ライフサイエンスコーパス: P-selectin glycoprotein ligand-1

1 by pretreatment of monocytes with Ab against P-selectin glycoprotein ligand 1.

2 nase B (Akt) and dependent on P-selectin and P-selectin glycoprotein ligand 1.

3 ted when the bacterium engaged its receptor, P-selectin glycoprotein ligand 1.

4 ockade of P-selectin or its leukocyte ligand P-selectin glycoprotein ligand-1.

5 d by monoclonal antibodies to L-selectin and P-selectin glycoprotein ligand-1.

6 C(high) monocytes to the CNS is regulated by P-selectin glycoprotein ligand-1.

7 ce deficient in the major P-selectin ligand, P-selectin glycoprotein ligand-1.

8 K562 cells transfected with P-selectin glycoprotein ligand-1, a ligand for P-selecti

9 f initial treatment with the soluble form of P-selectin glycoprotein ligand-1, a soluble ligand for P

10 As reported previously, P-selectin glycoprotein ligand 1 and a distinct 130-kDa

11 d and rejected grafts express high levels of P-selectin glycoprotein ligand 1 and glycosylated CD43.

12 edominant E-selectin ligands on NK cells are P-selectin glycoprotein ligand-1 and protease-resistant

13 heres (MSs) were conjugated with recombinant P-selectin glycoprotein ligand-1 and systemically inject

14 uding CD43, CD44, CD45, CD93, CD162 (PSGL-1; P-selectin glycoprotein ligand 1), and the surface-attac

15 s in the mucins, MUC2, MUC20, MUC21, protein P-selectin-glycoprotein ligand 1, and proteoglycan synde

16 E-selectin-mediated migration of Tc1 cells, P-selectin glycoprotein ligand-1 appears to be the sole

17 These results indicate that P-selectin and P-selectin glycoprotein ligand-1 are not required for le

18 thesis of E- and P-selectin ligands, such as P-selectin glycoprotein ligand 1, are unknown.

19 at utilizes sialyl Lewis x (sLe(x))-modified P-selectin glycoprotein ligand 1 as a receptor for infec

20 or with a supporting role for the P-selectin/P-selectin glycoprotein ligand 1 axis, followed by (2) f

21 ltransferases, C2GnT (Core2 transferase), or P-selectin glycoprotein ligand-1 between HL60var and typ

22 irectly shown to contribute to high-affinity P-selectin glycoprotein ligand-1 binding by P-selectin.

23 played on O-linked glycans, akin to those on P-selectin glycoprotein ligand-1, but distinct from the

24 e reduced tethering to the L-selectin ligand P-selectin glycoprotein ligand-1, but rolling velocity o

25 ectin-bearing microspheres or neutrophils on P-selectin glycoprotein ligand-1 by force decreased bond

26 To address whether the glycosylation of P-selectin glycoprotein ligand-1 by ppGalNAcT-1 is impor

27 tethering of these microspheres or cells to P-selectin glycoprotein ligand-1 by three transport mech

28 trafficking, and P-selectin and its ligand, P-selectin glycoprotein ligand-1, can modulate hemostasi

29 on an array of protein scaffolds, including P-selectin glycoprotein ligand-1, CD43, and CD44 (render

30 ther administration of a soluble recombinant P-selectin glycoprotein ligand-1 chimera (rPSGL-Ig) in c

31 significantly higher numbers of recombinant P-selectin glycoprotein ligand-1-conjugated MSs adhered

32 m-diameter microspheres with the recombinant P-selectin glycoprotein ligand-1 construct 19.ek.Fc.

33 O treatment reduced intragraft expression of P-selectin glycoprotein ligand-1, CX(3)CL1, CCL19, CCL20

34 pus was induced in female wild-type (WT) and P-selectin glycoprotein ligand-1 deficient (Psgl-1(-/-))

35 regulated on DCs by activated platelets in a P-selectin glycoprotein ligand 1-dependent manner.

