ライフサイエンスコーパス: PACS

1 PACS and CR provide cost savings only when a 12-year har

2 PACS patients encountered at tertiary referral centers m

3 PACS provides a general new technical capability that ex

4 PACS was achieved by PCR with a set of primers to anchor

5 PACS-1 associates with both AP-1 and AP-3, but not AP-2,

6 PACS-1 connects the clathrin adaptor AP-1 to acidic clus

7 PACS-1 directs the TGN localization of furin by binding

8 PACS-1 is a cytosolic protein involved in controlling th

9 PACS-1 is a cytosolic sorting protein that directs the l

10 PACS-1 is an intracellular sorting protein that mediates

11 PACS-1 knockdown results in the proteasome-mediated degr

12 PACS-1 links GGA3 to CK2, forming a multimeric complex r

13 PACS-1 progressively accumulates in the nucleus during c

14 PACS-1 re-expression through LNA-hsa-anti-miR-34a or -44

15 PACS-1-bound CK2 stimulates GGA3 phosphorylation, releas

16 PACS-2 also controls formation of ER lipid-synthesizing

17 PACS-2 co-localizes with ADAM17 on early endosomes and P

18 PACS-2 controls the apposition of mitochondria with the

19 PACS-2 is phosphorylated at Ser437 in vivo, and pharmaco

20 PACS-2 loss reduces ADAM17 cell-surface levels and ADAM1

21 osphofurin acidic cluster-sorting protein 1 (PACS-1) in the ciliary trafficking of the olfactory cycl

22 osphofurin acidic cluster sorting protein-1 (PACS-1) binding sites in the cytoplasmic tail caused Pol

23 osphofurin acidic cluster sorting protein-1 (PACS-1) is a multifunctional membrane traffic regulator

24 e for all 3 outcomes (sibling diagnosis: (1) PACS/PAC/PACG vs. OA, (2) PAC/PACG vs. PACS/OA, and (3)

25 licated in a second independent group of 165 PACS subjects.

26 osphofurin acidic cluster sorting protein 2 (PACS-2), mitofusins (Mfn1/2), and dynamin related protei

27 osphofurin acidic cluster sorting protein-2 (PACS-2) to acidic residues in the carboxyterminal tail o

28 osphofurin acidic cluster sorting protein-2 (PACS-2) to DR5-positive endosomes in Huh-7 cells where i

29 Two hundred ninety-eight eyes (231 PACS, 67 PAC or PACG) of 298 patients were analyzed.

30 f 71 AAC eyes, 71 fellow eyes of AAC, and 25 PACS eyes were recruited.

31 A PACS workstation significantly decreased the delays in o

32 e TGN localization of furin is directed by a PACS-1-mediated retrieval step.

33 The use of a PACS can result in the elimination of multiple time-inte

34 Use of a PACS improves the delivery of chest images, facilitates

35 examination was taken, and the presence of a PACS workstation influenced the time from radiographic e

36 taken at night or day, and the presence of a PACS workstation were significant predictors of the elap

37 ngles on paracoronal reformations by using a PACS angle tool.

38 iography (CR) hard copy, was compared with a PACS, which used CR images displayed on a multiviewer in

39 died in long-term longitudinal studies about PACS.

40 Additionally, PACS should aid in the identification of cell-specific o

41 up expense increased by a mean of 146% after PACS implementation from 4,221 dollars per 1,000 studies

42 5 during transition and 32, 22, and 18 after PACS implementation, with a maximum increase of as much

43 1 during transition and 53, 49, and 50 after PACS implementation, which resulted in a maximum increas

44 For differential accessibility analysis, PACS controls the false positive rate and achieves a 17%

45 for the Nef-SFK interaction or the AP-1 and PACS-1-dependent sequestering of internalized MHC-I, sug

46 sly unidentified cargo subsite on PACS-1 and PACS-2 interacted with a bipartite site on Nef formed by

47 of Nef with the sorting proteins PACS-1 and PACS-2 mediates key signaling and trafficking steps requ

48 ef and the PACS proteins on Rab5 (PACS-2 and PACS-1)- or Rab7 (PACS-1)-positive endosomes as determin

49 ower in AAC eyes than fellow eyes of AAC and PACS eyes (p < 0.01 for both) and AAC eyes demonstrated

50 osure and compared to fellow eyes of AAC and PACS eyes.

