ライフサイエンスコーパス: P-selectin

1 adhesion molecule-1, soluble E-Selectin, and P-Selectin).

2 ligand by using a ridged channel coated with P selectin.

3 lso decreased the upregulation of ICAM-1 and P-selectin.

4 We focused on Efb interaction with P-selectin.

5 a-granule proteins von Willebrand factor and P-selectin.

6 d binding affinity to that between SNX17 and P-selectin.

7 Th17, but not Th2 and regulatory T cells on P-selectin.

8 on of STXBP5 increased exocytosis of vWF and P-selectin.

9 t, and Tregs showed reduced capacity to bind P-selectin.

10 te adhesion molecules such as E-selectin and P-selectin.

11 tes expressed on leukocytes to endothelial E/P-selectin.

12 of the WPB cargos von Willebrand factor and P-selectin.

13 based microparticles of iron oxide targeting P-selectin.

14 us 24.4 +/- 13.3 ng/mL, P < 0.0001), soluble p-selectin (14.2 +/- 4.05 versus 33.2 +/- 15.2 ng/mL, P

15 ] in non-ICU patients; p<0.0001) and soluble P-selectin (15.9 ng/mL [4.8] vs 11.2 ng/mL [3.1]; p=0.00

16 (rho = 0.79), and expression levels of both P-selectin (37.4% +/- 14.7 [standard deviation] of vesse

17 Platelet count and P-selectin (a ubiquitous cargo of alpha-granules) were n

18 atelets to lymphocytes was blocked with anti-P-selectin Abs, and when this occurred we observed highe

19 1 (PAR1) thrombin receptor (TRAP-stimulated P-selectin, activated GPIIb-IIIa, and CD42b), independen

20 ERM domain bound to the sorting motif of the P-selectin adhesion protein, revealing both the architec

21 Both deletion and overexpression of P-selectin affected the survival of LSCs.

22 challenge, variation in VWFpp, VWFpp/Ag, and P-selectin among time-points was less than that among su

23 gher than in control ileum (5.1% +/- 3.7 for P-selectin and 4.8% +/- 2.3 for E-selectin).

24 and genetic data show an association between P-selectin and DR in the Jackson Heart Study.

25 further investigate the relationship between P-selectin and DR, we examined the association between P

26 anti-G-CSFR, as was the level of circulating P-selectin and ICAM-1.

27 molecular imaging, expression of endothelial P-selectin and intravascular recruitment of CX(3)CR-1-po

28 ligands modulate leukocyte trafficking, and P-selectin and its ligand, P-selectin glycoprotein ligan

29 via lumi-aggregometry and FACS analysis for P-selectin and LAMP-1 exposure.

30 gher plasma levels of PTX3 and its mediators P-selectin and matrix metalloproteinase-1 than normotens

31 endothelial cells constitutively synthesize P-selectin and mobilize it to the plasma membrane to med

32 ys followed by immunoblotting, we identified P-selectin and multimerin-1 as novel Efb interaction par

33 The interaction of both P-selectin and multimerin-1 with Efb is independent of f

34 The presence of P-selectin and normal levels of VPS33B and VPS16B in Nbe

35 lood, PAR1-AP-triggered TF exposure required P-selectin and PGSL-1.

36 late basal and inducible expression of human P-selectin and reveal human-specific differences in P-se

37 Baseline plasma levels of soluble P-selectin and soluble CD40 ligand and serum TxB2 were s

38 plasma inflammatory biomarkers, and carotid P-selectin and vascular cell adhesion molecule-1 express

39 CAM-1 and induced cell surface expression of P-selectin and VCAM-1.

40 minutes) mobilized Weibel-Palade body (WPB) P-selectin and VWF onto EC and vessel wall surfaces and

41 irculation of healthy individuals are CD41(+)P-selectin(+)and that distinct binding of patient plasma

42 on molecules relevant for leukocyte rolling (P-selectin) and platelet capture (von Willebrand factor

43 y higher platelets activation marker; CD62P (P-selectins) and higher mean fluorescent intensity (MFI)

44 Glycoprotein Ib (GPIb) shedding, exposure of P-selectin, and activated integrin alphaIIbbeta3 upon ac

45 ersed by shedding of endothelial E-selectin, P-selectin, and alphavbeta3 integrin, and leukocyte CD44

46 lar adhesion molecule-1, soluble E-Selectin, P-Selectin, and angiopoietin-2 (p < 0.0001 for all).