36 neutrophils roll over FLIPRs in a P-selectin/P-selectin glycoprotein ligand-1-dependent manner, retri

37 Mice lacking P-selectin or P-selectin glycoprotein ligand-1 did not have a prothrom

38 /hematopoietic cell E-/L-selectin ligand and P-selectin glycoprotein ligand-1) from hematopoietic cel

39 og of the naturally occurring binding ligand P-selectin glycoprotein ligand 1 fused to a human fragme

40 which contained two E-selectin ligands, the P-selectin glycoprotein ligand-1 glycoform "CLA," and CD

41 ty regulates thrombosis in a P-selectin- and P-selectin glycoprotein ligand-1-independent manner and

42 f infection and is mediated by chemokine- or P-selectin glycoprotein ligand-1-induced inside-out sign

43 D49d and CD49e, as well as to P-selectin and P-selectin glycoprotein ligand 1, inhibited basophil rol

44 vealed that CLP-2 homing involves P-selectin/P-selectin glycoprotein ligand 1 interactions, pertussis

45 ycoprotein ligand-1, but rolling velocity on P-selectin glycoprotein ligand-1 is not affected.

46 P-selectin glycoprotein ligand-1 is the best characteriz

47 n-associated antigen-1 activation that links P-selectin glycoprotein ligand-1 ligation to integrin ac

48 tern to LNs, neutrophils used L-selectin and P-selectin glycoprotein ligand-1, macrophage-1 Ag and LF

49 P-selectin glycoprotein ligand-1-mediated rolling of mou

50 eefold increase in O-linked glycosylation of P-selectin glycoprotein ligand-1 on the surface of leuko

51 rvival times of P-selectin dissociating from P-selectin glycoprotein ligand 1 or from an antibody in

52 ls through engagement of the selectin ligand P-selectin glycoprotein ligand-1 or the chemokine recept

53 urements of L- and P-selectin complexed with P-selectin glycoprotein ligand-1 or their respective ant

54 r BAY11-7082, antibodies neutralizing CD162 (P-selectin glycoprotein ligand-1) or VWF, or arginylglyc

55 Moreover, inhibiting tissue factor and P-selectin glycoprotein ligand-1 pathways impairs thromb

56 P-selectin glycoprotein ligand-1 plays an important role

57 teraction between P-selectin and its ligand (P-selectin glycoprotein ligand-1) plays a role in adenos

58 pendent of the mucin-like molecules CD43 and P-selectin glycoprotein ligand-1, previously implicated

59 ECA-452-reactive and nonreactive isoforms of P-selectin glycoprotein ligand 1 (PSGL-1) and can tether

60 Surface P-selectin glycoprotein ligand 1 (PSGL-1) and LFA-1 were

61 The receptor-ligand pair P-selectin and P-selectin glycoprotein ligand 1 (PSGL-1) are critically

62 Platelet GP Ibalpha and leukocyte P-selectin glycoprotein ligand 1 (PSGL-1) are membrane m

63 P-Selectin and P-selectin glycoprotein ligand 1 (PSGL-1) are vascular a

64 ocytophilum are linked to bacterial usage of P-selectin glycoprotein ligand 1 (PSGL-1) as a receptor

65 We identified P-selectin glycoprotein ligand 1 (PSGL-1) as an HIV-1 re

66 ospholipid antibodies, neutrophils clustered P-selectin glycoprotein ligand 1 (PSGL-1) by cortical ac

67 d with neutrophil activation, rolling ligand P-selectin glycoprotein ligand 1 (PSGL-1) expression, as

68 P-selectin glycoprotein ligand 1 (PSGL-1) is a mucin-lik

69 P-selectin glycoprotein ligand 1 (PSGL-1) is a sialomuci

70 residues in the leukocyte adhesion molecule P-selectin glycoprotein ligand 1 (PSGL-1) is required fo

71 P-selectin glycoprotein ligand 1 (PSGL-1) is the main P-

72 cule 1 failed to ameliorate ileitis, whereas P-selectin glycoprotein ligand 1 (PSGL-1) neutralization

73 ding of P-selectin on activated platelets to P-selectin glycoprotein ligand 1 (PSGL-1) on the microvi

74 However, mice lacking P-selectin glycoprotein ligand 1 (PSGL-1) or P-selectin,

75 nine, and interleukin 15, adhesion molecules P-selectin glycoprotein ligand 1 (PSGL-1), intercellular

76 e many candidate ligands for selectins, only P-selectin glycoprotein ligand 1 (PSGL-1), which also ac

77 Here we show that BACE1 acts on the P-selectin glycoprotein ligand 1 (PSGL-1), which mediate

78 ce probe to test the leukocyte adhesion bond P-selectin glycoprotein ligand 1 (PSGL-1)-P-selectin, we

79 tion of endothelial P-selectin and leukocyte P-selectin glycoprotein ligand 1 (PSGL-1).

