ライフサイエンスコーパス: P2X(7) receptor

1 rat cortex binding assay) and 15.9 nM (human P2X7 receptor).

2 h-promoting agent (acting at P2Y1, P2Y2, and P2X7 receptors).

3 with activation of the ATP-gated ionotropic P2X7 receptor.

4 ophages but not from macrophages lacking the P2X7 receptor.

5 al role in the transcriptional regulation of P2X7 receptor.

6 hought to be characteristic hallmarks of the P2X7 receptor.

7 o cellular responses typically attributed to P2X7 receptor.

8 S) stimulation and ATP signaling through the P2X7 receptor.

9 to be driven by unimpeded activation of the P2X7 receptor.

10 K(+) caused by stimulation of the purinergic P2X7 receptor.

11 a was unimpaired in macrophages deficient in P2X7 receptor.

12 of the extracellular loop of the full-length P2X7 receptor.

13 739 demonstrates that the tracer engages the P2X7 receptor.

14 reatment for epilepsy based on targeting the P2X7 receptor.

15 gonist sensitivity between the human and rat P2X7 receptors.

16 a(2+) permeability are difficult to apply to P2X7 receptors.

17 asses that selectively target P2X1, P2X3, or P2X7 receptors.

18 human embryonic kidney cells expressing rat P2X7 receptors.

19 esponse to SCI by activation of low-affinity P2X7 receptors.

20 l lines expressing recombinant human and rat P2X7 receptors.

21 ue-G, and KN-62, demonstrating activation of P2X7 receptors.

22 iate between the two widely used agonists at P2X7 receptors.

23 hemichannel protein that interacts with the P2X(7) receptor.

24 opper with residues in the ectodomain of the P2X(7) receptor.

25 e discovered to be novel antagonists for the P2X(7) receptor.

26 ls and that this released ATP autostimulates P2X(7) receptors.

27 ibly bacterial infection through ligation of P2X(7) receptors.

28 ferase-2 (ART2)-mediated ADP ribosylation of P2X(7) receptors.

29 y, we generated a new NOD stock deficient in P2X(7) receptors.

30 ls and human CD4(+) T cells express abundant P2X(7) receptors.

31 BALB/c mice, which express fully functional P2X(7) receptors.

32 ry pain; and the complex actions mediated by P2X(7) receptors.

33 of a nonselective permeation pathway by the P2X7 receptor, a phenomenon called "pore formation." How

34 mma disrupts the functionality of purinergic P2X7 receptors, a key step controlling eCB production by

35 Moreover, in vitro blockade of the P2X7 receptor abrogates the levels of these cytokines.

36 till convincing evidence indicating that the P2X7 receptor activates a separate pathway that permeate

37 ular Ca(2+) increase and K(+) depletion, the P2X7 receptor activates other peculiar responses whose m

38 Thus, "transient" P2X(7) receptor activation and Ca(2+) overload act as a

39 Local ATP signaling and P2X(7) receptor activation play a key role in the develo

40 lammasome activation and apoptosis linked to P2X(7) receptor activation.

41 -1 and release of mature IL-1beta induced by P2X(7) receptor activation.

42 e investigated whether LTB4 is produced upon P2X7 receptor activation and examined whether LTB4 modul

43 P2X7 receptor activation induces the release of differen

44 Evidence also shows that P2X7 receptor activation is linked to elevated expressio

45 These results indicate that P2X7 receptor activation leads to LTB4 formation, which

46 P2X7 receptor activation leads to the release of the pro

47 TLR2 agonists required pannexin-1 and P2X7 receptor activation to stimulate IL-1beta release.

48 investigated for dependence upon caspase-1, P2X7 receptor activation, and loss of membrane asymmetry

49 specific TLR agonists and was accelerated by P2X7 receptor activation.

50 reliant on active caspase-1, pannexin-1, and P2X7 receptor activation.

51 response to ATP concentrations that exclude P2X7 receptor activation.

