ライフサイエンスコーパス: P450

1 mes leading to oxidations such as cytochrome P450.

2 of Staphylococcus species that have a single P450.

3 PS, alter the expression of many cytochromes P450.

4 via the upregulation of mtROS and Cytochrome P450.

5 ncrease LMs products of ALOX5 and cytochrome p450.

6 a and 2.7% of other Firmicutes species, have P450s.

7 cern possible binding modes of several human P450s.

8 with CYP1A2, CYP1A1, and CYP2D6, but not all P450s.

9 Mutations and overexpression of P450 11B2 (also known as aldosterone synthase) can lead

10 data obtained to develop a kinetic model for P450 11B2 and tested this model by enzyme kinetics simul

11 P450 11B2 catalyzes aldosterone formation from 11-deoxyc

12 Human cytochrome P450 (P450) 11B2 catalyzes the formation of aldosterone, the m

13 In conclusion, P450 17A1 binds its steroid substrates via conformationa

14 me-binding heterocyclic nitrogen moieties in P450 17A1 inhibitors may not be necessary to achieve inh

15 nd S, respectively), the rates of binding to P450 17A1 were relatively slow.

16 We examined the interaction of P450 17A1 with its steroid substrates by analyzing progr

17 the triazole (S)-seviteronel (VT-464), with P450 17A1.

18 iomers of this inhibitor of cytochrome P450 (P450) 17A1 show some selectivity in differentially block

19 Aromatase, or cytochrome P450 19A1, catalyzes the aromatization of androgens to e

20 an increase in gene expression of cytochrome P450 1A but not glutathione S-transferase.

21 The androgen receptor (ar) and cytochrome P450 1A genes were associated with large shifts in allel

22 e 3-methylcholanthrene responsive cytochrome P450-1a ( cyp1a) transcript exhibited the greatest incre

23 The liver enzyme cytochrome P450 1A2 (CYP1A2) is responsible for 90% of caffeine met

24 who carry a functional variant at cytochrome P450 1A2 (CYP1A2), which makes them less effective at me

25 LiMAx test (enzymatic capacity of cytochrome P450 1A2).

26 The mammalian ancestor of the cytochrome P450 1B subfamily was herein characterized structurally

27 Binding of the steroid progesterone to P450 21A2 was also best described by a conformational-se

28 g and -degrading enzymes, such as cytochrome P450 26 (Cyp26 genes).

29 nes during embryogenesis requires Cytochrome P450 26b1 (Cyp26b1)-mediated degradation of retinoic aci

30 f their higher prevalence of poor cytochrome P450 2C19 metabolizers.

31 Binding of the P450s 2C8, 2D6, 3A4, 4A11, and 21A2 was best described b

32 mg/day for patients taking strong cytochrome P450 2D6 (CYP2D6) inhibitors).

33 Cytochrome P450 2D6 (CYP2D6) is a highly polymorphic gene whose pro

34 at mitochondrially targeted human cytochrome P450 2D6 (CYP2D6), supported by mitochondrial adrenodoxi

35 We observed that P450 2D6 binds its ligand rolapitant in a mechanism invo

36 KO) mice have increased levels of cytochrome P450 2E1 (CYP2E1), but the underlying mechanisms are unk

37 t described by conformational-selection, and P450 2E1 appeared to fit either mode.

38 Cytochrome P450 2J2 (CYP2J2) is responsible for the epoxidation of

39 only 229 species belonging to 37 genera have P450s; 38% of Bacilli species, followed by 14% of Clostr

40 stration, only mild inhibition of cytochrome P450 3A, and no evidence of cardiac- or phototoxicity in

41 so tested for metabolism by human cytochrome P450 3A4 (CYP3A4) and human aldehyde oxidase (hAOX) for

42 dependence of binding rates for varying both P450 3A4 and midazolam concentrations revealed discordan

43 in which conformationally distinct forms of P450 3A4 bind inhibitors rapidly and two distinct P450-i

44 were observed when inhibitors were added to P450 3A4 in 7-benzoyl quinoline O-debenzylation reaction

45 helped in overcoming a persistent cytochrome P450 3A4 induction problem.