80 ss dependent upon ligation of L-selectin and P-selectin glycoprotein ligand 1 (PSGL-1).

81 d lamina propria (LP) up-regulate functional P-selectin glycoprotein ligand 1 (PSGL-1).

82 iated antigen 1 (LFA-1) integrins, CD44, and P-selectin glycoprotein ligand 1 (PSGL-1).

83 tion of endothelial P-selectin and leukocyte P-selectin glycoprotein ligand 1 (PSGL-1).

84 and leukocyte surface glycoproteins CD45 and P-selectin glycoprotein ligand 1 (PSGL-1).

85 vironment (TME) facilitates VISTA binding to P-selectin glycoprotein ligand 1 (PSGL-1).

86 P-selectin glycoprotein ligand 1 (PSGL-1, CD162) and int

87 mic endothelial cells and lost expression of P-selectin glycoprotein ligand 1 (PSGL-1, CD162) and L-s

88 tion of T cells marked by down-regulation of P-selectin glycoprotein ligand 1 (PSGL-1; also known as

89 king antibodies against either P-selectin or P-selectin glycoprotein ligand-1 (PSGL-1) alone inhibite

90 selectin ligands are expressed on human HCs, P-selectin glycoprotein ligand-1 (PSGL-1) and a speciali

91 to human neutrophils requires expression of P-selectin glycoprotein ligand-1 (PSGL-1) and alpha1-3-f

92 CLA epitope on T cells has been described on P-selectin glycoprotein ligand-1 (PSGL-1) and associated

93 etween oligosaccharides from human leukocyte P-selectin glycoprotein ligand-1 (PSGL-1) and from zona

94 P-selectin glycoprotein ligand-1 (PSGL-1) and its glycos

95 P-selectin glycoprotein ligand-1 (PSGL-1) and L-selectin

96 antigen-1, and CXCR4 but lower expression of P-selectin glycoprotein ligand-1 (PSGL-1) and of L-selec

97 eshold shear to support leukocyte rolling on P-selectin glycoprotein ligand-1 (PSGL-1) and other vasc

98 The high affinity interaction between P-selectin glycoprotein ligand-1 (PSGL-1) and P-selectin

99 Bacterial recognition of P-selectin glycoprotein ligand-1 (PSGL-1) and the alpha2

100 lection fluorescence/epi intensity, and that P-selectin glycoprotein ligand-1 (PSGL-1) and the integr

101 Previous studies identified P-selectin glycoprotein ligand-1 (PSGL-1) as the essenti

102 face expression of CXCR2 and less pronounced P-selectin glycoprotein ligand-1 (PSGL-1) begin to incre

103 P-selectin glycoprotein ligand-1 (PSGL-1) binding to P-s

104 glycosulfopeptide binding site (2-GSP-6) on P-selectin glycoprotein ligand-1 (PSGL-1) but not for a

105 E-selectin binding to P-selectin glycoprotein ligand-1 (PSGL-1) can activate t

106 the off-rate of P-selectin interacting with P-selectin glycoprotein ligand-1 (PSGL-1) decreased with

107 ed antigen (CLA), a specialized glycoform of P-selectin glycoprotein ligand-1 (PSGL-1) defined by mon

108 this study, we show that mice deficient for P-selectin glycoprotein ligand-1 (PSGL-1) develop a more

109 L-selectin interacts with the dimeric mucin P-selectin glycoprotein ligand-1 (PSGL-1) expressed on l

110 n a shear field via bonding of L-selectin to P-selectin glycoprotein ligand-1 (PSGL-1) followed by a

111 (X) (sialyl-Lewis-X) epitope is expressed in P-selectin glycoprotein ligand-1 (PSGL-1) from neutrophi

112 P-selectin glycoprotein ligand-1 (PSGL-1) has long been

113 lectin-ligand at the N terminus of leukocyte P-selectin glycoprotein ligand-1 (PSGL-1) in humans and

114 blockade of P- and E-selectins by a soluble P-selectin glycoprotein ligand-1 (PSGL-1) in rat models

115 sphorylated myosin L chain, flotillin-2, and P-selectin glycoprotein ligand-1 (PSGL-1) in the uropod.

