ライフサイエンスコーパス: PC1

1 PC1 ('binge-eating'), accounting for 38% of variation, c

2 PC1 (negative loadings on uncultured Christensenellaceae

3 PC1 ablation reduced action potential duration in cardio

4 PC1 and Pacsin 2 co-localize on the lamellipodia of migr

5 PC1 and Pacsin 2-deficient kidney epithelial cells migra

6 PC1 and PC2 are secreted on urinary exosome-like vesicle

7 PC1 and PC2 were also associated with nasal obstruction,

8 PC1 binds to a 107-residue fragment containing the alpha

9 PC1 C terminus inhibited Kv4.3 currents to the same degr

10 PC1 explained 32.7% of the variation and depicted vertic

11 PC1 has a predicted molecular mass of ~460 kDa comprisin

12 PC1 has been shown to form a complex with PC2, and the s

13 PC1 is a complex polytopic membrane protein expressed in

14 PC1 is ubiquitously expressed, and its experimental abla

15 PC1 must also be proteolytically cleaved at a GPS site f

16 PC1 proteins included keratin intermediate filaments; pr

17 PC1 separated Basmati from the other two cultivars and P

18 PC1 surface localization in GANAB(-/-) cells was rescued

19 PC1 undergoes regulated cleavage that releases its C-ter

20 PC1 was associated with a SNP near PAX5 (P = 0.01).

21 PC1 was previously shown to slow cell proliferation and

22 PC1&PC2 independently predicted 90-day mortality (ORs 2.

23 PC1(mussel) and PC1(discharge) were closely linked to re

24 PC1-CTT physically interacts with TAZ, stimulating RunX2

25 PC1-deficient cardiomyocytes manifested a reduction in s

26 PC1/3 is an endoprotease that processes many prohormones

27 s was identified as a principal component 1 (PC1) with the highest expression in AD FA+ STSs.

28 duced expression of prohormone convertase 1 (PC1).

29 Polycystin-1 (PC1) and -2 (PC2), the two ADPKD gene products, are larg

30 oteins encoded by these genes, polycystin-1 (PC1) and polycystin-2 (PC2), form a plasma membrane rece

31 The ADPKD proteins, termed as polycystin-1 (PC1) and polycystin-2 (PC2), interact via their C-termin

32 in PKD1 or PKD2, which encode polycystin-1 (PC1) and polycystin-2 (PC2), respectively, cause autosom

33 PKD1 and PKD2 genes, encoding polycystin-1 (PC1) and polycystin-2 (PC2), respectively, lead to autos

34 ions in PKD1 and PKD2 encoding polycystin-1 (PC1) and polycystin-2 (PC2), respectively.

35 ltipass transmembrane proteins polycystin-1 (PC1) and polycystin-2 (PC2), respectively.

36 utations in the genes encoding polycystin-1 (PC1) and polycystin-2 (PC2), which form an ion channel c

37 in PKD1 or PKD2 which encodes polycystin-1 (PC1) and polycystin-2, respectively.

38 creens using the C-terminus of polycystin-1 (PC1) as bait.

39 Mutations in polycystin-1 (PC1) give rise to autosomal dominant polycystic kidney d

40 the BBSome, the ADPKD protein polycystin-1 (PC1) interacts with BBS1, BBS4, BBS5 and BBS8, four of t

41 Polycystin-1 (PC1) is a transmembrane protein originally identified in

42 Dysregulation of polycystin-1 (PC1) leads to autosomal dominant polycystic kidney disea

43 Polycystin-1 (PC1) mutations result in proliferative renal cyst growth

44 commonly caused by defects in polycystin-1 (PC1) or polycystin-2 (PC2), in which tubular epithelia f

45 her PKD1 or PKD2, which encode polycystin-1 (PC1) or polycystin-2 (PC2), respectively.

