ライフサイエンスコーパス: PCB

1 PCB 11 also altered several metabolic pathways, in parti

2 PCB 11 and its metabolites are present in human serum, a

3 PCB 155 and BDE 47 showed the highest slopes (0.77 and 0

4 PCB 28-induced mortality in flies was accompanied by loc

5 PCB concentrations in eggs increased with later hatch da

6 PCB congeners were categorized into structure-activity g

7 PCB exposure induced oxidative stress in the liver and l

8 PCB exposures recapitulated the target school air profil

9 PCB inhalation yielded mug/g E(209) PCB levels in tissue

10 PCB-77 attenuated development of obesity in females but

11 PCBs and OCPs shifted from equilibrium during ice/snow-c

12 PCBs are classified as xenoestrogens and carcinogens and

13 PCBs have the potential to be emitted from paint contain

14 PCBs minimized male secondary sexual characteristics, bu

15 PCBs were present in the cell culture medium (60.7-88.8%

16 CBs in colorants are less than 285 ng g(-1), PCB emissions from colorants in paint can cause environm

17 90), PCB 151 (HR 1.46, 95% CI 1.01 to 2.10), PCB 175 (HR 1.53, 95% CI 0.98 to 2.40) and p,p'-DDE (HR

18 Fourteen PBDEs, 17 PCBs, and 5 PCDD/Fs had quantification rates of >80%.

19 in vitro-in vivo extrapolations for all 209 PCB congeners.

20 PCB inhalation yielded mug/g E(209) PCB levels in tissues.

21 ls (PCB) 118 (HR 1.50, 95% CI 0.95 to 2.39), PCB 138 (HR 1.69, 95% CI 0.99 to 2.90), PCB 151 (HR 1.46

22 over time, whereas concentrations of Sigma(4)PCB, Sigma(5)OH-PCB, BDE-47, and oxychlordane declined l

23 he following ranges (pg/m(3)): 0.5-37.7 (E(6)PCB), 0.006-0.724 (E(17)PCDD/F), 0.05-5.5 (E(9)PBDE), 0.

24 39), PCB 138 (HR 1.69, 95% CI 0.99 to 2.90), PCB 151 (HR 1.46, 95% CI 1.01 to 2.10), PCB 175 (HR 1.53

25 stigated the partitioning of racemic PCB 91, PCB 95, PCB 132, and PCB 136 in HepG2 cells following a

26 the partitioning of racemic PCB 91, PCB 95, PCB 132, and PCB 136 in HepG2 cells following a 72 h inc

27 ues of dCYP1A2, we confirm human CYP1A2 as a PCB 28 metabolizing enzyme.

28 by means of commercial inkjet-printing on a PCB-integrated electrochemical biosensing platform.

29 ther than the more reduced and more abundant PCB.

30 The 12 most abundant PCBs were tested singly and as a mixture mimicking the c

31 In [Formula: see text] females administered PCB-77, IRS2 mRNA abundance was lower in adipose tissue

32 t] and [Formula: see text] mice administered PCB-77.

33 After 6 weeks, all PCBs found in the colorant were also found on the PUF.

34 ning of racemic PCB 91, PCB 95, PCB 132, and PCB 136 in HepG2 cells following a 72 h incubation.

35 d that CYP2A6 and CYP2B6 oxidized PCB 91 and PCB 132 in the meta position and that CYP2A6 oxidized PC

36 a minor role in the metabolism of PCB 95 and PCB 136 and formed meta-hydroxylated metabolites.

37 position and that CYP2A6 oxidized PCB 95 and PCB 136 in the para position.

38 in receptor substrate 2) mRNA abundance, and PCB-77 concentrations were quantified at week 16.

39 with respect to CYP mediated metabolism and PCB mediated neurotoxicity.

40 of lead, phthalates, selected nutrients, and PCBs.

