ライフサイエンスコーパス: PAG

1 PAG at 1 mm had no effect on HPV recorded in control PSS

2 PAG MBE thus demonstrates electrophoretic assays with mi

3 comparable after enoxaparin initiation (14% PAG v 10% AG).

4 cted a survey of members of Beyond Celiac (a PAG), collecting responses from 1832 U.S. adults ages 19

5 uals diagnosed with CeD who participate in a PAG.

6 HPV in rat IPA by generating sulphide via a PAG-sensitive pathway, presumably CSE.

7 s HDACs class IIa: hippocampus, n.accumbens, PAG, and cerebellum.

8 o support an appropriate response, activated PAG LepRb neurons, which project to and activate parabra

9 Activating PAG-projecting neurons in the preoptic area of the hypot

10 In contrast, activating PAG-projecting neurons in the central-medial boundary zo

11 Conversely, activating PAG-USV neurons selectively triggered USV production, ev

12 Furthermore, activating PAG LepRb neurons increased SNS activity and blood gluco

13 Indeed, activating PAG neurons that innervate the nucleus retroambiguus, bu

14 ental data of the kinase Csk and the adaptor PAG in primary human T cell immunological synapses.

15 activation during rejection in the amygdala, PAG and subgenual anterior cingulate cortex (sgACC), sug

16 Using phosphoproteomic analysis, PAG showed low levels of tyrosine phosphorylation in res

17 ogenous opioid release in the dorsal ACC and PAG was positively correlated with placebo-induced reduc

18 ioid system activation in the dorsal ACC and PAG, and as a trend, negatively with NEO Angry Hostility

19 s a dual role in modulating the amygdala and PAG in juveniles, we pharmacologically disinhibited each

20 u-opioid receptor activity in POM, BSTm, and PAG may underlie previous links identified between undir

21 ved mast cells (BMMCs) with PAG knockout and PAG knockdown and the corresponding controls.

22 (including the periaqueductal gray-PAG) and PAG-amygdala connectivity.

23 cular plating additives (SPS, Imep, PEI, and PAG) used in the semiconductor industry for the on-chip

24 s with significant differences between arms (PAG v AG) included muscle spasms (13% v 1%), neutropenia

25 multiprotein complexes that are found around PAG over 5 min of activation.

26 ses but prevents synaptic plasticity only at PAG synapses.

27 The CSE blocker PAG (dl-propargylglycine) significantly reduced the ampl

28 CAT antagonist aspartate (1 mm) and also by PAG.

29 hat this release was strongly antagonized by PAG, indicating that at this concentration PAG could ent

30 at the adjustment to temperature extremes by PAG corals was facilitated by the positive selection of

31 In caudal PAG, activity was localized to the ventrolateral region.

32 G and the ventrolateral column of the caudal PAG.

33 PTP1B regulated the interaction between CBP/PAG and CSK.

34 hosphorylated, the transmembrane protein CBP/PAG at Tyr-317, resulting in CSK recruitment.

35 y PAG, indicating that at this concentration PAG could enter cells intact and antagonize CSE.

36 Moreover, LPI depolarizes PAG neurons and upon intra-PAG microinjection, reduces n

37 oid receptor activation profoundly depresses PAG and RMTg inhibitory synapses but prevents synaptic p

38 chers from localizing responses to different PAG subregions.

39 he following: main effects of task in dorsal PAG and right LC; and main effect of temperature in RVM

40 ioning, electrical stimulation of the dorsal PAG (dPAG) produced unconditional responses (URs) compos

41 ors generated by the PAG, such as the dorsal PAG generating avoidance behavior, the lateral PAG gener

42 Stimulation in the dorsal PAG increased the firing of pre-I neurons, resulting in

43 ltrasonic vocalizations (USVs) in mice (i.e. PAG-USV neurons).

44 To examine PAG function in humans, researchers have relied primaril

45 ting with the Zn finger transcription factor PAG-3/Gfi to induce peptidergic neuron identity and dire

46 ification was knocked in the gene coding for PAG to determine the composition and dynamics of the mul

47 Our findings provide a model of the role for PAG in mouse primary CD4(+) T cells that is consistent w

48 y CeD care, and highlight an opportunity for PAGs to bring together patients and HCPs to improve mana

49 When BMMCs from PAG-knockout mice were activated via the KIT receptor, e

50 Activation of the GABAergic PAG terminals in the VTA promotes immobility, and optoge

51 opatterned free-solution-polyacrylamide gel (PAG) stacking interface at the head of the MBE microchan

52 ded in a thin layer of a polyacrylamide gel (PAG).