46 ective ciliary localization of polycystin-1 (PC1), a large integral membrane protein encoded by PKD1,

47 Mutations in Pkd1, encoding polycystin-1 (PC1), cause autosomal-dominant polycystic kidney disease

48 Polycystin-1 (PC1), encoded by the PKD1 gene that is mutated in the au

49 The polycystin-1 (PC1), polycystin-2 (PC2) and fibrocystin proteins, the r

50 idney as the result of reduced polycystin-1 (PC1).

51 ns in the gene (PKD1) encoding polycystin-1 (PC1).

52 product, the membrane protein polycystin-1 (PC1).

53 utations in the genes encoding polycystin-1 (PC1, PKD1) or polycystin-2 (PC2, PKD2) cause ADPKD, and

54 Through Jade-1, PC1 and PC1 cleaved forms may exert fine control of beta

55 that identification of B-1a.PC1(lo) and B-1a.PC1(hi) cells extends the concept of a layered immune sy

56 We conclude that identification of B-1a.PC1(lo) and B-1a.PC1(hi) cells extends the concept of a

57 Mutations in polycystin 1 and 2 (PC1 and PC2) cause the common genetic kidney disorder au

58 he family of prohormone convertases 1 and 2 (PC1 and PC2).

59 r PKD2 genes that encode Polycystin 1 and 2 (PC1/2), transmembrane proteins that translocate to the c

60 five longest mussel chronologies (1982-2003; PC1(mussel)) accounted for 47% of the dataset variabilit

61 s (PCs) furin and proprotein convertase 1/3 (PC1) cleave substrates at dibasic residues along the euk

62 proinsulin using prohormone convertase 1/3 (PC1/3) and then prohormone convertase 2 (PC2), this find

63 Proprotein convertase 1/3 (PC1/3) deficiency, an autosomal-recessive disorder cause

64 ge, .001-.03) and a reduced odds of having a PC1/2 of >=5 hours and having parasitemia 3 days after t

65 rasite clearance half-life (PC1/2), having a PC1/2 of >=5 hours, and having parasitemia 3 days after

66 By controlling Jade-1 abundance, PC1 and the PC1-CTF differentially regulate Jade-1-media

67 In addition, PC1 had a significant correlation with sex, body mass in

68 Additionally, PC1 coimmunoprecipitated with Kv4.3, and a modeled PC1 C

69 oded by two genes are associated with ADPKD: PC1 (pkd1), primarily a signaling molecule, and PC2 (pkd

70 l determinants of PC activation, we analyzed PC1/3, a paralogue of furin that is activated at a pH of

71 sion models between antioxidant capacity and PC1 and PC2 displayed strong linear correlations for NF

72 e levels, including Pdx1, Nkx6.1, GLUT1, and PC1/3.

73 PC1(mussel) and PC1(discharge) were closely linked to regional wintertim

74 int to a pivotal role of this organelle, and PC1, in disease-related pathological cardiac remodeling

75 Through Jade-1, PC1 and PC1 cleaved forms may exert fine control of beta-catenin

76 Further experiments showed that PC1 and PC1-5TMC reduce phosphorylation of eIF2alpha through inh

77 f a common precursor, proglucagon by PC2 and PC1, respectively.

78 One of the ARGs, PC1 beta-lactamase may also be a mobile element that fac

79 ite measure of four PS tasks, referred to as PC1.

80 However, the role of large COPII vesicles as PC1 transport carriers was not unambiguously demonstrate

81 CC) between the four PS measures, as well as PC1, were calculated to assess reliability.

82 INT-777 augmented PC1 expression in alpha cells and stimulated GLP-1 relea

83 PC1 and PC2 first interact in the ER before PC1 cleavage at the GPS/GAIN site and determined that PC

84 Correlations between PC1 calculated using genome-wide data versus each subset

85 lots showed a significant difference between PC1 low vs. high group.