41 s, the bioavailability of plastic-associated PCBs for lugworms and cod ranged from 14 to 42% and 45-8

42 Paclitaxel coated balloons (PCBs) are a promising non-implantable alternative to dru

43 ion, physical characteristics, and behavior, PCBs inhibit paternal reproductive success and have the

44 Here, we examined polychlorinated biphenyl (PCB) and polybrominated diphenyl ether (PBDE) residues a

45 al partitioning of polychlorinated biphenyl (PCB) and polybrominated diphenyl ether congeners is the

46 centrations of 205 polychlorinated biphenyl (PCB) congeners in 26 food items: beef steak, butter, can

47 around the former polychlorinated biphenyl (PCB) production plant in Anniston, Alabama.

48 The levels of polychlorinated biphenyl (PCBs), polybrominated diphenyl ethers (PBDEs) and induct

49 CI 0.90 to 2.61), polychlorinated biphenyls (PCB) 118 (HR 1.50, 95% CI 0.95 to 2.39), PCB 138 (HR 1.6

50 udy, we tested 25 polychlorinated biphenyls (PCBs) [PCB 3, 11, 52, 126, 136, and 153 and their releva

51 Lipophilic polychlorinated biphenyls (PCBs) accumulate with obesity, but during weight loss, l

52 Polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) concentration

53 a range of legacy polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) was undertake

54 luding lipophilic polychlorinated biphenyls (PCBs) and protein-associated per- and polyfluoroalkyl su

55 nce of lipophilic polychlorinated biphenyls (PCBs) and protein-associated poly- and perfluoroalkyl su

56 Polychlorinated biphenyls (PCBs) are environmental toxicants; PCB exposure has been

57 Polychlorinated biphenyls (PCBs) are known human carcinogens that are byproducts of

58 Polychlorinated biphenyls (PCBs) are toxic, persistent, and lipophilic chemical com

59 Polychlorinated biphenyls (PCBs) are widespread, persistent contaminants that can d

60 yrifos, lead, and polychlorinated biphenyls (PCBs) be systematically reviewed in order to assess thei

61 ioaccumulation of polychlorinated biphenyls (PCBs) by pelagic and mobile fish and shellfish.

62 Polychlorinated biphenyls (PCBs) had both agonistic and antagonistic effects on PPA

63 xposure to chiral polychlorinated biphenyls (PCBs) has been associated with neurodevelopmental disord

64 dechlorination of polychlorinated biphenyls (PCBs) has been observed in sediments over the last 3 dec

65 Degradation of polychlorinated biphenyls (PCBs) is initiated by cytochrome P450 (CYP) enzymes and

66 heavy metals and polychlorinated biphenyls (PCBs) over the past decade is discussed.

67 Polychlorinated biphenyls (PCBs) pose significant risk to the developing human brai

68 er kinetics of 14 polychlorinated biphenyls (PCBs) were measured in gut fluid mimic systems under thr

69 omagnification of polychlorinated biphenyls (PCBs), a globally prevalent group of regulated persisten

70 itous pollutants (polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), polybrominated

71 diphenyl ethers, polychlorinated biphenyls (PCBs), per- and polyfluoroalkyl substances (PFAS), and h

72 nd emerging POPs (polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and organ

73 lows reported for polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and organ

74 ntly higher total polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), tris(4-ch

75 l ethers (PBDEs), polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins and furans (PCD

76 icides (OCPs) and polychlorinated biphenyls (PCBs), which are biomagnified along the food web.

77 d and spiked with polychlorinated biphenyls (PCBs), with silicone films of variable thickness coated

78 situ treatment of polychlorinated biphenyls (PCBs).

79 evant mixtures of polychlorinated biphenyls (PCBs).

80 y the toxicity of polychlorinated biphenyls (PCBs); however, it is typically unknown how much PCB ent

81 ted between 1990 and 2017, that mean blubber PCB concentrations have fallen below the proposed thresh

82 of NZI media within a printed circuit board (PCB) integrated design.

83 ucted from a flexible printed circuit board (PCB), with a bespoke "dog-leg" track design, that can be

84 ntum dot devices on a printed circuit board (PCB).

85 d on the paper-based printed circuit boards (PCBs) absorbed bacteria-laden suspensions through capill

86 challenge to recycle printed circuit boards (PCBs) efficiently and environmentally friendly.

