ライフサイエンスコーパス: PBMC

1 PBMC composition and marker expression were overall simi

2 PBMC from HDM-allergics produced higher levels of IL-5 w

3 PBMC responses of 23 patients of the cohort and 23 healt

4 PBMC samples from D18 were submitted to RNAseq and 220 g

5 PBMC-engrafted NSG, NSG-MHC-DKO, and NSG-SGM3 mice were

6 PBMCs from ELGAN/ELBW neonates were collected at day 14,

7 PBMCs from healthy donors and/or respiratory epithelial

8 PBMCs isolated from RVVC patients (n=24) and healthy vol

9 PBMCs of children with difficult-to-control asthma treat

10 PBMCs were collected from 125 children with asthma (6-17

11 PBMCs were collected from 23/26 EBOV IgG-negative partic

12 after a ChAd155-RSV high dose was 108.3/106 PBMCs at D30, with no increase after the second dose.

13 on by PMA/ionomycin, TNF-alpha, or H(2)O(2), PBMCs from ulcerative colitis patients treated with NX-1

14 e tetravalent group and median 282 SFU/10(6) PBMCs in the trivalent group after the fourth vaccinatio

15 zes 9 multiplet-induced fake cell types in a PBMC dataset.

16 demonstrated by the inhibition of activated PBMC proliferation in a co-culture setting.

17 were selected for in vitro screening against PBMC samples from a cohort of chronic Chagas' disease pa

18 antifungal host defense against C. albicans PBMCs were stimulated with heat-killed (HK) C. albicans

19 d identification of EBV-infected cells among PBMCs.

20 Accordingly, we prospectively analyzed PBMCs both from septic patients (n = 10) and lipopolysac

21 alyzed cells infected in vitro with DENV and PBMC from an individual experiencing a natural DENV infe

22 Pre-weaning blood/graft gene expression and PBMC profiling may be useful as predictors of successful

23 otected methacholine challenges (SPMChs) and PBMC B2AR numbers (radioligand binding assay) and signal

24 cinated with seasonal influenza vaccine, and PBMC were collected before and up to 30 d after vaccinat

25 ranscriptomic analyses of ileal biopsies and PBMCs from inflammatory bowel disease patients, we ident

26 TNF-alpha ELISpot assays on whole blood and PBMCs were undertaken in control, critically ill nonsept

27 monocyte-derived dendritic cells (moDCs) and PBMCs.

28 ide DNA methylation levels in AECs, NECs and PBMCs were measured using the Infinium Human Methylation

29 to calculate the MES in both neutrophils and PBMCs.

30 DR3 levels (in plasma and PBMCs) were validated in unrelated cohorts (including lo

31 Additionally, serum and PBMCs samples were analyzed by metabolomics and transcri

32 (+) T-lymphocytes and NK cells in spleen and PBMCs), and apoptosis in IFNAR1-blocked pregnant mice du

33 the role of survivin in MG, we have assessed PBMCs from 29 patients with MG and 15 controls.

34 s from patients with easy-to-control asthma, PBMCs from those with difficult-to-control asthma had si

35 D8+ T cells) to the tumour-loaded autologous PBMCs compared to sCD40L.

36 We compared bulk PBMC findings with our previously published assessments

37 This was consistent with bulk PBMC transcriptomics and transient, low IFN-alpha levels

38 they induced the production of cytokines by PBMC and therefore may be useful tools in evaluating the

39 oids also enhance the synthesis of IL-17A by PBMCs, which, in excess, is associated with increased as

40 ers (type I and III interferons) produced by PBMCs transfected with NANPs.

41 sorted CD3(+) versus CD20(+) versus CD14(+) PBMC subpopulations indicated infection of the CD20(+) s

42 performed peripheral blood mononuclear cell (PBMC) analysis on a subgroup of 26 IgG-negative particip

43 rmined in peripheral blood mononuclear cell (PBMC) cultures.

44 atinib in peripheral blood mononuclear cell (PBMC) lysates from individual donors.

