ライフサイエンスコーパス: PDC

1 PDC activation abolished statin myopathy in rodent skele

2 PDC binds cooperatively (Hill coefficient = 2), while NA

3 PDC catalyzes the conversion of pyruvate to acetyl-CoA a

4 PDC depletion had an immediate impact on the activation

5 PDC flux depends on catalytic activity of the most impor

6 PDC is feasible with low mortality and is associated wit

7 PDC was modified to account for time to last viral load

8 PDC-E2 is a ubiquitous protein present in mitochondria o

9 PDC-E2 was found to localize unmodified within apoptotic

10 Three peptides, PDC-E2145-159, PDC-E2(249-263), and PDC-E2(629-643), elicited high-affi

11 Mean adherence was 0.77 +/- 0.28 (PDC +/- SD) at the patient level and 0.78 +/- 0.05 at th

12 and functions, though little is known about PDC-NK cell interactions during these infections.

13 -methyl-D-tryptophan significantly abrogates PDC-driven inducible Treg generation and suppressor cell

14 or, trans-pyrrolidine-2,4-dicarboxylic acid (PDC) for 3 weeks, or a higher level (50 muM) for 48 h, f

15 Although activated PDC killed the DR5-expressing HIV-infected Sup-T1 cell l

16 HFD+DCA activated PDC throughout and restored whole-body CHO use during ex

17 on of PDH by PDH phosphatase (PDP) activates PDC.

18 Only 49% of the patients adhered (PDC >/=80%) to all 3 therapies.

19 as with a mouse monoclonal antibody against PDC-E2 and AMA with an immunoglobulin A isotype.

20 ninsula, C9orf72 expansions do not cause ALS-PDC in Chamorros.

21 ewise, LRRK2 mutations do not cause Guam ALS-PDC.

22 ALS/PDC shares neuropathological features found in many neur

23 sclerosis/parkinsonism-dementia complex (ALS/PDC) is a fatal neurodegenerative disease found in the C

24 sclerosis/parkinsonism-dementia complex (ALS/PDC), or Alzheimer's disease, has been identified in mor

25 Thus, examining ALS/PDC may provide further explanations on how various prot

26 To identify loci for ALS/PDC, we conducted both genome-wide linkage and associati

27 cant evidence for two regions with novel ALS/PDC loci on chromosome 12 and supportive evidence for th

28 Elucidation of the genetic basis of ALS/PDC should improve our understanding of related neurodeg

29 Our results suggest that ALS/PDC may be influenced by as many as three loci, while il

30 eptides, PDC-E2145-159, PDC-E2(249-263), and PDC-E2(629-643), elicited high-affinity T cell responses

31 icromolar inhibitor of the class C ADC-7 and PDC-3 beta-lactamases.

32 (11.28%) users were adherent (MPR >=70% and PDC <=1.25), 51 (4.23%) were partly adherent (MPR >=70%

33 (4.23%) were partly adherent (MPR >=70% and PDC = 1.50) and 176 (14.60%) were switchers.

34 All Chamorro participants with ALS and PDC and control subjects had normal repeats, ranging fro

35 s PDHK1 kinase activity by promoting ATP and PDC binding.

36 en tacrolimus whole blood concentrations and PDC frequencies (Spearman r=-0.370, P=0.005) in 48 cross

37 g to Escherichia coli DHPR: NADH or CRAA and PDC (stable analog of DHP).

38 ipant demographics, baseline viral load, and PDC were explanatory variables.

39 ues indicate little synergy between NADH and PDC, (1)H- (15)N HSQC chemical shift perturbation and sa

40 a compelling interaction between STAT5A and PDC subunits in adipocytes under physiological condition

41 validate the interaction between STAT5A and PDC subunits in murine and human cultured adipocytes, as

42 iated by inhibition of both PDC survival and PDC function.

43 raction between ash plume, thunderstorm, and PDC transport during this secondary period of observed l

44 l beta-sheet structural conformation in anti-PDC-E2 recognition.