53 ith PEGPH20 plus nab-paclitaxel/gemcitabine (PAG) or nab-paclitaxel/gemcitabine (AG).

54 PA) of the endocytosed photoacid generators (PAGs).

55 accumulation of procyclin-associated genes (PAGs), these being co-transcribed by RNA polymerase I wi

56 SIV) virions with protein A-conjugated gold (PAG) nanoparticles using negative-stain electron microsc

57 strate in rats that the periaqueductal gray (PAG) affects motor systems at the following multiple lev

58 The periaqueductal gray (PAG) and amygdala are known to be important for defensiv

59 matergic axons from the periaqueductal gray (PAG) and lateral hypothalamic area (LHA) intensely inner

60 opposite coupling with periaqueductal gray (PAG) and the mismatch between actual and expected pain r

61 project to the midbrain periaqueductal gray (PAG) and the paraventricular nucleus of the thalamus, tw

62 el caudally through the periaqueductal gray (PAG) and then ventrally through the lateral lemniscus to

63 visions of the midbrain periaqueductal gray (PAG) are intricately (and differentially) involved in in

64 ncy have identified the periaqueductal gray (PAG) as a key brainstem structure implicated in endogeno

65 The periaqueductal gray (PAG) coordinates behaviors essential to survival, includ

66 euroinflammation in the periaqueductal gray (PAG) drives tolerance.

67 ons between the DMN and periaqueductal gray (PAG) dynamically tracked spontaneous attention away from

68 t parts of the midbrain periaqueductal gray (PAG) in the cat generates four different types of vocali

69 The periaqueductal gray (PAG) in the midbrain is known to coordinate behavioral a

70 Neurons in the periaqueductal gray (PAG) integrate negative emotions with the autonomic, neu

71 The periaqueductal gray (PAG) is a brain region involved in nociception modulatio

72 The periaqueductal gray (PAG) is an important center that controls spinal nocicep

73 The midbrain periaqueductal gray (PAG) is involved in many basic survival behaviors that a

74 ENT We demonstrate that periaqueductal gray (PAG) microglia contribute to the sexually dimorphic effe

75 ontributions of defined periaqueductal gray (PAG) neuronal populations in itch modulation in mice.

76 vels in dissociated rat periaqueductal gray (PAG) neurons, which express GPR55 mRNA.

77 co-injections into the periaqueductal gray (PAG) or into the spinal subarachnoid space.

78 The periaqueductal gray (PAG) orchestrates survival behaviors, with the dorsal (d

79 the hypothesis that the periaqueductal gray (PAG) participates in behaviors that involve changes in t

80 The midbrain periaqueductal gray (PAG) plays a central role in the descending control of v

81 which the mesencephalic periaqueductal gray (PAG) plays a central role, as demonstrated by the fact t

82 The midbrain periaqueductal gray (PAG) region is organized into distinct subregions that c

83 vances suggest that the periaqueductal gray (PAG) should also be engaged during cognitively demanding

84 neurons in the midbrain periaqueductal gray (PAG) that are transiently active in male mice when they

85 tream of neurons in the periaqueductal gray (PAG) that gate the production of ultrasonic vocalization

86 oglia activation in the periaqueductal gray (PAG), a central locus mediating the antinociceptive effe

87 ectivity (rs-fc) of the periaqueductal gray (PAG), a key region in the descending pain modulatory sys

88 PEs were encoded in the periaqueductal gray (PAG), a structure important for pain control and learnin

89 teral and ventrolateral periaqueductal gray (PAG), lateral parabrachial nucleus (LPB), caudal pressor

90 eptor 5 (mGluR5) in the periaqueductal gray (PAG), the key area of endogenous pain modulation, is per

91 (LepRb neurons) in the periaqueductal gray (PAG), the largest population of LepRb neurons in the bra

92 lateral portion of the periaqueductal gray (PAG), the Su3 and PV2 nuclei of the ventrolateral PAG, t

93 etween the amygdala and periaqueductal gray (PAG), which statistically mediated the effect of the 5-H

94 prefrontal cortex (PFC)-periaqueductal gray (PAG)-spinal cord pathway was identified that is critical

95 divisions, amygdala and periaqueductal gray (PAG).

96 accumbens, amygdala and periaqueductal gray (PAG).

97 terminalis (BSTm), and periaqueductal gray (PAG).

98 a, midline thalamus and periaqueductal gray (PAG).

99 nucleus (RMTg), and the periaqueductal gray (PAG).