46 ions, but details of the exact mechanisms of P450 3A4 inhibition are still unclear in many cases.

47 ases, consistent with multiple structures of P450 3A4 inhibitor complexes.

48 Upon mixing with inhibitors, P450 3A4 showed rapid binding as judged by a spectral sh

49 ocriptine, testosterone, and ketoconazole to P450 3A4 was consistent with an induced-fit or a conform

50 Cytochrome P450 (P450) 3A4 is the enzyme most involved in the metabolism

51 or-specific antibody development, cytochrome P450 3A5 genotype, pregraft sensitization, mo 3 glomerul

52 ed on 666 patients with available cytochrome P450 3A5 genotypes, the effect of the C/D ratio remained

53 nz (EFV) is an anti-HIV drug, and cytochrome P450 46A1 (CYP46A1) is the major brain cholesterol hydro

54 Cytochrome P450 46A1 (CYP46A1) or cholesterol-24-hydroxylase is res

55 ), which induces transcription of cytochrome P450 4A (CYP4A).

56 inst cancer cell lines expressing cytochrome P450 4F11.

57 Mammary-tissue-restricted cytochrome P450 4Z1 (CYP4Z1) has garnered interest for its potentia

58 The key BA synthesis enzyme cytochrome P450 A1 was absent in MGC and CGC; BA production in vitr

59 i.e. urea and albumin production, cytochrome P450 activity and induction studies) of the polystyrene

60 ith static organoid cultures, and cytochrome p450 activity reached levels equivalent to hepatocytes.

61 le directly kills Mtb by reducing cytochrome P450 activity.

62 albumin and apolipoprotein B and cytochrome P450 activity; cholangiocytes were functional, based on

63 of gcoA and pcaL, encoding a CYP255A2 family P450 and an ortho-cleavage pathway enzyme, respectively,

64 nd rifampicin (RIF), which affect cytochrome P450 and antiretroviral exposure.

65 kely attributable to the expanded cytochrome P450 and chitinase gene families.

66 e proteins hemoglobin, myoglobin, cytochrome P450 and cytochrome c, respectively.

67 tudy was to examine interactions between the P450 and HO-1 systems.

68 ral fusion protein constructed of cytochrome P450 and NADPH-cytochrome P450 reductase domains.

69 Given that DHA metabolism by cytochrome P450 and soluble epoxide hydrolase (sEH) enzymes affects

70 inding of substrates to some of the 57 human P450s and other mammalian P450s is more complex than a t

71 , thiolate-ligated heme-dependent cytochrome P450, and four nonheme oxygenases, namely, tetrahydrobio

72 gulation of agcA, encoding a CYP255A1 family P450, and the aph genes, previously shown to encode a me

73 ate thermodynamics of C-H bond activation in P450 are best described as follows: E(0')(Comp-I) = 1.22

74 The cytochromes P450 are heme-dependent enzymes that catalyze many vital

75 As the expressions of both HO-1 and P450s are affected by xenobiotic exposure, changes in HO

76 Only 18% of P450s are found to be involved in secondary metabolism a

77 number of P450s in the genome, Streptomyces P450s are much more diverse than those of Mycobacterium.

78 oxygenase 1 (HO-1) and the cytochromes P450 (P450s) are endoplasmic reticulum-bound enzymes that rely

79 tochrome P450 monooxygenases (termed CYPs or P450s) are hemoproteins ubiquitously found across all ki

80 Cytochromes P450 (P450s) are nature's catalysts of choice for performing d

81 chored monotopic proteins, cytochromes P450 (P450s), are enzymes that metabolize endobiotics (physiol

82 icant potential and plasticity of cytochrome P450 aromatic O-demethylases in the biological conversio

83 ofiled their susceptibility to metabolism by P450s associated with pyrethroid resistance in Anopheles

84 2) = 6.6; P = 0.01) suggesting a reversal of P450-based resistance in the absence of selection.

85 nisms, regulation, and many other aspects of P450 biochemistry.

86 The cytochrome P450 monooxygenase P450 BM3 (BM3) is a biotechnologically important and ver

87 P450 BM3 binds and oxidizes several mid- to long-chain f

88 The wild-type P450 BM3 enzyme binds inefficiently to many azole antifu

89 Flavocytochrome P450 BM3 is a natural fusion protein constructed of cyto

90 ing the structure and catalytic mechanism of P450 BM3.

