ライフサイエンスコーパス: P2X4 receptor

1 lar dynamics study of the closed form of the P2X4 receptor.

2 ding of these antagonists are present in the P2X4 receptor.

3 toma cells stably transfected with the human P2X4 receptor.

4 EK293 cells transfected to express the human P2X4 receptor.

5 mall-molecule antagonist 5-BDBD at the human P2X4 receptor.

6 aining valuable PET tracers for studying the P2X4 receptor.

7 ated current in WT cells, implying that both P2X4 receptor and another yet-to-be-identified P2X recep

8 s by which CCs are activated by pH sensitive P2X4 receptor and ectonucleotidases, providing a feedbac

9 ion results in the translocation of P2X1 and P2X4 receptors and pannexin-1 hemichannels to the immune

10 tivity of CCs via the purinergic ADORA2B and P2X4 receptors, and that luminal adenosine content is it

11 This study advances the understanding of P2X4 receptor antagonism and underscores the challenges

12 ons led to a series of compounds with potent P2X4 receptor antagonism, promising in vitro inhibition

13 Finally, treatment with the P2X4 receptor antagonist 5-BDBD reduced the severity of

14 velopment of 1,4-naphthodiazepinedione-based P2X4 receptor antagonists aimed at both therapeutic appl

15 P2X4 receptor antagonists have potential as drugs for th

16 P2X4 receptors are ATP-gated cation channels that are wi

17 Thus, our data indicate that P2X4 receptors are dynamically regulated mobile ATP sens

18 These studies provide evidence that P2X4 receptors are functionally important in hepatocyte

19 P2X4 receptors are likely involved because the calcium r

20 However, the nature of how plasma membrane P2X4 receptors are regulated in microglia is not fully u

21 ATP-gated ionotropic P2X4 receptors are up-regulated in activated microglia a

22 r at other sites in the nervous system where P2x4 receptors are widely expressed.

23 mpletely abolished the pH sensitivity of the P2X4 receptor at all agonist concentrations.

24 and localized ATP production that stimulated P2X4 receptors, Ca(2+) influx, and pseudopod protrusion

25 purification and pulldown assays reveal that P2X4 receptors complex with aminobutyric acid, type A (G

26 The chick P2X4 receptor (cP2X(4)R) mRNA was expressed in the heart

27 CXCL12 directly triggers a purinergic P2x4 receptor-dependent proinflammatory response of TEMR

28 2X receptors, ion currents through homomeric P2X4 receptors exhibit intermediate desensitization when

29 To identify P2X4 receptor-expressing cells, we generated BAC transge

30 well-characterized tool with which to study P2X4 receptor-expressing cells.

31 and potential use as PET tracers for imaging P2X4 receptor expression in cancer.

32 P2X4 receptor expression in the liver, liver histology,

33 Furthermore, increased surface P2X4 receptor expression significantly decreases the fre

34 de that pannexin-1 hemichannels and P2X1 and P2X4 receptors facilitate ATP release and autocrine feed

35 ever, it was not clear whether the lysosomal P2X4 receptors function as channels and how they are act

36 expressing tdTomato under the control of the P2X4 receptor gene (P2rx4).

37 In contrast, inhibition of P2X4 receptor had no effect on Th1 cells and on the prod

38 Cells expressing ATP-gated P2X4 receptors have proven problematic to identify and s

39 py structures of full-length wild-type human P2X4 receptor in apo closed, antagonist-bound inhibited,

40 eport the crystal structure of the zebrafish P2X4 receptor in complex with ATP and a new structure of

41 aracterize the electrophysiologic actions of P2X4 receptors in cardiac myocytes and to determine whet

42 cells, consistent with an important role of P2X4 receptors in mediating the ATP current not only in

43 also requires the activation of postsynaptic P2X4 receptors in OHCs.

44 t previously unanticipated roles for ATP and P2X4 receptors in the neural circuitry controlling feedi

45 The crystal structure of a P2X4 receptor, in combination with mutagenesis studies,

46 l and functional data regarding the P2X2 and P2X4 receptors indicate that the central trihelical TM2

47 hibition, mutation, or silencing of P2X1 and P2X4 receptors inhibits Ca(2+) entry, nuclear factors of

48 The P2X4 receptor is a ligand-gated ion channel activated by

49 The P2X4 receptor is a ligand-gated ion channel that is expr

50 The P2X4 receptor is a newly identified receptor expressed i

51 Activity of P2X4 receptor is associated with neuropathic pain, infla

52 The P2X4 receptor is implicated in various pathological cond

53 The P2X4 receptor is involved in immunological and inflammat

54 e and have shown further that ATP-responsive P2X4 receptor is required for Tbeta4-induced HUVEC migra

55 The P2X4 receptor is unique among family members in its sens

56 Ca(2+) entry through P2X4 receptors is known to trigger downstream signaling

57 We find that plasma membrane P2X4 receptor lateral mobility in resting microglial pro

58 GABA(A) receptors in recombinant system and P2X4 receptor-mediated GABAergic depression in SF-1 GFP-

59 nd clear evidence for functional presynaptic P2X4 receptor-mediated responses in terminals of AgRP-NP

60 ATP decreased cellular glycogen content; and P2X4 receptor messenger RNA increased in glycogen-rich l

61 uantum dot-labeled P2X4 receptors to explore P2X4 receptor mobility in the processes of resting and a

62 1 microM), while at recombinant rat P2X2 and P2X4 receptors no enhancing or antagonistic properties w

63 Genetic deletion of the PSD-95 or P2X4 receptors obliterated ATP-mediated down-regulation

64 ogical evidence for functional expression of P2X4 receptors on AgRP-NPY neuron somata, but instead, w

65 Accordingly, inhibition of the P2X4 receptor or direct mTOR blockade prevents induction

66 ned in myocytes from both wild-type (WT) and P2X4 receptor-overexpressing transgenic (TG) mice.

67 The P2X4 receptor (P2X4R) is a member of a family of puriner

68 P2X4 receptors (P2X4R) have emerged as potentially impor

69 Of the seven P2X subtypes, P2X4 receptors (P2X4Rs) are richly expressed in the brai

70 Activation of a cardiac myocyte P2X4 receptor protects against heart failure.

71 tures of the detergent-solubilized zebrafish P2X4 receptor provide a blueprint for receptor mechanism

72 The recent crystal structure of a P2X4 receptor provides a 3D view of their topology and a

73 Furthermore, inhibition of P2X4 receptor reduced the production of IL-17 but not of

74 on feeding-related regulation of presynaptic P2X4 receptor responses, and the rationale to explore ex

75 In the presence of the P2X4 receptor-selective allosteric enhancer ivermectin (

76 We analyzed the P2X4 receptor structure-activity relationship of a known

77 In intact heart study, the P2X4 receptor TG mouse exhibited significantly elevated

78 on with no associated heart pathology in the P2X4 receptor TG mouse suggests a novel physiologic role

79 use suggests a novel physiologic role of the P2X4 receptor, that of stimulating the cardiac contracti

80 Furthermore, in P2X4 receptors, this ability to alter ion selectivity ca

81 ncreased responsiveness of the overexpressed P2X4 receptor to endogenous ATP is responsible for the e

82 olecule imaging to track quantum dot-labeled P2X4 receptors to explore P2X4 receptor mobility in the

83 P2X4 receptors were expressed in hepatocytes and Kupffer

84 -2,4-disulfonate, with residues from the rat P2X4 receptor, which is insensitive to these antagonists

85 nsistent with overexpression of a functional P2X4 receptor with consequent increase in the receptor-m

86 Inhibition of P2X4 receptor with the specific antagonist 5-BDBD and sm