86 A positive association was found between PC1 and the risk of obese asthma (OR = 1.43, 95% CI 1.01

87 reveal a reciprocal functional link between PC1 and PC2 which is critically dependent on their inter

88 st important variable for explaining biology PC1 variability, and commercial catch the most important

89 and generalized additive models (for biology PC1-2) invoking only the climate modes produced residual

90 idate variables, resulting models of biology PC1-2 satisfied assumptions of independent residuals and

91 ry for taxa strongly associated with biology PC1-2 suggest plausible mechanistic explanations for the

92 sp are in the same protein complex, and both PC1 and Pacsin 2 are required for N-Wasp/Arp2/3-dependen

93 relations were found when adjusting for both PC1 and PC2 for either subset of AIMs (r(2) > 0.900).

94 PC2, whose dephosphorylation is mediated by PC1 binding through the recruitment of protein phosphata

95 althy human beta-cells process proinsulin by PC1/3 but not PC2, we suggest that there is a need to re

96 AMP amplified the activation of Src/STAT3 by PC1-p30.

97 sicles that completely encapsulate the cargo PC1 and are physically separated from ER.

98 Compared with wild-type cells, PC1-depleted immortalized renal collecting duct cells ha

99 in size and that N-terminal GPS/GAIN cleaved PC1 and PPC cleaved fibrocystin ectodomains can be relea

100 membranous COOH-terminal fragment of cleaved PC1 required an intact interaction with PC2.

101 Both linear models (for climate PC1) and generalized additive models (for biology PC1-2)

102 Collectively, PC1 proteins are associated with abnormalities in skin b

103 s of 19 LCVs, the first principal component (PC1) explained 27.7% of the total variance, and the PC1

104 ariables were the first principle component (PC1) of four regional climate parameters [sea surface te

105 ence EEMs revealed two principal components (PC1-tryptophan, PC2-tyrosine) that captured significant

106 between the first two principle components (PC1-PC2) best represented ARHI.

107 PC1, compared with control cells containing PC1.

108 elix 2 (NHLH2) and the prohormone convertase PC1 (encoded by PCSK1) were reduced in PWS patient induc

109 In proximal tubule-derived, PC1-knock-out cells, adenylyl cyclase 6 and 3 (AC6 and -

110 ding principal component of river discharge (PC1(discharge); r = -0.88; P < 0.0001).

111 type 1 (Pcsk1) expression, the gene encoding PC1/3, which controls GLP-1 production, was decreased in

112 pbp2a antibiotic-resistance genes, encoding PC1 and PBP2a, respectively.

113 creased the surface expression of endogenous PC1 and PC2 in vitro and in vivo and increased Wnt-activ

114 est that a test measuring the urine exosomal PC1/TMEM2 or PC2/TMEM2 ratio may have utility in diagnos

115 Crown cells express PC1-L1 and PC2, which may form a heteromeric polycystin

116 cells elaborated primary cilia and expressed PC1, PC2, and FPC at similar levels, and PKD and control

117 seropositivity were associated with a faster PC1/2 (range of the mean reduction in PC1/2, 0.47-1.16 h

118 Genome-wide association analyses for PC1-3 were conducted separately in each sample assuming

119 that PC2 acts as an essential chaperone for PC1 maturation and surface localization.

120 revealed that this motif is dispensable for PC1 trafficking to cilia.

121 e silenced exclusively in myofibroblasts for PC1 and evaluated the role of PC1 in fibrogenesis in adu

122 determined that GPS cleavage is required for PC1 trafficking to cilia.

123 mpelling results support a critical role for PC1 deficiency in PWS, more work needs to be done to ful

124 Our findings uncover a role for PC1 in regulating multiple Kv channels, governing membra

125 ggested the existence of 2 docking sites for PC1 within the N terminus of Kv4.3, supporting a physica

126 ative membrane-anchored C-terminal fragment (PC1-MAT) increased NHA2 levels.