51 ACD was less in AACG than CACG and PACS (P < .001).

52 ignificantly more in AACG eyes than CACG and PACS eyes (P < .001 and P = .007, respectively).

53 idely) acquisition, processing, display, and PACS software--with 4 sites stating that poor-quality im

54 localizes with ADAM17 on early endosomes and PACS-2 knockdown decreases the recycling and stability o

55 iated by GGA3, which directs TGN export, and PACS-1, which directs endosome-to-TGN retrieval.

56 anterior lens position than fellow eyes and PACS eyes, though lens thickness did not differ among th

57 e executing opposing sorting steps, GGA3 and PACS-1 bind to an overlapping CI-MPR trafficking motif a

58 lications for the distinction between LC and PACS and can guide clinical implementation of identifyin

59 age and sex were associated with both LC and PACS but in opposite directions.

60 Here, we show that Nef and PACS-1 combine to usurp the ARF6 endocytic pathway by a

61 ar age-adjusted incidences of PACG, PAC, and PACS were 0.29% (95% CI, 0.14-0.55), 0.46% (95% CI, 0.29

62 We apply PACS to datasets from various tissues and show its abili

63 PACG was defined as PACS or PAC with GON.

64 Primary angle closure (PAC) was defined as PACS with peripheral anterior synechiae (PAS) and/or IOP

65 In patients with bilateral asymptomatic PACS, eyes that underwent prophylactic LPI reached signi

66 genes could be so easily identified because PACS preferentially identifies coding instead of non-cod

67 ng pathway is not restricted to Nef, because PACS-2 is also required for trafficking of an endocytose

68 incidental findings increased from 19 before PACS to 31 during transition and 53, 49, and 50 after PA

69 follow-up studies increased from five before PACS to 15 during transition and 32, 22, and 18 after PA

70 p mutation increased the interaction between PACS-1 and cargo, whereas a Ser278-->Ala substitution de

71 Right eyes in patients with bilateral PACS and the PACS eye in asymmetrical disease (primary a

72 In patients with bilateral PACS or PAC, the right eye was analyzed, and in asymmetr

73 Angle closure was more prevalent in both PACS siblings (35.0%) and PAC/PACG siblings (36.7%) comp

74 is dependent on CK2 phosphorylation of both PACS-1 and its cargo.

75 Only 1 eye of CACG, PACS, and control subjects were selected.

76 del of Accessible Chromatin of Single cells (PACS), that allows complex hypothesis testing of accessi

77 this retrospective study, the cancer center PACS was mined for brain MRI scans acquired between Janu

78 ure was 13.6 times greater in angle closure (PACS or PAC/PACG) siblings compared with OA siblings (95

79 nd store the results back to another (cloud) PACS.

80 ctivated phosphorylation cascade controlling PACS-1- and GGA3-mediated CI-MPR sorting.

81 ng site 72PXXP(75), and M(20)-in controlling PACS-1-dependent sorting to the TGN, ARF6 activation, an

82 ts as an autoregulatory domain that controls PACS-1-directed sorting.

83 luating these factors can aid in customizing PACS management.

84 Together, these results demonstrate PACS-2 is required for Nef action and sorting of itinera

85 ted liver nodules independently on different PACS stations according to the LIRADS reporting system a

86 s suggests that TRAIL/DR5 triggers endosomal PACS-2 to recruit Bim and Bax to lysosomes to release ca

87 useful software that can be used to enhance PACS performance.

88 a + gamma >= 2 but always close to equality. PACS numbers: 61.43.Hv, 64.60.Ht, 68.03.Fg, 82.70.Dd.

89 ghest in AACG eyes, followed by fellow eyes, PACS, and CACG.

90 e role of one member of a novel gene family, PACS-1, in the localization of trans-Golgi network (TGN)

91 were developed to identify risk factors for PACS, PAC, and PACG.

92 y, we elucidate a novel nuclear function for PACS-1 in maintaining chromosomal integrity.