47 XCL2/MIP-2, MCP-1/CCL2, CXCR2, IL-6, ICAM-1, P-selectin, and C5aR) was suppressed by anti-G-CSFR, as

48 actor-alpha, monocyte chemotactic protein-1, P-selectin, and E-selectin in DBD compared with LD and D

49 ow levels of the prothrombotic proteins vWF, P-selectin, and ICAM1 and high levels of the antithrombo

50 The findings in humans suggest that PTX3, P-selectin, and matrix metalloproteinase-1 may be novel

51 ure protein (VWF:Ag) and propeptide (VWFpp), P-selectin, and platelet factor 4.

52 surface CD42b, unstimulated platelet surface P-selectin, and platelet forward light scatter (FSC) wer

53 f vascular cell adhesion molecule-1 (VCAM 1) P-selectin, and platelet glycoprotein-1balpha (GPIbalpha

54 WF) antigen, soluble thrombomodulin, soluble P-selectin, and soluble CD40 ligand, as well as coagulat

55 e shown that human and murine TIM-1 binds to P-selectin, and that TIM-1 mediates tethering and rollin

56 activating peptide (TRAP)-stimulated percent P-selectin- and activated glycoprotein (GP)IIb-IIIa-posi

57 al evaluations indicate improved activity as P-selectin antagonists for the axially configured analog

58 er fucoidan (from Fucus vesiculosus) or anti-P-selectin antibody (Rb40.34) during Days 21-35.

59 g with neutrophils and was inhibited by anti-P-selectin aptamer or anti-P-selectin glycoprotein ligan

60 aise important questions about why VWFpp and P-selectin are associated specifically with different im

61 ha-TNFR1 signaling and the adhesion molecule P-selectin are central mediators of these monocyte-CEC a

62 we expressed the entire ectodomain of mouse P-selectin as a monomer (sP-selectin) or as a disulfide-

63 mouse model, we identified brain endothelial P-selectin as a potential biomarker for transient ischae

64 affinity of fCS oligosaccharides for L- and P-selectins as determined by microarray binding of fCS o

65 Activated platelets that expressed P-selectin attached to vascular endothelium and macropha

66 rapeutic potential of targeting the fucoidan/P-selectin axis in PH.

67 The effects of the fucoidan/P-selectin axis on vascular remodeling and pulmonary hyp

68 iated in the presence of PRN694 show reduced P-selectin binding and impaired migration to CXCL11 and

69 Efb-N interaction with P-selectin inhibited P-selectin binding to its physiological ligand, P-select

70 ine responses by activated platelets through P-selectin binding, we found that interaction of monocyt

71 obulin variable domain was also required for P-selectin binding.

72 TGF-beta resulted in a gradual loss of E- or P-selectin-binding central and peripheral memory populat

73 P-selectin blockade by an antibody prevented complement

74 P-selectin blockage resulted in a marked reduction of PA

75 Blockage of P-selectin by administration of anti-P-selectin Rb40.34

76 recognition involved multiple receptors with P-selectin (CD62P) playing the central role.

77 In summary, P-selectin, cellular or soluble, through binding to PSGL

78 phage inflammatory protein 1, interleukin-1, P-selectin, cluster of differentiation 45-positive cells

79 tumor necrosis factor-alpha, E selectin, and P selectin, compared with controls.

80 vealed the critical impact of the triad TLR4/P-selectin/complement in the liver damage and its releva

81 ict thromboembolism was comparable to plasma P-selectin concentrations (thromboembolism, 78.3 ng/mL v

82 events diabetes-induced increases in soluble P-selectin concentrations and limits the impact of the d

83 P-selectin correlated with and predicted greater area of

84 oluble recombinant P-selectin had no effect, P-selectin coupled to 2 um beads triggered TF exposure.

85 TF ELISA, soluble P-selectin, d-dimer, FVIII, and C-reactive protein were

86 Studies in P-selectin-deficient mice confirmed a mechanistic role f

87 tion of anti-P-selectin Rb40.34 antibody and P-selectin-deficient mice improved vascular remodeling a

88 educed VAT inflammation in response to HFMs, P-selectin-deficient mice still developed glucose intole

89 ncreased blood pressure, an effect absent in P-selectin-deficient mice.

