binding protein (OnTEBP) rec
44                                              Oxytricha nova telomere end binding protein (OnTEBP) spe
45 terpoint to the interactions observed in the Oxytricha nova telomere end-binding and Schizosaccharomy
46 ferent non-cognate ssDNAs complexed with the Oxytricha nova telomere end-binding protein (OnTEBP) and
47                                              Oxytricha nova telomere end-binding protein specifically
48 Tl+ form of the G-quadruplex formed from the Oxytricha nova telomere sequence, d(G4T4G4), has been so
49 ucleotides with the repeat sequence found in Oxytricha nova telomeres.
50      The solution secondary structure of the Oxytricha nova telomeric 3' overhang, d(T4G4)2, has been
51 ic antiparallel G-quadruplex formed from the Oxytricha nova telomeric DNA sequence d(GGGGTTTTGGGG), a
52 -syn-anti-syn-anti pattern observed with the Oxytricha nova telomeric G-quadruplexes, have been well
53 ar model for the hairpin conformation of the Oxytricha nova telomeric repeat and consider its possibl
54  target a dimeric G-quadruplex formed by the Oxytricha nova telomeric sequence d(G(4)T(4)G(4)) with a
55 annel, transversal loops, and grooves of the Oxytricha nova's telomeres' G-quadruplex ( Oxy-GQ), in a
56 karyotes, and TEBP in the ciliated protozoan Oxytricha nova, exhibit sequence-specific binding to the
57 lymerase alpha gene, previously sequenced in Oxytricha nova, has been cloned from a genomic macronucl
58 sembled with telomere single-strand DNA from Oxytricha nova, our results highlight the relative simpl
59                                           In Oxytricha nova, telomere G-overhangs are protected by th
60 he telomere-binding protein alpha subunit of Oxytricha nova.
61 ymerase alpha (DNA pol alpha) in the ciliate Oxytricha nova.
62 f genomic DNA from Pneumocystis, Plasmodium, Oxytricha or Tetrahymena.
63                                              Oxytricha piRNAs map primarily to the somatic genome, re
64 strate that circular DNAs are transcribed in Oxytricha, producing rearrangement-specific long non-cod
65 is as massively scrambled and interrupted as Oxytricha's: 13.6% of its gene loci require programmed t
66 he current studies investigate the effect of Oxytricha single-stranded telomere DNA-binding protein s
67  with the duplex telomeric sequence from the Oxytricha species.
68 n orchestrate these genome rearrangements in Oxytricha, supporting an epigenetic model for sequence-d
69 ights into the solution conformations of the Oxytricha telomere binding protein subunits and serve as
70 me proteins, such as the beta-subunit of the Oxytricha telomere-binding protein, promote the formatio
71 -binding characteristics as the Euplotes and Oxytricha telomere-binding proteins.
72          A model for beta subunit binding by Oxytricha telomeric DNA sequences and a mechanism for qu
73 ther characterize structural polymorphism of Oxytricha telomeric DNAs, we have obtained and interpret
74 ick motifs, DNA refolding is specific to the Oxytricha telomeric hairpin and the retention of G.G pai
75 sence of the 5' thymidine tail preceding the Oxytricha telomeric repeat has no apparent effect on the
76 lts will be useful for probing structures of Oxytricha telomeric repeats in complexes with telomere e
77                   In some ciliates including Oxytricha, the macronuclear genome is particularly extre
78                                           In Oxytricha, the somatic genome is responsible for vegetat
79 MAC chromosomes and their gene expression in Oxytricha trifallax (CI: Spirotrichea).
80 ncoding DNA polymerasealpha(DNA polalpha) in Oxytricha trifallax and compared it to the previously pu
81 licing events in two micronuclear genomes of Oxytricha trifallax and Tetrahymena thermophila, we prov
82 or two completely sequenced ciliate genomes: Oxytricha trifallax and Tetrahymena thermophila.
83 earrangements in the single-celled eukaryote Oxytricha trifallax completely rewire its germline into
84 scribe a chimeric macronuclear chromosome in Oxytricha trifallax constructed from two smaller macronu
85                       The somatic nucleus of Oxytricha trifallax contains over 15,000 different chrom
86 ing development of the somatic macronucleus, Oxytricha trifallax destroys 95% of its germ line, sever
87 exaggerated process of genome rearrangement, Oxytricha trifallax destroys 95% of its germline genome
88       The macronuclear genome of the ciliate Oxytricha trifallax displays an extreme and unique eukar
89 sity is approximately 4.0%), suggesting that Oxytricha trifallax may have one of the largest known ef
90 l a set of Piwi-interacting RNAs (piRNAs) in Oxytricha trifallax that likewise enable genomic self ve
91  unusual genomic organization of the ciliate Oxytricha trifallax to screen for eukaryotic non-coding
92 During post-zygotic development, the ciliate Oxytricha trifallax undergoes massive programmed genome
93 d into these three genes during evolution of Oxytricha trifallax, slightly modifying scrambling patte
94 BP alpha subunit have now been identified in Oxytricha trifallax, Stylonychia mytilis, Euplotes crass
95          Three well-studied ciliates include Oxytricha trifallax, Tetrahymena thermophila, and Parame
96 otrichs, Stylonychia lemnae, S. mytilus, and Oxytricha trifallax, that independently derived the same
97  cloning and sequencing of the ortholog from Oxytricha trifallax.
98 e groups of ciliates, such as Stylonychia or Oxytricha, where extensive gene rearrangement occurs dur