ライフサイエンスコーパス: PCD

1 PCD can be a means to maintain homeostasis, prevent or p

2 PCD can result in the export of fitness from the cell to

3 PCD diagnostic quality was higher than EID diagnostic qu

4 PCD images were also used to calculate iodine concentrat

5 PCD is characterized by clinical variability and extensi

6 PCD provides spectral information, which may be used for

7 med genotype / phenotype correlations in 132 PCD patients carrying disease-causing DNAH5 mutations, f

8 Furthermore, we found that 24 PCD stage-specific miRNAs are aberrantly overexpressed i

9 CPA genes CFAP221, CFAP54, and SPEF2 have a PCD phenotype with defects in ciliary motility.

10 Exome sequencing of a PCD subject identified an apparent homozygous frameshift

11 ge analysis was performed in a family with a PCD subject.

12 d in ETI are well studied, how they activate PCD and confer disease resistance remains elusive.

13 GmNAC30 cooperates with GmNAC81 to activate PCD through the induction of the cell death executioner

14 dynamic hot spot." Kinetic regulation allows PCD to adopt two distinct functions.

15 Although PCD is common throughout the nervous system, its influen

16 nd biochemical methods to detect and analyze PCD processes in vivo and in planta.

17 the molecular participants in apoptotic and PCD cascades, successful identification of early master

18 ral gastrulation was lost by midline ECM and PCD inhibition but restored with exogenously induced PCD

19 Dose-reduced spiral unenhanced lung EID and PCD CT examinations were performed in 30 asymptomatic vo

20 -enhanced spiral and axial abdominal EID and PCD scans were acquired.

21 ents in the context of SI-induced events and PCD.

22 e leaves (in which perforation formation and PCD are occurring) as compared to all other leaf develop

23 ions, including the regulation of growth and PCD.

24 , including S-specific growth inhibition and PCD of root cells.

25 different between HL and NHL; whereas LE and PCD occur almost exclusively in patients with HL, sensor

26 esent the native 3D structures of normal and PCD-causing RSPH1-mutant human respiratory cilia in unpr

27 the group level via re-usable resources and PCD may also provide a mechanism for how groups beget ne

28 gative regulators of jasmonate signaling and PCD.

29 One difference between plant and animal PCD is the absence of phagocytosis in plants.

30 While the molecular control of some animal PCD forms such as apoptosis is known in great detail, we

31 Annular PCD (%) was defined as perfused capillary area divided b

32 biotrophic pathogens, because ETI-associated PCD could leave them vulnerable to necrotrophic pathogen

33 d significantly during senescence-associated PCD.

34 negatively regulates ETI and the associated PCD through a physical interaction with cyclin-dependent

35 Autophagy, PCD and DNA damage related proteins were also identified

36 ts were not differentially expressed between PCD and NPCD cells.

37 nses, and the mechanistic interfaces between PCD, cell stress and virus infection pathways.

38 nd to be S-nitrosylated at the onset of both PCDs.

39 uals from two unrelated families affected by PCD.

40 Canonical PCDs play an important role in amino acid hydroxylation,

41 three-dimensional fold similar to canonical PCDs, although the prominent active site cleft present i

42 he crystal structure of an alpha-carboxysome PCD-like protein from the chemoautotrophic bacterium Thi

43 nzymes is disrupted in the alpha-carboxysome PCD-like protein.

44 ify mutations in additional genes that cause PCD, we performed exome sequencing on three unrelated pr

45 As a coactivator, PCD is known as DCoH or dimerization cofactor of the tra

46 We conclude that this conserved PCD-like protein, renamed here alpha-carboxysome RuBisCO

47 Thus, whether conserved PCD regulatory mechanisms include plant apoptosis remain

48 tors negatively regulate ethylene-controlled PCD in the lace plant.

49 of cell death-1 (rcd-1), a gene controlling PCD in germinated asexual spores in the filamentous fung

50 ular matrix (ECM) and programmed cell death (PCD) along the embryonic midline.

51 Programmed cell death (PCD) and associated pathway genes, which are triggered b

52 hown how instrumental programmed cell death (PCD) can be in innate and adaptive immune responses.

