ライフサイエンスコーパス: PABP

1 PABP also interacts genetically and biochemically with E

2 PABP and eIF4B compete with eIF4A for binding eIFiso4G i

3 PABP binds several translation factors but is primarily

4 PABP cleavage did not affect eIF4GI-PABP interactions, a

5 PABP cleavage may be a common mechanism among certain vi

6 PABP has been found to stimulate translation initiation

7 PABP increases the efficiency of translation termination

8 PABP is able to bind the poly(A) tail of mRNA, as well a

9 PABP's function in translation termination depends on it

10 PABPs accelerate miRNA-mediated deadenylation, but this

11 ith the SG marker poly(A)-binding protein 1 (PABP-1), whereas inclusions in spinal cord, which contai

12 tein 3, and polyadenylate-binding protein 1 (PABP-1).

13 by the eukaryotic initiation factor (eIF) 4G/PABP/poly(A) tail interaction is achieved instead throug

14 und to be an mCRD-binding protein and also a PABP-interacting protein.

15 y and sufficient to regulate expression of a PABP TOP-containing reporter.

16 iation time of a cooperatively bound poly(A)/PABP complex as compared with a noncooperatively bound o

17 However, approximately 50% of the poly(A)/PABP complexes exhibit a noncooperative binding conforma

18 t translational initiation, shifted mRNA-A3G-PABP from polysomes into stress granules in a manner tha

19 ntrol animals receiving MCT injection alone (PABP 49.67+/-3.22 mmHg; RV/WH ratio 0.290+/-0.0265; wall

20 genome and by interactions with 2C, 3A, and PABP.

21 -related protein-4 (LARP4) binds poly(A) and PABP.

22 s assessed mechanisms whereby aldolase C and PABP control NF-L expression.

23 of mRNAs by simultaneously binding CAF1 and PABP.

24 there are interaction domains for eIF4A and PABP and we identify, for the first time, the interactio

25 Moreover, the eIF4B and PABP binding domains overlap.

26 A binding domain overlaps with the eIF4B and PABP binding domains.

27 c promoted the interaction between eIF4B and PABP but not the interaction between eIF4B and eIF4A or

28 These studies show that eIF4B and PABP enhance the interaction with the cap and probably a

29 However, when both eIF4B and PABP were present, not only was the energy barrier reduc

30 eIFiso4G was also observed between eIF4B and PABP.

31 promoting the interaction between eIF4B and PABP.

32 , respectively, in the presence of eIF4B and PABP.

33 osition, marked by dissociation of eIF4G and PABP, and by recruitment of DDX6.

34 f the core mRNP components eIF4E, eIF4G, and PABP and of the decay factor DDX6 in human cells.

35 In contrast, eIF3, G3BP, eIF4G, and PABP-1 are restricted to SGs, whereas DCP1a and 2 are co

36 ever, the relative importance of eIF4GII and PABP cleavage has not been determined.

37 onal repression of unlocalized grk mRNA, and PABP and Enc facilitate translational activation of the

38 talizing interplay between LARP4A, polyA and PABP.

39 A was found to be important for both RNA and PABP recognition, revealing a new role for this protein-

40 nd disrupted the association between TYF and PABP.

41 Interaction between UNR and PABP is necessary for the full destabilization function

42 tly measure interactions between poly(A) and PABPs.

43 Wheat PABP differs from animal PABP in that its RRM1 does not bind RNA as an individual

44 Although animal PABPs are well-studied proteins, the biological role, th

45 of cross-regulation between the Arabidopsis PABPs that belong to different classes but are simultane

46 urodegenerative disease-related proteins are PABPs.

47 with 2-[N-(alpha-picolyl)amino]benzophenone (PABP)] 2 via alkyl halide alkylations and Michael additi

48 The interaction between PABP and eIFiso4G was also stimulated by zinc but requir

49 ults demonstrate a novel interaction between PABP and several plant proteins sharing a SxLnpxApxFxP m

50 Lsm/LsmAD domain and indirectly via binding PABP that is itself directly bound to mRNA.

51 ression, which interferes with poly(A)-bound PABP, precluding PABP-enhanced microRNA-mediated inhibit

52 grated with other PAM2 protein activities by PABP as part of mRNA homeostasis.

53 viral replication compartments surrounded by PABP.

54 ection, only 25 to 35% of the total cellular PABP is cleaved; therefore, we hypothesized that the poo

55 ble database of experimentally characterized PABPs.