93 Prophylactic LPI for PACS is cost-effective across a spectrum of ages and sho

94 ffect major purchase decisions, not only for PACS but also for other supporting software and for moda

95 ACS-2 apoptotic activity and is required for PACS-2 to mediate trafficking of membrane cargo.

96 hese studies demonstrate the requirement for PACS-1 interactions with adaptor proteins in multiple pr

97 t of these factors were also significant for PACS, except for alanine aminotransferase and vitamin D.

98 and its parts and on supporting software for PACS.

99 re incurred by the radiology department from PACS implementation.

100 te-based angle calculations will differ from PACS angle measurements by no more than 4.02 degrees .

101 responsible for imaging capture either from PACS system or directly from an MRI scanner, or from raw

102 g splenocytes and embryonic fibroblasts from PACS-2(-/-) mice, we confirm genetically that Nef requir

103 -up visit, 93 eyes (25%) had progressed from PACS to PAC.

104 uilt to predict the risk of progression from PACS to PAC during 14 years of follow-up.

105 I, 0.63-0.75) in predicting progression from PACS to PAC, and inclusion of AS-OCT metrics did not imp

106 n increased 14-year risk of progression from PACS to PAC.

107 ompression will experience cost savings from PACS.

108 Full PACS-CR implementation would not provide cost savings fo

109 reas an increase in expression of functional PACS-1 leads to an increase in HCMV titer, suggesting th

110 ion excluding adults with baseline glaucoma, PACS, PAC, pseudophakia at baseline or follow-up, or las

111 asymmetrical disease (i.e., when one eye had PACS and the other eye had PAC), the eye with PAC was an

112 Hence, PACS-2 sustains ADAM17 cell-surface activity by divertin

113 Together, our results identify PACS-2 as a novel sorting protein that links the ER-mito

114 Here we identify PACS-2 as an essential TRAIL effector, required for kill

115 imate the odds of prevalent angle closure in PACS or PAC/PACG siblings compared with OA siblings.

116 ntion/executive and verbal memory, common in PACS, persisted in most subjects without association wit

117 ntation and caused a Nef mutant defective in PACS binding to localize to distorted endosomal compartm

118 one in controlling inflammation after LPI in PACS.

119 aseline predictors for progression to PAC in PACS eyes.

120 a significant increase in the angle width in PACS.

121 However, in response to apoptotic inducers, PACS-2 translocates Bid to mitochondria, which initiates

122 acute complications of SARS-CoV-2 infection (PACS, defined by clinical diagnosis), separately.

123 ns, 106,563 patients) from the institutional PACS and two external datasets (19,393 and 1,158 patient

124 Placing dose distribution information into PACS facilitates central access into the electronic medi

125 Keywords: PACS, Computer Applications-General (Informatics), Diagn

126 Multi-PACS was applied between a normal osteoblast and four OG

127 The extended method is termed multi-PACS.

128 ction, while adenoviral expression of mutant PACS-1 causes similar mislocalization.

129 Consequently, disruption of the Nef-PACS interaction repressed Nef-induced MHC-I down-regula

130 about the molecular basis underlying the Nef-PACS interaction.

131 Expression of dominant-negative PACS-1 causes a mislocalization of both furin and mannos

132 Furthermore, expression of dominant-negative PACS-1 inhibits the ability of HIV-1 Nef to downregulate

133 on of this motif yielded a dominant-negative PACS-1 molecule that can still bind to acidic cluster mo

134 78-->Ala mutation yields a dominant-negative PACS-1 molecule that selectively blocks retrieval of PAC

135 otype of the more severely affected eye: OA, PACS, or PAC/PACG.

136 % of PAC/PACG siblings compared with 4.9% of PACS siblings (P = 0.07) and 0% of OA siblings (P = 0.00

137 fornia Santa Cruz genome browser analysis of PACS-1 micro RNAs (miR), revealed two 8-base target sequ

138 rylates PACS-1Ser(278), promoting binding of PACS-1 to CI-MPR to retrieve the receptor to the TGN.

139 of mitochondria with the ER, as depletion of PACS-2 causes BAP31-dependent mitochondria fragmentation

140 0.6), gender (P = 0.7), and distribution of PACS versus PAC or PACG (P = 0.7).