116 The role of P-selectin glycoprotein ligand-1 (Psgl-1) in this proces

117 erminus as an extension of membrane-anchored P-selectin glycoprotein ligand-1 (PSGL-1) inhibited inte

118 inhibited by anti-P-selectin aptamer or anti-P-selectin glycoprotein ligand-1 (PSGL-1) inhibitory ant

119 P-selectin glycoprotein ligand-1 (PSGL-1) is a dimeric m

120 P-selectin glycoprotein ligand-1 (PSGL-1) is a disulfide

121 P-selectin glycoprotein ligand-1 (PSGL-1) is a disulfide

122 P-selectin glycoprotein ligand-1 (PSGL-1) is a high-affi

123 P-selectin glycoprotein ligand-1 (PSGL-1) is a homodimer

124 P-selectin glycoprotein ligand-1 (PSGL-1) is a large (24

125 P-selectin glycoprotein ligand-1 (PSGL-1) is a mucin on

126 P-selectin glycoprotein ligand-1 (PSGL-1) is a mucin-lik

127 P-selectin glycoprotein ligand-1 (PSGL-1) is a mucin-lik

128 P-selectin glycoprotein ligand-1 (PSGL-1) is a muclin-li

129 P-selectin glycoprotein ligand-1 (PSGL-1) is constitutiv

130 Leukocyte P-selectin glycoprotein ligand-1 (PSGL-1) is expressed a

131 Further analyses indicate that P-selectin glycoprotein ligand-1 (PSGL-1) is expressed i

132 we found that the E-selectin-binding form of P-selectin glycoprotein ligand-1 (PSGL-1) is expressed o

133 P-selectin glycoprotein ligand-1 (PSGL-1) is present on

134 uggested that glycosylation and sulfation of P-selectin glycoprotein ligand-1 (PSGL-1) is required fo

135 Dissociation of bonds between L-selectin and P-selectin glycoprotein ligand-1 (PSGL-1) loaded at a co

136 re mediated through binding of P-selectin to P-selectin glycoprotein ligand-1 (PSGL-1) located on the

137 P-selectin monoclonal antibody (mAb) or anti-P-selectin glycoprotein ligand-1 (PSGL-1) mAb would redu

138 prevention of platelet-leukocyte binding via P-selectin glycoprotein ligand-1 (PSGL-1) may be benefic

139 Interactions between P-selectin and P-selectin glycoprotein ligand-1 (PSGL-1) mediate the ea

140 P-selectin glycoprotein ligand-1 (PSGL-1) mediates rolli

141 P-selectin glycoprotein ligand-1 (PSGL-1) mediates the c

142 P-selectin glycoprotein ligand-1 (PSGL-1) mediates the i

143 P-selectin glycoprotein ligand-1 (PSGL-1) modified by al

144 Here, we demonstrate that a subset of P-selectin glycoprotein ligand-1 (PSGL-1) molecules is c

145 while P-selectin interacts exclusively with P-selectin glycoprotein ligand-1 (PSGL-1) on leukocytes.