91 t a wild-type cytochrome P450 monooxygenase (P450(BM3) from Bacillus megaterium, CYP102A1) has promis

92 port here the rational design of a series of P450(BM3)-based variants with dramatically enhanced C-H

93 Reported here are P450-BM3 mutants that catalyze the oxidative hydroxylati

94 s become increasingly clear that cytochromes P450 can cycle back and forth between two extreme confor

95 ain apparent ultrashort radical lifetimes in P450 catalysis, but they are best considered together.

96 dition is one of the key steps in cytochrome P450 catalysis.

97 These engineered and natural P450 catalysts can promote the intramolecular C-H aminat

98 13)-apocarotenol substrates were produced by P450-catalyzed biotransformation and microbial/plant enz

99 the discovery of highly selective cytochrome P450-catalyzed methylcubane oxidations which notionally

100 Unlike other reported P450-catalyzed methylcubane oxidations, the designed met

101 se studies provided a basis for constructing P450 chimeras to gain further insight into the features

102 plexed form of the orteronel- or seviteronel-P450 complex is not a prerequisite for enzyme inhibition

103 nce energy transfer (BRET), HO-1 formed HO-1*P450 complexes with CYP1A2, CYP1A1, and CYP2D6, but not

104 ha-OH pregnenolone was held constant and the P450 concentration increased, the binding rate increased

105 Alterations of hepatic P450 content through synthesis, inactivation, or proteol

106 pathogenic or commensal lifestyle influences P450 content to such an extent that species belonging to

107 Previous studies implicate cytochrome P450 (CYP) 2B11 as an important clearance mechanism for

108 dentified rifamycin induced DMEs, cytochrome P450 (CYP) 2C8/3A4/3A5, SULT2A, and UGT1A4/1A5 and predi

109 g and diabetes suppressed hepatic cytochrome P450 (CYP) 2R1, the main vitamin D 25-hydroxylase respon

110 biphenyls (PCBs) is initiated by cytochrome P450 (CYP) enzymes and includes PCB oxidation to OH-meta

111 netic interactions with catabolic cytochrome P450 (CYP) enzymes can inhibit chemical elimination path

112 The human cytochrome P450 (CYP) enzymes CYP3A4 and CYP3A5 metabolize most dru

113 idonic acid epoxides generated by cytochrome P450 (CYP) enzymes have been linked to increased tumor g

114 ctional role of drug metabolizing cytochrome P450 (CYP) enzymes in human plasma exosomes are yet to b

115 The superfamily of hepatic cytochrome P450 (CYP) enzymes is responsible for the intrinsic clea

116 Human cytochrome P450 (CYP) enzymes play an important role in the metabol

117 to be derived from discoidol via cytochrome P450 (CYP)-catalyzed oxidative cleavage.

118 ase (COX), lipoxygenase (LOX), or cytochrome P450 (CYP).

119 Cytochrome P450 (CYP)3A is the most abundant CYP enzyme in the huma

120 onsible for drug metabolism (i.e. cytochrome P450 [CYP] 3A4, CYP1A2).

121 Cytochrome P450 (P450, CYP) enzymes are the major catalysts involved in t

122 Cytochromes P450 (P450, CYP) metabolize a wide variety of endogenous and e

123 The bacterial cytochrome P450 CYP101B1 from Novosphingobium aromaticivorans DSM 1

124 ethers (PBDEs) and induction of cytochrome's P450 (CYP1A1 and CYP2B isoforms) were evaluated.

125 Human cytochrome P450 (P450) CYP2B6 undergoes nitric oxide (NO)-dependent prote

126 expression and also analyzed for cytochrome P450 (CYP3A4) zonation and glycogen accumulation through

127 rt on a terpene synthase (DdTPS8)-cytochrome P450 (CYP521A1) gene cluster that produces a novel C12 t

128 avodiiron proteins (FLVs) or in a cytochrome p450 (CYP55), we show that FLVs contribute to NO reducti

129 establish that CYP6P9b combines with another P450, CYP6P9a, to additively exacerbate the reduced effi

130 resistant mosquitoes were detected, with the P450 Cyp6z18 showing the highest differential gene expre

131 gene encoding an uncharacterized cytochrome P450, CYP71A27 Loss of this gene resulted in 2 different

132 to leubethanol is catalyzed by a cytochrome P450 (CYP71D616) of the CYP71 clan.

