ライフサイエンスコーパス: PDZ domain

1 protein, the NHERF family and SNX27 (related PDZ domains).

2 nd Golgin45 as novel partners for the MYO18A PDZ domain.

3 equires a conformational change in the IL-16 PDZ domain.

4 Secreted IL-16 contains a characteristic PDZ domain.

5 DegS trimer contains a protease domain and a PDZ domain.

6 ical and non-canonical Wnt signaling via its PDZ domain.

7 lexinB2 forms a secondary interface with the PDZ domain.

8 HE3 (C-terminus) primarily through the SNX27 PDZ domain.

9 ker TGN38 upon deletion of either the ACT or PDZ domain.

10 myotilin, and other Z-disc proteins via the PDZ domain.

11 interact with flexible loop residues of the PDZ domain.

12 pha isoform, additionally, has an N-terminal PDZ domain.

13 le holding the protease inactive through its PDZ domain.

14 an extended antiparallel beta-sheet with the PDZ domain.

15 he two subsites anchoring the peptide to the PDZ domain.

16 the affinity of these peptides for the MAST2-PDZ domain.

17 rajectory from the Tiam2 wild-type to the QM PDZ domain.

18 rates or peptides that bind to either of its PDZ domains.

19 discussed in the context of previous work on PDZ domains.

20 nal peptides activate DegS by binding to its PDZ domains.

21 It encodes a protein with multiple PDZ domains.

22 f EBP50 is regulated by the occupancy of its PDZ domains.

23 ding specificity and promiscuity of the five PDZ domains.

24 ed experimental and computational studies of PDZ domains.

25 though full activity requires the Par-6 CRIB-PDZ domains.

26 basis for the binding selectivity of NHERF1 PDZ domains.

27 ion mode both for MyTH4-FERM tandems and for PDZ domains.

28 fold, and can occupy as many as 15% of these PDZ domains.

29 Thus, the findings herein identify SCRIB PDZ domains 1 and 4 as high affinity alpha(1D)-AR intera

30 y in situ and in vitro assays revealed SCRIB PDZ domains 1 and 4 to be high affinity alpha(1D)-AR PDZ

31 t N-cadherin binds to PSD-95/SAP90/DLG/ZO-1 (PDZ) domain 2 of the glutamate receptor interacting prot

32 It features a PDZ domain, a BAR domain, and an acidic C-terminal tail

33 e photoswitch across the binding groove of a PDZ domain, a conformational transition, similar to the

34 Our data suggest the concept that the multi-PDZ-domain adaptor protein GRIP1 can act as a scaffold a

35 and membrane-binding surfaces of the BAR and PDZ domains adjacent to each other on the concave side o

36 ported by simulations suggest that intrinsic PDZ domain affinities are finely tuned and encode specif

37 In this report, we demonstrate that the PDZ domain allows the recruitment of nNOS to nuclei, thu

38 d a novel interaction between Par-3's second PDZ domain and a highly conserved aPKC PDZ-binding motif

39 dly describes a unique interaction between a PDZ domain and an arrestin-like fold.

40 tor 1 (Ppr1), which bridges between the Rip1 PDZ domain and anti-sigma factor M (Anti-SigM), a Rip1 s

41 of nNOS can behave as a bona fide class III PDZ domain and bind to C-terminal sequences with acidic

42 ins insert within the binding groove of this PDZ domain and determine the subcellular distribution of

43 trol DVL conformations via modulation of the PDZ domain and its interaction with DVL C-terminus.

44 that places the receptor-binding site of the PDZ domain and membrane-binding surfaces of the BAR and

45 he PDLIM family of proteins, which contain a PDZ domain and one or more LIM domains, protein interact

46 SNX27 contains a PDZ domain and serves as a cargo selector for the retrom

47 peptides initiate a steric clash between the PDZ domain and the L3 loop that results in a structural

48 artner for AE1 in human kidney, via PDLIM5's PDZ domain and the PDZ binding motif in AE1C.

49 ilt a protein domain microarray that harbors PDZ domains and 14-3-3 proteins.

50 protein E3KARP/NHERF2, which consists of two PDZ domains and a tail containing an ezrin-binding domai

51 interactions between the individual Scribble PDZ domains and beta-PIX.

52 r the specificity between the vast number of PDZ domains and ligands in the cell.

53 ckbone hydrogen bonds between four different PDZ domains and peptides corresponding to natural protei

54 lity to specifically engage beta-PIX via its PDZ domains and provide a mechanistic platform for under

55 The affinities of recombinant Scribble PDZ domains and the synthetic peptides representing the

56 nd Npt2a involves competition between NHERF1 PDZ domains and the target proteins.

57 Here, we used the Tiam2 PSD-95/Dlg/ZO-1 (PDZ) domain and a quadruple mutant (QM), engineered by s

58 tic density 95/disks large/zona occludens-1 (PDZ) domains and a tail ending in an ezrin-binding domai

59 >= 130-fold selectivity over closely related PDZ domains, and a serum t(1/2) of >24 h.

60 ssion of two phenotypic programs through its PDZ domains, and these programs form the mechanistic bas

61 inal PDZ-binding motif that can bind to Dlg1 PDZ domains, appears to function independently of Dlg1 i

62 previous experiments using only the isolated PDZ domain are consistent with the simplest scenario for

63 ture, and show that allosteric networks in a PDZ domain are highly dependent on the supertertiary str

64 PDZ domains are abundant protein interaction modules and

65 PDZ domains are classic examples of dynamic allostery wi

66 PDZ domains are common domains that serve to provide spe

67 red constructs finding that both the DEP and PDZ domains are dispensable for canonical signaling only

68 PDZ domains are the most prominent biological structural

69 PDZ domains are typically characterized by a defined glo

70 ength protein, the dynamics is lost when the PDZ domains are unable to bind ligand.