127 Peritoneal macrophages isolated from PC1/3 KO mice also demonstrate elevated cytokine secreti

128 at animals with reduced levels of functional PC1 and PC2 in the kidney exhibited severe, rapidly prog

129 rylation of PC2 in the absence of functional PC1 could contribute to cyst initiation in PKD1 patients

130 Pkd1 mutant mice but the mechanism governing PC1 activation of RunX2 is unclear.

131 fic antibodies have been raised using hapten PC1 (a 1:1 mixture of 9-hydroxy- and 6-hydroxy-phenazine

132 These individuals harbor PC1 loss-of-function mutations in their cardiomyocytes,

133 e survival of low PC1 was 89.6% and the high PC1 was 95.9%.

134 protein EGLN3 (or PHD3), which hydroxylates PC1.

135 f large cargo, such as 300-nm procollagen I (PC1) molecules, from the endoplasmic reticulum (ER) to t

136 of PKD cell lines, which exhibit defects in PC1 expression and collagen compaction.

137 ogenesis is most likely driven by defects in PC1 maturation.

138 Humans and mice deficient in PC1 display hyperphagic obesity, hypogonadism, decreased

139 he well-described GPS/GAIN cleavage event in PC1 at 3048 aa and the proprotein convertase cleavage (P

140 n-coupled receptor proteolysis site (GPS) in PC1.

141 l inhibition of HDAC6 reduced cyst growth in PC1-knock-out mice.

142 Intracellular Ca(2+) was higher in PC1-knock-out cells than in control cells.

143 (acetoxymethyl ester) reduced cAMP levels in PC1-knock-out cells.

144 faster PC1/2 (range of the mean reduction in PC1/2, 0.47-1.16 hours; P range, .001-.03) and a reduced

145 c alpha cells enhances hyperglycemia-induced PC1 expression thereby releasing GLP-1, which in turn in

146 Interestingly, PC1 does not activate autophagy generally.

147 potential duration in cardiomyocytes lacking PC1.

148 Moreover, cells lacking PC1 expression use less O2 and show less mitochondrial C

149 otein expression was higher in cells lacking PC1, compared with control cells containing PC1.

150 phosphorylated in cells and tissues lacking PC1.

151 ons that control levels of a beta-lactamase, PC1, and a penicillin-binding protein poorly acylated by

152 ds to PC2 and that expression of full-length PC1 accelerates the transport of the HDAC6-PC2 complex t

153 Overexpression of full-length PC1 in HEK293 cells significantly reduced the current de

154 We show here that full-length PC1 that interacts with PC2 via a C-terminal coiled-coil

155 3 currents to the same degree as full-length PC1.

156 itivity on the parasite clearance half-life (PC1/2), having a PC1/2 of >=5 hours, and having parasite

157 When challenged with lipopolysaccharide, PC1/3 KO mice are more susceptible to septic shock than

158 The 5YLM-free survival of low PC1 was 89.6% and the high PC1 was 95.9%.

159 In Caenorhabditis elegans and mammals, PC1 and PC2 act in the same genetic pathway, act in a se

160 D proteins (PC1 and PC2), and reduced mature PC1 was seen in GANAB(+/-) cells.

161 e is associated with the level of the mature PC1 glycoform.

162 nequimolar reduction (20%-25%) of the mature PC1 glycoform.

163 regulates PC1 maturation; therefore, mature PC1 levels are a determinant of disease severity in PKD2

164 west transmission intensity and slowest mean PC1/2.

165 nvertase (PC) family comprises nine members: PC1/3, PC2, furin, PC4, PC5/6, PACE4, PC7, SKI-1/S1P, an

166 immunoprecipitated with Kv4.3, and a modeled PC1 C-terminal structure suggested the existence of 2 do

167 Finally, a naturally occurring human mutant PC1(R4228X) manifested no suppressive effects on Kv4.3 c

168 A novel PC1/3 variant introducing an Arg to Gln amino acid subst

169 In the absence of PC1-p30, cAMP dampened EGFR- or IL-6-dependent activatio

170 ment-binding protein-dependent activation of PC1.

171 aturation and in vitro catalytic activity of PC1/3.

172 Analysis of PC1 proteins expression in an independent adult AD cohor

173 ene, ALG9, and in vitro cell-based assays of PC1 protein maturation to functionally validate it.