87 re of the aquatic food web to sediment-bound PCBs with minimal disruption to the environment.

88 e of industrial PCBs was banned in 1978, but PCBs continue to be formed in industrial and consumer pr

89 most foods and found manufacturing byproduct PCBs, including PCB11, in tilapia and catfish.

90 ow much PCB enters the cells and, for chiral PCBs, if the partitioning is atropselective.

91 P2E1, and CYP3A4 in the metabolism of chiral PCBs.

92 s capable of rapidly extracting ("cleaning") PCBs from food inside the gut, thus demonstrating that t

93 ation and characterization of two commercial PCB manufacturing gold electroplating processes for bios

94 bility to recycle a wide range of commercial PCBs, including boards made of typical anhydride epoxy o

95 These results demonstrate that complex PCB 11 metabolite profiles are formed in HepG2 cells tha

96 In contrast, PCB concentrations in two Arctic lakes (West and East La

97 lative concentrations of each chemical (DEHP.PCB interaction for: DNA fragmentation; human p < 0.001,

98 Mono- and dichlorinated PCBs were released from the colorant at a faster rate th

99 3,3'-Dichlorobiphenyl (PCB 11) is a byproduct of industrial processes and detec

100 The interaction analysis between different PCBs and WBCs provides only a small overlap between sexe

101 In addition, PCDD/PCDF and dl-PCB mass loads increased by 5- to 12-fold and by 23- to

102 positive role in reducing PCDD, PCDF and dl-PCB transport within the study period, with reductions r

103 ulted in a mean decrease in PCDD + PCDF + dl-PCB TEQ concentrations: 64% for cucumber and 69% for zuc

104 Sludge- or sediment-born PCDDs, PCDFs and dl-PCBs may be removed using phytoremediation.

105 nd dioxin-like polychlorinated biphenyls (dl-PCBs) in the Pilica River and Sulejow Reservoir were fou

106 THR are not a predominant mechanism driving PCB DNT.

107 designed for rapid detection, which employs PCB-integrated sample delivery, achieving DNA quantifica

108 This is the first study to emulate PCB exposures in a school and comprehensively evaluate t

109 ptimize expression of pathway genes, enhance PCB production via a translational fusion of the biosynt

110 rfacing the system with micro-drives or flex-PCB cables for recording from multiple brain regions, as

111 s a shielding layer, as part of the flexible PCB design, and represents the minimum dimensional footp

112 there was a general trend of higher fluvial PCB/OCP concentrations associated with the spring snow m

113 lowest limit of detection (LoD) to date for PCB-based DNA biosensors of 57 fM is reported.

114 ifferences in the bioaccumulation factor for PCB/OCPs in zooplankton between West and East Lakes were

115 y significant adjusted odds ratios (ORs) for PCBs 74, 99, 138, 153, 167, 177, 183, and 187, ranging f

116 roups and recycle electronic components from PCBs.

117 pporting the case for in situ formation from PCBs.

118 used to characterize human health risks from PCBs and their metabolites.

119 Hence, in this study, a fully PCB-integrated enzymatic glucose quantification Lab-on-C

120 ell-characterized legacy contaminants (e.g., PCBs).

121 by the fact that 80% of the individuals had PCB levels above the toxicity threshold for negative phy

122 (PCB 95), 2,2',3,3',4,6'-hexachlorobiphenyl (PCB 132), and 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136

123 132), and 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) by different human P450 isoforms.

124 Feeding flies high PCB 28 concentrations caused lethality.

125 nt with observation in human exposed to high PCB levels.

126 h consumption was associated with 15% higher PCBs [geometric mean (GM) ratio = 1.15; 95% confidence i

127 In contrast, how PCBs affect paternal reproductive success is largely unk

128 logies preventing cross-study syntheses, how PCBs biomagnify at food web, regional, and global scales

129 evels of hydroxy-sulfonated-PCBs and hydroxy-PCBs.

130 They were found, along with hydroxy-PCBs, in soil samples coming from a site historically co

131 Traces of para-hydroxylated PCB metabolites were detected in incubations with CYP2E1

132 1.93 (95% CI: 0.93, 4.00)] and estrogenic II PCB group [HR = 1.90 (95% CI: 0.96, 3.78)] but were weak

133 s studies, we found evidence of a decline in PCB concentrations over the last 20 years.