56 Also, 3C(pro) is more efficient in cleaving PABP in ribosome-enriched fractions than 2A(pro) in vitr

57 ble to immunoprecipitate BC1 RNA, confirming PABP's presence in the BC1 RNP.

58 C domain interaction between two consecutive PABPs promotes cooperative binding.

59 KPAF4, a pentatricopeptide repeat-containing PABP which sequesters the A-tail and impedes mRNA degrad

60 premature termination codon, by controlling PABP activity.

61 m cells/neurons) and/or limiting cytoplasmic PABP (e.g., viral infection, cell stress).

62 ePAB is the predominant cytoplasmic PABP in Xenopus oocytes and early embryos and prevents d

63 Thus, cytoplasmic PABP accumulation is translationally controlled in HCMV-

64 The DB-PABP is a comprehensive, manually curated and searchable

65 The DB-PABP is maintained at the University of Kansas.

66 The DB-PABP was implemented as a MySQL relational database.

67 Assaying RNA-dependent PABP-eIF4G association in cell extracts suggests that RN

68 validating that this is the sole detectable PABP cleavage site.

69 The kinetic effects of eIF4B, PABP, and wheat germ eIFiso4F with two mRNA cap analogue

70 l as other initiation factors (eIF4A, eIF4G, PABP, and eIF3).

71 PABP cleavage did not affect eIF4GI-PABP interactions, and the results of kinetics experimen

72 th explain little of the variation in either PABP association or mRNP organization more generally.

73 We find that C. elegans PABPs are required for miRNA-mediated silencing in embry

74 we implicate the two Caenorhabditis elegans PABPs (PAB-1 and PAB-2) in miRNA-mediated silencing, and

75 The 5' UTR within the mRNA encoding PABP contains a terminal oligopyrimidine (TOP) element f

76 ical and biochemical depletion of endogenous PABP increases the instability of the transcript suggest

77 In contrast, eight expressed PABP genes are present in Arabidopsis thaliana.

78 t eukaryotes examined have only one or a few PABPs.

79 hemistry of eRF3 and PAIP1/2 competition for PABP binding, we quantified the effects of PAIPs on tran

80 onic mRNAs and resulted in a requirement for PABP.

81 ive mode is the most stable conformation for PABPs binding onto the poly(A).

82 IP1 and PAIP2 inhibited the activity of free PABP on translation termination in vitro However, after

83 t ICP27 and UL47 jointly displace Paip2 from PABP.

84 for a particular modulator of PABP function, PABP-interacting protein 2a (PAIP2A), in the normal term

85 f the nucleophilic glycine equivalent Ni-Gly-PABP [Ni(II) complex of glycine Schiff base with 2-[N-(a

86 leotides and phasing consistent with greater PABP dissociation in the absence of LARP4.

87 rget mRNA deadenylation, and identify GW182, PABP, and deadenylase subunits CAF1 and CCR4 as factors

88 As little is known about how PABP can interact with RNA and three distinct translatio

89 s reveal a novel direct involvement of human PABP in the stabilization of mRNA by protecting the 5' e

90 , therefore, is reminiscent of that of human PABP-interacting protein 2 (Paip2).

91 d domain (SxLnpnApxFxP) in common with human PABP-CT interactors, and with Arabidopsis ERD15 (early-r

92 Surprisingly, ICP27-PABP-eIF4G complexes act independently of the effects of

93 Importantly, we find that ICP27-PABP forms a complex with, and requires the activity of,

94 on structural information concerning type II PABPs and an example of a single RRM domain protein that

95 nd are relevant to understanding how type II PABPs function in mRNA processing and human disease.

96 Remarkably, preventing the rise in PABP abundance by RNAi impaired eIF4E binding to eIF4G,

97 inding to their overlapping binding sites in PABP by preferentially promoting the interaction between

98 ing protein (PABP), significantly increasing PABP abundance.

99 Instead, HCMV-induced PABP accumulation resulted from new protein synthesis an

100 While virus-induced PABP accumulation did not require p70 S6K, it was inhibi

101 e, zebrafish and Drosophila further involved PABPs in microRNA (miRNA)-mediated silencing, but throug

102 This LARP4 activity requires its PABP-interaction domain and the RNA-binding module which

103 nical translation factor, eIF4G, which lacks PABP- and cap binding complex-interacting domains, is re

104 hat includes the RNA-binding proteins Larp1, PABP, and Ago2.