174 ase in the setting of impaired biogenesis of PC1.

175 g reaction that reconstitutes the capture of PC1 into large COPII vesicles.

176 rge COPII vesicles are bona fide carriers of PC1.

177 pliced XBP1 (XBP1s) enhanced GPS cleavage of PC1 in SEC63-deficient cells, and XBP1 overexpression in

178 We find that the cleaved CTT of PC1 (PC1-CTT) stimulates the transcriptional coactivator

179 show that the carboxy-terminal tail (CTT) of PC1 is released by gamma-secretase-mediated cleavage and

180 In vivo, depletion of PC1 in activated fibroblasts after myocardial infarction

181 Diagnostics of PC1 indicate previous year's local Air Temperature varia

182 , and alpha-toxin (PLAT) signature domain of PC1 using nuclear magnetic resonance, biochemical, cellu

183 Expression of PC1-p30 changed the cellular response to cAMP signaling.

184 missense mutations is a resulting failure of PC1 to traffic to cilia regardless of GPS cleavage.

185 estigated clinical and molecular features of PC1/3 deficiency.

186 and confirmed that only the cleaved form of PC1 exits the ER and can rescue the embryonically lethal

187 A proteolytic fragment of PC1 corresponding to the cytoplasmic tail, PC1-p30, is o

188 embrane-anchored C-terminal tail fragment of PC1 elevated NHA2.

189 lates the surface expression and function of PC1 and PC2.

190 pite its medical importance, the function of PC1 remains poorly understood.

191 ed maturation and defective glycosylation of PC1.

192 in PC7 KO mice but not in the hippocampus of PC1/3 KO mice.

193 Induction of PC1 in MDCK cells inhibited NHA2 expression with concord

194 orm leads to stunted cilia and inhibition of PC1 on primary cilia.

195 phosphorylation-dependent internalization of PC1 is closely linked to its function in renal developme

196 Involvement of PC1-regulated eIF2alpha phosphorylation and a PKR-eIF2al

197 m individuals with PKD1 mutations, levels of PC1 and PC2 were reduced to 54% (P<0.02) and 53% (P<0.00

198 a results in reduced ciliary localization of PC1 and elongated cilia, suggesting a role for PP1alpha

199 controlling the subcellular localization of PC1 and PC2 are poorly understood.

200 PP1alpha and impair ciliary localization of PC1.

201 Loss of PC1 expression profoundly alters cellular energy metabol

202 required for GPS cleavage and maturation of PC1, and activation of XBP1 can protect against polycyst

203 ein expression levels, and overexpression of PC1 but not a carboxy-terminal truncation mutant increas

204 The C-terminal 11 transmembrane portion of PC1 undergoes three cleavage events in vivo.

205 dent activation of STAT3; in the presence of PC1-p30, cAMP amplified Src-dependent activation of STAT

206 various histidines within the propeptide of PC1/3 and examined how such alterations can modulate pH-

207 me in the discovery cohort, and the ratio of PC1/TMEM2 or PC2/TMEM2 could be used to distinguish indi

208 to determine the pathophysiological role of PC1 in cardiomyocytes.

209 ibroblasts for PC1 and evaluated the role of PC1 in fibrogenesis in adult rat fibroblasts and myofibr

210 in diameter and accelerates the secretion of PC1.

211 soleucine and valine on the negative side of PC1 and porcine gelatin was correlated to the polar side

212 erine and methionine on the positive side of PC1; bovine gelatin was correlated to the non-polar side

213 roteins involved in the endosomal sorting of PC1 and PC2 could lead to new therapeutic approaches in

214 Conversely, suppression of PC1/3 blocked processing of proinsulin but not proglucag

215 otif in the intracellular C-terminal tail of PC1 functions as a CTS in an ADP ribosylation factor 4 (

216 length nor the plasma membrane targeting of PC1.

217 e mechanisms that control the trafficking of PC1 and PC2, as well as their broader physiological role

218 kout of BBS4, impairs ciliary trafficking of PC1 in kidney epithelial cells.