90 ngineered to overproduce soluble P-selectin (P-selectin(DeltaCT/DeltaCT) mice).

91 significantly enhanced, indicating that the P-selectin(DeltaCT/DeltaCT) neutrophils were primed for

92 in-induced PNA formation was solely platelet P-selectin dependent.

93 plasticity consisted of rapid and selective P-selectin-dependent binding of PMPs to a CCR6(+)HLA-DR(

94 mRNA during contact hypersensitivity reduced P-selectin-dependent inflammation in Selp(KI) (/-) mice.

95 o a HFD for 24 h quickly induces a transient P-selectin-dependent inflammatory phenotype in the VAT b

96 let-leukocyte complexes in vivo and platelet/P-selectin-dependent polymorphonuclear cell migration in

97 However, TNF-alpha did not further reduce P-selectin-dependent rolling velocities.

98 abeling with GSAO, together with exposure of P-selectin, distinguishes necrotic from apoptotic platel

99 nd endothelial cells induces shedding of the P-selectin ectodomain into the circulation.

100 se experiments define a novel VEGF-miR-1-Mpl-P-selectin effector pathway in lung Th2 inflammation and

101 ysaccharidic ligand of the adhesion molecule P-selectin, exhibits antiproliferative properties.

102 blood and further demonstrate that platelet P-selectin exposure is necessary and sufficient.

103 uced reactive oxygen species (ROS) regulated P-selectin exposure upon agonist stimulation and the lig

104 signalling to integrin alpha(IIb)beta(3) or P-selectin exposure upon agonist-induced activation in p

105 ed alphaIIbbeta3 integrin activation but not P-selectin exposure, Ca(2+) mobilization, beta3-talin1 i

106 sis of platelet surface-bound fibrinogen and P-selectin exposure.

107 ulating platelet-monocyte aggregates (PMAs), p-selectin expression (P-SEL), and integrin alphaIIbbeta

108 -terminal CGHC motif of PDI is important for P-selectin expression and ATP secretion through a non-al

109 lungs and PASMCs were used for assessment of P-selectin expression and function.

110 ; P < .01 vs L1-injected mice) and increased P-selectin expression and GPIIb/IIIa activation in plate

111 p-regulation of circulating platelet surface P-selectin expression and the formation of platelet-leuk

112 Compound 6b also inhibited platelet P-selectin expression and thus may diminish atherosclero

113 emonstrated the ability for Abeta to enhance p-selectin expression at the CEC surface and induce cyto

114 indicated the ability for Abeta to increase p-selectin expression at the cell surface and promote ac

115 atelets from COVID-19 patients had increased P-selectin expression basally and upon activation.

116 P-selectin expression by the endothelium may enhance VTE

117 gnificant reductions in stimulated (ex vivo) P-selectin expression compared with the placebo group (P

118 Clinical imaging of P-selectin expression for disease characterization could

119 atelet integrin alphaIIbbeta3 activation and P-selectin expression in a Toll-like receptor 2 (TLR2)-d

120 poxia and low NO bioavailability upregulated P-selectin expression in endothelial cells in an additiv

121 L5 but not L1 induced tissue factor and P-selectin expression in human aortic ECs (P < .01), the

122 NK inhibition reduced fibrinogen binding and P-selectin expression of d12 platelet-like particles (PL

123 induced integrin alpha2bbeta3 activation and P-selectin expression that are partially corrected by in

124 ntima) and endothelial activation (increased P-selectin expression).

125 C3a and C5a generation, endothelial P-selectin expression, and adhesion of human primary and

126 ADP-stimulated platelet fibrinogen binding, P-selectin expression, and platelet aggregation were low

127 In contrast, SFLLRN-mediated P-selectin expression, ATP secretion, phosphorylation of

128 We found (1) no significant changes for P-selectin expression, PAC-1 binding, delta-granule cont

129 latelet aggregation, fibrinogen binding, and P-selectin expression, whereas the GSK3 inhibitor CHIR99

130 The induced P-selectin expression, which reflects platelet degranula

131 phosphoprotein platelet reactivity index and P-selectin expression.

