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1 P. gingivalis (ATCC 33277) was grown in broth culture, a
2 P. gingivalis colonization of the periodontal pockets ma
3 P. gingivalis did not increase Wnt3a mRNA levels, a find
4 P. gingivalis DPP5 was composed of 684 amino acids with
5 P. gingivalis has also been detected in human placentas
6 P. gingivalis IgG1 and IgG2 were analyzed.
7 P. gingivalis infection induced the expansion of three s
8 P. gingivalis is found on and within oral and gingival e
9 P. gingivalis LPS and AGE in combination caused signific
10 P. gingivalis secretes proteolytic gingipains (Kgp and R
11 P. gingivalis signature genes based on its activated eff
12 P. gingivalis utilizes protease-generated peptides deriv
13 P. gingivalis was associated with ACPAs (P = 0.04).
14 P. gingivalis-infected WT mice exhibited significantly i
15 P. gingivalis-NDK during infection inhibits extracellula
16 cetemcomitans, 2.48 (1.34, 4.58), P = 0.004; P. gingivalis, 3.41 (1.78, 6.58), P = 0.0003; T. dentico
17 2X7 receptor expression was upregulated in a P. gingivalis oral infection model, and reduced IFN-gamm
19 >75 IU/mL exhibited five-fold more abundant P. gingivalis levels than patients below the threshold.
23 Simvastatin, being highly effective against P. gingivalis while not affecting commensal microbiota,
24 significant association between IgG against P. gingivalis and ACPAs in pre-RA and markers of RA acti
26 Smoking alters the humoral response against P. gingivalis and may increase P. gingivalis infectivity
27 like lipids) affords a mechanism that allows P. gingivalis to persist in homeostasis with its host.
30 +) cells, CD19(+) CD1d(hi) CD5(+) cells, and P. gingivalis-binding CD19(+) cells were significantly h
31 tionship between Streptococcus cristatus and P. gingivalis, and identified arginine deiminase (ArcA)
32 A direct physical contact between fungi and P. gingivalis was initiated via a modulation of gene exp
34 correlation between the visfatin levels and P. gingivalis (r = 0.266, P <0.05), whereas no correlati
35 Although a trend for higher F. nucleatum and P. gingivalis concentrations in aCCP-positive patients w
36 ) between the number of cells in S phase and P. gingivalis invasion, the organism was more highly ass
37 ion of information on age, sex, smoking, and P. gingivalis results provided an area under the curve o
38 e expression profile induced by TNFalpha and P. gingivalis, suggesting a critical role for HDAC3 in G
39 inostat) significantly reduced TNFalpha- and P. gingivalis-inducible expression and/or production of
41 alveolar bone loss, with a reduction in anti-P. gingivalis serum antibody titers compared with wild-t
42 monstrated alveolar bone loss and serum anti-P. gingivalis antibody titers equivalent to wild-type in
43 njection of collagen-antibody (ArthriomAb) + P. gingivalis, administration of Kava-205Me was able to
44 achment and enhanced exfoliation of attached P. gingivalis but had no influences on F. nucleatum bact
48 demonstrate that direct interaction between P. gingivalis and S. cristatus is necessary for the cell
49 activation of the uPA proteolytic cascade by P. gingivalis being required for the pathogen to induce
50 ta-Catenin activation in epithelial cells by P. gingivalis may contribute to a proliferative phenotyp
52 ested to counteract inflammation elicited by P. gingivalis In this study, the effects of A. muciniphi
55 he Fim fimbriae, which are also expressed by P. gingivalis These results support a donor strand-based
56 truction of crestal alveolar bone induced by P. gingivalis colonization occurred regardless of the pr
57 Thus, the inflammatory response induced by P. gingivalis infection promotes the expansion of immune
58 +) Ly6C(++) subpopulation of MDSC induced by P. gingivalis infection was able to differentiate into o
60 cci can antagonize the phenotypes induced by P. gingivalis, indicating functionally specialized roles
66 gly, we also discovered that SLs produced by P. gingivalis can be delivered to host cells independent