105 a commonality matrix, a function of listing PABPs by the number of interacting polyanions and a stri

106 Here we demonstrate that the minor PABP isoform PABPC4 is expressed in erythroid cells and

107 nts include the RNA binding proteins Modulo, PABP, and Smooth, the known localization factor Swallow,

108 to enhance formation of activated eIF4F*mRNA*PABP complexes competent to recruit 43S pre-initiation c

109 pping functions in forming native eIF4G*mRNA*PABP complexes.

110 e extracts was almost completely in A3G-mRNA-PABP complexes that shifted reversibly between polysomes

111 mmunofluorescence microscopy showed A3G-mRNA-PABP stress granules only partially overlapping with Sta

112 In human ALS spinal cord neurons, PABP accumulates abnormally, suggesting that prolonged s

113 Here, we establish that new PABP synthesis is translationally controlled by the HCMV

114 Decreased nuclear PABP availability is accompanied by genome-wide changes

115 sPABPN1 has a domain architecture of nuclear PABPs (PABPNs) with a single RNA recognition motif (RRM)

116 ells, where PABP is redistributed to nuclei, PABP accumulated in the cytoplasm of HCMV-infected cells

117 on termination in the presence or absence of PABP.

118 F4G protein levels, the overall abundance of PABP mRNA, together with the half-life of the polypeptid

119 ition was poly(A) dependent, and addition of PABP to extracts restored translation.

120 2 decapping activity reduced the affinity of PABP for cap association and consequently its ability to

121 The specific association of PABP with the cap occurred only within the context of th

122 ng, suggestive of a regulated association of PABP with the cap.

123 as microRNAs, influence the associations of PABP and other core factors, and do so without substanti

124 In addition, binding of PABP to poly(A) RNA stimulates 3C(pro)-mediated cleavage

125 Binding of PABP to the RNA 5' end required the presence of the cap

126 g poly(A) tails, suggesting that cleavage of PABP and IRES trans-activating factors polypyrimidine tr

127 ), like PV 3C(pro), mediates the cleavage of PABP as part of its strategy to inhibit cellular transla

128 d the substrate determinants for cleavage of PABP by 2A protease (2A(pro)) or 3C protease (3C(pro)).

129 t translation shutoff, requiring cleavage of PABP by 3Cpro and of eIF4G by 2Apro.

130 bit cap-poly(A) synergy, partial cleavage of PABP by 3Cpro inhibited translation of endogenous mRNAs

131 These results suggest that cleavage of PABP contributes to viral translation shutoff that is re

132 ecific proteins accumulated, and cleavage of PABP occurred in virus-infected cells.

133 efines a unique mechanism whereby control of PABP abundance regulates eIF4F assembly.

134 o interact with the carboxy terminus (CT) of PABP in yeast two-hybrid and in vitro binding assays.

135 data illustrate the importance of the CTD of PABP in poly(A)-dependent translation in mammalian cells

136 f these polypeptides modulates the degree of PABP-mediated enhancement of mRNA expression.

137 2 (PAIP1 and PAIP2), bind the same domain of PABP and regulate its translation-related activity.

138 proteases separated the C-terminal domain of PABP that binds translation factors eIF4B and eRF3 from

139 make direct contact with the MLLE domain of PABP, and their competition for the MLLE is thought to r

140 F3 from the N-terminal RNA-binding domain of PABP.

141 The effect of PABP cleavage by the norovirus r3CL(pro) was analyzed in

142 omplexes act independently of the effects of PABP-eIF4G on cap binding to promote small ribosomal sub

143 s its levels of expression when an excess of PABP is transiently provided in trans.

144 Immunoprecipitation of PABP-associated ribonucleoprotein complexes of human spi

145 virus infection and that the interaction of PABP with translation initiation factors, ribosomes, or

146 nting LARP4 PAM2w interacts with the MLLE of PABP within the affinity range measured for other PAM2 m

147 unctional role for a particular modulator of PABP function, PABP-interacting protein 2a (PAIP2A), in

148 nd eIF4B interact with distinct molecules of PABP to increase the stability of the interaction betwee

149 RNA-binding protein, as a binding partner of PABP that interacts with PABP in an RNA-independent mann

150 therefore, we hypothesized that the pool of PABP associated with polysomes may be preferentially tar

151 have investigated what cleavage products of PABP are produced in vivo and the substrate determinants

152 n representing the C-terminal end of RRM1 of PABP that overlaps with the N-proximal eIFiso4G interact

153 n domain for eIF4G is present in the RRM1 of PABP, whereas eIFiso4G interacts at two sites, i.e. one

154 nc controls the partner protein selection of PABP such that the interaction with eIF4B is preferred o

155 An antibody against the C terminus of PABP is able to immunoprecipitate BC1 RNA, confirming PA

156 The N-terminus of PABP is responsible for the high binding specificity and

157 r a comprehensive and searchable database of PABPs.