132 also significantly decreased agonist-induced P-selectin expression.

133 a nonsignificant trend toward an increase in P-selectin expression.

134 appaBbeta degradation mediated apoptosis and P-selectin expression.

135 s and suppressed cellular growth and induced P-selectin expression.

136 Excess of P-selectin extracellular domain significantly impaired E

137 bitor 1, monocyte chemoattractant protein-1, P-selectin, fibrinogen, receptor activator of nuclear fa

138 tin and reveal human-specific differences in P-selectin function.

139 and DR, we examined the association between P-selectin genotype and DR.

140 We demonstrate Th17 cells express CD44, P-selectin glycoprotein ligand (PSGL)-1, and CD43.

141 We identified P-selectin glycoprotein ligand 1 (PSGL-1) as an HIV-1 re

142 d with neutrophil activation, rolling ligand P-selectin glycoprotein ligand 1 (PSGL-1) expression, as

143 and leukocyte surface glycoproteins CD45 and P-selectin glycoprotein ligand 1 (PSGL-1).

144 d and rejected grafts express high levels of P-selectin glycoprotein ligand 1 and glycosylated CD43.

145 og of the naturally occurring binding ligand P-selectin glycoprotein ligand 1 fused to a human fragme

146 ted when the bacterium engaged its receptor, P-selectin glycoprotein ligand 1.

147 P-selectin glycoprotein ligand-1 (PSGL-1) and its glycos

148 antigen-1, and CXCR4 but lower expression of P-selectin glycoprotein ligand-1 (PSGL-1) and of L-selec

149 face expression of CXCR2 and less pronounced P-selectin glycoprotein ligand-1 (PSGL-1) begin to incre

150 this study, we show that mice deficient for P-selectin glycoprotein ligand-1 (PSGL-1) develop a more

151 P-selectin glycoprotein ligand-1 (PSGL-1) has long been

152 lectin-ligand at the N terminus of leukocyte P-selectin glycoprotein ligand-1 (PSGL-1) in humans and

153 sphorylated myosin L chain, flotillin-2, and P-selectin glycoprotein ligand-1 (PSGL-1) in the uropod.

154 erminus as an extension of membrane-anchored P-selectin glycoprotein ligand-1 (PSGL-1) inhibited inte

155 inhibited by anti-P-selectin aptamer or anti-P-selectin glycoprotein ligand-1 (PSGL-1) inhibitory ant

156 Here, we demonstrate that a subset of P-selectin glycoprotein ligand-1 (PSGL-1) molecules is c

157 dhesion receptor L-selectin forms bonds with P-selectin glycoprotein ligand-1 (PSGL-1) on other leuko

158 P-selectin glycoprotein ligand-1 (PSGL-1) was identified

159 electin binding to its physiological ligand, P-selectin glycoprotein ligand-1 (PSGL-1), both in cell

160 P-selectin glycoprotein ligand-1 (PSGL-1), CD43, and CD4

161 gated the function of the adhesion molecule, P-selectin glycoprotein ligand-1 (PSGL-1), that is upreg

162 We find that targeting the BMME with P-selectin glycoprotein ligand-1 (PSGL-1)-targeted BTZ a

163 g to the adhesion and co-inhibitory receptor P-selectin glycoprotein ligand-1 (PSGL-1).

164 ropod, the "nucleopod," which is capped with P-selectin glycoprotein ligand-1 (PSGL-1).

165 minus of the leukocyte cell-surface molecule P-selectin glycoprotein ligand-1 (PSGL-1, CD162) are imp

166 ar adhesion molecule-1 (ICAM-1, CD54), CD44, P-selectin glycoprotein ligand-1 (PSGL-1, CD162), cytoki

167 eously express functional rolling machinery (P-selectin glycoprotein ligand-1 [PSGL-1] and Sialyl-Lew

168 pus was induced in female wild-type (WT) and P-selectin glycoprotein ligand-1 deficient (Psgl-1(-/-))

169 Mice lacking P-selectin or P-selectin glycoprotein ligand-1 did not have a prothrom

170 /hematopoietic cell E-/L-selectin ligand and P-selectin glycoprotein ligand-1) from hematopoietic cel