45 lyzed 181 peripheral blood mononuclear cell (PBMC) samples from 64 PLWH starting ART during early HIV

46 lation in peripheral blood mononuclear cell (PBMC) samples from HIV-positive (HIV(+)) participants wh

47 n for 120 peripheral blood mononuclear cell (PBMC) samples of patients with idiopathic pulmonary fibr

48 mples, 29 peripheral blood mononuclear cell (PBMC) samples, and 32 plasma samples.

49 we modify peripheral blood mononuclear cell (PBMC)-derived CD8 T cells to express the CCR9 chemokine

50 Thus, peripheral blood mononuclear cell (PBMC)-derived induced pluripotent stem cells (iPSC) were

51 eral blood and lymph node mononuclear cells (PBMC and LNMC) during ART suppression.

52 MKP-1 in peripheral blood mononuclear cells (PBMC) after in vitro stimulation with either anti-CD3/an

53 In both peripheral blood mononuclear cells (PBMC) and macrophages, omega-3 increased ATP-linked oxyg

54 V DNA in peripheral blood mononuclear cells (PBMC) by real-time PCR revealed levels similar to those

55 onses of peripheral blood mononuclear cells (PBMC) collected from male rhesus macaques classified as

56 ssion in peripheral blood mononuclear cells (PBMC) derived from these IPF study subjects.

57 mples of peripheral blood mononuclear cells (PBMC) from 5 antiretroviral therapy (ART)-suppressed par

58 ssion in peripheral blood mononuclear cells (PBMC) from 77 Holocaust survivor offspring and 15 compar

59 genes in peripheral blood mononuclear cells (PBMC) from ASD children, their non-ASD siblings, and age

60 ted with peripheral blood mononuclear cells (PBMC) from long-term ART-suppressed HIV-infected donors.

61 Peripheral blood mononuclear cells (PBMC) from perinatally infected children from the Childr

62 etent in peripheral blood mononuclear cells (PBMC) of all RMs tested.

63 ed human peripheral blood mononuclear cells (PBMC) proliferation, significantly outperforming a decli

64 lyses of peripheral blood mononuclear cells (PBMC) RNA from subjects enrolled in the Clinical Trials

65 reatment peripheral blood mononuclear cells (PBMC) samples.

66 ength in peripheral blood mononuclear cells (PBMC) significantly decreased with age, no correlation w

67 asma and peripheral blood mononuclear cells (PBMC) were also genotyped.

68 tions in peripheral blood mononuclear cells (PBMC) were found to be at least 10-fold higher than the

69 reserved peripheral blood mononuclear cells (PBMC) were obtained from infants from 2 randomized contr

70 genes in peripheral blood mononuclear cells (PBMC); and (2) characterize the temporal pattern of earl

71 ng human peripheral blood mononuclear cells (PBMCs) and a CAR construct that enables the expression o

72 dhere to peripheral blood mononuclear cells (PBMCs) and DF-1 cells and cause apoptosis in PBMCs.

73 Nomes in peripheral blood mononuclear cells (PBMCs) and extracellular vesicles (EVs) from severely il

74 in peripheral blood mononuclear cells (PBMCs) and in cell pellets from CSF.

75 genes in peripheral blood mononuclear cells (PBMCs) and lesion biopsy specimens obtained from CL pati

76 imulated peripheral blood mononuclear cells (PBMCs) and skin punch biopsies of IBH lesions and health

77 in human peripheral blood mononuclear cells (PBMCs) and synergistic in human FLT3-differentiated mBMD

78 ng human peripheral blood mononuclear cells (PBMCs) and the SupT1 cell line.

79 culating peripheral blood mononuclear cells (PBMCs) are referred to as "defective" by virtue of havin

80 found in peripheral blood mononuclear cells (PBMCs) derived from patients with autoimmune disease sys

81 llenging peripheral blood mononuclear cells (PBMCs) derived from patients with confirmed treatment-na

82 tides on peripheral blood mononuclear cells (PBMCs) from 14 HLA I typed subjects.