134 There was no significant decrease in PCB concentrations in non-bioamended plots with or witho

135 These results demonstrate sex differences in PCB-77-induced regulation of glucose homeostasis of mice

136 s disease mortality such that an increase in PCB blubber concentrations of 1 mg kg(-1) lipid correspo

137 The reduction in PCB levels in food indicates that dietary exposure is co

138 tential than GAC, allowing for reductions in PCB-bioaccumulation of up to 89%.

139 (SXRKO) and to elucidate the role of SXR in PCB-153 metabolism and promotion of its harmful effects.

140 s, suggesting a role of the immune system in PCB-related cancer development.

141 y cytochrome P450 (CYP) enzymes and includes PCB oxidation to OH-metabolites, which often display a h

142 of sum total PCB (PCB(ST)), seven indicator PCB congeners, and their sum (PCB(E7)).

143 The manufacture of industrial PCBs was banned in 1978, but PCBs continue to be formed

144 to an aqueous concentration of about 1 ng/L PCB 61.

145 eding Drosophila with lower chlorinated (LC) PCB congeners 28, 52 or 101 resulted in the detection of

146 neurofilament light chain increase after LC-PCB exposure, indicating neuronal damage.

147 h obesity, but during weight loss, liberated PCBs act as ligands of the aryl hydrocarbon receptor (Ah

148 We examined the effects of lifelong PCB exposure on the reproductive processes of male fathe

149 4, 6.73), as well as for two estrogenic-like PCB groups, and the thyroid-like group [ORs ranging from

150 xposed to high concentrations of dioxin-like PCBs had changes in gene expression, reduced offspring c

151 te higher toxic equivalencies of dioxin-like PCBs in exposed females than males.

152 During weight loss, PCB-77 impaired glucose tolerance of males.

153 lutch-to-female mass ratio resulted in lower PCB concentrations in females than in males during the i

154 triple quadruple mass spectrometry, the mean PCB level in maternal serum was 2.22 ng/mL.

155 The methoxylated PCB metabolites were observed for the first time in a hu

156 It is important to monitor PCBs in wildlife, particularly in highly exposed populat

157 ome females may remobilize and transfer more PCBs to their eggs, by delaying migration several weeks,

158 ); however, it is typically unknown how much PCB enters the cells and, for chiral PCBs, if the partit

159 were formed by HepG2 cells exposed to 10 muM PCB 11, including monohydroxylated, dihydroxylated, meth

160 ls were approximately 0.4-0.8% of the native PCB levels in soils and about twice the levels of hydrox

161 mportant role in the oxidation of neurotoxic PCBs to chiral OH-PCBs in humans.

162 concentrations of tri- to nonachlorobiphenyl PCB congeners by as much as 95%.

163 f airborne exposures to legacy and nonlegacy PCBs, placing children at risk.

164 lationship for dioxin-like non-ortho (non-o)-PCB TEQs [fourth vs. first quartile: 3.66 (95% CI: 1.40,

165 The results were strongest for the di-o-PCBs [hazard ratio (HR) = 1.93 (95% CI: 0.93, 4.00)] and

166 e reported for dioxin-like mono-o- and non-o-PCBs as well as for nondioxin-like estrogenic and thyroi

167 eparture for quantitative risk assessment of PCB DNT, and identify in vitro assays for screening othe

168 We also found strong associations of PCB congener distributions with Aroclors in most foods a

169 onstrated biosensor proves the capability of PCB-based DNA biosensors for high sensitivity and paves

170 ent on the freely dissolved concentration of PCB 61 both in sediment and in sediment-free microcosms.

171 tally exposed to a low dose (54 mug/kg/d) of PCB-153.

172 We compared effects of PCB-77 on weight gain or loss and glucose homeostasis in

173 e serious implications for the management of PCB contamination in the U.K. and reinforce the need to

174 veloping human brain; however, mechanisms of PCB developmental neurotoxicity (DNT) remain controversi

175 Here, we investigated the metabolism of PCB 11 and the associated metabolomics changes in HepG2

176 ver, little is known about the metabolism of PCB 11 in humans.