52 o studies have reported parasite death after P2X7-receptor activation in various cell types.

53 found that during a murine model of sepsis, P2X7 receptor activity is important for maintaining elev

54 Likewise, the purinergic P2X7 receptor acts as a direct conduit for Ca(2+)-influx

55 Methods: P2X7 receptor affinity and specificity, pharmacokinetics

56 Acini were stimulated with the P2X(7) receptor agonist, (benzoylbenzoyl)adenosine 5' tr

57 usly, the authors demonstrated that BzATP, a P2X(7) receptor agonist, enhanced corneal epithelial mig

58 ll patch clamp studies, exposure to the P2X4/P2X7 receptor agonist 2'3'-O-(4-benzoyl-benzoyl)-adenosi

59 apoptosis in response to treatment with the P2X7 receptor agonist benzoyl-ATP.

60 Acini were stimulated with the P2X7 receptor agonist, (benzoylbenzoyl)adenosine 5' trip

61 ed treatment with lipopolysaccharide and the P2X7 receptor agonist, benzylated ATP, suggesting that n

62 P2Y2, P2Y4, P2Y6, and P2Y12, and at P2X4 and P2X7 receptors), an immunosuppressant (acting at P2Y11),

63 ng mechanisms were prevented by knocking out P2X7 receptor and by the use of specific antagonists.

64 iprotein inflammasome complex, including the P2X7 receptor and caspase-1.

65 However, the roles of P2X7 receptor and intracellular K(+) in IL-1beta secreti

66 Furthermore, we demonstrated that P2X7 receptor and NLRP3 transcription were modulated in

67 -induced cell death in oocytes co-expressing P2X7 receptor and pannexin 1.

68 n experiments with HEK cells, which lack the P2X7 receptor and showed strikingly increased response t

69 S. aureus supernatant was independent of the P2X7 receptor and the essential TLR adaptors MyD88 and T

70 ry cytokines through mechanisms depending on P2X7 receptors and Px1 HCs.

71 g lipin-2 decreases ion currents through the P2X7 receptor, and downstream events that drive IL-1beta

72 2X3, and 10-fold selectivity versus P2X4 and P2X7 receptors, and inhibited collagen-induced platelet

73 In this context, P2X7 receptor antagonism could be a promising strategy t

74 X1 receptor antagonist NF449, the purinergic P2X7 receptor antagonist A438079, and azidothymidine (AZ

75 he centrally available, potent, and specific P2X7 receptor antagonist JNJ-47965567 (30 mg/kg) signifi

76 The selective P2X7 receptor antagonist JNJ-47965567 partly replicated

77 ependent receptor occupancy studies with the P2X7 receptor antagonist JNJ-54175446 were obtained in r

78 alf-maximal inhibitory concentration) of the P2X7 receptor antagonist JNJ-64413739 is 1.0 +/- 0.2 nM

79 y 10-100 nM) and selective (> or = 100-fold) P2X(7) receptor antagonists against the other P2 recepto

80 ally restored by coinstillation of P2X(1) or P2X(7) receptor antagonists or of caffeine with LPS.

81 Other P2X7 receptor antagonists, however, had no effect on LT

82 N'-aryl acyl hydrazides were identified as P2X7 receptor antagonists.

83 ular constituent immunoreactive for specific P2X7 receptor antiserum in the kainate-induced seizure a

84 P2X(7) receptors are ATP-gated cation channels; their ac

85 P2X(7) receptors are distinct from other ATP-gated P2X r

86 P2X7 receptors are ATP-gated ion channels that contribut

87 P2X7 receptors are important in the regulation of inflam

88 P2X7 receptors are involved not only in physiological fu

89 P2X7 receptors are nonselective cation channels gated by

90 pressing a rat P2X7 receptor indicating that P2X7 receptors are not involved in stimulation of ATP re

91 TP injection or conditioning lesion, whereas P2X7 receptors are not.

92 ATP-gated P2X7 receptors are prominently expressed in inflammatory

93 pore-forming properties of human and rodent P2X7 receptors are sensitive to perturbations of cholest