67 e outer membrane vesicles (OMVs) produced by P. gingivalis have been shown to play a role in periodon
68 o serine-glycine lipids are also produced by P. gingivalis The goal of this investigation was to dete
70 Part of the virulence factors secreted by P. gingivalis are the essential cysteine peptidases ging
72 working hypothesis that synthesis of SLs by P. gingivalis is central to its ability to manipulate th
79 Simvastatin was most efficient and decreased P. gingivalis counts more than 1,300-fold relative to th
82 Amuc_1100 on macrophage polarization during P. gingivalis infection were evaluated in a murine model
85 ion of beta-catenin in the nucleus following P. gingivalis infection was confirmed by immunofluoresce
87 ed that a protective environment existed for P. gingivalis within developed fungal biofilm formed und
89 -mediated activation of JAK2 is required for P. gingivalis-induced inflammatory cytokine production a
90 , we investigated another potential role for P. gingivalis in RA etiopathogenesis, based on the gener
92 lly, although the secretion of IL-1beta from P. gingivalis-infected macrophages was dependent on NLRP
94 ata show, for the first time, that OMVs from P. gingivalis mediate increased vascular permeability, l
95 nt mice (Kit(W-sh/W-sh)) were protected from P. gingivalis-induced alveolar bone loss, with a reducti
96 ucture of the CTD of gingipain B (RgpB) from P. gingivalis, alone and together with a preceding immun
98 ured GECs or green-fluorescent-protein (GFP)-P. gingivalis-NDK transfected GECs revealed a perinuclea
99 d their effects on Porphyromonas gingivalis (P. gingivalis) elicited inflammation were evaluated in v
100 ency in myeloid cells also promotes a higher P. gingivalis lipopolysaccharide-induced inflammatory re
101 chronic in vitro infection model to test if P. gingivalis can induce DNA methylation in normal gingi
103 d limited cell surface gingipain activity in P. gingivalis 381 renders this strain more immune-stimul
104 chondrial dehydrogenase activity but also in P. gingivalis-LPS-induced production of IL-6, TNF-alpha,
106 the benefit appears to stem from changes in P. gingivalis levels in the DHA + aspirin treatment grou
111 lls, reduces expression of Wnt3a and Dvl3 in P. gingivalis-infected gingival tissues, and increases d
112 lectively alter virulence gene expression in P. gingivalis, and PGN_0294 and PGN_0806 may serve as re
114 r results show a novel phenomenon present in P. gingivalis-induced FGR, with relevance to human disea
115 ponse against P. gingivalis and may increase P. gingivalis infectivity, strengthening the evidence th
116 ity in aged mice may contribute to increased P. gingivalis colonization following inoculation and inc
117 ll four tested statins efficiently inhibited P. gingivalis growth and significantly decreased the cum
118 ression and production of several well-known P. gingivalis virulence factors including fimbrial prote
119 ated with fluorescein isothiocyanate-labeled P. gingivalis, and phagocytosis was measured in a fluoro
120 de tissues and significantly (p < 0.01) less P. gingivalis-induced bone resorption compared with cont
121 led wild-type Porphyromonas gingivalis, live P. gingivalis protease-deficient mutant KDP128, and live
130 In our PDL progenitor cell culture model, P. gingivalis LPS increased H3K4me3 histone methylation
131 eared even more pronounced, by six-fold more P. gingivalis (P = 0.025), in patients with a DAS-28 sco
133 or microbiome that influence the ability of P. gingivalis to colonize the placenta may drive differe
134 lly, SAPP was able to impinge the ability of P. gingivalis to dysregulate innate immunity by repressi
135 iodontitis model, we assessed the ability of P. gingivalis to produce ISAR and FGR in Sprague Dawley
136 brain infections decreases the abundance of P. gingivalis DNA in brain and mitigates the neurotoxic
139 nstead correlated with increasing amounts of P. gingivalis DNA in the placentas of the C57BL/6J dams.