177 layed only a minor role in the metabolism of PCB 95 and PCB 136 and formed meta-hydroxylated metaboli

178 The rate of PCB emissions from paint colorants is a function of the

179 In plasma samples of PCB exposed humans, levels of the neurofilament light ch

180 nimal proteins are more important sources of PCB dietary exposure in this study population.

181 at account for the atropselective binding of PCBs to biological macromolecules are, therefore, needed

182 Overall concentrations of PCBs and perfluorooctanesulfonic acid (PFOS) were 1.6 an

183 Although concentrations of PCBs in colorants are less than 285 ng g(-1), PCB emissi

184 rs of the in vitro cardiovascular effects of PCBs.

185 elation between net volatilization fluxes of PCBs and seawater salinity.

186 ow different responses to the interaction of PCBs with WBCs, suggesting a role of the immune system i

187 4-Hydroxy (OH) and 4-sulfate metabolites of PCBs 11 and 52 had no TH activity; but 4-OH PCB 52 had h

188 ects, whereas sulfation and methoxylation of PCBs resulted in diminished bioactivity.

189 posures, we generated an airborne mixture of PCBs, called the School Air Mixture (SAM), to match the

190 the sulfonation of an industrial mixture of PCBs.

191 Oxidation of PCBs, especially to di-hydroxylated and quinone metaboli

192 o predict the atropselective partitioning of PCBs in biological systems.

193 rigin, their role in the degradation path of PCBs, and their fate, as well as their (still unknown) t

194 The relative congener patterns of PCBs and PBDEs were similar in all of the species.

195 contaminated by the industrial production of PCBs and in background soils.

196 consistent with published data on a range of PCBs and allowed for the estimation of the associated di

197 In situ treatment of PCBs using an AC agglomerate as a delivery system for bi

198 ditions toward a clear net volatilization of PCBs and most of the OCPs during snow/ice-free condition

199 PCBs 11 and 52 had no TH activity; but 4-OH PCB 52 had higher potency than the parent congener towar

200 vated levels of the PCB-153 metabolite, 3-OH-PCB-153, were found in exposed SXRKO mice compared to ex

201 4-OH-PCB 11 (3,3'-dichlorobiphenyl-4-ol) and the correspondin

202 as concentrations of Sigma(4)PCB, Sigma(5)OH-PCB, BDE-47, and oxychlordane declined linearly.

203 corresponding catechol metabolite, 4,5-di-OH-PCB 11 (3',5-dichloro-3,4-dihydroxybiphenyl), were unamb

204 ner-specific atropselective enrichment of OH-PCB metabolites.

205 he oxidation of neurotoxic PCBs to chiral OH-PCBs in humans.

206 Their hydroxylated metabolites (OH-PCBs) are also potentially toxic to the developing human

207 ng human brain; however, the formation of OH-PCBs by human cytochrome P450 (P450) isoforms is poorly

208 ersistent organic pollutants (POPs: PCBs, OH-PCBs, p, p'-DDE, HCB, beta-HCH, oxychlordane, BDE-47, an

209 A pilot study was conducted for 409 days on PCB impacted sediments in four 400 m(2) plots located in

210 RNA interference and analyzed the effect on PCB 28-derived metabolite formation by assaying 3-OH-2',

211 on covalently immobilized glucose oxidase on PCB-integrated electrodes.

212 The sample-to-answer time of our Lab-on-PCB device is less than 1 min (sample delivery of few se

213 aves the way for their integration in Lab-on-PCB DNA diagnostic microsystems.

214 We report the development of a Lab-on-PCB DNA diagnostic platform, exploiting peptide nucleic

215 Lab-on-PCB is currently considered as a candidate technology ad

216 udy also showcases a fully integrated Lab-on-PCB microsystem designed for rapid detection, which empl

217 work demonstrates the feasibility of Lab-on-PCB patches in terms of biosensing performance, paving t

218 In the context of an integrated Lab-on-PCB wearable patch extracting interstitial fluid from th

219 [Formula: see text] mice administered VEH or PCB-77, and male [Formula: see text] and [Formula: see t

220 and female C57BL/6 mice administered VEH or PCB-77, female [Formula: see text] and [Formula: see tex

221 Study design was vehicle (VEH) or PCB-77 administration while fed a high-fat (HF) diet for

222 n the meta position and that CYP2A6 oxidized PCB 95 and PCB 136 in the para position.