146 we focused on adhesion dynamics that involve P-selectin glycoprotein ligand-1 (PSGL-1) on MM cells an

147 dhesion receptor L-selectin forms bonds with P-selectin glycoprotein ligand-1 (PSGL-1) on other leuko

148 ated platelets through a mechanism involving P-selectin glycoprotein ligand-1 (PSGL-1) on the microve

149 Containing most of the L-selectin and P-selectin glycoprotein ligand-1 (PSGL-1) on their tips,

150 d P- and L-selectin to their natural ligand, P-selectin glycoprotein ligand-1 (PSGL-1) over the predi

151 P-selectin glycoprotein ligand-1 (PSGL-1) serves as the

152 endothelium express P-selectin, which binds P-selectin glycoprotein ligand-1 (PSGL-1) that is expres

153 In inflamed venules, leukocytes use P-selectin glycoprotein ligand-1 (PSGL-1) to roll on P-s

154 Leukocytes use the cell-surface mucin P-selectin glycoprotein ligand-1 (PSGL-1) to tether to a

155 Under shear stress, leukocytes use P-selectin glycoprotein ligand-1 (PSGL-1) to tether to a

156 bond formation rates on their common ligand P-selectin glycoprotein ligand-1 (PSGL-1) under shear fl

157 ics of selectins (P-, L-, and E-selectin) to P-selectin glycoprotein ligand-1 (PSGL-1) via computatio

158 P-selectin glycoprotein ligand-1 (PSGL-1) was identified

159 an in vitro flow model and a blocking mAb to P-selectin glycoprotein ligand-1 (PSGL-1) were used to d

160 ts on sialyl Lewis X expression displayed by P-selectin glycoprotein ligand-1 (PSGL-1) with sialylate

161 We tested the hypothesis that deficiency of P-selectin glycoprotein ligand-1 (Psgl-1) would improve

162 P-selectin glycoprotein ligand-1 (PSGL-1), a dimeric muc

163 P-selectin glycoprotein ligand-1 (PSGL-1), a heavily gly

164 is an inducible carbohydrate modification of P-selectin glycoprotein ligand-1 (PSGL-1), a known surfa

165 P-selectin binds to the N-terminal region of P-selectin glycoprotein ligand-1 (PSGL-1), a mucin on le

166 L-selectin bind to the N-terminal region of P-selectin glycoprotein ligand-1 (PSGL-1), a mucin on le

167 A candidate ligand for L-selectin is P-selectin glycoprotein ligand-1 (PSGL-1), a mucinlike p

168 A mouse homolog of P-selectin glycoprotein ligand-1 (PSGL-1), a P-selectin

169 enge increase on blood or BAL eosinophils of P-selectin glycoprotein ligand-1 (PSGL-1), a receptor fo

170 P-selectin glycoprotein ligand-1 (PSGL-1), a sialomucin

171 id adhesion of beads coated with recombinant P-selectin glycoprotein ligand-1 (PSGL-1), an E-selectin

172 we showed that E-selectin ligand-1 (ESL-1), P-selectin glycoprotein ligand-1 (PSGL-1), and CD44 enco

173 neutrophils roll on P- or E-selectin, engage P-selectin glycoprotein ligand-1 (PSGL-1), and signal ex

174 ophils is linked to neutrophil expression of P-selectin glycoprotein ligand-1 (PSGL-1), as well as si

175 electin binding to its physiological ligand, P-selectin glycoprotein ligand-1 (PSGL-1), both in cell

176 P-selectin glycoprotein ligand-1 (PSGL-1), CD43, and CD4

177 Current evidence suggests that P-selectin glycoprotein ligand-1 (PSGL-1), E-selectin li

178 Ethanol (0.3% by volume) had no effect on P-selectin glycoprotein ligand-1 (PSGL-1), L-selectin, o

179 and its leukocyte ligand, a homodimer termed P-selectin glycoprotein ligand-1 (PSGL-1), mediate the e

180 gated the function of the adhesion molecule, P-selectin glycoprotein ligand-1 (PSGL-1), that is upreg

181 We hypothesize that P-selectin glycoprotein ligand-1 (PSGL-1), the common li

182 do not generate microthrombi in mice lacking P-selectin glycoprotein ligand-1 (PSGL-1), the leukocyte

183 P-selectin glycoprotein ligand-1 (PSGL-1), the primary l

184 pressing PMPs bridge leukocytes that express P-selectin glycoprotein ligand-1 (PSGL-1), thereby allow

185 lities of selectins and the selectin ligand, P-selectin glycoprotein ligand-1 (PSGL-1), to support te

186 e predominant leukocyte L-selectin ligand is P-selectin glycoprotein ligand-1 (PSGL-1), which display

187 P-selectin blockade is completely absent in P-selectin glycoprotein ligand-1 (PSGL-1)-/- mice or wil

188 intravascular neutrophils through P-selectin/P-selectin glycoprotein ligand-1 (PSGL-1)-mediated bindi

189 We find that targeting the BMME with P-selectin glycoprotein ligand-1 (PSGL-1)-targeted BTZ a

190 rate determinant differentially expressed on P-selectin glycoprotein ligand-1 (PSGL-1).