143 ce gingipain activity reduce the capacity of P. gingivalis 33277 to stimulate host cell innate immune
146 crease oncogenic potential, and consortia of P. gingivalis and F. nucleatum are synergistically patho
151 These data demonstrate that encapsulation of P. gingivalis plays a key role in the alveolar bone reso
154 infected with P. gingivalis show evidence of P. gingivalis infiltration, along with various neuropath
155 ly, we find that in vivo clonal expansion of P. gingivalis-specific Th cells and induced regulatory T
156 t growth rate was not altered by exposure of P. gingivalis to SAPP, while monospecies and heterotypic
159 Bypassing LCs with systemic immunization of P. gingivalis resulted in a predominantly P. gingivalis-
161 rmed fimbriae (pili) mediate interactions of P. gingivalis with other bacteria and with host cells th
164 f A. actinomycetemcomitans or serotype K1 of P. gingivalis, higher levels of TLR2 or TLR4, respective
165 g/muL), sialidase (23 ng/muL), and levels of P. gingivalis (0.23%) and T. forsythia (0.35%), receiver
170 testing such compounds in the management of P. gingivalis elicited inflammation, especially in the m
171 t could be exploited for the manipulation of P. gingivalis levels in oral communities and preventing
173 Ultrastructural and confocal microscopy of P. gingivalis-co-cultured GECs or green-fluorescent-prot
176 esults, using conditional fimbria mutants of P. gingivalis, show that P. gingivalis infection of MoDC
177 s and two isogenic non-capsulated mutants of P. gingivalis, this study aimed to analyze whether P. gi
179 uch and increases neutrophil phagocytosis of P. gingivalis in the transgenic animals; cutaneous fat d
180 vE1 increased the neutrophil phagocytosis of P. gingivalis in WT animals but had no impact in db/db a
182 ether, the results indicate the potential of P. gingivalis to disrupt the control system of KLKs, pro
184 ew insight into the biological properties of P. gingivalis LPS lipid A moiety that could critically m
188 portant role of PDLSCs in the recognition of P. gingivalis, paracrine recruitment and activation of a
191 apsular-defective knockout mutant strains of P. gingivalis induced less alveolar bone resorption than
194 mmensal bacterium, inhibited the survival of P. gingivalis in dual-species biofilms via the secretion
195 ptosome and XIAP as intracellular targets of P. gingivalis, contributing to the deterioration of peri
198 contributes further to our understanding of P. gingivalis-induced modulation of miRNAs and their phy
199 study, we sought to explore the virulence of P. gingivalis (Pg) affecting glycogen synthase kinase 3
201 1780, analyzed the impact of SPT deletion on P. gingivalis gene expression (RNA-Seq analysis), and be
203 Here we identify gingipains as the only P. gingivalis proteases responsible for SPINK6 degradati
204 ent serotypes of A. actinomycetemcomitans or P. gingivalis is TLR2 or TLR4 dependent, respectively.
205 ent serotypes of A. actinomycetemcomitans or P. gingivalis is Toll-like receptor 2 (TLR2) and/or TLR4
206 ) with different A. actinomycetemcomitans or P. gingivalis serotypes in the presence or absence of an
208 compared to that in sham-infected WT mice or P. gingivalis-infected TLR9(-/-) mice, which were resist
211 sion between mice treated with ligation plus P. gingivalis infection and mice treated with ligation a
212 of P. gingivalis resulted in a predominantly P. gingivalis-specific Th1 response regardless of whethe
213 Moreover, deletion of PPAD did not prevent P. gingivalis-mediated intestinal barrier breakdown and
214 CX3CR1(hi) monocyte/macrophages promote P. gingivalis survival by downregulating neutrophil phag
217 ith the function of Mfa fimbriae by reducing P. gingivalis adhesion to Streptococcus gordonii in a du
218 nsidered as an effective method for reducing P. gingivalis biofilm on implant surfaces, while being s
221 eptide array analysis, we identified several P. gingivalis-binding sites of ArcA, which led to the di
223 Finally, pan-HDACi and HDAC3/6i suppressed P. gingivalis-induced expression of IL1B, CCL2, CCL5, CX
228 mokine receptor knockout mice and found that P. gingivalis clearance is significantly improved in the