133 leads to the identification of a cytochrome P450 (CYP728B70) that can catalyze oxidation of a methyl

134 Cytochromes P450 (CYPs) catalyze various oxidative transformations i

135 and selected supersomes of single cytochrome P450 (cyt P450) enzymes on the magnetic beads provided a

136 Cytochrome P450-dependent metabolism of the anti-HIV drug nevirapin

137 computationally-predicted endogenous target P450 detoxification genes, Cyp6g1 and Cyp6g2, and also a

138 sed that such chemoresistance via cytochrome P450/drug transporters can be reversed with the use of a

139 We identified a cytochrome P450 enzyme AsCYP72A475 as a triterpene C-21beta hydroxy

140 eport the characterization of the cytochrome P450 enzyme BotCYP from a bottromycin biosynthetic gene

141 ng of a 48-variant library of the cytochrome P450 enzyme CYP102A1 (P450BM3), followed by targeted mut

142 The catalysts, derived from a cytochrome P450 enzyme in which the native cysteine axial ligand ha

143 CYP17A1 is a cytochrome P450 enzyme with 17-alpha-hydroxylase and C17,20-lyase a

144 PE), TH regulates expression of a cytochrome P450 enzyme, cyp27c1, that converts vitamin A(1) into vi

145 tridone B is catalyzed by an epoxide-forming P450 enzyme, followed by carbon skeletal rearrangement.

146 he native C-H hydroxylation mechanism of the P450 enzyme.

147 teasomal degradation of the cytochrome P450 (P450) enzyme CYP2B6.

148 n-O-deethylase (EROD) activity of cytochrome P450 enzymes and continuous accumulation of fluoxetine a

149 fcutter bee, Megachile rotundata, lacks such P450 enzymes and is >2,500-fold more sensitive to the ne

150 However, extant P450 enzymes are typically relatively unstable, with T (

151 a to conduct the first large-scale survey of P450 enzymes associated with RiPP biosynthetic gene clus

152 d determined that the camalexin biosynthetic P450 enzymes copurified with these enzymes.

153 Cytochrome P450 enzymes have tremendous potential as industrial bio

154 PPARgamma pathway, and higher expression of P450 enzymes involved in VPA metabolism may underlie the

155 Mammalian cytochrome P450 enzymes often metabolize many pharmaceuticals and o

156 re metabolized and inactivated by cytochrome P450 enzymes primarily within the liver.

157 lpha-demethylases (CYP51) are the cytochrome P450 enzymes required for biosynthesis of sterols in euk

158 Reconstructed ancestral cytochrome P450 enzymes tend to have variable substrate selectivity

159 at several managed bee species have specific P450 enzymes that are preadapted to confer intrinsic tol

160 iptome data to identify candidate cytochrome P450 enzymes that may catalyse C-21beta oxidation.

161 ocatalytic platform of engineered cytochrome P450 enzymes to carry out efficient cyclopropene synthes

162 directed evolution, we engineered cytochrome P450 enzymes to catalyze this abiological reaction under

163 alkaloids tested inhibited select cytochrome P450 enzymes, suggesting a potential risk for adverse in

164 e and function of this unique class of plant P450 enzymes, we have characterized the enzyme C4H1 from

165 omatic cross-linking performed by cytochrome P450 enzymes.

166 -phenylimidazole, an inhibitor of cytochrome P450 enzymes.

167 adducts were compared with 10 different cyt P450 enzymes.

168 Cytochrome P450 (P450) enzymes are major catalysts involved in the oxidat

169 ed supersomes of single cytochrome P450 (cyt P450) enzymes on the magnetic beads provided a broad spe

170 me containing epoxidases, such as cytochrome P450 epoxidases.

171 cticide resistance mediated by the candidate P450s examined.

172 ct P450 function and, conversely, changes in P450 expression can influence HO-1.