158 henotypes are mitigated by overexpression of PABPs, inhibition of rDNA transcription, or alterations

159 evelopment through the direct recruitment of PABPs.

160 Our results refine the roles of PABPs in miRNA-mediated silencing and support a model wh

161 th the poly(A) tail exacerbate dependency on PABP for deadenylation, more potent miRNA-binding sites

162 icantly, Paip2 accumulation was dependent on PABP accrual, as preventing PABP1 accumulation suppresse

163 agment identified a 3C(pro) cleavage site on PABP between amino acids Q437 and G438, severing the C-t

164 Mutagenesis of the RNA binding or PABP interaction motifs decrease LARP4 association with

165 4A with eIFiso4G in the presence of eIF4B or PABP.

166 y reduced in the presence of either eIF4B or PABP.

167 Thus, a better understanding of PA/PABP interactions may not only enhance our understanding

168 n of 3Cpro in HeLa cells resulted in partial PABP cleavage and similar inhibition of translation.

169 PC1, but not its physiologic binding partner PABP-interacting protein 2 (Paip2), in the nucleus.

170 cumber ( Cucumis sativus L.) proteins, PCI6 (PABP-CT-interacting) and PCI243 were identified based on

171 esting that the diversification of the plant PABP genes has occurred prior to the split of monocots a

172 onal structure and RNA-binding mode of plant PABPs remain largely uncharacterized.

173 Such a high complexity of the plant PABPs might enable a very fine regulation of organismal

174 which enhanced binding of eIF4G and possibly PABP with 100k protein, and simultaneous interaction wit

175 terferes with poly(A)-bound PABP, precluding PABP-enhanced microRNA-mediated inhibition and canonical

176 nt reduction in pulmonary arterial pressure (PABP, 31.67+/-6.03 mmHg, P<0.01), an attenuation of righ

177 The norovirus r3CL(pro) PABP cleavage products were indistinguishable from those

178 hat 3C(pro) plays a major role in processing PABP during virus infection and that the interaction of

179 further indicate that RNA1 and Box1 promote PABP binding, in addition to RNA binding, by the eIF4G1

180 tion with PABP that is sufficient to promote PABP recruitment and necessary for ICP27-mediated activa

181 o by the cytoplasmic poly(A)-binding protein PABP through a direct and specific binding to the 5' end

182 ase (3Cpro) cleaves poly(A)-binding protein (PABP) and removes the C-terminal domain (CTD) that inter

183 f stress granules, poly (A) binding protein (PABP) and TIA-1, appear to be present in the oocyte RNP

184 mains for eIF4E and poly(A)-binding protein (PABP) are thought to enhance formation of activated eIF4

185 decided to examine poly(A) binding protein (PABP) as a candidate member of the RNP.

186 hown here that the poly (A)-binding protein (PABP) binds the body of the NF-L transcript and increase

187 Cleavage of poly(A)-binding protein (PABP) by 3C(pro) has been shown to be a necessary compon

188 script excludes the poly(A)-binding protein (PABP) from the complex.

189 vage of eIF4GII and poly(A)-binding protein (PABP) has been recently proposed to contribute to comple

190 Participation of a poly(A) binding protein (PABP) in coupling of editing and 3' modification process

191 radictory roles for poly(A)-binding protein (PABP) in facilitating both protection and deadenylation.

192 ere found to cleave poly(A)-binding protein (PABP) in the absence of other viral proteins.

193 We show that Cup and polyA-binding protein (PABP) interact physically with Sqd and with each other i

194 bundant cytoplasmic poly(A) binding protein (PABP) is a highly conserved multifunctional protein, man

195 Poly(A)-binding protein (PABP) is a major component of the messenger RNA-protein

196 Eukaryotic poly(A)-binding protein (PABP) is a ubiquitous, essential factor involved in mRNA

197 A FLAG-tagged poly(A)-binding protein (PABP) is expressed in a specific tissue and mRNA from th

198 nctional homolog of poly(A) binding protein (PABP) known as nonstructural protein 3 (NSP3) for transl

199 equestration of the poly(A)-binding protein (PABP) Nab2.

200 fection on the host poly(A)-binding protein (PABP) remains unknown.