53 ing limb development, programmed cell death (PCD) contributes to separation of the digits.

54 Programmed cell death (PCD) functions in a variety of processes including growt

55 atured high levels of programmed cell death (PCD) in a concentration-dependent manner as measured by

56 Programmed cell death (PCD) in filamentous fungi prevents cytoplasmic mixing fo

57 Programmed cell death (PCD) in multicellular organisms is a vital process in gr

58 ain VL domain, caused programmed cell death (PCD) in mutant RAS expressing cells when each variable r

59 ve been implicated in programmed cell death (PCD) in other species.

60 ed immunity (ETI) and programmed cell death (PCD) in plants, is a novel transmembrane nucleoporin.

61 i (AAL) toxin induces programmed cell death (PCD) in susceptible tomato (Solanum lycopersicum) leaves

62 (ROS) production and programmed cell death (PCD) in tapetal cells, resulting in delayed or premature

63 ed the involvement of programmed cell death (PCD) in the process.

64 Programmed cell death (PCD) induced by endoplasmic reticulum (ER) stress is imp

65 Programmed cell death (PCD) is a crucial process both for plant development and

66 Programmed cell death (PCD) is an important mechanism for destroying cells in a

67 Programmed cell death (PCD) is central to organism development and for a long t

68 Programmed cell death (PCD) is critical for development and responses to enviro

69 Programmed cell death (PCD) is essential for several aspects of plant life, inc

70 Programmed cell death (PCD) is usually considered a cell-autonomous suicide pro

71 Programmed cell death (PCD) occurs in several forms including apoptosis and nec

72 to trigger selective programmed cell death (PCD) of at least lung, breast, and colorectal cancer cel

73 ty, is able to induce programmed cell death (PCD) of CD38(+) multiple myeloma tumor cell lines when c

74 determinants triggers programmed cell death (PCD) of incompatible pollen.

75 growth inhibition and programmed cell death (PCD) of self-pollen.

76 ns is associated with programmed cell death (PCD) of the infected cell.

77 on can lead to either programmed cell death (PCD) or acclimation.

78 s is a RIP1-dependent programmed cell death (PCD) pathway that is distinct from apoptosis.

79 tress acclimation and programmed cell death (PCD) pathways in plants, fungi, protozoa, bacteria and a

80 In mammalian cells, programmed cell death (PCD) plays important roles in development, in the remova

81 A plethora of diverse programmed cell death (PCD) processes has been described in living organisms.

82 everal indicators for programmed cell death (PCD) that are often observed in phytoplankton in respons

83 sis, a unique form of programmed cell death (PCD) that is characterized by DNA fragmentation, chromat

84 ecule that can induce programmed cell death (PCD) through the action of the OXIDATIVE STRESS INDUCIBL

85 ssing neurons undergo programmed cell death (PCD) within 24 hours after adult eclosion.

86 nity (ETI), involving programmed cell death (PCD), as a major defence mechanism against biotrophic pa

87 stress, UPR promotes programmed cell death (PCD).

88 lopmentally regulated programmed cell death (PCD).

89 al and hypersensitive programmed cell death (PCD).

90 ysEP) associated with programmed cell death (PCD).

91 often associated with programmed cell death (PCD).

92 progenitors or their programmed cell death (PCD).

93 l postnatal period of programmed cell death (PCD).

94 le 7% of RBCs undergo programmed cell death (PCD).

95 ling pathway known as programmed cell death (PCD).

96 groups demonstrated progressively decreasing PCD.

97 for paraneoplastic cerebellar degeneration (PCD) in HL and dermato/ polymyositis in both HL and NHL,

98 ated paraneoplastic cerebellar degeneration (PCD) is unclear.

99 dation (ECD) and photocatalytic degradation (PCD) technologies for saline water purification, with a

100 to pterin-4alpha-carbinolamine dehydratase (PCD) enzymes.