45 mal stoichiometry of this in vitro assembled PDC for E2p:E3BP:E1p:E3 is 40:20:40:20.

46 romatin immunoprecipitation (ChIP) to assess PDC's ability to interact with STAT5 DNA-binding sites.

47 The average PDC was 77% for patients in the generic group and 71% fo

48 PDC have been controversial, partly because PDC show features of both lymphocytes and dendritic cell

49 Furthermore, both PDC xenografts and patient-derived xenografts confirm CD

50 vo, an effect mediated by inhibition of both PDC survival and PDC function.

51 -producing activity was attributable to both PDC and NK cell defects.

52 ncer, while PDKs may be further activated by PDC by binding to the E2.E3BP core.

53 ignificantly reduced IFN-alpha production by PDC in vitro in response to CpG A ligands or inactivated

54 production of type I interferons in vitro by PDC from HIV-1-infected patients may not represent dimin

55 not late-stage poorly differentiated cancer (PDC).

56 f cells within the piezo dispense capillary (PDC) prior to arraying.

57 The presence of CXCR7+ CCR10low PDC-E2-specific ASCs suggests a mechanistic basis for th

58 fections impair plasmacytoid dendritic cell (PDC) and natural killer (NK) cell subset numbers and fun

59 Blastic plasmacytoid dendritic cell (PDC) neoplasm (BPDCN) is an aggressive hematological mal

60 he function of plasmacytoid dendritic cells (PDC) in chronic human immunodeficiency virus type 1 (HIV

61 Plasmacytoid dendritic cells (PDC) represent a distinct immune cell type specialized i

62 rturbations of plasmacytoid dendritic cells (PDC), including diminished frequencies in the peripheral

63 ein 3, Pseudomonas-derived cephalosporinase (PDC), and MurA with ceftazidime-avibactam-fosfomycin, an

64 as the primary-and likely sole-S. cerevisiae PDC phosphatase, closing a key knowledge gap about the r

65 itA sensor domains, and this PhoQ-DcuS-CitA (PDC) sensor fold is seen to be distinct from the superfi

66 ntains an inserted repeat of PhoQ/DcuS/CitA (PDC) domains, and similarity between sequence and struct

67 o, using the pyruvate dehydrogenase complex (PDC) activator, dichloroacetate (DCA), would blunt activ

68 reduction in pyruvate dehydrogenase complex (PDC) activity (P < 0.05), and increased glycogen degrada

69 itochondrial pyruvate dehydrogenase complex (PDC) are also present and functional in the nucleus of m

70 1) regulates pyruvate dehydrogenase complex (PDC) by acetylating pyruvate dehydrogenase (PDH) and PDH

71 The pyruvate dehydrogenase complex (PDC) catalyzes the conversion of pyruvate into acetyl-Co

72 The human pyruvate dehydrogenase complex (PDC) comprises four multidomain components, E1, E3, E2 a

73 nhibition of pyruvate dehydrogenase complex (PDC) in cancer cells.

74 The human pyruvate dehydrogenase complex (PDC) is a 9.5-megadalton catalytic machine that employs

75 The pyruvate dehydrogenase complex (PDC) is a critical mitochondrial enzyme that catalyzes p

76 Mammalian pyruvate dehydrogenase complex (PDC) is a key multi-enzyme assembly that is responsible

77 The pyruvate dehydrogenase complex (PDC) is a multienzyme assembly that converts pyruvate to

78 itochondrial pyruvate dehydrogenase complex (PDC) is crucial for glucose homeostasis in mammalian cel

79 itochondrial pyruvate dehydrogenase complex (PDC) is down-regulated by phosphorylation catalyzed by p

80 Human pyruvate dehydrogenase complex (PDC) is down-regulated by pyruvate dehydrogenase kinase

81 The pyruvate dehydrogenase complex (PDC) is the primary metabolic checkpoint connecting glyc

82 itochondrial pyruvate dehydrogenase complex (PDC) plays a crucial role in regulation of glucose homoe

83 ing inhibits pyruvate dehydrogenase complex (PDC)-controlled carbohydrate (CHO) oxidation, which cont

84 lyzed by the pyruvate dehydrogenase complex (PDC).