219 i.e. 13-fatty, falling at positive value of PC1; this fit the aroma perception of this varietal.

220 of Negroamaro wines have negative values of PC1 and they are negatively correlated with the second m

221 04) variant both exhibits adverse effects on PC1/3 activity and is prevalent in the population sugges

222 btilisin/kexin type 1 with modest effects on PC1/3 in vitro have been associated with obesity in five

223 lation variance (principal component one, or PC1) was strongly correlated with genomically determined

224 d alpha cells do not express Nkx6.1, Pdx1 or PC1/3 in agreement with the presence of a separate popul

225 ts distinguished different anatomical parts (PC1 and PC2) and cultivation systems (PC3) into well-def

226 The 2 first PC (PC1 and PC2) construct outcome variables on CSF biomarke

227 The model using "1(st) PC (PC1) + clinical information" had the highest performance

228 We find that the cleaved CTT of PC1 (PC1-CTT) stimulates the transcriptional coactivator TAZ

229 conserved in the PC1 propeptide (PRO(PC1)), PC1 nonetheless activates at pH~5.5 within the dense cor

230 that designates these as the CG2, GC2, PC3, PC1, C3, and GP2 classes of superbases.

231 riments to determine whether the polycystins PC1 and PC2 (encoded by Pkd1 and Pkd2) and the transcrip

232 Pkd2-/- mice, complete loss of PC2 prevented PC1 maturation.

233 idue is conserved in the PC1 propeptide (PRO(PC1)), PC1 nonetheless activates at pH~5.5 within the de

234 We propose that the 11-span membrane protein PC1 is a BBSome cargo and that the components of the BBS

235 ganelle and its requisite signaling protein, PC1, are required for critical elements of fibrogenesis,

236 ciliary localization of the ADPKD proteins (PC1 and PC2), and reduced mature PC1 was seen in GANAB(+

237 For the 5-year mortality rate, PC1 did not contribute to an improvement to the model wi

238 e measured enzymatic activity of recombinant PC1/3 proteins.

239 ystic disease in a murine model with reduced PC1 function that is unrelated to SEC63 inactivation.

240 Our results indicate that PC2 regulates PC1 maturation; therefore, mature PC1 levels are a deter

241 ional co-regulatory protein to the TAZ/RunX2/PC1-CTT complex.

242 Wild-type and cardiomyocyte-specific PC1 knockout mice were analyzed by echocardiography.

243 ductions in islet, hypothalamic, and stomach PC1 content.

244 ort validated differential expression of STS PC1 proteins in the skin of adult patients with AD with

245 The differential expression of STS PC1 proteins was confirmed in a replicate cohort of adul

246 f PC1 corresponding to the cytoplasmic tail, PC1-p30, is overexpressed in ADPKD.

247 We found that the PLAT domain targets PC1 to the plasma membrane in polarized epithelial cells

248 ranslocation of the PC1 C-terminal tail/TAZ (PC1-CTT/TAZ) complex, leading to increased runt-related

249 e segments and the intracellular C-terminus (PC1-5TMC) down-regulate the phosphorylation of protein k

250 culating natural IgM and intestinal IgA than PC1(hi) cells.

251 knockout mouse kidney epithelial cells that PC1 and its truncation mutant comprising the last five t

252 The results of this study demonstrate that PC1 trafficking and expression require GPS cleavage and

253 We further demonstrate that PC1, Pacsin 2 and N-Wasp are in the same protein complex

254 Here, we demonstrated that PC1 and PC2 first interact in the ER before PC1 cleavage

255 eIF2alpha phosphorylation, demonstrated that PC1-5TMC inhibits apoptosis of HEK293T cells in a PKR-eI

256 Here we describe that PC1 and PC2 must interact and form a complex to reach th

257 mmunoprecipitation experiments we found that PC1 truncation mutants associate with PKR, or with PKR a

258 We found that PC1(lo) cells develop from an early wave of B-1a progeni

259 These findings indicate that PC1/3 is involved in the processing of one or more enter

260 n-induced ER Ca(2+) release, indicating that PC1 can modulate mitochondrial function.

