ライフサイエンスコーパス: PDIM

1 PDIM loss can also reduce the efficacy of the BCG Pasteu

2 PDIMs and PGLs are important effectors of virulence.

3 required for aminoglycoside resistance and a PDIM/PGL biosynthetic enzyme, rescued PDIM/PGL productio

4 We performed whole-genome resequencing of a PDIM-deficient clone and identified a spontaneous point

5 Additionally, PDIM's affinity for cholesterol promoted this phenotype;

6 oducing bacterial growth and selects against PDIM-negative mutants, analogous to in vivo conditions.

7 Although PDIM has been implicated in NO defense, this result indi

8 could be transferred between the FAS-II and PDIM biosynthetic pathways.

9 tK and Eis NATs, and between iron uptake and PDIM and PGL synthesis in M. marinum.

10 evels of virulence-associated lipids such as PDIMs and TDM.

11 ds, and suggest that drugs aimed at blocking PDIM and/or PGL production might synergize with antibiot

12 led to increased abundance and mass of both PDIM and SL-1.

13 rulence factors, phthiocerol dimycocerosate (PDIM) and sulfolipid-1 (SL-1), are controlled by the ava

14 he surface lipid phthiocerol dimycocerosate (PDIM) exhibited significant death rates, and consequentl

15 Phthiocerol dimycocerosate (PDIM) is an essential virulence lipid of Mycobacterium t

16 enes involved in phthiocerol dimycocerosate (PDIM) virulence lipid synthesis confer resistance to aut

17 ted lipid called phthiocerol dimycocerosate (PDIM) which is found only in pathogenic mycobacteria.

18 biosynthesis of phthiocerol dimycocerosate (PDIM), a cell wall lipid that is required for full virul

19 in synthesis of phthiocerol dimycocerosate (PDIM), a surface lipid critical for virulence during acu

20 envelope lipid, phthiocerol dimycocerosate (PDIM), dampens macrophage inflammatory responses to Mtb.

21 Phthiocerol dimycocerosate (PDIM), one of the most abundant outer membrane lipids, p

22 rface glycolipid phthiocerol dimycocerosate (PDIM).

23 orting the lipid phthiocerol dimycocerosate (PDIM).

24 virulence lipid phthiocerol dimycocerosate (PDIM).

25 virulence lipid phthiocerol dimycocerosate (PDIM).

26 Phthiocerol dimycocerosates (PDIMs) and phenolic glycolipids (PGLs) are structurally

27 nvelope lipids [phthiocerol dimycocerosates (PDIMs)], glycolipids [phosphatidyl-myo-inositol mannosid

28 ace-associated phthiocerol dimycoceroserate (PDIM) lipids to mask underlying pathogen-associated mole

29 how that propionate supplementation enhances PDIM-producing bacterial growth and selects against PDIM

30 rol and phthiodiolone dimycocerosate esters (PDIMs).

31 re synthesis and virulence, was required for PDIM and phenolic glycolipid (PGL) production.

32 n Mt demonstrated that papA5 is required for PDIM synthesis.

33 ppsD(G44C) point mutation is responsible for PDIM deficiency, virulence attenuation in NOS2(-/-) and

34 us, we have identified coordinated roles for PDIM, known to be essential for mycobacterial virulence,

35 wth of PDIM-producing bacilli, selecting for PDIM-negative variants.

36 son insertions affecting genes implicated in PDIM synthesis; the third has a disruption in a gene enc

37 Importantly, we detected increased PDIM synthesis in bacteria growing within host tissues a

38 During acute infection, PDIM was dispensable for Mtb survival in alveolar macrop

39 uberculosis preventive therapy by inhibiting PDIM spread.

40 The mean probable daily intake (PDIM) of FB1 was 63.3 ng kg(-1)body weight day(-1), whic

41 hat the pre-XDR M.tb strain with the largest PDIMs:PIMs ratio had decreased uptake, but increased int

42 a simple approach to screen for and maintain PDIM production, and reveals how discrepancies between t

43 In mice, PDIM protected Mtb from LAP and classical autophagy.

44 In the absence of PDIM, these PAMPs signal a Toll-like receptor (TLR)-depe

45 esistance increases, and provide evidence of PDIM isomers only present in the DR-M.tb strains studied

46 y of methylmalonyl-CoA impedes the growth of PDIM-producing bacilli, selecting for PDIM-negative vari

47 However, we found that the impact of PDIM depended on the method used to prepare Mtb.

48 uired for proper subcellular localization of PDIM.

49 ne candidate except changes in production of PDIM.

50 Host restriction of PDIM-deficient M. tuberculosis was not alleviated by the

51 ding complemented strain control in terms of PDIM and PGL production.

52 ads to a mutant that produces only traces of PDIMs and PGLs, has a slight growth yield increase and d

53 ly following infection, mycobacteria rely on PDIM to evade Myd88-dependent recruitment of microbicida

54 e data suggest that in addition to producing PDIMs, the growing phthiocerol product can also be shutt

55 and a PDIM/PGL biosynthetic enzyme, rescued PDIM/PGL production, and virulence of the DeltambtK stra

56 f sodium propionate or Mycobactin J restored PDIM/PGL production in the DeltambtK strain.

57 acids, cholesterol or vitamin B(12) restores PDIM-positive bacterial growth.

58 ro culturing rapidly selects for spontaneous PDIM-negative mutants that have attenuated virulence and

59 We conclude that PDIM biosynthesis is required for M. tuberculosis resist

60 These findings demonstrate that PDIM contributes to Mtb virulence and immune evasion, re

61 Using ppsD mutant Mtb, we found that PDIM inhibits LC3-associated phagocytosis (LAP) by inhib

62 We additionally found that PDIM transport is required for virulence in mice lacking

63 We found that PDIM's methyl-branched lipid tails enabled it to spread

64 Taken together, these data indicate that PDIM protects M. tuberculosis from an early innate host

65 ed in NO defense, this result indicates that PDIM has other roles during infection.

66 Analysis of surface lipids showed that PDIM synthesis is increased in a sigM-disrupted strain a

67 These findings suggest that PDIMs may play an important role in drug resistance and

68 tide-associated protein (Pap) encoded in the PDIM synthesis gene cluster, as well as PapA5 homologs f

69 We show that the PDIMs:PIMs ratio increases as drug resistance increases,

70 Thus, PDIM is important for resisting an interferon-gamma-inde

71 s, we developed a chemical approach to track PDIM during Mycobacterium marinum infection of zebrafish

72 ility can rapidly screen for M. tuberculosis PDIM production.

73 y-deficient mice succumbed to infection with PDIM-deficient Mtb, with impairments in B-cell accumulat