100 ain structures plus the periaqueductal gray (PAG).

101 activity (including the periaqueductal gray-PAG) and PAG-amygdala connectivity.

102 dividual columns of the periaqueductal grey (PAG) during breathlessness and its conditioned anticipat

103 The midbrain periaqueductal grey (PAG) lies at the heart of the defence-arousal system and

104 c nucleus, STN) and the periaqueductal grey (PAG), which have now been recorded from in humans during

105 al frontal pole (mFP) and periaquiduct grey (PAG) are significantly greater in the verum acupuncture

106 also participate in patient advocacy groups (PAGs) for education and support.

107 projections from multiple types, except PFC->PAG (periaqueductal gray).

108 activity of the molecularly homogeneous PFC->PAG type against two heterogeneous classes in several tw

109 ral communities in the Persian/Arabian Gulf (PAG) withstand unusually high salinity levels and regula

110 transmembrane adaptor protein PAG/CBP (here, PAG) is expressed in multiple cell types.

111 However, PAG-projecting neurons most potently encoded choice in c

112 orsomedial nucleus and lateral hypothalamus, PAG, and LPB.

113 We identified PAG as a substrate of PTP1B, and dephosphorylation aboli

114 cose concentrations, while ablating LepRb in PAG neurons augmented glucose mobilization in response t

115 ng to the short separation lengths needed in PAG MBE, we reduced the separation channel length to dem

116 The lack of a blatant phenotype in PAG-deficient mice has impeded our understanding of the

117 Here we investigate how these individual PAG columns are differently involved with respiratory th

118 ealed that POA(PAG) neurons directly inhibit PAG interneurons, which in turn inhibit PAG-USV neurons,

119 (SOM(+)) neurons, which can directly inhibit PAG neurons, and some of which innervate both the PAG an

120 hereas Amg(C/M-PAG) neurons directly inhibit PAG-USV neurons.

121 ibit PAG interneurons, which in turn inhibit PAG-USV neurons, whereas Amg(C/M-PAG) neurons directly i

122 ed in the lateral column of the intermediate PAG and howls and hisses in the ventrolateral column of

123 the ventrolateral column of the intermediate PAG.

124 The descending facilitatory actions of intra-PAG PGs play a direct and central role in the maintenanc

125 , LPI depolarizes PAG neurons and upon intra-PAG microinjection, reduces nociceptive threshold in the

126 To investigate PAG involvement during cognitive engagement, we develope

127 ved in ventrolateral PAG (vlPAG) and lateral PAG (lPAG), where activity scaled with breathlessness in

128 teral PAG, and aspects of the dorsal lateral PAG, appear to be key communicating circuitry for 'centr

129 istive loading, with activity in the lateral PAG (lPAG) during resistive loading, revealing spatially

130 timulation in the medial part of the lateral PAG converted the pre-I neurons into inspiratory phase-s

131 imulation in the lateral part of the lateral PAG generated an early onset of the pre-I neuronal disch

132 G generating avoidance behavior, the lateral PAG generating fight and flight, and the ventrolateral P

133 imulation in the ventral part of the lateral PAG induced tachypnea but inhibited pre-I cell firing, w

134 uclei, whereas those confined to the lateral PAG preferentially labeled hypothalamic and midbrain aud

135 e manner, the PAG, in particular the lateral PAG, and aspects of the dorsal lateral PAG, appear to be

136 tified in a crescentic column of the lateral PAG, as well as in the Edinger-Westphal, the lateral hab

137 w coalesces human and animal studies to link PAG neuropathways to specific elements of psychiatric di

138 urn inhibit PAG-USV neurons, whereas Amg(C/M-PAG) neurons directly inhibit PAG-USV neurons.

139 edial boundary zone of the amygdala (Amg(C/M-PAG) neurons) transiently suppressed USV production with

140 halamus, and the periaqueductal gray matter (PAG) are involved in these circuits; so, too, are the br

141 ions such as the periaqueductal gray matter (PAG) plays a critical role in acute and chronic pain.

142 ct mainly to the periaqueductal grey matter (PAG), predominantly ipsilaterally.

143 Injections in the medial PAG produced dense label within hindbrain auditory nucle

144 ith glycosphingolipid-enriched microdomains (PAG).

145 Crucially, stronger activity in the midbrain/PAG during this preparatory stage of freezing predicted

146 l neurobiotin injections into the midshipman PAG to both map its auditory-vocal circuitry and allow e

147 eine was abolished by pretreatment with 1 mm PAG.