171 trafficking, and P-selectin and its ligand, P-selectin glycoprotein ligand-1, can modulate hemostasi

172 on an array of protein scaffolds, including P-selectin glycoprotein ligand-1, CD43, and CD44 (render

173 tern to LNs, neutrophils used L-selectin and P-selectin glycoprotein ligand-1, macrophage-1 Ag and LF

174 pendent of the mucin-like molecules CD43 and P-selectin glycoprotein ligand-1, previously implicated

175 Tregs, forming the Sialyl Lewis X moiety on P-selectin glycoprotein ligand-1, would improve their tr

176 f infection and is mediated by chemokine- or P-selectin glycoprotein ligand-1-induced inside-out sign

177 C(high) monocytes to the CNS is regulated by P-selectin glycoprotein ligand-1.

178 t in E-selectin ligand-1 (ESL-1), or in both P-selectin glycoprotein-1 (PSGL-1) and ESL-1, to explore

179 ated monocytes, although soluble recombinant P-selectin had no effect, P-selectin coupled to 2 um bea

180 Soluble P-selectin has been identified as a biomarker of cancer-

181 onstrated variation in expression of IL-1ra, P-Selectin, IL-4 and IL-5; ZIKV-infected donors demonstr

182 onstrated variation in expression of IL-1ra, P-Selectin, IL-4, RANK-L, CD40L and C3a.

183 Moreover, NETosis was also promoted by P-selectin-immunoglobulin fusion protein but not by cont

184 Inhibition of P-selectin in 20 and 40 weeks atherosclerotic mice resul

185 ive of this review is to outline the role of P-selectin in cardiovascular inflammatory conditions and

186 The up-regulation of P-selectin in endothelial cells and platelets contribute

187 tin promoter and transcriptionally activated P-selectin in hypoxia.

188 ase pathways to upregulate the expression of P-selectin in platelets, while inducing reactive oxygen

189 Higher basal P-selectin in Selp(KI) (/) (KI) mice compensated for thi

190 e sRBC adhesion, we found a central role for P-selectin in sRBC adhesion.

191 icient mice confirmed a mechanistic role for P-selectin in the initiation of leukocyte trafficking, m

192 Chronic hypoxia caused an upregulation of P-selectin in the medial layer of the small pulmonary ar

193 a indicate a previously unrecognized role of P-selectin in the proliferative response of PASMCs assoc

194 expression, leukocytes rolled more slowly on P-selectin in trauma-stimulated venules of Selp(KI) (/)

195 ifferences in expression of human and murine P-selectin in vivo.

196 ace activated glycoprotein (GP) IIb-IIIa and P-selectin in WAS/XLT patients were proportional to plat

197 plication increased plasma levels of soluble P-selectin in wild-type but not in MC-deficient mice.

198 uch as intercellular adhesion molecule-2 and P-selectin, in breast cancer cells and HUVECs, and antib

199 Expression of the venular adhesion molecule P-selectin increased in endothelial cells from day 1 to

200 s but not conventional CD4(+) T cells became P-selectin independent, and Tregs showed reduced capacit

201 Considering that P-selectin induces prothrombotic and proinflammatory sig

202 uals with AERD and had no effect on platelet P-selectin induction.

203 Efb-N interaction with P-selectin inhibited P-selectin binding to its physiolog

204 immunohistochemistry of eNOS, endothelin-1, P-selectin, intercellular adhesion molecule 1, and vascu

205 filtration-related adhesion molecules (e.g., P-selectin, intercellular adhesion molecule 1, and vascu

206 leading to monocyte adherence, implying that P-selectin is a putative therapeutic target to prevent m

207 P-selectin is an adhesion molecule involved in interacti

208 P-selectin is an adhesion molecule translocated to the s

209 The platelet alpha-granule membrane protein P-selectin is expressed at 48% of wild-type levels and e

210 dual targeting properties, as we found that P-selectin is not only expressed on tumor endothelium bu

211 monocyte-platelet interactions via PSGL-1 or P-selectin is not sufficient to prevent platelet-mediate

212 ding by activated platelets, suggesting that P-selectin is the main receptor for Efb on the surface o

213 l-Palade bodies, with membrane expression of P-selectin known to bind C3b and trigger the AP, and the

214 Placebo-adjusted changes in soluble P-selectin level were -9.5% (p = 0.25) and -22.0% (p < 0

215 sma calpain activities and increased soluble P-selectin level.