101 Pterin-4a-carbinolamine dehydratase (PCD) is a highly conserved enzyme that evolved a second,

102 H)/pterin-4alpha-carbinolamine dehydratases (PCD)-like protein is the causative mutation in a seedlin

103 leaves due to salicylic acid (SA)-dependent PCD, revealing roles for myoinositol or inositol derivat

104 leaves due to salicylic acid (SA)-dependent PCD.

105 by the lack of reliable reporters to detect PCD processes.

106 Passive cavitation detection (PCD) is a method proposed to monitor the microbubble act

107 s intact using passive cavitation detection (PCD), MRI-contrast agents and, importantly, also by sens

108 nvestigate whether photon-counting detector (PCD) technology can improve dose-reduced chest computed

109 Developmental PCD in the Drosophila ovary is an intriguing example of

110 ic promoter-reporter lines for developmental PCD in Arabidopsis.

111 t the large-scale nonapoptotic developmental PCD in the Drosophila ovary occurs by an alternative cel

112 ed a robust down-regulation of developmental PCD genes and an up-regulation of the genes involved in

113 Moreover, different cases of developmental PCD share a set of cell death-associated genes.

114 ry conserved core machinery of developmental PCD.

115 tion for the obtained paper-based CL device (PCD), it was examined for the detection of phenolic anti

116 Why did PCD evolve?

117 ng human normal plasma cell differentiation (PCD).

118 ype of childhood primary ciliary dyskinesia (PCD) and ultrastructural defects and genotype is poorly

119 to diagnosis of primary ciliary dyskinesia (PCD) in the United Kingdom consists of assessing ciliary

120 Primary ciliary dyskinesia (PCD) is a genetic disorder in which impaired ciliary fun

121 Primary ciliary dyskinesia (PCD) is a genetically heterogeneous recessive disorder o

122 Primary ciliary dyskinesia (PCD) is a genetically heterogeneous syndrome that result

123 Primary ciliary dyskinesia (PCD) is a genetically heterogeneous, autosomal-recessive

124 Primary ciliary dyskinesia (PCD) is an autosomal recessive disorder frequently cause

125 Primary ciliary dyskinesia (PCD) is an inherited chronic respiratory obstructive dis

126 Primary ciliary dyskinesia (PCD) originates from dysfunction of motile cilia, causin

127 h are typical of primary ciliary dyskinesia (PCD), a condition caused by motile cilia defects.

128 common cause of primary ciliary dyskinesia (PCD), a congenital disorder of ciliary beating, characte

129 been linked with primary ciliary dyskinesia (PCD), a disorder characterized by ciliary dysmotility; y

130 e major cause of primary ciliary dyskinesia (PCD), an inherited disorder of ciliary and flagellar dys

131 cystic fibrosis, primary ciliary dyskinesia (PCD), and select immunodeficiencies(3).

132 diatric syndrome primary ciliary dyskinesia (PCD).

133 diseases such as primary ciliary dyskinesia (PCD).

134 lung disease in primary ciliary dyskinesia (PCD).

135 iopathy known as primary ciliary dyskinesia (PCD).

136 defects such as primary ciliary dyskinesia (PCD; OMIM: 612518).

137 deletion of the mazF gene does not eliminate PCD in wild-type strain DK1622 as originally seen in DZF

138 Enhanced PCD due to hyperglycemia was specific to necroptosis as

139 ential regulatory mechanism specific for ETI/PCD induction.

140 For PCD, initial rates of ~330 mumol L(-1).h(-1) and 205 mum

141 ditional bacteria, and found no evidence for PCD enzymatic activity.

142 Image noise was significantly lower for PCD images in all BMI groups (P < .001 for groups 1 and

143 tically active chloroplasts are required for PCD to occur in mips1, but this process is independent o

144 nce is a highly specific diagnostic test for PCD, and it improves the speed and availability of diagn

145 labeled antibodies as a diagnostic tool for PCD.

146 er onset of daily wet cough than typical for PCD, and better lung function (FEV1), compared with 75 a

147 e applied cerebrospinal fluid and serum from PCD patients as well as CDR2 and CDR2L antibodies to neu

148 Furthermore, PCD is a means for solving a central problem of group li

149 s performed in pairwise comparisons of group PCD values.