173 ed genes, chitinase 1 (CHIT1) and cytochrome P450 family 1 subfamily B member 1 (CYP1B1), both previo

174 Cytochrome P450 family 102 subfamily A member 1 (CYP102A1) is a sel

175 The human cytochrome P450 family 11 subfamily B member 2 (hCYP11B2) gene enco

176 ism (SNP) rs7175922 in aromatase (cytochrome P450 family 19 subfamily A member 1 [CYP19A1]).

177 y reported that overexpression of cytochrome P450 family 24 subfamily A member 1 (CYP24A1) increases

178 ng to RA by catabolic activity of cytochrome P450 family 26 enzymes.

179 reases in homeobox A1 (Hoxa1) and cytochrome P450 family 26 subfamily A member 1 (Cyp26a1) transcript

180 Cytochrome P450 family 26 subfamily B member 1 (CYP26B1) regulates

181 Cytochrome P450 family 27 subfamily B member 1 (CYP27B1) and CYP24A

182 utaryl-CoA reductase (Hmgcr), and cytochrome P450 family 7 subfamily A member 1 (Cyp7a1), as well as

183 , flower-specific gene encoding a cytochrome P450 family 79D protein (PrCYP79D73), which catalyzed th

184 CYP2J2, a member of the Cytochrome P450 family of enzymes, is the most abundant epoxygenase

185 l genes coding for members of the cytochrome P450 family were upregulated.

186 mon genetic variation in CYP2C19 (cytochrome P450, family 2, subfamily C, polypeptide 19) *2 and *3 a

187 Since then, the P450 field has grown extensively, with significant progr

188 ssed this challenge by evolving a cytochrome P450 for highly efficient carbene transfer to indoles, p

189 Cytochrome P450 monooxygenases (P450s) found in all domains of life are known for their

190 with those of well-investigated cytochromes P450 from mammals and bacteria enabled us to identify th

191 road substrate scope, whereas the homologous P450 from tylosin-producing Streptomyces fradiae (TylHI)

192 es in HO-1 expression can potentially affect P450 function and, conversely, changes in P450 expressio

193 We studied a cytochrome P450 gene from A. officinalis, AoCYP94B1, and its putati

194 at cis-regulatory variants of the cytochrome P450 gene, CYP6P9b, are associated with pyrethroid resis

195 overexpression of the duplicated cytochrome P450 genes CYP6P9a and CYP6P9b, and also the fixation of

196 iptome analysis identified overexpression of P450 genes known to confer pyrethroid resistance (Cyp9K1

197 If giant virus P450 genes were acquired from a host, we suggest it coul

198 A number of cytochrome P450 genes were downregulated in response to infection.

199 bolism-based resistances include cytochromes P450, GSH S-transferases, glucosyl and other transferase

200 Cytochromes P450 have been recently identified as a promising class

201 nd interaction of nitric oxide (NO) with the P450 heme are necessary for NO to trigger ubiquitination

202 e comprising two major domains: a cytochrome P450 (heme-binding) catalytic domain and a NADPH-cytochr

203 Cytochrome P450 monooxygenases (CYPs/P450s), heme thiolate proteins, are well known for their

204 ycCI and biochemically characterized a third P450 homolog from the chalcomycin biosynthetic pathway i

205 of a BAHD acyltransferase and two cytochrome P450 hydroxylases.

206 ion of XplA and BezE, two "atypical" natural P450s implicated in the degradation of a man-made explos

207 Genome-wide analysis of P450s in 972 Firmicutes species belonging to 158 genera

208 and biocatalytically significant cytochrome P450s in cell lysate, microsomes, and bacteria.

209 he first report on comprehensive analysis of P450s in Firmicutes.

210 Determining the origin and function of P450s in giant viruses may help to discern the origin of

211 h genera have essentially the same number of P450s in the genome, Streptomyces P450s are much more di

212 The catalytic efficiency of P450s in these non-native transformations is however sig

213 P450 inhibitor piperonyl butoxide (PBO) significantly en

214 3A4 bind inhibitors rapidly and two distinct P450-inhibitor complexes exist en route to the final enz

215 me of the 57 human P450s and other mammalian P450s is more complex than a two-state system and has be

216 -specific probe for CYP3A4, a key cytochrome P450 isoform responsible for the oxidation of most clini

217 Atropselective analysis revealed P450 isoform-dependent and congener-specific atropselect

218 achlorobiphenyl (PCB 136) by different human P450 isoforms.