85 consequently pyruvate dehydrogenase complex (PDC).

86 ition of the pyruvate dehydrogenase complex (PDC).

87 units of the pyruvate dehydrogenase complex (PDC).

88 onent of the pyruvate dehydrogenase complex (PDC-E2), has unique features, including continuous high

89 bunit of the pyruvate dehydrogenase complex (PDC-E2), the major mitochondrial autoantigen of PBC and

90 onent of the pyruvate dehydrogenase complex (PDC-E2).

91 onent of the pyruvate dehydrogenase complex (PDC-E2).

92 sis (ALS) and parkinsonism-dementia complex (PDC) exist in Japanese on the Kii Peninsula of Japan and

93 lerosis (ALS)/parkinsonism dementia complex (PDC) of Guam.

94 ds for inspecting protein-detergent complex (PDC) interfaces require high concentrations of protein a

95 pyruvate dehydrogenase multienzyme complex (PDC) and thereby controls the rate of oxidative decarbox

96 pyruvate dehydrogenase multienzyme complex (PDC) is a key regulatory point in cellular metabolism li

97 ndrial pyruvate dehydrogenase (PDH) complex (PDC) acts as a central metabolic node that mediates pyru

98 ), the pyruvate dehydrogenase (PDH) complex (PDC) links glycolysis and the TCA cycle.

99 lfide bond within the lipoic-acid-conjugated PDC-E2 moiety, i.e., by an electrophilic agent renders P

100 onlinearities in parametric down-conversion (PDC) of X-rays to long wavelength radiation in gallium a

101 age 4.5 years after first visit (converters; PDC).

102 io (MPR) and the Proportion of days covered (PDC) approach.

103 was measured by proportion of days covered (PDC) during 180 days following hospital discharge.

104 iption fill) and proportion of days covered (PDC), a standard claims-based measure of adherence, asse

105 measured by the proportion of days covered (PDC).

106 roviral therapy (proportion of days covered [PDC] >=90%) and virally suppressed (HIV RNA <200 copies/

107 (measured as the proportion of days covered [PDC] up to 1 year) and a composite outcome comprising ho

108 ime of a deadly pyroclastic density current (PDC) and thunderstorm.

109 matory functions, and plasmacytoid CD123 DC (PDC), which may have tolerogenic potential, were measure

110 atory functions, and plasmacytoid CD123+ DC (PDC), which may have tolerogenic potential, were measure

111 nisms, the action of pyruvate decarboxylase (PDC) and pyruvate formate lyase (PFL)-enzymes that catal

112 rboxylase (BFDC) and pyruvate decarboxylase (PDC) are both thiamin diphosphate-dependent enzymes.

113 Pyruvate decarboxylase (PDC) uses thiamine diphosphate as an essential cofactor

114 Plant pyruvate decarboxylases (PDC) catalyze the decarboxylation of pyruvate to form ac

115 a induced Pdk4 gene expression and decreased PDC activity.

116 tability, formation of small PDCs, decreased PDC surface flexibility, and potential to mediate crysta

117 was higher and was associated with decreased PDC frequencies.

118 of the E2 subunit of pyruvate dehydrogenase (PDC-E2) are detected in 95% of patients with primary bil

119 the E2 component of pyruvate dehydrogenase (PDC-E2) involving autoantibody and autoreactive cluster

120 of the E2 subunit of pyruvate dehydrogenase (PDC-E2).

121 A = catechol rhodanine acetic acid) and DHP (PDC = pyridine dicarboxylate) binding sites.

122 le hydrolysis of 2-pyrone-4,6-dicarboxylate (PDC) to 4-oxalomesaconate and 4-carboxy-2-hydroxymuconat

123 umarin analogues by a pyridinium dichromate (PDC)-mediated chemoselective allylic oxidation.