94 These data point to the P2X7 receptor as a checkpoint regulator of Tfh cells; th

95 ive stress in ALS microglia and identify the P2X7 receptor as a promising target for the development

96 P2X7 receptors associate with cholesterol-rich lipid raf

97 The function of P2X(7) receptors (ATP-gated ion channels) in innate immu

98 The ligand-gated ion channel P2X7 receptor attracts special attention due to its wide

99 The P2X7 receptor binds extracellular ATP to mediate numerou

100 r gadolinium chloride, or siRNA silencing of P2X(7) receptors blocks calcium entry and inhibits T-cel

101 nistration of an inhibitor of the purinergic P2X7 receptor blocks the anxiety caused by HFD.

102 f pannexin-1-hemichannel (PNX1) coupled with P2X7-receptor blocks the infection-induced eATP release

103 of fluorescent dyes in many cells expressing P2X7 receptors, but controversy persists as to whether s

104 , in SOD1-G93A microglia, the stimulation of P2X7 receptor by 2'-3'-O-(benzoyl-benzoyl) ATP enhanced

105 lts demonstrate that the open channel of the P2X7 receptor can allow passage of molecules with sizes

106 itionally, it has been demonstrated that the P2X7 receptor can induce PLA2 activation and arachidonic

107 We further show that activation of P2X7 receptors can lead to the release of tumor necrosis

108 The ATP-gated P2X7 receptor channel (P2X7R) operates as a cytolytic an

109 de during activation by endogenous ATP-gated P2X7 receptor channels, the exogenous bacterial ionophor

110 cto-ribosylation reactions known to activate P2X(7) receptor/channels in other cell types.

111 C57BL/6 mice that express poorly functional P2X(7) receptors, compared to control BALB/c mice, which

112 we present crystal structures of a mammalian P2X7 receptor complexed with five structurally-unrelated

113 Considering that extracellular ATP through P2X7 receptor constitutes a neuron-to-microglia alarm si

114 dings suggest that P2X receptors, especially P2X(7) receptors, contribute to ATP- and BzATP-induced C

115 cing T-cell activation through the ATP-gated P2x7 receptor controlling Ca2(+) influx.

116 al inhibition of both maternal and offspring P2X7 receptors could reverse the compromised brain devel

117 Patch clamp analysis of P2X7 receptor currents carried by Na(+) and N-methyl-D-g

118 eptic mice displayed enhanced agonist-evoked P2X7 receptor currents, and synaptosomes from these anim

119 In P2X7 receptor deficient mice (P2rx7-/-), the social inte

120 fficient to induce motor neuron death by the P2X7 receptor-dependent activation of the Fas pathway.

121 TLR agonists induced P2X7 receptor-dependent IL-1beta release in both monocyt

122 ion by means of its fimbriae in a purinergic P2X7 receptor-dependent manner.

123 The generation of prothrombotic MPs required P2X7 receptor-dependent production of ROS leading to inc

124 e data suggest that PDI regulates a critical P2X7 receptor-dependent signaling pathway that generates

125 c receptor P2X, ligand-gated ion channel, 7 (P2X7 receptor; encoded by P2rx7) induced activation (dec

126 blocking effect of antagonists to P2X(4) and P2X(7) receptors expressed by microglial cells in neurop

127 mat binds to the P2rx7 enhancer and promotes P2X7 receptor expression in the absence of HDAC3.

128 These results were relevant in vivo since P2X7 receptor expression was upregulated in a P. gingiva

129 ymocyte survival and is required to suppress P2X7 receptor expression.

130 cted but potentially important points in the P2X7 receptor field.

131 tative measures of the Ca(2+) current of the P2X7 receptor for the first time, and suggest that the c

132 study, we investigate the effect of loss of P2X7 receptor function on retinal structure and function

133 Lack of P2X7 receptor function reduced phagocytosis at all ages

134 nalgesic tolerance, without affecting normal P2X7 receptor function.