83 rsts and peripheral blood mononuclear cells (PBMCs) from 17 adult asthmatics after a long-term use of

84 Peripheral blood mononuclear cells (PBMCs) from 25 patients with chronic periodontitis (CP)

85 uated in peripheral blood mononuclear cells (PBMCs) from FRDA patients and from non-related healthy c

86 tion, in peripheral blood mononuclear cells (PBMCs) from healthy donors and patients with ASD.

87 cells in peripheral blood mononuclear cells (PBMCs) from healthy donors incubated with infliximab or

88 ata from peripheral blood mononuclear cells (PBMCs) from healthy donors to distinguish cell-type-spec

89 ormed on peripheral blood mononuclear cells (PBMCs) from PBC patients (n = 33) and age-/sex-matched h

90 les in stimulated primary mononuclear cells (PBMCs) from RVVC and healthy individuals.

91 profile peripheral blood mononuclear cells (PBMCs) from seven patients hospitalized for COVID-19, fo

92 from 2 million peripheral mononuclear cells (PBMCs) in 14 HAM/TSP patients, 34 MS patients and 20 hea

93 sting of peripheral blood mononuclear cells (PBMCs) in a subset of study participants.

94 lysis of peripheral blood mononuclear cells (PBMCs) isolated from healthy controls and drug-naive pat

95 ation in peripheral blood mononuclear cells (PBMCs) longitudinally collected from a cohort of elderly

96 In the peripheral blood mononuclear cells (PBMCs) of COVID-19 patients, we observed reduced express

97 S) using peripheral blood mononuclear cells (PBMCs) of individuals naturally exposed to DENV or immun

98 ation in peripheral blood mononuclear cells (PBMCs) of patients with BD and healthy individuals.

99 hy donor peripheral blood mononuclear cells (PBMCs) or NK cells, even at high (25 uM) concentrations.

100 rd-party peripheral blood mononuclear cells (PBMCs) pretreated with anti-HLA antibody positive (HS) o

101 files in peripheral blood mononuclear cells (PBMCs) pretreated with Whole Smoke-Conditioned Medium (W

102 om whole peripheral blood mononuclear cells (PBMCs) results in the most reliable BCR repertoire data,

103 IgE and peripheral blood mononuclear cells (PBMCs) to flour extracts used in the bakery in practice.

104 etics of peripheral blood mononuclear cells (PBMCs) under basal conditions or in situations that prom

105 TKO pig peripheral blood mononuclear cells (PBMCs) using sera from humans, several OWMs, and two New

106 iations, peripheral blood mononuclear cells (PBMCs) were collected from 21 children (aged 1-19 years)

107 evels in peripheral blood mononuclear cells (PBMCs) were similar among infected and uninfected macaqu

108 ed human peripheral blood mononuclear cells (PBMCs) were suppressed by MSC bioreactor culture confirm

109 ation of peripheral blood mononuclear cells (PBMCs) with antigen.

110 ation of peripheral blood mononuclear cells (PBMCs) with novel Kgp synthetic peptides.

111 th human peripheral blood mononuclear cells (PBMCs) with poly I:C-activated hPDL cells was performed.

112 added to peripheral blood mononuclear cells (PBMCs), and ADE and NK cell activation were simultaneous

113 ation in peripheral blood mononuclear cells (PBMCs), and the potential antiinflammatory effect of boo

114 ted into peripheral blood mononuclear cells (PBMCs), plasma, and serum.

115 l model, peripheral blood mononuclear cells (PBMCs), that is highly predictive of cytokine responses.

116 nd human peripheral blood mononuclear cells (PBMCs), the propagation of the two viruses was restricte

117 tion) of peripheral blood mononuclear cells (PBMCs), which was normalized in metformin-treated guinea

118 Cs), and peripheral blood mononuclear cells (PBMCs).

119 (IgA) in peripheral blood mononuclear cells (PBMCs).

120 al human peripheral blood mononuclear cells (PBMCs).

121 omics in peripheral blood mononuclear cells (PBMCs).

122 nd human peripheral blood mononuclear cells (PBMCs).

123 epatocytes and peripheral mononuclear cells (PBMCs).

