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1 PDGFB can mediate the development of mouse spinal tumors
3 creased expression of EMP-1, NOTCH-1, FLT-1, PDGFB, and several other genes that may contribute to th
6 n were positive for fusion of the COL1A1 and PDGFB loci in 7 patients; and RT-PCR showed the COL1A1-P
7 of three genes (coding for CXCR7, ITGB2, and PDGFB) significantly inhibits C. pneumoniae entry, but t
9 CTTNBP2, MYC (alias c-myc), PTEN, MEN1, and PDGFB] in six nonrecurrent and seven recurrent radical p
10 alysis of the array data identified NFIB and PDGFB as the 2 major candidate target oncogenes that may
13 past 2 years, 3 genes (SLC20A2, PDGFRB, and PDGFB) were identified as causative of primary familial
16 bits the endothelial Pdgfb transcription and PDGFB growth signaling to the non-coronary leaflet mesen
21 results confirmed the association of VWF and PDGFB with VTE after correction for multiple testing, wh
23 e (MYORG), platelet-derived growth factor B (PDGFB) and platelet-derived growth factor receptor beta
24 cell genes platelet-derived growth factor B (PDGFB) and vascular endothelial cell growth factor recep
28 naling via platelet-derived growth factor B (PDGFB), expressed by endothelial cells, and its receptor
29 11 (IL11), platelet-derived growth factor-B (PDGFB), and hyaluronan synthase 2 (HAS2), as well as the
38 ing neutrophils in HCC or monocyte-deficient PDGFB-driven and Nf1-silenced GBM models extend the surv
39 previously unknown role for platelet-derived PDGFB, whereby it promotes and maintains vascular integr
42 odels incorporating human-relevant EGFRvIII, PDGFB and NF1 driver mutations to characterize the genot
44 onocyte chemoattraction in monocyte enriched PDGFB-driven GBM invokes a compensatory neutrophil influ
45 xpression of platelet-derived growth factor (PDGFB) in human pulmonary arterial endothelial (HPAE) ce
46 sed higher ISGs together with elevated FGF2, PDGFB, and XIAP, compared with CL derived from day 18 cy
49 rain calcification, and mice hypomorphic for PDGFB (Pdgfbret/ret) present with brain vessel calcifica
50 studies reveal a previously unknown role for PDGFB-to-PDGFRbeta paracrine signaling in the promotion
51 ng, with potential key mechanistic roles for PDGFB, MMP12, and SPARCL1 in orchestrating fibrosis.
54 sed of 363 primary human breast tumors, high PDGFB protein expression was prognostic for brain metast
55 ed in patient breast tumors for decades, how PDGFB-to-PDGFRbeta tumor-stroma signaling mediates breas
57 eviously, we have reported that mutations in PDGFB in humans are associated with primary familial bra
59 th clinical phenotypes of ADCA-DN, including PDGFB and PRDM8 for cerebellar ataxia, psychosis and dem
60 ring and quantitative PCR analysis indicates PDGFB-driven tumours have a highly inflammatory microenv
62 e ligand induction, and its preferred ligand PDGFB is released by neighboring epithelial and endothel
66 transcription factor to drive expression of PDGFB, leading to resistance to palbociclib by enhancing
67 abolism genes and promotes the expression of PDGFB, which activates mTOR signalling and the downstrea
69 iplatelet therapy or selective inhibition of PDGFB might reduce biliary fibrosis in patients with liv
70 this patient demonstrates that inhibition of PDGFB receptor tyrosine kinase activity can significantl
75 uced circulating serum and hepatic levels of PDGFB and significantly reduced progression of fibrosis
77 MDR2-null mice normalized hepatic levels of PDGFB within 48 hours, reducing levels of a marker of HS
79 ion that results in dermal overexpression of PDGFB and favors the development of fibrotic tumors migh
81 reveals that it is not just the presence of PDGFB, but how it is presented to pericytes, that determ
83 Platelets constitute a major reservoir of PDGFB and are continuously activated in the tumor microe
90 e clinical prognostic and therapeutic use of PDGFB-to-PDGFRbeta signaling in women with breast cancer
91 d in Nestin-positive brain cells by PDGFA or PDGFB overexpression with Cdkn2a or Tp53 co-mutations.
92 e Akt pathway and collaborates with K-Ras or PDGFB in the development and progression of two major ty
93 on decreased expression of oncogenes (PDGFA, PDGFB, and TGFB1) and increased expression of tumor supp
94 arkers near PDGFalpha (PDGFA) and PDGFbeta, (PDGFB) also failed to maintain significance after correc
96 elet-derived growth factor beta polypeptide [PDGFB], vascular endothelial growth factor [VEGF], vascu
98 involving 9p23-p22.3 (NFIB) and 22q12-qter (PDGFB) may be of importance for disease progression in a
99 ied the RCAS/Tv-a model where RCAS-Cre, RCAS-PDGFB, and RCAS-H3.3K27M were used to drive tumourigenes
100 de gliomas are generated by introducing RCAS-PDGFB-RFP and RCAS-Cre in a Nestin/tv-a; TP53(fl/fl) PTE
105 n 1-year-old wild-type (WT) and J20 mice (Tg:PDGFB-APPSwInd), overexpressing human amyloid precursor
109 moving inhibitory regulatory elements in the PDGFB mRNA, we are able to substantially elevate its exp
111 known as mural cells, are recruited through PDGFB (platelet-derived growth factor B)-PDGFRB (platele
114 n injury model, with positive correlation to PDGFB (platelet-derived growth factor subunit B) and MMP
117 se that induces SMC migration in response to PDGFB, mechanistically via modulation of contractile mar
120 lar lumen structures and hypoxia upregulates PDGFB expression and stimulates accumulation of alphaSMA
123 Mutations in seven genes (SLC20A2, XPR1, PDGFB, PDGFRB, MYORG, NAA60, and JAM2) are associated wi