135 no and carboxyl termini in the regulation of P2X7 receptor gating.

136 TCR activation up-regulates P2X(7) receptor gene expression.

137 PS followed by ATP-induced activation of the P2X(7) receptor; GFP also was released under these condi

138 Our in vitro findings revealed that P2X7 receptor has a dual role, being critical not only f

139 Overall, we conclude that the P2X7 receptor has a role in periodontal immunopathogenes

140 he present study suggests that targeting the P2X7 receptor has anticonvulsant and possibly disease-mo

141 The P2X7 receptor has since been shown to play a leading rol

142 lly relevant strategy by which to antagonize P2X7 receptors has yet, to the best of our knowledge, be

143 ular ATP signaling, particularly through the P2X7 receptor, has considerable translational potential,

144 sue, followed by activation of high-affinity P2X7 receptors, has previously been implicated in second

145 idely distributed in the nervous system, and P2X7 receptors have roles in neuropathic pain and in the

146 pothesized that the ATP-activated macrophage P2X7 receptors implicated in nucleotide-mediated macroph

147 ron microscopy structures of full-length rat P2X(7) receptor in apo and ATP-bound states.

148 ) gene were used to evaluate the role of the P2X(7) receptor in nucleotide-evoked fluid secretion.

149 oal here was to characterize the role of the P2X(7) receptor in the repair of in vivo corneal epithel

150 Our recent studies have shown that P2X(7) receptors in neurons and astrocytes activate NLRP

151 These results suggest an important role of P2X(7) receptors in neuropathic pain and therefore a pot

152 P2X(7) receptors in turn activate alpha(1D)-AR to increa

153 We expressed the rat P2X7 receptor in human embryonic kidney cells and measur

154 f a ligand gated ion channel, the purinergic P2X7 receptor in MIA-induced autism-like behavioral and

155 ent study shows that loss of function of the P2X7 receptor in mice induces retinal changes representi

156 Therefore, we investigated the role of the P2X7 receptor in response to crystal-induced cytokine re

157 ivo characteristics suitable for imaging the P2X7 receptor in the brain and warrants further studies

158 an (18)F-labeled PET ligand for imaging the P2X7 receptor in the brain.

159 element in the transcriptional regulation of P2X7 receptor in the nervous system.

160 ed cell death, indicating a primary role for P2X7 receptors in both of these effects.

161 annels mediate innate immunity downstream of P2X7 receptors in human macrophages.

162 showed that prolonged agonist activation of P2X7 receptors in non-neuronal cells did not lead to cyt

163 In addition, the released ATP activates P2X7 receptors in satellite cells that enwrap each DRG n

164 HDAC3-deficient DP thymocytes upregulate the P2X7 receptor, increasing sensitivity to ATP-induced cel

165 ophages; however, only monocytes also showed P2X7 receptor-independent release of mature IL-1beta.

166 K293 cells and HEK293 cells expressing a rat P2X7 receptor indicating that P2X7 receptors are not inv

167 lytic cleavage of IL-1F6 was noted following P2X(7) receptor-induced release.

168 Here, we show for first time that P2X7 receptor induces the release of CD14 in extracellul

169 onists, compounds with ancillary P2X4 and/or P2X7 receptor inhibition were discovered.

170 The P2X(7) receptor inhibitor A438079 had no effect on ATP-s

171 tivation, each of which was inhibited by the P2X(7) receptor inhibitors Brilliant Blue G or A 438079.

172 le translational potential, given that novel P2X7-receptor inhibitors are already available for clini

173 es through mediation of integrin beta(3) and P2X7 receptor interactions in primed cells.