124 culating peripheral blood mononuclear cells (PBMCs).

125 of human peripheral blood mononuclear cells (PBMCs).

126 Y5Y) and peripheral blood mononuclear cells (PBMCs).

127 in human peripheral blood mononuclear cells (PBMCs).

128 and the peripheral blood mononuclear cells (PBMCs)isolated from the circulating blood from 4 hr afte

129 ed total peripheral blood mononuclear cells (PBMCs, 106,545 cells) and dendritic cells (19,806 cells)

130 FU/10(6) peripheral blood mononuclear cells [PBMCs] in the tetravalent group and median 282 SFU/10(6)

131 d blood (peripheral blood mononuclear cells [PBMCs]).

132 or comparison = 0.013) compared with control PBMCs.

133 e established and characterized by culturing PBMCs from healthy donors and patients with a history of

134 inical development against 126 Clade A, C, D PBMC-derived primary African isolates.

135 on and IFN-gamma release in cocultures of DC-PBMC.

136 NK cell-depleted PBMCs had increased ADE as compared to whole PBMCs.

137 activated NK cells back into the NK-depleted-PBMCs or to purified monocytes decreased ADE.

138 Last, oral NR administration enhanced PBMC respiration and reduced proinflammatory cytokine ge

139 Epithelial-PBMC co-cultures showed robust IFN-gamma-dependent CXCL9

140 a limited number of differentially expressed PBMC and EV miRNAs appear significantly associated with

141 The extracts were not cytotoxic for PBMC in vitro up to 500 ug/ml, while immunomodulatory ef

142 reated PBMCs (Allo-CFC-1) and serum used for PBMC pretreatment (Allo-CFC-2) in Allo-CFC, and serum us

143 reated PBMCs (Allo-CFC-1) and serum used for PBMC pretreatment (Allo-CFC-2) in Allo-CFC, and serum us

144 Depletion of MAIT cells from PBMC resulted in decreased total production of IFNgamma,

145 ndogenous TL1A is also rapidly released from PBMC cultures in response to bacterial triggering, there

146 97 subjects with asthma and 97 controls from PBMCs.

147 RNA was extracted from PBMCs, sorted B cells, and nasal biopsy samples for heav

148 Total RNA isolated from PBMCs was hybridized onto the Affymetrix Human Gene 2.0

149 ry human hepatocytes treated with media from PBMCs stimulated with (R)-7, supporting the clinical dev

150 Gene expression profiles from PBMCs treated with low equi-nicotine units (0.3 mug/mL)

151 Of these, 1/23 participants had PBMCs which produced anti-EBOV-specific IgG antibodies u

152 ied one IgM/IgG negative participant who had PBMCs which produced anti-EBOV-specific antibodies upon

153 of sterile inflammation by treating healthy PBMCs with mitochondrial damage-associated molecular pat

154 However, PBMCs from patients with ESKD treated with paricalcitol

155 tiation of mouse bone marrow cells and human PBMC into immunosuppressive M-MDSC.

156 high affinity, and effectively blocks human PBMC responses to IL-33.

157 used BiFET to study TF footprints from human PBMC and pancreatic islet ATAC-seq samples to show its u

158 ced induced production of IFN-gamma in human PBMC culture, and increased survival of influenza A-infe

159 We used a novel human PBMC culture platform, a mouse model of peanut allergy,

160 Upon adoptive transfer of human PBMC, this reductionist system allowed us to study human

161 restricted to in vitro studies and to human PBMC serving as primary cell source.

162 t in vitro both murine splenocytes and human PBMCs secrete CCL22 spontaneously without any further st

163 ranscriptomic and repertoire data from human PBMCs in a variety of clinical settings.

164 on of IFN-gamma and IL-10 from healthy human PBMCs and decreased bacterial clearance activity of whol

165 In human PBMCs, we have demonstrated that blockade of IL-4/IL-13

166 edict cell types for mouse leukocytes, human PBMCs and human T cell sub types.