219 cal phenomena can be proposed to predict how P450s may achieve various other modes of reactivity by c

220 This study shows that the P450-mediated metabolic resistance imposes a high fitnes

221 w of the evidence for presence of cytochrome P450-mediated metabolic resistance mechanisms across Afr

222 he fitness cost associated with the CYP6P9a (P450-mediated metabolic resistance) in the major African

223 emonstrate that while deuteration can reduce P450 metabolite formation, impacts on phase II metabolis

224 , a naturally occurring bioactive cytochrome P450 metabolite of docosahexaenoic acid, a major constit

225 yeicosatetraenoic acid (EEQ) is a cytochrome P450 metabolite of eicosapentaenoic acid (EPA) and a pow

226 sidered when employing deuteration to reduce P450 metabolite-related hepatotoxicity.

227 = 0.83 [0.69, 0.96]), followed by cytochrome p450 metabolites using adaptive elastic-net (AUC = 0.74

228 the first example of a wild-type cytochrome P450 monooxygenase (CYP116B46 from Tepidiphilus thermoph

229 Additionally, a cytochrome P450 monooxygenase (CYP99A17), which genomically cluster

230 We report that a wild-type cytochrome P450 monooxygenase (P450(BM3) from Bacillus megaterium,

231 4-hydroxylase (C4H; CYP73A) is a cytochrome P450 monooxygenase associated externally with the endopl

232 The cytochrome P450 monooxygenase P450 BM3 (BM3) is a biotechnologicall

233 pid hole hopping escape routes in cytochrome P450 monooxygenase, cytochrome c peroxidase, and benzyls

234 They are synthesized by cytochrome P450 monooxygenases (CYPs) and degraded by soluble epoxi

235 Cytochrome P450 monooxygenases (CYPs/P450s), heme thiolate proteins

236 Cytochrome P450 monooxygenases (P450s) found in all domains of life

237 Cytochrome P450 monooxygenases (termed CYPs or P450s) are hemoprote

238 he heme ligation in chloroperoxidases or cyt P450 monooxygenases and peroxidases, respectively.

239 epoxidation of aromatic nuclei by cytochrome P450 monooxygenases is one of the major metabolic pathwa

240 rr strain, whereas induction of ALDH1A1 and P450 mRNAs was similar between the strains.

241 Previously, we discovered that the bacterial P450 MycCI from the mycinamicin biosynthetic pathway in

242 ing enabled identification of the cytochrome P450, NzeB (Streptomyces sp. NRRL F-5053), which catalyz

243 We also found that cytochrome P450 oxidases involved in cutin and suberin production a

244 owing oral THC administration for cytochrome P450 oxidoreductase (Por), involved in toxin processing

245 Congenital adrenal hyperplasia due to P450 oxidoreductase deficiency results in disrupted dehy

246 ical bioreductive enzymes such as cytochrome P450 oxidoreductase is likely to be futile.

247 to a carboxylic group by TcCHH, a cytochrome P450 oxidoreductase.

248 Human cytochrome P450 (P450) 11B2 catalyzes the formation of aldosterone,

249 enantiomers of this inhibitor of cytochrome P450 (P450) 17A1 show some selectivity in differentially

250 Cytochrome P450 (P450) 3A4 is the enzyme most involved in the metab

251 Human cytochrome P450 (P450) CYP2B6 undergoes nitric oxide (NO)-dependent

252 nt proteasomal degradation of the cytochrome P450 (P450) enzyme CYP2B6.

253 Cytochrome P450 (P450) enzymes are major catalysts involved in the

254 Cytochrome P450 (P450, CYP) enzymes are the major catalysts involve

255 Cytochromes P450 (P450, CYP) metabolize a wide variety of endogenous

256 techniques, and discovered a pivotal role of P450-P450 interactions and of multiple-ligand binding.