261 We propose that PC1 modulates actin cytoskeleton rearrangements and dire

262 Here, we report that PC1 interacts with Pacsin 2, a cytoplasmic phosphoprotei

263 Here, we show that PC1-p30 interacts with the nonreceptor tyrosine kinase S

264 Further experiments showed that PC1 and PC1-5TMC reduce phosphorylation of eIF2alpha thr

265 We have now shown that PC1 overexpression leads to increased degradation of PC2

266 Taken together, these results suggest that PC1 regulates ciliary PC2 protein expression levels and

267 These results suggest that PC1, via its cleaved cytoplasmic tail, integrates signal

268 own-regulate PC2 expression, suggesting that PC1-PC2 interaction is necessary for PC2 regulation.

269 The PC1 score was associated with the prevalence of frailty

270 The PC1 was independently associated with 5YLM in multivaria

271 The PC1-CTT increases the interaction between TAZ and RunX2

272 The PC1-p30-mediated activation of Src/STAT3 was independent

273 The PC1/3 knock-out (KO) mouse model has allowed us to eluci

274 The PC1/TMEM2 ratio correlated inversely with height-adjuste

275 plained 27.7% of the total variance, and the PC1 score exhibited consistent correlations with diverse

276 By controlling Jade-1 abundance, PC1 and the PC1-CTF differentially regulate Jade-1-mediated transcri

277 The relationship between the PC1 score and frailty was subsequently examined in a sub

278 jection of messenger RNA (mRNA) encoding the PC1-CTT into pkd1-morphant fish restores bone mineraliza

279 For the PC1, Kaplan-Meier plots showed a significant difference

280 results reveal a physiological role for the PC1-PLAT domain in renal epithelial cells and suggest th

281 S consisting of 8 residues (RHKVRFEG) in the PC1 C tail.

282 Although this residue is conserved in the PC1 propeptide (PRO(PC1)), PC1 nonetheless activates at

283 d a compound predicted to bind to PC2 in the PC1:PC2 C-terminal tail region with helix:helix interact

284 stimulated the nuclear translocation of the PC1 C-terminal tail/TAZ (PC1-CTT/TAZ) complex, leading t

285 Further deconvolution of the PC1 top-correlated segments revealed that these segments

286 Expression of the PC1-CTT is sufficient to rescue the dorsal body curvatur

287 eper" that fine-tunes the sensitivity of the PC1/3 propeptide to facilitate the release inhibition at

288 Proline substitutions on the PC1-proximal side completely abolished transport and red

289 Therefore, the PC1 score represents principal information shared by bio

290 n PC1 is expressed, PC2 that is not bound to PC1 is directed to aggresomes and subsequently degraded

291 or neuroendocrine features of PWS are due to PC1 deficiency.

292 Adoptively transferred PC1(lo) cells secreted significantly more circulating na

293 tins and the clathrin adaptor AP2 to trigger PC1 internalization.

294 Furthermore, ectopic expression of wild-type PC1 in ADPKD iPS-derived hepatoblasts rescued ciliary PC

295 uncovered a new pathway suggesting that when PC1 is expressed, PC2 that is not bound to PC1 is direct

296 e of B-1a progenitors in fetal life, whereas PC1(hi) cells are generated from a later wave after birt

297 However, the mechanisms by which PC1 and other ciliary proteins traffic to the primary ci

298 (ELVs) (100-nm diameter vesicles), in which PC1 is present in a cleaved form and may be complexed wi

299 titutes a key mechanistic link through which PC1 mediates its physiological functions.

300 ed the clinical features of 13 children with PC1/3 deficiency and performed sequence analysis of PCSK

301 In a study of 13 children with PC1/3 deficiency caused by disruption of PCSK1, failure

302 UPR and that SEC63 exists in a complex with PC1.