167 In endotoxin-stimulated human PBMCs, IP inhibition reduces the secretion of several pr

168 In stimulated human PBMCs, nc886 expression strongly correlated with IFN-gam

169 Treated human PBMCs and human mast cells were assessed by fluorescence

170 Using human PBMCs, we confirmed in this study that gammadelta T cell

171 In PBMC, pregnancy stimulated transcription of IFI6, RSAD2,

172 the reduction of Th2 cytokines and IL-10 in PBMC cultures.

173 ripts was compared between P and NP, both in PBMC and PMN.

174 This study was conducted in PBMC of 20 HIV-infected virally suppressed children on A

175 No differences in PBMC responses were found between patients and controls.

176 ese data suggest that intact proviral DNA in PBMC and LNMC during ART suppression is likely the direc

177 ncy-induced transcription of select genes in PBMC and peripheral blood polymorphonuclear cells (PMN).

178 moves aberrant expression of marker genes in PBMC datasets.

179 rify the levels of the cytokines produced in PBMC cultures after 48 hours.

180 viruses closely match viral DNA sequences in PBMC and LNMC during ART suppression.

181 In PBMCs isolated from patients with ESKD, TRAF3 protein le

182 In PBMCs of asthmatic and control children, NIP45 mRNA dire

183 fied in individual cell types were absent in PBMCs.

184 PBMCs) and DF-1 cells and cause apoptosis in PBMCs.

185 Immunological responses were assessed in PBMCs using mass cytometry.RESULTSA total of 19 patients

186 proteins MnSOD and Nrf2 was observed both in PBMCs and AC16 cardiomyocytes.

187 Apoptotic cells in PBMCs and tissues increased during peak viral load.

188 ant change in the percent of CD8+ T cells in PBMCs, and 37 differentially accessible transcription fa

189 highlight that diet and age cause changes in PBMCs recovered from different strains of rats.

190 xpression of the dsRNA-containing circRNA in PBMCs or T cells derived from SLE can alleviate the aber

191 Cellular mtDNA content in PBMCs was higher than in peripheral blood and a surprisi

192 Telomere length decreased in PBMCs at 24 wk compared to baseline in all strains, indi

193 However, a 100-fold increase in SIV DNA in PBMCs was associated with only a 2-fold increase in the

194 ed with TAF in SMCs was 6% that of TFV-dp in PBMCs.

195 SMPD3 was elevated in PBMCs from obese individuals and positively corelated wi

196 However, the opposite was found in PBMCs.

197 ther with the impaired expression of Gal9 in PBMCs and DCs appears to have a role in the development

198 cing CD4 T cells was significantly higher in PBMCs than BM.

199 IL-31 was increased in PBMCs and exclusively detectable in skin lesions of IBH-

200 used to decipher EV-A71-host interactions in PBMCs.

201 ncrease in the production of IL-10 levels in PBMCs stimulated with the peptides as well as an increas

202 E(2)) further diminished IFN-gamma levels in PBMCs, and supplementation of cells with nonsteroidal an

203 ed the expression levels of those markers in PBMCs taken from ASD patients in response to orally-deli

204 B2AR downregulation measured in PBMCs does not appear to reflect LOBP.

205 expression through epigenetic mechanisms in PBMCs from FA children.

206 ponsiveness to endotoxin is also observed in PBMCs from individuals with milk and egg allergy.

207 e bioenergetics and antioxidant responses in PBMCs whereas lack of PINK1 upregulates compensatory gly

208 AF3) by the VDRA paricalcitol was studied in PBMCs from patients with ESKD, cytokine-stimulated cells

209 esponse to sulforaphane ex vivo treatment in PBMCs from healthy donors by real-time quantitative PCR.

210 s explain clear gene regulatory variation in PBMCs from AS patients, providing a foundational framewo

211 Depletion of TREM-1 in EV-A71-infected PBMCs with peptide LP17 resulted in decreased levels of

212 nts, poly I:C-activated hPDL cells inhibited PBMCs proliferation and increased mRNA expression of for

213 One week after intrasplenic PBMC injection, in situ hybridization of the spleen demo

214 anges in the molecular responses of isolated PBMCs.