150 Homozygous mice have PCD characterized by hydrocephalus, male infertility, an

151 NoDR group demonstrated consistently higher PCD compared to the control group in all 7 annuli, reach

152 omatography-post column derivatisation (HPLC-PCD) system detected a dense collection of high antioxid

153 cylic acid (SA) signaling and hypersensitive PCD, BiP overexpression further induced NRP-mediated cel

154 tion of the genes involved in hypersensitive PCD triggered by nonhost-pathogen interactions.

155 data indicate that during the hypersensitive PCD, BiP positively regulates the NRP cell death signali

156 other phytohormone pathways and/or important PCD components.

157 nking metacaspase expression and activity in PCD induced mortality in Trichodesmium.

158 R2L is the major antigen of Yo antibodies in PCD.

159 ased metabolic demand, while the decrease in PCD that follows in NPDR and PDR results largely from an

160 The most frequently mutated gene in PCD, DNAH5 is associated with randomization of body asym

161 toxic compounds that have been implicated in PCD, also depended on interdigital vascular patterning.

162 gene encoding DRC1, CCDC164, are involved in PCD pathogenesis.

163 t affect ciliary structure and nucleation in PCD(4), but the regulation of mucociliary transport rema

164 is still unclear whether they participate in PCD onset, execution, or both.

165 h the prominent active site cleft present in PCD enzymes is disrupted in the alpha-carboxysome PCD-li

166 epidermal growth factor-related receptor) in PCD and mGluR5 in limbic encephalitis (LE).

167 a unique genotype-phenotype relationship in PCD, and suggests that mutations in RSPH1 may be associa

168 ntified that a mutation in DNAAF2 results in PCD and that 40% of these patients also experience later

169 y orientation and impairs MCC and results in PCD.

170 ting that salicylate plays a crucial role in PCD downstream of jasmonate.

171 ntuitive positive role of the vasculature in PCD.

172 Relative to healthy controls, increased PCD values in the NoDR group likely represent an autoreg

173 her of the two ZmHbs is sufficient to induce PCD through a pathway initiated by elevated NO and Zn(2+

174 bition but restored with exogenously induced PCD.

175 g root apical meristems from hypoxia-induced PCD through mechanisms initiated by nitric oxide and med

176 ify two negative regulators of light-induced PCD that modulate OXI1 expression: DAD1 and DAD2, homolo

177 High light-induced PCD thus results from a tight control of the relative ac

178 hat OXI1 is a new regulator of (1)O2-induced PCD, likely acting upstream of jasmonate.

179 During SI-induced PCD, we previously observed a major acidification of the

180 integral and essential event for SI-induced PCD.

181 of cathepsin B and PBA1 in ER-stress-induced PCD (ERSID).

182 Jasmonate (JA) promotes AAL toxin induced PCD in a COI1 (coronatine insensitive 1, JA receptor)-de

183 endent JA pathway enhances AAL toxin induced PCD through regulating the redox status of the leaves, o

184 ammaR-mediated cross-linking of DARA induces PCD of CD38-expressing multiple myeloma tumor cells, whi

185 Suppression of ZmHb2 induces PCD in the anchoring cells, allowing the embryos to deve

186 tion in interdigital vessel number inhibited PCD, resulting in syndactyly, whereas an increment in ve

187 tion in both ROS production and interdigital PCD.

188 asculature positively regulates interdigital PCD.

189 limb development in regulating interdigital PCD by ROS production.

190 the miRNA-30b/c/d-mediated regulation of key PCD factors (IRF4, PRDM1, ELL2 and ARID3A).

191 ational analyses have identified several key PCD components, and we recently identified the mips1 mut

192 reas suppression of ZmHb1 results in massive PCD, leading to abortion.

193 FEV1), compared with 75 age- and sex-matched PCD cases (73.0 vs. 61.8, FEV1 % predicted; P = 0.043).

194 FcgammaRs induce DARA cross-linking-mediated PCD.

195 guing example of nonapoptotic, nonautonomous PCD, providing insight on the diversity of cell death me

196 dynamic expression modulation during normal PCD.

197 al changes in their expression during normal PCD.