141 bolic homeostasis, whereas downregulation of PACS-2 or IP3R1, proteins important for ER-mitochondria

142 The pathophysiologic drivers of PACS in patients previously infected with COVID-19 who w

143 We demonstrate the effectiveness of PACS through several analysis tasks, including supervise

144 (65), with the furin binding region (fbr) of PACS-1 is crucial for this Nef function.

145 contact was present in approximately half of PACS eyes and approximately two thirds of PAC/PACG eyes

146 Furthermore, inhibition of PACS-1 activity in infected cells leads to a decrease in

147 We have now investigated the interaction of PACS-1 with heterotetrameric adaptor complexes.

148 The introduction of PACS into radiology practice for lumbar spinal MR imagin

149 embrane permeabilization, shRNA knockdown of PACS-2 in Huh-7 cells reduced TRAIL-induced apoptosis an

150 ting that short interfering RNA knockdown of PACS-2 phenocopies the gene knock-out.

151 shRNA-targeted knockdown of PACS-2 prevents recruitment of Bim or Bax to lysosomes,

152 rmore, the siRNA studies showed that loss of PACS-1 expression was accompanied by increased nuclear g

153 Loss of PACS-1 with siRNA or exogenous expression of hsa-miR-34a

154 Moreover, genetic loss of PACS-2 or inhibition of class I PI3K prevents Nef-mediat

155 n cervical cancer leads to overexpression of PACS-1 and suppression of DNA damage response, resulting

156 We have observed overexpression of PACS-1, a cytosolic sorting protein in primary cervical

157 The prevalence of PACS, PAC, and PACG were 8.1% (95% CI: 7.3%-9.0%; N = 35

158 the homeostatic and apoptotic properties of PACS-2 that mediate TRAIL action.

159 olecule that selectively blocks retrieval of PACS-1-regulated cargo molecules to the TGN.

160 of having PAC/PACG compared with siblings of PACS probands, although the association was not signific

161 tudies identify the phosphorylation state of PACS-2 Ser437 as a molecular switch that integrates cell

162 analysis identified 3 distinct subgroups of PACS subjects based on AS-OCT and biometric parameters.

163 his study was part of a prospective trial of PACS.

164 s stating that poor-quality images appear on PACS.

165 Here we show that an acidic cluster on PACS-1, which is highly similar to acidic cluster sortin

166 clearly represent the best available data on PACS management, additional parameters however may need

167 tor, but not TGN46, is strictly dependent on PACS-1.

168 ich is the first of two parts, will focus on PACS and its parts and on supporting software for PACS.

169 A previously unidentified cargo subsite on PACS-1 and PACS-2 interacted with a bipartite site on Ne

170 d PACS1 syndrome mice to show that PACS1 (or PACS-1) is an HDAC6 effector and that the R203W substitu

171 ture archiving and communication systems (or PACS), ultrasonography, computed tomography, magnetic re

172 Data were collected from our PACS.

173 mber area, were compared between early PACD (PACS) and late PACD (PAC and PACG) groups.

174 Bound CK2 also phosphorylates PACS-1Ser(278), promoting binding of PACS-1 to CI-MPR to

175 transition and 27, 17, and 14 in the 3 post-PACS years.

176 s statistically significant during each post-PACS year.

177 udies increased the most from two in the pre-PACS year to 11 during transition and 27, 17, and 14 in

178 m 4,221 dollars per 1,000 studies in the pre-PACS year to 9,307 dollars, 13,426 dollars, 10,558 dolla

179 lation state-dependent furin-sorting protein PACS-1, and mirrors the trafficking pathway described re

180 n and interacts with the TGN sorting protein PACS-1.

181 iRNA screen, we identify the sorting protein PACS-2 as a regulator of ADAM17 trafficking and ErbB sig

182 65)-dependent binding to the sorting protein PACS-2 targets Nef to the paranuclear region, enabling P

183 cation of a multifunctional sorting protein, PACS-2, that integrates ER-mitochondria communication, E

184 interaction of Nef with the sorting proteins PACS-1 and PACS-2 mediates key signaling and trafficking

185 We show that CNGB1b contains two putative PACS-1 binding sites, which are phosphorylated by the se

186 n between Nef and the PACS proteins on Rab5 (PACS-2 and PACS-1)- or Rab7 (PACS-1)-positive endosomes

187 oteins on Rab5 (PACS-2 and PACS-1)- or Rab7 (PACS-1)-positive endosomes as determined by bimolecular

188 Our Markov model randomized PACS eyes to LPI or observation for 40 one-year cycles (

189 The determination that recombinant PACS-2 bound Bim but not Bax in vitro and that shRNA kno

190 s 14-3-3 with high affinity, which represses PACS-2 apoptotic activity and is required for PACS-2 to

191 s dephosphorylation of Ser437, reprogramming PACS-2 to promote apoptosis.