215 neurotrophic factor were altered in PINK1-KO-PBMCs and by psychological distress.

216 enhanced the glycolytic capacity in PINK1-KO-PBMCs but not in WT-PBMCs.

217 using an XF metabolic bioanalyzer, PINK1-KO-PBMCs showed significantly increased oxidative phosphory

218 the feasibility of preferentially localizing PBMC-derived CD8 T cells to the small intestine and enab

219 was performed with baseline and longitudinal PBMC samples of a cohort of patients with acute, chronic

220 In this study, we collected longitudinal PBMC samples from people starting ART and measured immun

221 ntify monocytes as the major type of maxRNA+ PBMCs and prioritize 11 candidate maxRNAs for functional

222 was 1.4, 4.1, and 3.6 log(10) copies/million PBMCs for individuals who initiated ART at FI, FII, and

223 dosing observed in mouse and TFV-DP in mouse PBMC.

224 and IL-6(+) T cells was detected in early MS-PBMCs, whereas NFAT1(hi)T-bet(hi)CD4(+) T cells were dec

225 For ADCC, normal PBMCs were incubated with Farage B (FB) cells with HS or

226 while showing no cytotoxicity against normal PBMCs, NIH3T3, and HEK293 cells.

227 The 5' capture scRNAseq analysis of PBMC not only recapitulated previously published reports

228 In vitro, costimulation of PBMC with DR3-specific mAb increased the magnitude of HI

229 and 20, blood was collected for isolation of PBMC and PMN from heifers that were retrospectively clas

230 However, a major limitation of PBMC engraftment is development of acute xenogeneic graf

231 fraction were unaffected by the presence of PBMC conditioned medium, with no observable differences

232 ne responses and transcriptional profiles of PBMC, reinforcing the importance of early TI.

233 ess of dose alters resting transcriptomes of PBMC, with the largest impact seen in innate immune cell

234 and attenuate proinflammatory activation of PBMCs in HF.TRIAL REGISTRATIONClinicalTrials.gov NCT0372

235 Transcriptomic analysis of PBMCs after AS03-adjuvanted H5N1 vaccination revealed ea

236 titative serum proteomics, flow cytometry of PBMCs, and pathway analyses were employed to identify no

237 Incubation of PBMCs with infliximab-TNF complexes resulted in a 4.74-f

238 Our cross-phenotype investigation of PBMCs and plasma/brain proteins provides a more sensitiv

239 paration of pyrogen-free NANPs, isolation of PBMCs from freshly collected human blood, and analysis o

240 Global gene expression profiles of PBMCs from 43 drug-naive patients presenting with joint

241 The ex vivo response of PBMCs to L (V) panamensis partially reflected that of le

242 o in vitro Ebola glycoprotein stimulation of PBMCs isolated before and after vaccination.RESULTSWe sh

243 Stimulation of PBMCs with NiSO(4) induced CD154 expression on ~0.1% (me

244 generated by the human adoptive transfer of PBMCs or the cotransplantation of hematopoietic stem cel

245 However, pre-treatment of PBMCs with physiologically-relevant concentrations of ge

246 We performed in vitro kinetic assays on PBMCs in 195 MS patients and 60 matched controls and qua

247 evaluated whether innate NK cell activity or PBMC transcriptional profiles were associated with decre

248 No patient with U-MRD by NGS in BM or PBMC was MRD+ in plasma.

249 Human moDCs or PBMCs were incubated with proteins and evaluated for exp

250 ve CD8(+) T cell responses in HSAN-I patient PBMCs and Sptlc2-deficient mice were restored by supplem

251 The patients' PBMCs showed increased levels of signal transducer and a

252 ted by functional assays using the patients' PBMCs.

253 In the presence of platelets, PBMCs produced less IFN-gamma upon stimulation with HK C

254 aride-induced nitric oxide production in rat PBMCs were positively correlated.

255 ular lipid uptake and the bioactivity in rat PBMCs.

256 and 24 wk to assess chemistry and to recover PBMCs.