198 gulating networks of significance for normal PCD and malignant plasma cell biology.

199 CP loss is seen in up to 28% of PCD cases, in whom laterality determination specified by

200 first report on the practical application of PCD using a nanomaterial assisted CL reaction.

201 at local glucose levels alter the balance of PCD pathways, and that clinically relevant outcomes may

202 The molecular basis of PCD regulation in the lace plant is unknown, however eth

203 Here, we examine the ecological effects of PCD in different microbial scenarios and conclude that P

204 also provided insight into the evolution of PCD in unicellular photoautotrophs, the impact of PCD on

205 ution resulted in elevation and expansion of PCD.

206 rons for survival and modulate the extent of PCD.

207 Both individuals had clinical features of PCD but normal ciliary axoneme structure.

208 ls with RSPH1 mutations had some features of PCD; however, nasal nitric oxide levels were higher than

209 n up new avenues of research in the field of PCD and developmental tissue remodeling.

210 H1D3 are responsible for an X-linked form of PCD causing disruption of early axonemal dynein assembly

211 In animals and plants, different forms of PCD play crucial roles in development, immunity, and res

212 cum), as monitored by measuring hallmarks of PCD in plants.

213 n unicellular photoautotrophs, the impact of PCD on the fate of natural phytoplankton assemblages and

214 one is compelled to consider the impacts of PCD beyond the cell, for death obviously lowers the fitn

215 The estimated incidence of PCD is approximately 1 per 15,000 births, but the preval

216 e are relatively few documented instances of PCD in bacteria.

217 h should improve diagnosis and management of PCD.

218 e homologs of caspases, the key mediators of PCD in animals.

219 es the gene-trapped allele as a new model of PCD.

220 ither as a negative or positive modulator of PCD events.

221 Interestingly, prior to the onset of PCD, the autopod vasculature undergoes extensive pattern

222 The performance of PCD showed no statistically significant difference compa

223 y 1 per 15,000 births, but the prevalence of PCD is difficult to determine, primarily because of limi

224 nterdigital areas, as the genetic program of PCD provides the first layer and vascular patterning ser

225 or inositol derivatives in the regulation of PCD.

226 ectly involved in the negative regulation of PCD.

227 and highlight a positive functional role of PCD in development.

228 Here, we identified a suppressor of PCD by screening for mutations that abolish the mips1 ce

229 Our understanding of PCD regulation in plants has advanced significantly over

230 r the control of the beam intensity based on PCD employ a full-pulse analysis and may suffer from a l

231 omatic embryogenesis through their effect on PCD.

232 es may depend on glucose-mediated effects on PCD.

233 xyl-propylene carbonate-graft-dodecanol; PEG-PCD) to prepare micelles.

234 wer Ni concentrations than our physiological PCD assay and that the results are predictive of physiol

235 To study tonoplast rupture, a plant PCD feature, both confocal and electronic microscopies w

236 ommonly regulated genes during diverse plant PCD processes in Arabidopsis (Arabidopsis thaliana).

237 oplasts may play a central role during plant PCD as for mitochondria in animal cells, but it is still

238 pressed in plants, successfully impact plant PCD.

239 Here, we identified a regulator of plant PCD by screening for mutants that display transcriptomic

240 the regulation of the diverse types of plant PCD.

241 uch regulators can trigger or suppress plant PCD.

242 In plants, PCD occurs during development as well as in response to

243 Here we describe a potential PCD pathway in Pseudomonas aeruginosa that enhances the

244 une responses and avoid detection to prevent PCD and allow infection.

245 n Initial human experience with dose-reduced PCD chest CT demonstrated lower image noise compared wit

246 ose a double safety mechanism that restricts PCD to interdigital areas, as the genetic program of PCD

247 es, suggest a mechanism for the milder RSPH1 PCD phenotype and demonstrate that cryo-electron tomogra

248 early mortality and typically develop severe PCD-associated phenotypes of hydrocephalus, mucociliary

249 ring several key hallmark features of the SI PCD signaling pathway, notably activation of a DEVDase/c

250 t reactive oxygen species (ROS) signal to SI-PCD.