216 in the lung endothelium; and reduced surface P-selectin levels in IL-13-stimulated endothelial cells.

217 , and other traditional risk factors, higher P-selectin levels were associated with any DR (odds rati

218 Surface P-selectin levels were measured by using flow cytometry.

219 Our data demonstrate that TIM-1 is a major P-selectin ligand with a specialized role in T cell traf

220 pmel T cells upregulate expression of CD44, P-selectin ligand, and granzyme B.

221 munoglobulin and mucin domain 1 (TIM-1) is a P-selectin ligand.

222 E- and P-selectin ligands (E- and P-ligs) guide effector memory

223 bility, which was restored by injecting anti-P-selectin mAb to prevent neutrophil rolling and arrest.

224 nd platelets activation (CD41, CD42 & CD62P (P- selectins)) markers.

225 l changes in the endothelial layer through a P-selectin/matrix metalloproteinase-1 pathway.

226 Our data suggest that antagonism of P-selectin may ameliorate accumulation of macrophages in

227 Future molecular MRI targeting P-selectin may be used to improve diagnosis, follow-up o

228 Plasma VWFpp and P-selectin may be useful as surrogates of functional and

229 argeting lymphocyte CD4 (MBCD4), endothelial P-selectin (MBPSel), or isotype control antibody (MBIso)

230 Endothelial E- and P-selectins mediate lymphocyte trafficking in inflammato

231 tibody but was not induced by platelets from P-selectin(-/-) mice.

232 lecular magnetic resonance imaging targeting P-selectin might aid in the diagnosis of transient ischa

233 nules that contain von Willebrand factor and P-selectin, molecules that regulate hemostasis and infla

234 mRNA in tissues but only slightly increased P-selectin mRNA after injection of TNF-alpha or LPS.

235 Blunted up-regulation of P-selectin mRNA during contact hypersensitivity reduced

236 ncrease P-selectin mRNA in mice but decrease P-selectin mRNA in humans.

237 interleukin 1beta, and LPS markedly increase P-selectin mRNA in mice but decrease P-selectin mRNA in

238 ressed more P-selectin on platelets and more P-selectin mRNA in tissues but only slightly increased P

239 nsing GTPase, which localizes to a subset of P-selectin-negative WPBs.

240 a phenomenon that was inhibited by platelet P-selectin neutralization or integrin alphaIIb/beta3 blo

241 Immunohistochemical staining for ICAM-1, P-selectin, nitrotyrosine, and poly(ADP)ribose showed a

242 sue neutrophil infiltration in wild type and P-selectin-null mice but not in E-selectin-null mice.

243 Leukocyte adhesion to P-selectin on activated platelets and endothelial cells

244 These data show that P-selectin on activated platelets rapidly triggers TF ex

245 ophil histone citrullination and presence of P-selectin on circulating neutrophils were elevated.

246 (/) (KI) mice constitutively expressed more P-selectin on platelets and more P-selectin mRNA in tiss

247 control the induction of ligands for E- and P-selectin on Th cell subsets remains poorly understood.

248 RT(-/-) platelets displayed no difference in P-selectin or alphaIIbbeta3 activation upon stimulation

249 addressin, E-, L-selectin and Mac-1 but not P-selectin or LFA-1.

250 pendent of its reported cognate ligands vWF, P-selectin or Mac-1, offering a potential target against

251 Mice lacking P-selectin or P-selectin glycoprotein ligand-1 did not h

252 We anticipate that blockade of TLR4, P-selectin, or the complement system could prevent liver

253 soluble CD40 ligand (p < 0.001) and soluble P-selectin (p < 0.001), serum TxB2 (p = 0.030), mean pla

254 Blockade of P-selectin (P-sel)/PSGL-1 interactions holds significant

255 from mice engineered to overproduce soluble P-selectin (P-selectin(DeltaCT/DeltaCT) mice).