148 t MAb or CD4-only (no MAb) showed negligible PAG association, as did a vesicle-rich fraction devoid o

149 tracing studies revealed that nearly 50% of PAG-projecting VMHdm/c neurons send collateral projectio

150 Furthermore, activation of PAG GABAergic neurons or inhibition of glutamatergic neu

151 on the sensory and autonomic consequences of PAG activation.

152 with a profound reduction of excitability of PAG neurons.

153 dence from our own and other laboratories of PAG control of motor outflow is also discussed.

154 nts establish that a dedicated population of PAG neurons gives rise to a descending circuit necessary

155 The role of PAG as a negative regulator of immunoreceptor signaling

156 Genetic silencing of PAG-USV neurons rendered males unable to produce USVs an

157 Low-frequency stimulation of PAG afferents in vitro unexpectedly causes long-term pot

158 Thus, decreased leptin action on PAG LepRb neurons augments the autonomic response to nox

159 pitulates the effects of TbNMD3 depletion on PAG mRNAs and mRNAs accumulated in the nucleus of TbNMD3

160 the MSCs of human major SGs, namely parotid (PAG), sublingual (SLG) and submandibular (SMG) glands.

161 vivo pharmacology reveal that these BLA-PFC-PAG connections alter pain behaviors by reducing descend

162 Tyrosine-phosphorylated PAG serves as an anchor for C-terminal SRC kinase, an in

163 n the preoptic area of the hypothalamus (POA(PAG) neurons) elicited USV production in the absence of

164 it mapping in brain slices revealed that POA(PAG) neurons directly inhibit PAG interneurons, which in

165 te vocalization by activating the prefrontal-PAG-NRA-motoneuronal pathway, and, at the same time, the

166 nd in nNOS-knockout (KO) mouse preparations, PAG shifted the transwall gradient in the depolarizing d

167 asing H2S donor GYY4137 and propargylglycin (PAG), an inhibitor of cystathionine-gamma-lyase (CSE), a

168 that the CSE inhibitor dl-propargylglycine (PAG, 500 mum) had no effect on the transwall gradient.

169 ulature, demonstrated that propargylglycine (PAG, 1 mm) had little or no effect on the NPV caused by

170 The transmembrane adaptor protein PAG/CBP (here, PAG) is expressed in multiple cell types.

171 ptide via lentiviral vector injection in rat PAG to sequester soluble TNF (solTNF), we demonstrate th

172 in patients with HA-high tumors who received PAG.

173 o regions, the lateral column of the rostral PAG and the ventrolateral column of the caudal PAG.

174 In the rostral PAG, activity was localized to lateral and dorsomedial s

175 antly, the individual strength of the spinal-PAG coupling predicted individual pain ratings highlight

176 connectivity and more dynamic resting state PAG-DMN functional connectivity were associated with the

177 pain; and (iii) across individuals, stronger PAG-DMN structural connectivity and more dynamic resting

178 o with increased activity in the subcortical PAG and other midbrain regions involved in the regulatio

179 Surprisingly, PAG GABAergic neurons, but not glutamatergic neurons, ma

180 support for the hypothesis that the teleost PAG is centrally involved in auditory-vocal integration.

181 Thus, the teleost PAG may have functional subdivisions playing different r

182 entral striatum, amygdala, midline thalamus, PAG, anterior insula and ACC are rich in MORs and compri

183 These results demonstrate that PAG microglia are sexually dimorphic in both basal and L

184 However, animal studies indicate that PAG analgesia is mediated largely via caudal brainstem s

185 The combined data indicate that PAG can function as both a positive and a negative regul

186 combined with axonal tracing indicates that PAG-USV neurons gate downstream vocal-patterning circuit

187 h former biochemical studies indicating that PAG is constitutively phosphorylated in resting T cells

188 These findings show that PAG stimulation changes the activity of the pre-Botzinge

189 Our data show that PAG-deficient BMMCs exhibit impaired antigen-induced deg

190 In vivo experiments showed that PAG is a positive regulator of passive systemic anaphyla

191 The data suggest that PAGs may be an attractive alternative PDT modality to se

192 The PAG has also been implicated in auditory-vocal integrati

193 The PAG receives strong projections from higher limbic regio

194 The PAG, LC, and RVM were anatomically discriminated using a

195 ch fear conditioning naturally activated the PAG.