191 ctin binds to the N-terminal region of human P-selectin glycoprotein ligand-1 (PSGL-1).

192 o severely impaired binding of P-selectin to P-selectin glycoprotein ligand-1 (PSGL-1).

193 recognition of L-selectin may be mediated by P-selectin glycoprotein ligand-1 (PSGL-1).

194 ligand for P-selectin on human leukocytes is P-selectin glycoprotein ligand-1 (PSGL-1).

195 g to the adhesion and co-inhibitory receptor P-selectin glycoprotein ligand-1 (PSGL-1).

196 sion of leukocytes through interactions with P-selectin glycoprotein ligand-1 (PSGL-1).

197 hat cleaves mucin type glycoproteins such as P-selectin glycoprotein ligand-1 (PSGL-1).

198 ropod, the "nucleopod," which is capped with P-selectin glycoprotein ligand-1 (PSGL-1).

199 uman leukocyte cell surface selectin-ligand, P-selectin glycoprotein ligand-1 (PSGL-1).

200 ed to a leukocyte cell-surface glycoprotein, P-selectin Glycoprotein Ligand-1 (PSGL-1).

201 rophage adherence promoted signaling through P-selectin glycoprotein ligand-1 (PSGL-1)/Akt/mTOR that

202 minus of the leukocyte cell-surface molecule P-selectin glycoprotein ligand-1 (PSGL-1, CD162) are imp

203 ar adhesion molecule-1 (ICAM-1, CD54), CD44, P-selectin glycoprotein ligand-1 (PSGL-1, CD162), cytoki

204 gulant microparticles in human blood through P-selectin glycoprotein ligand-1 (PSGL-1; encoded by the

205 inistration of a recombinant soluble form of P-selectin glycoprotein ligand-1 (PSGL-1; the recombinan

206 on in vivo and on P-selectin in vitro, where P-selectin-glycoprotein-ligand-1 (PSGL-1) is found in di

207 eously express functional rolling machinery (P-selectin glycoprotein ligand-1 [PSGL-1] and Sialyl-Lew

208 5 (a leukocyte adhesion blocking mAb against P-selectin glycoprotein ligand-1; PSGL-1).

209 to mouse neutrophils, this was dependent on P-selectin glycoprotein ligand 1 (PSGL1), alpha(L)beta(2

210 erized by a Bcl6-dependent downregulation of P-selectin glycoprotein ligand 1 (PSGL1, a CCL19- and CC

211 ced synthesis of C2-O-sLe(x) associated with P-selectin glycoprotein ligand-1, reduced cell tethering

212 d the lifetimes of P-selectin complexes with P-selectin glycoprotein ligand-1, revealing both catch a

213 teraction with its leukocyte ligand, PSGL-1 (P-selectin glycoprotein ligand 1), the interaction with

214 cking molecules, including CCR9, L selectin, P selectin glycoprotein ligand-1, the integrin subunits

215 singly, however, donor T cells deficient for P-selectin glycoprotein ligand 1, the most well describe

216 y use multiple P-selectin ligands apart from P-selectin glycoprotein ligand 1 to interact with P-sele

217 nd that eosinophils and neutrophils both use P-selectin glycoprotein ligand-1 to form stable conjugat

218 trafficking is dependent upon the binding of P-selectin glycoprotein ligand-1 to P- and E-selectin on

219 amed endothelium in vivo and cooperates with P-selectin glycoprotein ligand-1 to recruit neutrophils

220 t caNFATc1 enhances expression of functional P-selectin glycoprotein ligand-1, up-regulates Fas ligan

221 Tregs, forming the Sialyl Lewis X moiety on P-selectin glycoprotein ligand-1, would improve their tr