251 ealed that hollow-stemmed lines had stronger PCD-associated signals in the pith cells compared to sol

252 ception with 1-methylcyclopropene suppressed PCD, increased BAX inhibitor-1, an effective attenuator

253 ferent microbial scenarios and conclude that PCD can increase biological complexity.

254 Recent research has revealed that PCD is complex, with at least a dozen cell death modalit

255 The PCD Foundation is developing a network of clinical cente

256 CCDC65, was absent in airway cells from the PCD subject and CCDC65-silenced cells.

257 in the spinal canal, which was lower in the PCD than the EID images because of beam hardening (20 HU

258 Results - 65.9% (87 / 132) of the PCD patients carrying disease-causing DNAH5 mutations ha

259 vered that heterologous co-expression of the PCD-like protein from Halothiobacillus neapolitanus with

260 l-based complementation assay, we tested the PCD-like proteins from T. intermedia and two additional

261 on of directional flow likely underlying the PCD-like phenotypes.

262 mutant strain putatively indicates that the PCDs are a result of genomic DNA damage.

263 These PCD indicators represent a powerful resource that can be

264 higher transcript levels in NPCD compared to PCD cells.

265 reduction in cellular activity could lead to PCD.

266 he range of ciliary defects that can lead to PCD.

267 Plant effector-triggered PCD also shares with mammalian apoptosis the involvement

268 This effector-triggered PCD is partly analogous to pyroptosis, an inflammatory h

269 smium from the South Pacific Ocean triggered PCD under Fe-limitation and high light along with enhanc

270 te pollen and seed development by triggering PCD and tapetal cell degradation.

271 SI in field poppy (Papaver rhoeas) triggers PCD in incompatible pollen.

272 candidate genes in 70 genetically undefined PCD patients.

273 yanobacterium Trichodesmium, which undergoes PCD under low iron and high-light stress.

274 els were also determined in cells undergoing PCD and cells not undergoing PCD (NPCD cells).

275 ells undergoing PCD and cells not undergoing PCD (NPCD cells).

276 vegetative and generative tissues undergoing PCD.

277 Further genetic screening of unrelated PCD subjects identified a second proband with a compound

278 caspase-like activities were stimulated upon PCD induction, inhibitor treatments of these proteolytic

279 Thus, host and pathogen each may use PCD as a survival-promoting strategy.

280 In particular, plants and animals utilize PCD to control pathogen invasion and infected cell popul

281 nscript levels in mature stage leaves, where PCD is not occurring.

282 y lysis or other means can be harmful, while PCD can evolve by providing advantages to relatives.

283 es from the data reviewed here is that while PCD carries an obvious cost to the cell, it can be a dri

284 h PCD and normal staining in all 252 in whom PCD was considered highly unlikely.

285 n 413 unrelated probands, including 325 with PCD and 88 with idiopathic bronchiectasis, revealed bial

286 Sepsis reversal was achieved with PCD alone in 62.5%.

287 h plant hormone signaling is associated with PCD and PTI, both FB1-triggered cell death and suppressi

288 Here we report a novel gene associated with PCD but without ciliary ultrastructural abnormalities ev

289 se activity, which have been associated with PCD in other phytoplankton species.

290 members of critical pathways associated with PCD.

291 scovery cohort of 35 patients diagnosed with PCD by ciliary ultrastructure, and a diagnostic accuracy

292 of enhanced kidney tissue was improved with PCD iodine mapping compared with EID (5.2 +/- 1.3 vs 4.0

293 has been routinely observed to increase with PCD induction in Trichodesmium.

294 sequencing of 67 additional individuals with PCD with ODA defects from 58 families revealed CCDC114 m

295 participants younger than 19 years old with PCD were evaluated prospectively at six centers in North

296 ccessfully identified 22 of 25 patients with PCD and normal staining in all 252 in whom PCD was consi

297 Patients with PCD experience malfunctions in cilia motility, which can

298 ide levels were higher than in patients with PCD with other gene mutations (98.3 vs. 20.7 nl/min; P <

299 c cause is not defined for all patients with PCD.

300 kinocilia, and establish a useful zebrafish PCD model.