124 ection in vivo and document a lack of direct PDC cytolytic activity against autologous infected or un

125 is correlated across these and other double-PDC sensor proteins.

126 C-NK cell culture experiments, CpG-enhanced, PDC-dependent NK cell activity was cell contact and IFN-

127 her TLR2 ligands, PSA is better at enhancing PDC expression of costimulatory molecules required for p

128 We evaluated PDC-dependent NK cell killing and gamma interferon (IFN-

129 antly decreased frequency of pDCs expressing PDC-TREM, a modulator of TLR-mediated IFN production.

130 ontext, different preparative approaches for PDC-NCs as well as some of their properties will be pres

131 ctivates the NF-kappaB pathway essential for PDC survival.

132 strate that the IDO pathway is essential for PDC-driven Treg generation from CD4(+)CD25(-) T cells an

133 phosphorylation (inactivation) at E1 by four PDC kinases (PDKs), and reactivation by two PDC phosphat

134 e accumulation appears to have resulted from PDC activation status limiting pyruvate flux, most proba

135 Functional PDC can form in mitochondria outside of the matrix in so

136 PDC core (tE2/E3BP) and native bovine heart PDC core (bE2/E3BP) obtained by small-angle X-ray scatte

137 is the principal isozyme regulating hepatic PDC.

138 In heterologous PDC-NK cell assays, impaired PDC-NK cell killing activit

139 Higher PDC (adjusted odds ratio [AOR], 1.74 per 1-level increas

140 The human PDC is organized around a 60-meric dodecahedral core com

141 The human PDC is subject to inactivation at E1 by serine phosphory

142 o the immune system of intact immunoreactive PDC-E2 within apoptotic blebs.

143 In heterologous PDC-NK cell assays, impaired PDC-NK cell killing activity was largely attributable to

144 butable to an NK cell defect, while impaired PDC-NK cell IFN-gamma-producing activity was attributabl

145 In PDC "knockout" (KO) animals, the long-term regenerative

146 hase fields for the formation of bedforms in PDC deposits.

147 were no significant differential changes in PDC among beneficiaries with at least 1 prescription fil

148 tulating some clinical symptoms described in PDC-deficient patients.

149 than controls, membrane TRAIL expression in PDC from HIV(+) subjects was increased.

150 ds ratio [AOR], 1.74 per 1-level increase in PDC category [95% confidence interval {CI}, 1.30-2.34])

151 including transcription factors involved in PDC development (SpiB, Irf8) and function (Irf7).

152 IAV exposure resulted in PDC maturation by upregulation of CD86 expression and IF

153 PDH kinase inactivates PDC by phosphorylating PDH at specific serine residues,

154 Exercise increased PDC activation and whole-body CHO use in HFD, but to a l

155 creased ACAT1 activity, leading to increased PDC flux and oxidative phosphorylation with attenuated c

156 cate that during uncontrolled HIV infection, PDC-dependent NK cell function is impaired, which is in

157 CRP directly inhibited PDC IFNalpha release, promoted PDC differentiation, and

158 the apotope of biliary cells contains intact PDC-E2; this apotope, in a setting that includes granulo

159 that BECs translocate immunologically intact PDC-E2 to apoptotic bodies and create an apotope.

160 years in a single institution with intended PDC.

161 d hexanoic acids and the xenobiotic 6BH into PDC-E2.

162 e to aberrantly incorporate xenobiotics into PDC-E2.

163 structures of human recombinant full-length PDC core (rE2/E3BP), truncated PDC core (tE2/E3BP) and n

164 R5-expressing HIV-infected Sup-T1 cell line, PDC did not lyse primary autologous HIV(+) CD4(+) T cell

165 ly higher MDC counts and significantly lower PDC frequencies (P=0.017) during the 1- to 60-day time p

166 The activity of mammalian PDC is regulated through reversible phosphorylation gove

167 ross-sectional subjects revealed that an MDC:PDC ratio more than or equal to 1.78 was associated with