223 demonstrated that CYP2A6 and CYP2B6 oxidized PCB 91 and PCB 132 in the meta position and that CYP2A6

224 heptachlor, hexabromobiphenyl, mirex, PBDEs, PCBs, PCDDs, PCDFs, PeCB, PFOA, and PFOS) monitored in 9

225 -normalized concentrations of sum total PCB (PCB(ST)), seven indicator PCB congeners, and their sum (

226 tested 25 polychlorinated biphenyls (PCBs) [PCB 3, 11, 52, 126, 136, and 153 and their relevant meta

227 ormation of 2,2',3,4',6-pentachlorobiphenyl (PCB 91), 2,2',3,5',6-pentachlorobiphenyl (PCB 95), 2,2',

228 l (PCB 91), 2,2',3,5',6-pentachlorobiphenyl (PCB 95), 2,2',3,3',4,6'-hexachlorobiphenyl (PCB 132), an

229 Unlike most CBCRs that bind phycocyanobilin (PCB), a phycobilin naturally occurring in cyanobacteria

230 oduction of the chromophore phycocyanobilin (PCB), and an output promoter to control transcription of

231 s indicate that concentrations of many POPs (PCBs, DDT, HCHs, endosulfan) have declined significantly

232 ends of persistent organic pollutants (POPs: PCBs, OH-PCBs, p, p'-DDE, HCB, beta-HCH, oxychlordane, B

233 CC-G) were tested for remediation potential (PCB-bioaccumulation reduction) and adverse effects on th

234 g characteristics, it is possible to predict PCB microbial dechlorination in sediments.

235 , class, and feeding location best predicted PCB(E7) and all seven congeners.

236 d, region, and class most strongly predicted PCB(ST), while similarly, region, class, and feeding loc

237 As predicted, PCBs and OCPs biomagnified (TMF >1), while all chlorinat

238 s of exposure to PCB-153, the most prevalent PCB congener in human tissues, on SXR knockout mice (SXR

239 n the U.K. and reinforce the need to prevent PCBs entering the marine environment to ensure that leve

240 We investigated the partitioning of racemic PCB 91, PCB 95, PCB 132, and PCB 136 in HepG2 cells foll

241 alth benefits for each scenario from reduced PCB levels in Hudson River fish, and health risks from E

242 sophila CYPs (dCYPs) whose knockdown reduced PCB 28-derived OH-metabolites and suppressed PCB 28 indu

243 In search of an animal model reflecting PCB metabolism and toxicity, we tested Drosophila melano

244 Thus, novel insights regarding PCB biomagnification across taxonomic, food webs, region

245 AhR deficiency reversed PCB-77-induced glucose impairment of obese males losing

246 meat diet, a BMF(lim) (averaged over several PCB congeners) of approximately 41 was observed, whereas

247 Along this line, we show PCB 28-initiated caspase activation in differentiated fl

248 arity within the tube-achieved from a single PCB.

249 Some PCB emissions were detected on the PUF after 1 day.

250 We also discovered that PCB(ST), PCB(E7), and the seven indicator congeners all occur in

251 n as a result of exposure to the six studied PCB congeners were sex- and WBC type specific.

252 Sulfonated-PCB levels were approximately 0.4-0.8% of the native PCB

253 n of two classes of contaminants: sulfonated-PCBs and hydroxy-sulfonated-PCBs.

254 about twice the levels of hydroxy-sulfonated-PCBs and hydroxy-PCBs.

255 pK(a) of sulfonated- and hydroxy-sulfonated-PCBs, they possess negligible volatility, supporting the

256 ants: sulfonated-PCBs and hydroxy-sulfonated-PCBs.