174 Mice deficient in the P2X(7) receptor (involved in IL-1 release) or caspase-1

175 ase and autocrine, positive feedback through P2X(7) receptors is required for the effective activatio

176 The P2X7 receptor is a non-selective cation channel activate

177 IL-1beta in the brain, and antagonism of the P2X7 receptor is a novel therapeutic strategy to dampen

178 The P2X7 receptor is a trimeric channel with three binding s

179 The P2X7 receptor is a trimeric ligand-gated ion channel act

180 The P2X7 receptor is an adenosine triphosphate-gated ion cha

181 The P2X7 receptor is an ATP-gated ion channel known for its

182 The P2X7 receptor is an ionotropic receptor predominantly ex

183 previous reports, our results indicate that P2X7 receptor is not required for crystal-induced CKD an

184 The P2X7 receptor is unique in having an intracellular carbo

185 In our study, we show that the ATP-gated P2X7 receptor is upregulated in experimental epilepsy an

186 exin channels and blocking activation of the P2X(7) receptor, is neuroprotective for stretched neuron

187 ad to a better understanding of not only the P2X7 receptor itself but also some important physiologic

188 unctional studies, our data suggest that the P2X7 receptor itself constitutes a lipid-composition dep

189 xogenous LTB4, and macrophages obtained from P2X7 receptor knockout mice eliminated L. amazonensis wh

190 V-2 infection may trigger hyperactivation of P2X7 receptors leading to NLRP3 inflammasome stimulation

191 at hyperoxia induces K(+) efflux through the P2X7 receptor, leading to inflammasome activation and se

192 indings suggest a noxious mechanism by which P2X7 receptor leads to enhanced oxidative stress in ALS

193 Activation of the P2X7 receptor leads to opening of the characteristic dye

194 ptosomes from these animals showed increased P2X7 receptor levels and altered calcium responses.

195 tivation by mithramycin A reduced endogenous P2X7 receptor levels in primary cultures of cortical neu

196 P2X7 receptor levels were increased in hippocampal subfi

197 re exist functional data suggesting that the P2X7 receptor may also activate other intracellular sign

198 Gln have >85% loss of 'pore' function of the P2X7 receptor measured by ATP-induced ethidium uptake.

199 infection inhibits extracellular-ATP (eATP)/P2X7-receptor mediated cell death in gingival epithelial

200 ernata release ATP, which in turn stimulates P2X(7) receptor-mediated Ca(2+) uptake across the plasma

201 gonists of PLA(2) and Cl(-) channels abolish P2X7 receptor-mediated current facilitation, membrane pe

202 lagellin proceeds normally in the absence of P2X7 receptor-mediated cytoplasmic K(+) perturbations.

203 ctivation of the NLRP3 inflammasome utilizes P2X7 receptor-mediated potassium efflux.

204 The P2X7 receptor mediates extracellular ATP signaling impli

205 AM or by low or no extracellular Ca(2+); and P2X(7) receptor mRNA and protein were expressed in RPE c

206 conserved in the ectodomain of all mammalian P2X(7) receptors, none of which is homologous to previou

207 Neither inhibitors of P2X(7) receptors nor removal of extracellular Mg(2+) or

208 one (compound 35), were found to have robust P2X7 receptor occupancy at low doses in rat with ED50 va

209 the agonist-gated Ca(2+) flux of recombinant P2X7 receptors of dog, guinea pig, human, monkey, mouse,

210 This study investigated the effect of P2X(7) receptors on infection-induced renal scarring in

211 ted intraocular pressure, and stimulation of P2X(7) receptors on retinal ganglion cells can be lethal

212 3cr1-deficient MPs express increased surface P2X7 receptor (P2RX7), which stimulates IL-1beta maturat

213 The ATP-gated P2X(7) receptor (P2X(7)R) is a promising therapeutic tar

214 P2X(7) receptors (P2X(7)Rs) are ATP-gated ion channels t

215 Increased P2X7 receptor (P2X7R) activity is a cardinal feature of

216 The P2X7 receptor (P2X7R) belongs to the P2X family of ATP-g

217 n1 (Panx1) channel and purinergic ionotropic P2X7 receptor (P2X7R) blockers.