257 The patient's PBMC produced a substantial amount of IL-5 and IL-13 in

258 observed increased frequencies of SLAMF7(+) PBMCs in HIV(+) individuals in a clinical phenotype-depe

259 The TFV-dp SMC:PBMC ratio was also significantly lower with TAF.

260 d CD8(+) T cell reactivity to donor-specific PBMCs in 24 patients who had received living-donor kidne

261 In vitro ovalbumin-stimulated PBMC were analyzed by flow cytometry for presence of ova

262 erferon-gamma levels of endotoxin-stimulated PBMCs from children allergic to milk or egg, but not pea

263 pha/IL-10 ratio in Candida hyphae-stimulated PBMCs were significantly higher in patients than control

264 s (n = 10) and lipopolysaccharide stimulated PBMCs from healthy volunteers (n = 20).

265 re mirrored in lipopolysaccharide stimulated PBMCs taken from healthy volunteers.

266 he main producers of IL-23 in LPS-stimulated PBMCs.

267 In (LPS/ATP-stimulated) PBMCs, IL-18/TNF/caspase-1 were all significantly decrea

268 placebo-controlled, time course SLIT study, PBMCs and nasal biopsy samples were collected from 40 ad

269 diagnostic accuracy and efficacy levels than PBMCs.

270 Overall our results demonstrate that PBMC-engrafted NSG models are rapid, sensitive, and repr

271 orest classification algorithm revealed that PBMC-, NEC-, and AEC-based methylation data yielded 31 l

272 Our findings suggest that PBMC DNA methylation-based models may be useful as bioma

273 oosting the NAD level.METHODSWe compared the PBMC mitochondrial respiration of 19 hospitalized patien

274 xerted a lower classification error than the PBMC-based DNAm markers (p-value = 0.0002).

275 protein 5 induction by FLU) increased in the PBMCs of patients with difficult-to-control and easy-to-

276 ally linked to mitochondrial function of the PBMCs.

277 should assess the prognostic value of their PBMC mRNA expression of OXTR, AVPR1A, and IGF1.

278 apeutic-stimulated cytokine release in these PBMC-based NSG models captures the variation in cytokine

279 greater IgM binding and cytotoxicity to TKO PBMCs than humans or NWMs.

280 Cytotoxicity of OWM sera to TKO PBMCs was significantly greater than of human serum, but

281 rm, and results were generally comparable to PBMC-based ELISpot.

282 However, several pathways were unique to PBMCs, and several pathways identified in individual cel

283 In our in vitro model, MitoDAMP-treated PBMCs secreted IL-6 that impaired mitochondrial respirat

284 of imlifidase on these assays, serum-treated PBMCs (Allo-CFC-1) and serum used for PBMC pretreatment

285 ffect of IdeS on these assays, serum-treated PBMCs (Allo-CFC-1) and serum used for PBMC pretreatment

286 Compared with microparticle unchallenged PBMCs, total NF-kappaB and p-NF-kappaB were significantl

287 omas comparing to microparticle unchallenged PBMCs.

288 ture exhibited by the patients' unstimulated PBMCs parallels the hyperinflammatory state associated w

289 wo-step assay with high specificity, we used PBMCs from kidney recipients (n = 87).

290 ELISpot analysis was performed using PBMC fraction from patient whole-blood samples.

291 We validated these results using PBMC samples from patients with idiopathic pulmonary fib

292 with a more traditional ELISpot assay using PBMCs in sepsis.

293 We sought to examine whether in vitro PBMC responses to corticosteroids relate to the clinical

294 tokine secretion was measured after in vitro PBMC restimulation with low-dose IL-15, alone or in comb

295 When PBMC mobilized by FL/GCSF/AMD3100 were transplanted into

296 PBMCs had increased ADE as compared to whole PBMCs.

297 by NGS was lowest in BM (25%), compared with PBMC (55%) or plasma (75%).

298 Compared with PBMCs from patients with easy-to-control asthma, PBMCs f

299 on, immunodeficient mice were engrafted with PBMCs from these allergic donors plus the respective all

300 tic capacity in PINK1-KO-PBMCs but not in WT-PBMCs.