257 The identification of sulfonated-PCBs was confirmed by the chemical synthesis of referenc

258 even indicator PCB congeners, and their sum (PCB(E7)).

259 PCB 28-derived OH-metabolites and suppressed PCB 28 induced lethality including dCYP1A2.

260 chlorination of 2,3,4,5-tetrachlorobiphenyl (PCB 61) to 2,3,5-trichlorobiphenyl (PCB 23) by an organo

261 Previous studies demonstrated that PCB-77 administration to obese male mice impaired glucos

262 rum, and emerging evidence demonstrates that PCB 11 is a developmental neurotoxicant.

263 We also discovered that PCB(ST), PCB(E7), and the seven indicator congeners all

264 ironmentally triggered NDDs and suggest that PCB effects on the THR are not a predominant mechanism d

265 factor: log K(ow) relationships suggest that PCB uptake is often near equilibrium between log K(ow) 5

266 sing polymers containing ester groups as the PCB substrate in consideration of eco-friendly and effic

267 History Questionnaire II, we calculated the PCB dietary exposure in mothers and children participati

268 inating and oxidizing bacteria decreased the PCB concentration in the top 7.5 cm by up to 52% and the

269 Therefore, coastal seawater mirrored the PCB congener profile and increased concentrations in sno

270 absorption arises from incorporation of the PCB biosynthetic intermediate 18(1),18(2)-dihydrobiliver

271 -based model provided a good estimate of the PCB levels in the cells and cell culture medium.

272 Elevated levels of the PCB-153 metabolite, 3-OH-PCB-153, were found in exposed

273 from less contaminated sites based on their PCB and PBDE concentrations.

274 Congener-specific air and tissue PCB profiles were assessed using gas chromatography with

275 cates that dietary exposure is comparable to PCB inhalation exposures reported for the same study pop

276 om the nominal cell culture concentration to PCB tissue levels and vice versa.

277 ale and female mice responded differently to PCB-77 and AhR deficiency in body weight (BW) regulation

278 larger in SXRKO mice chronically exposed to PCB-153 compared to vehicle and WT controls.

279 SXRKO mice perinatally exposed to PCB-153 displayed elevated oxidative stress, symptoms of

280 n or loss in male and female mice exposed to PCB-77.

281 of hydroxylated metabolites upon exposure to PCB-153, leading to oxidative stress, hemolytic anemia,

282 as to investigate the effects of exposure to PCB-153, the most prevalent PCB congener in human tissue

283 HepG2 cells were exposed for 24 h to PCB 11 in DMSO or DMSO alone.

284 maintaining proper metabolism in response to PCB-153 exposure.

285 identify potential sex-specific responses to PCB-exposure we established gene expression profiles in

286 ions between gene expression and exposure to PCBs, while correcting for confounders, in particular di

287 ons due to increased inhalation exposures to PCBs and fine particulate matter (PM2.5), using disabili

288 different biological response mechanisms to PCBs between the two sexes.

289 lipid-normalized concentrations of sum total PCB (PCB(ST)), seven indicator PCB congeners, and their

290 iphenyls (PCBs) are environmental toxicants; PCB exposure has been associated with adverse effects on

291 iphenyl (PCB 61) to 2,3,5-trichlorobiphenyl (PCB 23) by an organohalide-respiring bacterium, Dehalobi

292 ely posited mechanisms are tested here using PCBs identified in pregnant women in the MARBLES cohort

293 ics and is activated or inhibited by various PCB congeners.

294 oncentration for the target contaminants was PCBs > PBDEs and the accumulation values were linked to

295 assessing and managing risk associated with PCB-contaminated sediments and waters in protecting vuln

296 genes that are significantly associated with PCB-exposure in the female subpopulation already indicat

297 ated carbon (AC) agglomerate bioamended with PCB dechlorinating and oxidizing bacteria decreased the

298 ce or supplement optogenetic cell lines with PCB.

299 t not [Formula: see text] males treated with PCB-77 exhibited impaired glucose tolerance.

300 fed [Formula: see text] females treated with PCB-77 has less weight gain, and [Formula: see text] fem

301 pathways are identified in association with PCBs and WBCs.