192 ce, we confirm genetically that Nef requires PACS-2 to localize to the paranuclear region and assembl

193 institution into the receiving institution's PACS significantly decreased the rates of subsequent ima

194 ferential amplification of coding sequences (PACS) to screen multiple samples simultaneously.

195 ferential amplification of coding sequences (PACS), that was applied to identify differentially expre

196 Analyses in vitro and in vivo show PACS-1 has properties of a coat protein and connects fur

197 e of cells post 24-h serum starvation showed PACS-1 nuclear localization at G(1)-S phase of the cell

198 Since PACS is not dependent on the existence of a poly A tail

199 Our approach, PCR-activated cell sorting (PACS), uses TaqMan PCR to detect nucleic acids within si

200 k washout period: once by using the standard PACS-like viewer and once by using the dedicated viewer.

201 Identifying primary angle closure suspect (PACS) eyes at risk of angle closure is crucial for its m

202 ACG) eyes, 40 primary angle-closure suspect (PACS) eyes, and 27 normal eyes underwent complete examin

203 Primary angle closure suspect (PACS) was defined as non-visible posterior trabecular me

204 egorized with primary angle-closure suspect (PACS), and 16 persons (0.8%) were categorized with prima

205 PACD includes primary angle-closure suspect (PACS), primary angle-closure (PAC), and PACG.

206 anagement of primary angle closure suspects (PACS), chronic primary angle closure (CPAC), and chronic

207 a cohort of primary angle-closure suspects (PACS).

208 ndividuals with postacute COVID-19 syndrome (PACS) and normal pulmonary function, xenon 129 ((129)Xe)

209 ive profile of post-acute COVID-19 syndrome (PACS) patients with cognitive complaints, exploring the

210 patients with post-acute COVID-19 syndrome (PACS), abnormal gas-transfer and pulmonary vascular dens

211 persistence in post-acute COVID-19 syndrome (PACS).

212 picture archiving and communication system (PACS) to rapidly retrieve and review exactly where, when

213 picture archiving and communication system (PACS) without being printed to film, and 108 were printe

214 picture archiving and communication system (PACS) workstation in the MICU shortens those delays.

215 picture archiving and communication system (PACS) workstation, with standard, locally determined cen

216 e picture archival and communication system (PACS) workstation.

217 picture archiving and communication system (PACS) workstations equipped with software for two- and t

218 picture archiving and communication system (PACS), as well as some of the useful software that can b

219 picture archiving and communication system (PACS), automatically curated, and used for semisupervise

220 picture archiving and communication system (PACS), run an artificial intelligence (AI) algorithm on

221 picture archiving and communication system (PACS)-like viewer.

222 picture archiving and communication systems (PACS) are a major focus of imaging informatics, there ar

223 Picture Archiving and Communication Systems (PACS) with liver nodule were included in the study, 37 o

224 picture archiving and communication systems (PACS), a huge number of images and cases are available.

225 It was also less in fellow eyes than PACS eyes (P = .04).

226 e HCMV envelope glycoprotein B (gB) and that PACS-1 function is required for normal TGN localization

227 o more than 5 degrees and 95% confident that PACS tool-based angle measurements will differ from the

228 Additionally, we demonstrate that PACS can be used to sort and enrich cells via TaqMan PCR

229 We show here that PACS-1 interacts with the cytoplasmic domain of the HCMV

230 Additionally, we show that PACS-1 is expressed in OSNs and interacts in complex wit

231 Superresolution imaging showed that PACS-2- and Mfn-mediated membrane apposition or hydropho

232 o an increase in HCMV titer, suggesting that PACS-1 is required for efficient production of HCMV.