257 Heme oxygenase 1 (HO-1) and the cytochromes P450 (P450s) are endoplasmic reticulum-bound enzymes tha

258 Cytochromes P450 (P450s) are nature's catalysts of choice for perfor

259 ER)-anchored monotopic proteins, cytochromes P450 (P450s), are enzymes that metabolize endobiotics (p

260 e treated with OCA, the levels of cytochrome P450 potentially involved in VPA metabolism were increas

261 ong eicosanoids, lipoxygenase and cytochrome p450 products performed best in identifying overall and

262 y versus other PDE enzymes, clean cytochrome P450 profile, in vivo target occupancy, and promise for

263 of lifestyle seems to profoundly affect the P450 profiles in the bacterial species belonging to the

264 , plants, oomycetes and fungi has shown that P450s profiles in these organisms are affected by their

265 However, the impact of lifestyle on P450 profiling in bacteria is scarcely reported.

266 The cytochrome P450 proteins contain heme as a cofactor and are involve

267 stabilization is of the functionally active P450 proteins, leading to corresponding statistically si

268 functional features of C4H to those of other P450 proteins.

269 ing) catalytic domain and a NADPH-cytochrome P450 reductase (CPR) domain containing FAD and FMN cofac

270 cytochrome b5 reductase (B5R) and cytochrome P450 reductase (CPR) were measured in aortic SMCs.

271 t rely on the same protein, NADPH-cytochrome P450 reductase (POR), to provide the electrons necessary

272 The enzyme uses NADPH-cytochrome P450 reductase as a donor of electrons and hydroxylates

273 ns and a large deletion of the non-catalytic P450 reductase domain, which chemoselectively C(3)-alkyl

274 cted of cytochrome P450 and NADPH-cytochrome P450 reductase domains.

275 the interaction of CYP71A13 and Arabidopsis P450 Reductase1 was observed.

276 tion of a reconstructed ancestral cytochrome P450, revealing key features that appear to contribute t

277 nerated from the combination of an evolvable P450 scaffold and an iridium-porphyrin cofactor.

278 sions in the glycosyltransferase, cytochrome P450, shikimate hydroxycinnamoyl transferase, lysine dec

279 Cytochrome P450 side-chain cleavage enzyme (SCC or CYP11A1) catalyz

280 st 40 years, my interest has been cytochrome P450 structure-function and structure-activity relations

281 oxygenases; however, the recently discovered P450 subfamily TxtE utilizes O(2) and NO to nitrate arom

282 e findings highlight the complexity of human P450-substrate interactions and that conformational-sele

283 Our work highlights the complex nature of P450/substrate interactions and raises interesting quest

284 on and diversity of the enormously important P450 superfamily.

285 improves subsequent decoration by cytochrome P450s, supporting efficient conversion of (S)-(-)-limone

286 Although the HO-1 and P450 systems are interconnected owing to their common el

287 ly, we identified a non-canonical cytochrome P450 that catalyses the remarkable ring expansion reacti

288 sterol 14alpha-demethylases) are cytochromes P450 that catalyze multistep reactions.

289 independently recruited pairs of cytochromes P450 that catalyze oxidative 5,6-spiroketalization of ch

290 the identification of CYP88A13, a cytochrome P450 that catalyzes the C-16alpha hydroxylation of medic

291 oid-resistant, often with elevated levels of P450s that can metabolise and neutralise diverse substra

292 n be applied to mechanistic studies of other P450s that catalyze multistep reactions, such as C-C bon

293 Here, we describe P450s that catalyze the O-demethylation of lignin-derive

294 o be involved in secondary metabolism and 89 P450s that function in the synthesis of specific seconda

295 This effort yielded a P450 variant with 11 amino acid substitutions and a larg

296 Directed evolution of a serine-ligated P450 variant, P411-C10, yielded a lineage of engineered

297 that enabled rapid analysis of thousands of P450 variants and comprehensive directed evolution via r

298 The Adler phage P450 was classified as CYP102L1, and the crystal structu

299 genetically encoded cytochrome P411 enzymes (P450s whose Cys axial ligand to the heme iron has been r

300 By identifying related P450s with complementary specificities for lignin-releva

301 lus, Lactococcus and Leuconostoc do not have P450s, with the exception of a handful of Staphylococcus