168 We conclude that an elevated MDC:PDC ratio associates with early small bowel allograft re

169 We conclude that an elevated MDC:PDC ratio associates with liver graft rejection, which o

170 Among rejectors, a significantly higher MDC:PDC ratio (P=0.004) was associated with numerically high

171 s analysis showed a significantly higher MDC:PDC ratio (P=0.043, F-test) among rejectors, compared wi

172 ng characteristic analysis revealed that MDC:PDC ratio more than or equal to 1.52 was associated with

173 tudinal and cross-sectional cohorts, the MDC:PDC ratio was higher and was associated with decreased P

174 1-0.9 percentage points; or 0.6% of the mean PDC [78.2%], P = .01 for both).

175 1-0.5 percentage points; or 0.4% of the mean PDC [82.3%], P = .003) and for metformin in the 2012 and

176 by a corresponding decrease in mitochondrial PDC levels, suggesting a translocation from the mitochon

177 Dynamic translocation of mitochondrial PDC to the nucleus provides a pathway for nuclear acetyl

178 70-fold lower than that of Zymomonas mobilis PDC.

179 tion that AMAs recognize xenobiotic modified PDC-E2 with higher titers than native PDC-E2 raises the

180 E2-2 directly activated multiple PDC-enriched genes, including transcription factors invo

181 We found that multiple PDC subunits interact with hormone-activated STAT5A in a

182 Muscle PDC activity was the same at 2 h and 6 h, but was 65% lo

183 and cathepsin-L activity, and reduced muscle PDC activity.

184 i.e. polymer-derived ceramic nanocomposites (PDC-NCs), which have been shown to be promising material

185 dified PDC-E2 with higher titers than native PDC-E2 raises the possibility that the earliest events i

186 gait (lower pace) deviates from that of non-PDC approximately 4 years prior to diagnosis.

187 95% CI: 1.54 to 1.76) for being nonadherent (PDC <80%) to all 3 therapies.

188 Nuclear PDC levels increased in a cell-cycle-dependent manner an

189 Inhibition of nuclear PDC decreased acetylation of specific lysine residues on

190 We found that knockdown of nuclear PDC in isolated functional nuclei decreased the de novo

191 pically localizes to the cytosol or nucleus, PDC normally resides within the mitochondrial matrix whe

192 tested whether pharmacological activation of PDC overrides these diet-induced changes.

193 Also, pharmacological activation of PDC restores HFD-mediated inhibition of CHO oxidation du

194 and cathepsin-L mRNA, increased activity of PDC and reduced proteasome activity compared with simvas

195 Activity of PDC is inhibited by phosphorylation via the pyruvate deh

196 e data strongly suggest that the activity of PDC is regulated by different isozymes in different tiss

197 However, addition of PDC to SOD1 mutant slices resulted in substantial MN inj

198 The origin and lineage affiliation of PDC have been controversial, partly because PDC show fea

199 lucidate the cellular and molecular basis of PDC development.

200 t normally binds the lipoic acid cofactor of PDC-E2, reacts as well or better to PBC sera than native

201 concert to control molecular composition of PDC and contribute to the Warburg effect.

202 any individual lipoyl domains or the core of PDC.

203 A) forestall binding of the lipoyl domain of PDC to these mutants, analogous to wild-type PDK2 in the

204 lar homology with the inner lipoyl domain of PDC-E2; such chemicals have been proposed as potential e

205 major histocompatibility class I epitope of PDC-E2.

206 ency significantly reduced the expression of PDC-TREM on pDCs from both NZM2410 and C57BL/6 mice.

207 underlie the distinct 'lymphoid' features of PDC.

208 The C-8 and C-11 carboxylate groups of PDC are coordinated within the active site via ion pair

209 The kinetic constants for the hydrolysis of PDC are 340 s(-1) and 9.8 x 10(6) M(-1) s(-1) (k(cat) an

210 s determined by conducting the hydrolysis of PDC in (18)O-labeled water and subsequent (13)C nuclear

211 e must be deprotonated for the hydrolysis of PDC.