218 Agonist properties of the P2X7 receptor (P2X7R) differ strikingly from other P2X r

219 Here, we demonstrate that stimulation of the P2X7 receptor (P2X7R) for ATP alkalinizes lysosomes in c

220 The P2X7 receptor (P2X7R) for ATP is a therapeutic target fo

221 nine (Arg, R) at codon 460 of the purinergic P2X7 receptor (P2X7R) has repeatedly been associated wit

222 The proposed presence of P2X7 receptor (P2X7R) in neurons has been the source of

223 The P2X7 receptor (P2X7R) is a promising target for neuroinf

224 Among all P2X receptors, the P2X7 receptor (P2X7R) is a well-defined therapeutic targ

225 The P2X7 receptor (P2X7R) is an adenosine triphosphate-gated

226 The P2X7 receptor (P2X7R) is an ATP-gated nonselective catio

227 The ATP-gated ionotropic P2X7 receptor (P2X7R) modulates glial activation, cytoki

228 The P2X7 receptor (P2X7R) orchestrates neuroinflammation, an

229 We find that the P2X7 receptor (P2X7R) plays an important role in LL-37 i

230 The P2X7 receptor (P2X7R) regulates many cellular functions.

231 previously that activation of the purinergic P2X7 receptor (P2X7R) triggers sAPPalpha shedding from n

232 ling purinergic receptors, predominantly the P2X7 receptor (P2X7R), via an ATP analog initiate innate

233 We recently reported that P2X7 receptor (P2X7R)-induced activation of caspase-1 in

234 was inhibited by a specific inhibitor of the P2X7 receptor (P2X7R).

235 enin release (>/=2-fold), whereas purinergic P2X7 receptors (P2X7R) blockade with A740003 (3 microM)

236 involving autocrine activation of ionotropic P2X7 receptors (P2X7R) by ATP.

237 tes/macrophages in response to activation of P2X7 receptors (P2X7R) by extracellular ATP.

238 gh the inhibition of the P2X purinoceptor 7 (P2X7) receptor (P2X7R), an ATP-gated ion channel, and a

239 Blockading P2X7 receptor(P2X7R) provides neuroprotection toward var

240 Purinergic ionotropic P2X7 receptors (P2X7Rs) are closely associated with exci

241 P2X7 receptors (P2X7Rs) are ligand-gated ion channels se

242 P2X7 receptors (P2X7Rs) are unique purinergic receptors

243 o ethidium (Etd(+)) and Ca(2+) by activating P2X7 receptors (P2X7Rs) that open pannexin hemichannels

244 tracellular ATP binds to and signals through P2X7 receptors (P2X7Rs) to modulate immune function in b

245 Antagonizing the ATP-dependent P2X7 receptor pathway of inflammasome activation signifi

246 We demonstrate that ATP acting via the P2X7 receptor pathway promotes a Th17 polarizing microen

247 Here, we show that P2X(7) receptors play a key role in calcium influx and d

248 eveal cholesterol as a negative regulator of P2X7 receptor pore formation, protecting cells from P2X7

249 lent cations with ectodomain residues of the P2X(7) receptor, primarily involving combined interactio

250 Taken together, these data suggest that the P2X7 receptor promotes inflammatory infiltrates, proinfl

251 P2X(7) receptor protein and BzATP-activated inward catio

252 BM chimeras revealed that P2X7 receptor prothrombotic function was present in both

253 e results demonstrate that the ATP-sensitive P2X(7) receptor regulates fluid secretion in the mouse s

254 The P2X7 receptor regulates cell growth through mediation of

255 -1 hemichannels to the immune synapse, while P2X7 receptors remain uniformly distributed on the cell

256 +/- 0.6 nM at the recombinant human and rat P2X7 receptor, respectively, and the binding affinity is

257 Enhancement of P2X7 receptor responses may be useful in pathogen cleara

258 Here we show that the ATP-gated ionotropic P2X7 receptor restricts the expansion of aberrant Tfh ce

259 Interestingly, lack of P2X(7) receptors resulted in diminished macrophage infil

260 P2X7 receptors (Rs) constitute a subclass of ATP-sensiti

261 tly, we identified a novel pathway involving P2X7 receptor scavenger function expressed on ocular imm

262 as been suggested previously that purinergic P2X7 receptor signaling is critical for crystal-induced

263 ith cellular activation typically induced by P2X7 receptor signaling.