196 The changes of rs-fc among the PAG, rACC and ventral striatum were significantly associ

197 fish depend on vocal communication, and the PAG is a central component of the midshipman vocal-motor

198 ipatory midbrain activity centred around the PAG supports decision-making by facilitating action prep

199 escending pain-modulatory system such as the PAG, the hypothalamus, and the amygdala.

200 ated the functional relationship between the PAG and amygdala in two different settings, fear conditi

201 ectional pattern of connectivity between the PAG and known sites in both the descending vocal-motor a

202 The reduced rs-fc between the PAG and rACC/mPFC was associated with increased migraine

203 oA patients showed reduced rs-fc between the PAG and rostral anterior cingulate cortex/medial prefron

204 After treatments, rs-fc between the PAG and the rACC in MwoA patients significantly increase

205 eurons, and some of which innervate both the PAG and paraventricular nucleus of the thalamus.

206 hough morphine is thought to act in both the PAG and RVM by pre-synaptic inhibition of inhibitory GAB

207 However, the information encoded by the PAG during these survival behaviors is poorly understood

208 integration of sensorimotor functions by the PAG is considered, as part of coordinated defence behavi

209 ith the different behaviors generated by the PAG, such as the dorsal PAG generating avoidance behavio

210 ic), which was critical for dissociating the PAG from the greater signal variability in the aqueduct.

211 rwhelming evidence of a pivotal role for the PAG in coordinating motor responses essential to surviva

212 p down control of sensory functions from the PAG, including selective control of different modalities

213 esults move us towards understanding how the PAG might be intricately involved in human responses to

214 strength (7-T) fMRI techniques to image the PAG at high resolution (0.75 mm isotropic), which was cr

215 onal vocal expressions are segregated in the PAG and that the PAG uses the NRA as a tool to gain acce

216 An early imbalance in TE events in the PAG arm led to a clinical hold; thereafter, patients wit

217 maximal, a field potential was evoked in the PAG by the auditory fear conditioned stimulus (CS).

218 hat increased activation of microglia in the PAG contributes to the attenuated response to morphine o

219 f GABAergic and glutamatergic neurons in the PAG is modulated in an opposing manner during chloroquin

220 demonstrated by the fact that lesions in the PAG lead to complete mutism in cats, monkeys, as well as

221 that interfering with GPR55 signaling in the PAG may promote analgesia.

222 In the PAG of arthritic, but not naive, rats, there is enhanced

223 induced greater microglia activation in the PAG of females compared with males and was accompanied b

224 ts and establish that TLR4 inhibition in the PAG of females reverses the sex differences in morphine

225 Effect sizes in the PAG were comparable in magnitude to those in many of the

226 We then labeled cell types in the PAG, LPB, medulla, and spinal cord to better define the

227 enerated by neurochemical stimulation in the PAG.

228 l modulation of scratching by neurons in the PAG.

229 how an effective treatment can influence the PAG rs-fc in MwoA patients.

230 entifies novel neural pathways that link the PAG to fear-evoked motor responses.

231 ata are viewed in an integrative manner, the PAG, in particular the lateral PAG, and aspects of the d

232 Moreover, the PAG also fulfils many requirements of a command centre.

233 for segmenting and spatially normalizing the PAG.

234 ive images segregated into subregions of the PAG along both dorsal/ventral and rostral/caudal axes.

235 Due to the recent formation of the PAG and its subsequent shift to a hot climate, these cor

236 etermining how the individual columns of the PAG interact with higher cortical centres, both at rest

237 In humans, the same regions of the PAG that give rise to adaptive anger/fight, fear/panic,

238 s chronic with the maladaptive coping of the PAG to pain sensation.

239 leted cells we confirm the regulation of the PAG transcripts by TbNMD3 and using reporter constructs

240 tudinally oriented functional modules of the PAG, but overlaps none of them.

241 y of symbiotic algae across >5,000 km of the PAG, the Gulf of Oman, and the Red Sea coastline, we sho

242 rolateral to the aqueduct on the edge of the PAG.

243 revealing the functional architecture of the PAG.

244 during stimulation in different parts of the PAG.

245 the insula and attentional activation of the PAG.

246 ioid modulation of pain, with a focus on the PAG as a sexually dimorphic core of descending opioid-in

247 ymbionts cryptically distributed outside the PAG.

248 mporary fear-conditioning models present the PAG as downstream of the amygdala, directing the appropr

249 Our data reveal the PAG as a source of highly opioid-sensitive GABAergic aff

250 Animal data indicate that the PAG acts via caudal brainstem structures to control noci

251 near support vector machines showed that the PAG discriminated high versus low working memory load co

252 ic and chemogenetic techniques show that the PAG is a rich substrate for the integration of active an

253 ction-resistant cells also suggests that the PAG plays a role in encoding fear memories.