256 ebrand factor with a supporting role for the P-selectin/P-selectin glycoprotein ligand 1 axis, follow

257 adhere to intravascular neutrophils through P-selectin/P-selectin glycoprotein ligand-1 (PSGL-1)-med

258 ocytes and neutrophils roll over FLIPRs in a P-selectin/P-selectin glycoprotein ligand-1-dependent ma

259 Covariate data including P-selectin plasma levels and genotypes were collected in

260 nd strongly correlated with plasma levels of P-selectin, platelet factor 4, and platelet basic protei

261 ducible factor 1alpha) directly bound to the P-selectin promoter and transcriptionally activated P-se

262 14 skipping and soluble versus transmembrane P-selectin protein production.

263 es the ratio of transmembrane versus soluble P-selectin protein production.

264 two additional receptor-ligand interactions, P-selectin &PSGL-1 and Notch &DLL1.

265 receptor) was expressed at all CNS barriers, P-selectin (PSGL-1-receptor) was mainly detected at the

266 Because of the importance of P-selectin-PSGL-1 binding in the interaction between pla

267 y an immunoregulatory role via inhibition of P-selectin-PSGL-1-dependent formation of platelet-leukoc

268 Willebrand factor, soluble CD40 ligand, and P-selectin), pulmonary inflammation and oxidative stress

269 kage of P-selectin by administration of anti-P-selectin Rb40.34 antibody and P-selectin-deficient mic

270 but was independent of the platelet GPIb and P-selectin receptors.

271 blocking their association to fibrinogen and P-selectin, respectively.

272 et activation markers such as plasma soluble P-selectin, soluble CD40 ligand, and serum thromboxane B

273 was determined by quantification of soluble P-selectin (sP-selectin) and glycoprotein VI (sGPVI).

274 Plasma soluble P-selectin (sP-selectin) is elevated threefold to fourfo

275 lular adhesion molecule-1 (sICAM-1), soluble P-selectin (sP-selectin), systolic blood pressure (SBP),

276 membrane-labeled mouse neutrophils rolled on P-selectin substrate at 10 dyn/cm(2).

277 red by alphaIIbbeta3 integrin activation and P-selectin surface exposure.

278 ly contributes to the inhibition of platelet P-selectin surface expression.

279 fectors expressing high levels of binding to P-selectin, T-bet, and Blimp-1, and that more of them se

280 By encapsulating BYL719 into P-selectin-targeted nanoparticles, we achieve specific a

281 tracellular adhesion molecule-1, E-selectin, P-selectin, TAT (thrombin/antithrombin complex), tumor n

282 miR-1 recruited P-selectin, thymic stromal lymphopoietin, eotaxin-3, and

283 d platelet granule release, translocation of P-selectin to the cell surface, and a consequent increas

284 igher levels of vWF in the plasma, increased P-selectin translocation, and more platelet-endothelial

285 ically, TLR4-dependent surface expression of P-selectin triggered an unconventional mechanism of comp

286 ble cluster of differentiation 40 ligand and p-selectin (two markers of platelet activation), and zon

287 rties of these modified cells to L-, E-, and P-selectin under hydrodynamic shear were compared with b

288 targeting the endothelial adhesion molecule P-selectin unmasks the pathological events that take pla

289 comes were assessed: ADP-stimulated platelet P-selectin, unstimulated platelet fibrinogen binding, an

290 is dissociated from alpha-granule secretion (P-selectin up-regulation) and occurs more gradually, wit

291 Antibody blockade of adhesion molecules P-selectin, von Willebrand factor (VWF), E-selectin, vas

292 P-selectin was persistently upregulated in PASMCs of hum

293 Platelet activation (P-selectin) was measured by flow cytometry.

294 hereas vascular cell adhesion molecule-1 and P-selectin were not required, deficiency of E-selectin i

295 b, an antibody against the adhesion molecule P-selectin, were evaluated in patients with sickle cell

296 s was rescued by depleting the gene encoding P-selectin, which is upregulated in Alox15-deficient ani

297 ular calcium and endothelial presentation of P-selectin, which supports monocyte binding.

298 s the release of the proinflammatory ligand, P-selectin, while diverting WPBs carrying non-inflammato

299 because they bind all selectins (L-, E-, and P-selectin) with high affinity under hydrodynamic shear

300 is a recombinant monoclonal antibody against P-selectin, with potential anti-inflammatory, antithromb