201 Polyadenylate-binding protein (PABP) stimulates translation termination via interaction

202 ssociate with polyadenylate-binding protein (PABP) suppressed behavioral rhythms and decreased abunda

203 E), eIF4G, and poly(A) tail-binding protein (PABP) that circularizes mRNAs, promoting translation and

204 oly(A) tail and the poly(A)-binding protein (PABP) to achieve maximal IRES-mediated translational eff

205 ins aldolase C and poly (A)-binding protein (PABP) undergo competitive interactions in cells coexpres

206 iation of the polyadenylate-binding protein (PABP) with the cap-binding complex.

207 The poly(A)-binding protein (PABP), a key component of different ribonucleoprotein co

208 h polyribosomes and poly(A)-binding protein (PABP), a key regulator of mRNA translation.

209 The poly(A)-binding protein (PABP), a protein that contains four conserved RNA recogn

210 ncoding eIF4E, Larp1, polyA binding protein (PABP), and Ago2.

211 A, eIF4G, eIF3, the poly(A)-binding protein (PABP), and RNA.

212 on factor eIF4G and poly(A)-binding protein (PABP), and strongly and selectively enhances the level o

213 ap-binding complex, poly(A)-binding protein (PABP), as well as per and tim transcripts.

214 sis of the cellular poly(A) binding protein (PABP), significantly increasing PABP abundance.

215 il becomes bound by poly(A) binding protein (PABP), which in turn binds eIF4G and helps it displace M

216 he MLLE domain of the PolyA-binding protein (PABP).

217 F-associated factor poly(A) binding protein (PABP).

218 A and interact with poly(A) binding protein (PABP).

219 nteracting with the poly(A) binding protein (PABP).

220 anslation regulator poly(A)-binding protein (PABP).

221 as well as cellular poly(A) binding protein (PABP).

222 rs, mRNA, rRNA, and poly(A) binding protein (PABP).

223 the cellular polyadenylate-binding protein (PABP).

224 y(A) tail (PAT) and poly(A)-binding protein (PABP).

225 ds both poly(A) and poly(A)-binding protein (PABP).

226 ss granule component, polyA-binding protein (PABP).

227 eraction with polyadenylate-binding protein (PABP).

228 eIF4GI, poly(A)-binding protein (PABP)1, eIF3, eIF4AI, and eIF2alpha coimmunopurify with

229 Poly(A)-binding proteins (PABPs) are multifunctional proteins that play important

230 otides (poly A) and poly A binding proteins (PABPs) for optimal expression, we complexed synthetic mR

231 anions (PAs) and polyanion-binding proteins (PABPs) have been found to play significant roles in many

232 Cytoplasmic poly(A)-binding proteins (PABPs) link mRNA 3' termini to translation initiation fa

233 Poly(A)-binding proteins (PABPs) play crucial roles in mRNA biogenesis, stability,

234 Poly(A) binding proteins (PABPs) specifically bind the polyadenosine tail of mRNA

235 eins interact with poly(A)-binding proteins (PABPs), which are critical for the initiation of transla

236 and A3F, including poly(A)-binding proteins (PABPs), YB-1, Ro-La, RNA helicases, ribosomal proteins,

237 ons of the cognate poly(A)-binding proteins (PABPs).

238 ail and associated poly(A)-binding proteins (PABPs).

239 bacterially expressed 3C cleaved recombinant PABP in vitro in the absence of any virus-encoded or euk

240 partially rescued by addition of recombinant PABP in vitro.

241 hat tissue is thus tagged by the recombinant PABP and separated from mRNA in other tissues by co-immu

242 iverse RNA-binding proteins directly recruit PABP, in a non-poly(A) tail-dependent manner, to stimula

243 Expression of 3C(pro) cleavage-resistant PABP in cells increased translation of nonreplicating vi

244 Further, expression of cleavage-resistant PABP in cells reduced the accumulation of viral RNA and

245 fected cells expressing a cleavage-resistant PABP variant, viral RNA synthesis and infectious virus p

246 ction of this activity, the levels of RPS17, PABP, eEF1A, and eEF2 proteins are also diminished in DM

247 NA decay at short lengths known to sensitize PABP dissociation in response to deadenylation machinery

248 es and RNA-binding mode of a Citrus sinensis PABP (CsPABPN1).