229 Based on these results, we hypothesize that P. gingivalis induces S. mitis cell death by an unknown
231 istent with previous reports indicating that P. gingivalis invasion of cells is mediated by alpha5 in
233 fimbria mutants of P. gingivalis, show that P. gingivalis infection of MoDCs induces an angiogenic m
235 A luciferase reporter assay showed that P. gingivalis increased the activity of the beta-catenin
237 This study shows for the first time that P. gingivalis preferentially associates with and invades
239 K1, and AKT were selectively degraded by the P. gingivalis lysine-specific gingipain (Kgp) in human e
240 onor strand-based assembly mechanism for the P. gingivalis fimbriae and demonstrate the feasibility o
241 nt on the nrfAH operon are also found in the P. gingivalis genome, we show that their gene products p
242 ed whether autocitrullinated proteins in the P. gingivalis proteome serve as cross-activation targets
246 anism and central roles in pathogenesis, the P. gingivalis fimbriae are attractive targets for anti-i
248 nction had greater production of antibody to P. gingivalis, greater IL-12 expression, and more plasma
249 ese data reveal a multidimensional aspect to P. gingivalis-S. gordonii interactions and establish pAB
252 at IRF6 is likely to promote inflammation to P. gingivalis through its regulation of IL-36gamma.
253 ly expressed in dysfunctional cells prior to P. gingivalis stimulation, the cytokine expression was i
254 showed an augmented inflammatory response to P. gingivalis in the presence of hyperlipidemic PA level
255 ) and increased in all groups in response to P. gingivalis inoculation (P < 0.01), whereas bone remod
256 tokine production in WT cells in response to P. gingivalis, thereby implicating TLR9 in inflammatory
260 ing lymph nodes were higher in IL-33-treated P. gingivalis-infected mice versus phosphate buffered sa
262 ion of ACPA through the activity of a unique P. gingivalis peptidylarginine deiminase (PPAD) produced
266 givalis, this study aimed to analyze whether P. gingivalis encapsulation induces more severe alveolar
267 this investigation was to determine whether P. gingivalis produces additional lipid classes similar
269 eal a new host-pathogen interaction in which P. gingivalis activates a critical host proteolytic path
271 cristatus as the signaling molecule to which P. gingivalis responds by repressing the expression and
272 re found to be higher in individuals in whom P. gingivalis was detected than for those without P. gin
273 Infection of gingival epithelial cells with P. gingivalis did not influence the phosphorylation stat
274 ic treatment of normal epithelial cells with P. gingivalis introduced de novo DNA methylation within
275 in the oral cavity following challenge with P. gingivalis Our findings provide an explanation for ba
278 fected SOCS-3-knockout mice as compared with P. gingivalis-infected WT mice by direct morphologic mea
279 Wnt3a mRNA levels, a finding consistent with P. gingivalis-induced proteolytic processing causing the
281 matory cytokine IL-10 after incubations with P. gingivalis and F. nucleatum, as well as significantly
282 ges (BMM) and THP-1 cells were infected with P. gingivalis (MOI = 20:1) and a panel of cytokines were
283 row and spleen cells from mice infected with P. gingivalis and controls for surface expression of CD1
284 -engrafted Kit(W-sh/W-sh) mice infected with P. gingivalis demonstrated alveolar bone loss and serum
285 phages from A20-deficient mice infected with P. gingivalis displayed increased NF-kappaB activity and
287 bserved in the gingiva of mice infected with P. gingivalis in a periodontitis oral gavage model.
288 The brains of mice orally infected with P. gingivalis show evidence of P. gingivalis infiltratio
289 ne destruction following oral infection with P. gingivalis Mast cell-deficient mice (Kit(W-sh/W-sh))
290 e model of pregnancy and oral infection with P. gingivalis, C57BL/6J mice developed low fetal weight,
295 g at week 10, mice were infected orally with P. gingivalis (W50) or placebo to induce alveolar bone l
299 significantly increased with treatment with P. gingivalis LPS plus CpG compared to those in mice tre