212 colysis and the TCA cycle by inactivation of PDC has only minor effects on cell replication.

213 fect on the overall rates of inactivation of PDC in kinase reaction.

214 was largely responsible for inactivation of PDC in tissues of muscle origin and brown adipose tissue

215 Incidence of PDC characterized by prostate weight of more than 1 g wa

216 PDCs, preventing glucocorticoid induction of PDC death and the consequent reduction of systemic IFN-a

217 eron (IFN-alpha) production and induction of PDC-dependent tumor necrosis factor (TNF)-related apopto

218 d muscle PDK4 upregulation and inhibition of PDC and CHO oxidation in humans.

219 nhibits muscle CHO oxidation at the level of PDC during prolonged contraction, and is paralleled by t

220 t of carbohydrate oxidation, at the level of PDC, and up-regulation of muscle protein degradation, in

221 e the integrity and specific localization of PDC-E2 during induced apoptosis.

222 ationship between the nano/microstructure of PDC-NCs and their properties will be highlighted.

223 rrently, there are two conflicting models of PDC (E2+E3BP) core organisation: the 'addition' model (6

224 ge commitment and gene expression program of PDC.

225 rincipally responsible for the regulation of PDC activity in that tissue.

226 nsive analysis of the amino acid residues of PDC-E2 lipoyl beta-sheet with AMA specificity is lacking

227 pha production was reduced responsiveness of PDC to de novo stimulation, not diminished per cell IFN-

228 velopmental origin and genetic similarity of PDC and classical antigen-presenting DC have been establ

229 A second crystal structure of PDC in complex with fluoride shows that the ion organize

230 The current understanding of PDC regulation involves inhibitory serine phosphorylatio

231 tudy was to investigate the effect of CRP on PDC and monocyte responses to nucleoprotein autoantigens

232 -gamma and granzyme B activity (dependent on PDC and NK cells) were impaired in viremic HIV infection

233 derived cell lines (PDCs) of stromal and one PDC of tumorigenic origin were generated from breast or

234 he 2-oxo-dehydrogenase pathway, particularly PDC-E2.

235 Three peptides, PDC-E2145-159, PDC-E2(249-263), and PDC-E2(629-643), eli

236 biochemistry, we define Ptc6p as the primary PDC phosphatase in S. cerevisiae Our analyses further su

237 tly inhibited PDC IFNalpha release, promoted PDC differentiation, and increased late endosome localiz

238 In purified PDC-NK cell culture experiments, CpG-enhanced, PDC-depen

239 Real-time PCR analysis of purified PDC from patients prior to and during treatment interrup

240 ated bovine serum albumin (BSA), recombinant PDC-E2 (rPDC-E2) or BSA alone.

241 Here, using an in vitro reconstituted PDC, we provide densitometry, isothermal titration calor

242 on factor alpha (PPARalpha) mRNA and reduced PDC activation.

243 ession of PDK isoforms and therefore reduced PDC activity prevails in cancer and diabetes.

244 mechanisms, which act in concert to regulate PDC activity and promote the Warburg effect.

245 essibility, which act in concert to regulate PDC activity and promote the Warburg effect.

246 Deciphering which kinase regulates PDC in organisms at specific times or places has been ch

247 isozymes to explore their role in regulating PDC activity.

248 ety, i.e., by an electrophilic agent renders PDC-E2 immunogenic in a genetically susceptible host.

249 orylation of PDH by PDH phosphatase restores PDC activity.

250 NA lowers PDHalpha phosphorylation, restores PDC activity, reverts the Warburg metabolic phenotype, d

251 tilized a mouse model of hepatocyte-specific PDC inactivation to determine the need for this metaboli

252 d GTP, with the formation of 6BH-substituted PDC-E2 predominating in an ATP-rich environment.

253 al therapy (ART) interruption and by testing PDC cytolytic function against autologous HIV-infected C

254 and histological subtype and is better than PDC without- MCR.