249 Vertebrates encode six PABP isoforms that vary in abundance, distribution, deve

250 he EMCV 3C proteinase mediates site-specific PABP cleavage and demonstrate that PABP cleavage by 3C r

251 that EMCV infection stimulates site-specific PABP proteolysis, resulting in accumulation of a 45-kDa

252 se was necessary and sufficient to stimulate PABP cleavage in uninfected cells, and bacterially expre

253 whereas the C-terminus is known to stimulate PABP multimerization on poly(A).

254 tro However, after binding the poly(A) tail, PABP became insensitive to suppression by PAIPs and effi

255 s poly(A) nuclease(s) to the 3' poly(A) tail-PABP complex.

256 minal sequencing of the resulting C-terminal PABP fragment identified a 3C(pro) cleavage site on PABP

257 thermore, we have identified four N-terminal PABP cleavage products produced during PV infection and

258 lting in accumulation of a 45-kDa N-terminal PABP fragment in virus-infected cells.

259 -specific PABP cleavage and demonstrate that PABP cleavage by 3C regulates EMCV replication.

260 Our findings indicate that PABP-eIF4G association is only one of several interactio

261 an in vitro translation system, we show that PABP directly stimulates translation termination.

262 Our results show that PABP in ribosome-enriched fractions is preferentially cl

263 Based on our findings, we suggest that PABP enhances the productive binding of the eRF1-eRF3 co

264 ansposition process, these data suggest that PABP may contribute to the SINE retrotransposition proce

265 nstability of the transcript suggesting that PABP shields the NF-L mRNA from aldolase attack.

266 The PABP interaction domains for eIF4G and eIFiso4G were dis

267 in Azoospermia-like (Dazl), also employs the PABP-eIF4G interaction in a similar manner.

268 t eIF4G1 can functionally substitute for the PABP-binding segment to rescue the function of an eIF4G1

269 slational activation and the function of the PABP-eIF4G complex in translation initiation.

270 tivate translation initiation as part of the PABP-eIF4G-eIF4E complex that stimulates the initial cap

271 ion in cell extracts suggests that RNA1, the PABP-binding domain, and two conserved elements (Box1 an

272 line with previous studies showing that the PABP C-terminal domain also interacts with additional pr

273 leavage and a competing interaction with the PABP.

274 nd eIFiso4G exhibited competitive binding to PABP, supporting the overlapping nature of their interac

275 lly cleaved in vitro and in vivo compared to PABP in other fractions.

276 Although total PABP levels were unchanged, HSV-1 infection prompted acc

277 Using glutathione S-transferase-PABP pull-down and proteomic analyses, we identified sev

278 F2alpha in the pioneer round of translation, PABP-interacting protein 2, which is known to destabiliz

279 transposon and a nonfunctional transposase (PABP 44.33+/-4.04 mmHg; RV/WH ratio 0.280+/-0.01; wall t

280 ition vector, we examined the effects of two PABPs (encoded by PABPN1 and PABPC1) on the retrotranspo

281 ation (i.e., the internal arrangement of two PABPs on a poly(A) streak in which the C-termini face to

282 ooperative binding conformation of wild-type PABPs indicates that the C-C domain interaction doubles

283 Furthermore, the variant PABP-interacting motif 2 (PAM2w) featured in the N-termi

284 mphasize that closed-loop mRNP formation via PABP-eIF4G interaction is non-essential in vivo.

285 Wheat PABP differs from animal PABP in that its RRM1 does not

286 of the protein interaction domains in wheat PABP was investigated.

287 a- or gammaherpesvirus-infected cells, where PABP is redistributed to nuclei, PABP accumulated in the

288 Paradoxically, while PABP accumulation promotes human cytomegalovirus (HCMV)

289 mediates a physical interaction of ATX2 with PABP in addition to promoting ATX2 assembly with polyrib

290 sults suggest that ORF transit combined with PABP function contribute to interactions between ribosom

291 dent, and replenishment of the extracts with PABP restored translation.

292 FUS to stress granules and interaction with PABP are RNA dependent.

293 We reveal a direct interaction with PABP that is sufficient to promote PABP recruitment and

294 binding partner of PABP that interacts with PABP in an RNA-independent manner.

295 mammalian neurons MKRN1-short interacts with PABP to locally control the translation of dendritic mRN

296 nal dendrites, MKRN1-short co-localizes with PABP in granule-like structures, which are morphological

297 nd in proteins that interact physically with PABP.

298 maintain poly(A)-RNA levels in balance with PABPs and other RBPs with mutable substrate specificity

299 he post-transcriptional level, compared with PABPs of other eukaryotes.

300 synthetic mRNA containing a poly A tail with PABPs in a stoichiometric manner and stabilized the ribo