233 The PACS tool-based measured and coordinate-based calculated

234 eyes in patients with bilateral PACS and the PACS eye in asymmetrical disease (primary angle closure

235 revented the interaction between Nef and the PACS proteins on Rab5 (PACS-2 and PACS-1)- or Rab7 (PACS

236 Here we identify the sites on Nef and the PACS proteins required for their interaction and describ

237 amates in Nef do not functionally engage the PACS-1 fbr.

238 (32% classified as cases) and 108,407 in the PACS cohort (with 2% being cases).

239 h a greater percentage of angles open in the PACS group compared with the PAC/PACG group (52.4% vs. 3

240 Results The PACS query extracted 31 150 line annotations, yielding 1

241 ced by 45% with direct image transfer to the PACS compared with the time required in the film-based m

242 (i) The binding of Nef to the PACS-1 fbr in vitro is much weaker than the binding of t

243 the binding of the canonical furin AC to the PACS-1 fbr.

244 o obtain information during periods with the PACS workstation compared with periods without the works

245 2c did not interfere with the PACS-2-dependent trafficking of Nef required for the Nef

246 Without the PACS workstation, higher occupancy, higher aggregate sev

247 This PACS-2-dependent targeting pathway is not restricted to

248 ugh LNA-hsa-anti-miR-34a or -449a or through PACS-1 cDNA transfection led to the reversal of DNA dama

249 Thus, PACS identified CSTs approximately 13.5 times more often

250 n 1487 consecutive ED patients, CD import to PACS was attempted between February 1 and August 31, 200

251 CD import to PACS was successful in 78% (1161 of 1487) of patients.

252 reports for each of 5 years: 1 year prior to PACS introduction, 1 year during transition to PACS, and

253 CS introduction, 1 year during transition to PACS, and 3 consecutive years thereafter.

254 /PACG vs. PACS/OA (P = 0.01) or PAC/PACG vs. PACS (P = 0.001).

255 ) PAC/PACG vs. PACS/OA, and (3) PAC/PACG vs. PACS), adding no model improvement when compared to diag

256 ratio testing for prediction of PAC/PACG vs. PACS/OA (P = 0.01) or PAC/PACG vs. PACS (P = 0.001).

257 : (1) PACS/PAC/PACG vs. OA, (2) PAC/PACG vs. PACS/OA, and (3) PAC/PACG vs. PACS), adding no model imp

258 DICOM image viewing software CARESTREAM Vue PACS (Carestream Health Inc., USA) were used to measure

259 d after implementation of an enterprise-wide PACS; the numbers and types of imaging examinations perf

260 At 2 weeks after LPI, 7 patients (6 with PACS and 1 with PAC) in the nepafenac group and 2 patien

261 apital and operational costs associated with PACS implementation during an 8-year time horizon.

262 trolling inflammation after LPI in eyes with PACS and PAC.

263 Seventy-nine eyes with PACS, CPAC, or CPACG and better than 20/50 visual acuity

264 Prevention trial who had untreated eyes with PACS.

265 ion defect percent (VDP) in individuals with PACS evaluated 3 and 15 months after COVID-19 infection.

266 These acidic cluster motifs interact with PACS-1, a connector protein that is required for the tra

267 and two acidic clusters, which interact with PACS-1, a cytosolic protein, to mediate retrograde trans

268 i-detector row scanners and interpreted with PACS workstations enable depiction of pancreas divisum.

269 /- 15, three women) and 34 participants with PACS (mean age, 53 years +/- 13, 18 women), of whom 22 w

270 In this prospective study, participants with PACS aged 18-80 years were enrolled between July 2020 an

271 Participants with PACS underwent spirometry, diffusing capacity of the lun

272 In this prospective study, patients with PACS aged 18-80 years with a positive polymerase chain r

273 ) in the nepafenac group and 2 patients with PACS in the bromfenac group achieved the primary end poi

274 In a South Indian population with PACS or PAC/PACG, LPI results in significant anterior ch

275 A short sequence within PACS-1 that is essential for binding to AP-1 has been id

276 cted PACG (sPACG) was defined as GON without PACS or PAC but with evidence of prior laser iridotomy o