254 We hypothesized that the PAG promotes these behaviors by changing the firing of p

255 sions are segregated in the PAG and that the PAG uses the NRA as a tool to gain access to the motoneu

256 Thus, the PAG represents a neuromodulatory hub that regulates both

257 prefrontal cortex and the projections to the PAG and brainstem can be studied with precision.

258 s identify two major forebrain inputs to the PAG that trigger and suppress vocalization, respectively

259 vides an expected value-related input to the PAG, which then conveys PE signals to prefrontal regions

260 sitive neurons, putatively projecting to the PAG, which-similarly to the human population-mediated th

261 In turn, the PAG has strong access to the caudal medullary nucleus re

262 al responses to threat in animals, while the PAG has previously only been considered as a single enti

263 iumvirate in attentional analgesia: with the PAG activated by attentional load; specific RVM regions

264 e density of microglia were noted within the PAG of male or female rats, microglia exhibited a more "

265 aracterization of MD-2 expression within the PAG revealed dense MD-2 expression throughout the vlPAG.

266 ation with pronociceptive actions within the PAG under normal conditions.

267 One of these PAGs, which had a significantly lower dark cytotoxicity

268 This PAG-EMG coupling was only present for the onset of freez

269 in anxiety and pain in which the amygdala to PAG pathway is also implicated.

270 Blockade of morphine binding to PAG TLR4 with (+)-naloxone potentiated morphine antinoci

271 In patients with HA-high tumors (PAG v AG), the objective response rate was 45% versus 31

272 imbic mPFC, the medial amygdala, and ventral PAG.

273 context conditional stimuli, neither ventral PAG nor BLA stimulation supported fear conditioning.

274 In contrast, stimulation of ventral PAG and the basolateral amygdalar complex (BLA) evoked f

275 haracterized dopamine neurons in the ventral PAG (vPAG)/dorsal raphe (DR) region are a potentially cr

276 g pattern of activity from dorsal to ventral PAG along the rostrocaudal axis mirrors structural and f

277 ostral portions of lateral and ventrolateral PAG columns in humans is modulated by cognitive load.

278 ivity increases in lateral and ventrolateral PAG.

279 Activation was observed in ventrolateral PAG (vlPAG) and lateral PAG (lPAG), where activity scale

280 in rats that activation of the ventrolateral PAG (vlPAG) affects motor systems at multiple levels of

281 We showed activity in the ventrolateral PAG (vlPAG) during anticipation of resistive loading, wi

282 g glutamatergic neurons in the ventrolateral PAG (vlPAG) powerfully promote non-rapid eye movement (N

283 ting fight and flight, and the ventrolateral PAG generating freezing and immobility.

284 ng, whereas stimulation in the ventrolateral PAG inhibited not only pre-I cells but also the diaphrag

285 Moreover, the ventrolateral PAG of KO rats displayed elevated overall activity and i

286 rojections from the PFC to the ventrolateral PAG region and its downstream targets.

287 the Su3 and PV2 nuclei of the ventrolateral PAG, the cuneiform nucleus, the mesencephalic reticular

288 ode A-nociceptive information, even after VL-PAG COX-1 inhibition, whereas the encoding of C-nocicept

289 instem ventrolateral periaqueductal grey (VL-PAG), which control the spinal processing of nociceptive

290 Inhibition of VL-PAG COX-1 in anaesthetised rats increased firing thresho

291 we determined the effect of inhibition of VL-PAG COX-1 on dorsal horn wide dynamic-range neurons evok

292 1 (COX-1)-prostaglandin system within the VL-PAG alters spinal nociceptive reflexes evoked by C-nocic

293 rgic descending control mechanisms in the VL-PAG.

294 s, with the dorsal (dPAG) and ventral (vPAG) PAG concerned respectively with innate and learnt fear r

295 nderstanding of the mechanisms through which PAG exerts its negative-regulatory role in TCR signaling

296 ase PTPN22 and lipid phosphatase SHIP-1 with PAG following T cell activation suggests that both coope

297 bone marrow-derived mast cells (BMMCs) with PAG knockout and PAG knockdown and the corresponding con

298 n respectively modulated their coupling with PAG and thalamus across individuals.

299 Inhibition of CSE with PAG resulted in increased viral replication and chemokin

300 PFS was significantly improved with PAG treatment overall (hazard ratio [HR], 0.73; 95% CI,