264 As BzATP binds to the P2X(7) receptor, specific characteristics of this recept

265 Dissipation of ATP by CD39 reduced P2X7 receptor stimulation and thereby suppressed baselin

266 We also found that, following P2X7 receptor stimulation, the phosphorylation of ERK1/2

267 The P2X(7) receptor subtype is a pharmacological target beca

268 However, whether and how P2X7 receptor suppression protects blood-brain barrier(B

269 that can differentiate between forms of the P2X(7) receptor that have a key role in cancer.

270 uncovered a novel site (Y382-384) within the P2X7 receptor that can be targeted to blunt the developm

271 drial ATP production, and stimulate P2X4 and P2X7 receptors that elicit interleukin 2 production and

272 In the absence of the P2X(7) receptor, the expression of proteins in the corne

273 iggers, through activation of the purinergic P2X7 receptor, the formation of the inflammasome, a mult

274 m channels is less potent than inhibition of P2X7 receptors, there may be significant inhibition of s

275 Hence, this study suggests the P2X(7) receptor to be an appealing antifibrotic target a

276 ATP appeared to also act through the P2X(7) receptor to inhibit muscarinic-induced fluid secr

277 of alpha(1D)-AR releases ATP, which induces P2X(7) receptors to increase [Ca(2+)](i) but not to stim

278 ATP uses P2X(3) and P2X(7) receptors to stimulate an increase in [Ca(2+)](i)

279 ctivates the inflammasome via the purinergic P2X7 receptor to cause inflammation and hyperoxic acute

280 agonists plus ATP, the latter activating the P2X7 receptor to decrease intracellular K+ levels.

281 ns circumvent the requirement of ATP and the P2X7 receptor to induce caspase-1 activation via Nlrp3.

282 OD1-G93A mice and SOD1-G93A mice lacking the P2X7 receptor to investigate the effects of both pharmac

283 ease, which in turn activated the purinergic P2X7 receptor to mediate cytotoxicity.

284 cells, the activation of M3AChRs stimulates P2X7 receptors to increase [Ca2+]i and protein secretion

285 ing pathways that overlap with those used by P2X7 receptors to increase [Ca2+]i, but they also use si

286 to become self sustaining through action of P2X7 receptors to open pannexin hemichannels and then co

287 they also use signaling pathways not used by P2X7 receptors to stimulate protein secretion.

288 d origin show robust expression of ATP-gated P2X7 receptors, two-transmembrane ion channels permeable

289 strate that ATP signaling through macrophage P2X7 receptors uncouples the thioredoxin (TRX)/TRX reduc

290 Finally, we found that Sp1 mediates P2X7 receptor up-regulation in neuroblastoma cells cultu

291 Furthermore, alpha(1D)-AR compared with P2X(7) receptors use different cellular mechanisms to in

292 P2X7 receptor was higher expressed in murine atheroscler

293 Interestingly, we found that the P2X7 receptor was upregulated in the chronic phase of EA

294 blue G (BBG), best known as an antagonist of P2X7 receptors, was found to inhibit voltage-gated sodiu

295 Using macrophages lacking the P2X7 receptor, we observed that ATP was not able to redu

296 P2X(7) receptors were present in the lacrimal gland by R

297 The authors previously showed that P2X(7)receptors were functional in the lacrimal gland.

298 PET ligands for the P2X7 receptor will not only be valuable to assess centra

299 lular ATP with apyrase, by inhibition of the P2X(7) receptor with A438079, zinc, or AZ 10606120, and

300 Activation of P2X(7) receptors with (benzoylbenzoyl)adenosine 5'-triph