255 Sutendra et al. now demonstrate that PDC can translocate from the mitochondria to the nucleus

256 We also demonstrate that PDC inhibition in cancer cells is associated with normox

257 There is previous evidence that PDC localizes to cancer cell nuclei where it plays a rol

258 challenge the long standing hypothesis that PDC is involved in BCAA-derived aldehyde formation in fr

259 these previous findings, we hypothesize that PDC may modulate STAT5's ability to regulate gene expres

260 er difference (STD) titrations indicate that PDC induces a more dramatic conformational change than N

261 unofluorescence microscopy, we observed that PDC-E2 is present within the adipocyte nucleus where it

262 These analyses revealed that PDC-E2 is bound to a STAT5-binding site in the promoter

263 hosphatase(s) responsible for activating the PDC in S. cerevisiae has not been conclusively defined.

264 al activities that are not stimulated by the PDC core.

265 vels of other PDK isoforms stimulated by the PDC core.

266 A central issue concerning the PDC structure is the subunit stoichiometry of the E2p/E3

267 nly demonstrate additional functions for the PDC enzyme, but also challenge the long standing hypothe

268 ept for slight differential increases in the PDC for beta-blockers in the 2012 entry cohort (adjusted

269 largely focused on specific residues in the PDC-E2 lipoyl domain critical in maintaining the lipoyl

270 To directly determine the regulation of the PDC by phosphorylation, we developed a complete set of p

271 basal activity of PDK4 in the absence of the PDC core.

272 Phosphorylation of the PDC E1 subunit was identified as a key inhibitory modifi

273 itate a massively parallel assessment of the PDC interfacial interactions under a fairly broad range

274 ion profile and impaired IFN response of the PDC.

275 a identify E4F1 as a master regulator of the PDC.

276 pithelial cells (BECs) uniquely preserve the PDC-E2 epitope following apoptosis.

277 which specifically tethers E3 dimers to the PDC.

278 re, it appears that the overall flux through PDC in a given tissue largely reflects the properties of

279 Pyruvate flux through PDC is regulated via phosphorylation (inactivation) at E

280 IRT3 and recruits acetyltransferase ACAT1 to PDC, resulting in increased inhibitory lysine acetylatio

281 PDP1 dissociates SIRT3 and recruits ACAT1 to PDC.

282 e mice, by measuring levels of antibodies to PDC-E2, immunohistology of liver, and expression of Gal-

283 SOD1 mutant animals that were not exposed to PDC.

284 phosphocreatine (PCr) concentrations) or to PDC inhibition, whereas after 24 h, muscle lactate accum

285 yl acetyltransferase (E2) to recruit PDP1 to PDC.

286 shifted from extra-pleural pneumonectomy to PDC with the goal of MCR.

287 light the importance of loss of tolerance to PDC-E2 as well as a critical role for the interleukin (I

288 s-pyrrolidine-2,4-dicarboxylic acid (l-trans-PDC) or by partial suppression of GLAST using siRNA inte

289 t full-length PDC core (rE2/E3BP), truncated PDC core (tE2/E3BP) and native bovine heart PDC core (bE

290 PDC kinases (PDKs), and reactivation by two PDC phosphatases.

291 5-year survival of patients undergoing PDC with MCR in multi-modality setting is approaching 25

292 acellular mechanism or mechanisms underlying PDC-induced Treg generation are unknown.

293 roles in cellular metabolism, understanding PDC regulation is pivotal to understanding the larger me

294 n of exercise were used to estimate CHO use, PDC activation, and mRNAs associated with insulin, fat,

295 While PDC from HIV-infected subjects expressed less interferon

296 remely limited activity with pyruvate, while PDC has no activity with benzoylformate.

297 ith BBr3 and oxidized to the o-quinones with PDC.

298 e fact that AMA-containing sera reacted with PDC-E2 on apoptotic BECs without a requirement for perme

299 blast population were uniquely reactive with PDC-E2, detected in the CXCR7+ CCR10low plasmablast popu

300 ntify potentially antigenic sequences within PDC-E2 (an important hepatic autoantigen) that contain a