71 PDZ domains are widely conserved protein interaction mod

72 ut other parts of the protein, including the PDZ domain, are apparently required for stabilizing the

73 hibitor for the CFTR-associated ligand (CAL) PDZ domain as a potential treatment for cystic fibrosis.

74 specificity in the Tiam1 PDZ into the Tiam2 PDZ domain, as a model system to investigate the role of

75 uct comprising two distinct covalently bound PDZ domains belonging to a protein called Whirlin, a sca

76 Most PDZ domains bind peptides in a canonical conformation in

77 However, a subset of PDZ domains bind peptides with a bent main-chain conform

78 For example, several PDZ domains bind the cystic fibrosis (CF) transmembrane

79 or light-assisted control of interactions of PDZ domain binding motifs with their cognate domains by

80 hich binds to neurexins, and mutation of the PDZ-domain binding sequence of neurexin-3beta blocked it

81 terminal neurexin sequence with an unrelated PDZ-domain binding sequence that does not bind to CASK f

82 ous proteins is the presence of a C-terminal PDZ domain-binding motif (PBM) in Tax1, previously repor

83 istic mutations in NS1: the avian virus-type PDZ domain-binding motif ESEV (which affects virulence)

84 demonstrate the in vivo significance of the PDZ domain-binding motif in the correct expression of Na

85 Similarly, the mutation in the PDZ domain-binding motif of NS1 altered its binding to c

86 esidues of NaV1.5 (Ser-Ile-Val) constitute a PDZ domain-binding motif that interacts with PDZ protein

87 The PDZ domain binds to the C terminus of its proposed natur

88 for its specific interaction with the PICK1 PDZ domain, but a functional consequence of this interac

89 have captured the binding of a peptide to a PDZ domain by unbiased molecular dynamics simulations.

90 nase-2 (PLK2) decreases its affinity for the PDZ domains by several fold, which would free PDZ domain

91 We show that a PDZ domain can be entirely redesigned using a "physics-b

92 w that the peptide-binding pocket of the Dvl PDZ domain can be occupied by Dvl's own highly conserved

93 It remains unknown why individual PDZ domains can bind the extreme C terminus of very dive

94 Yet, Scribble PDZ domains can still exhibit unique binding profiles to

95 analysis showed that PDZ4, but not the other PDZ domains, can bind vesicles that mimic the plasma mem

96 of the BAR domain (2K-E mutation) or of the PDZ domain (CC-GG mutation) was sufficient to reproduce

97 hat NHERF1 is a diffuse ensemble of variable PDZ domain configurations and a disordered C-terminal ta

98 de recognition specificity in the Syntrophin PDZ domain, confirming the designed interaction biochemi

99 omeric bowl-shaped structure with a lid-like PDZ domain connected by a substrate-sensing hinge that r

100 binding motif at its C-terminus and binds to PDZ domain containing 1 (PDZK1), which is required for i

101 Here we show that Frmpd1 (FERM and PDZ domain containing 1) is transcribed from an alternat

102 membrane associated guanylate kinase, WW and PDZ domain containing 2 and protein tyrosine phosphatase

103 profile analysis and functional clustering, PDZ domain-containing 1 (PDZK1) was revealed to be downr

104 Complex formation between PLEKHA7, PDZ domain-containing 11 (PDZD11), tetraspanin 33, and t

105 embrane-associated guanylate kinase, WW, and PDZ domain-containing 2 (MAGI2) through whole-exome sequ

106 w that not all of the PDZ domains of a multi-PDZ domain-containing adaptor protein are required for i

107 ein, C-terminus and CFTR-associated ligand), PDZ domain-containing guanine nucleotide exchange factor

108 ry factor proteins (NHERFs) (NHERF1, NHERF2, PDZ domain-containing kidney protein 1, and PDZ domain-c

109 PDZ domain-containing kidney protein 1, and PDZ domain-containing kidney protein 2), Golgi-associate

110 Here, we identify the PDZ domain-containing Membrane-associated Guanylate Kina

111 gia have three distinct NOS genes, including PDZ domain-containing NOS.

112 Here, we report the identification of PDZ domain-containing protein 11 (PDZD11) as a new inter

113 We identified the PDZ domain-containing protein 8 (PDZD8) as a critical co

114 hRNA-mediated knockdown of the GluA2 binding PDZ domain-containing protein interacting with C kinase

115 cal CAR(Ex8) are negatively regulated by the PDZ domain-containing protein MAGI-1 (membrane-associate

116 In contrast, the multiple PDZ domain-containing protein Pals1-associated tight jun

117 We discovered that the PDZ domain-containing protein Sipa1l1 (signal-induced pr

118 teracting protein 1 (TIP1) which is a 14 kDa PDZ domain-containing protein that is overexpressed in c

119 Several PDZ domain-containing proteins (PDZ proteins for short)

120 with the PDZ-binding motif of EphB2 through PDZ domain-containing proteins and can promote the reten

121 ew the known functional interactions between PDZ domain-containing proteins and GPCRs and provide ins

122 These PDZ domain-containing proteins include the membrane-asso

123 Several PDZ domain-containing proteins were identified that inte

124 ional mechanisms involving interactions with PDZ domain-containing proteins, lipid microdomains and a

125 PTHR contains a type I PDZ ligand that binds PDZ domain-containing proteins.

126 on its ability to interact with cadherin and PDZ domain-containing proteins.

127 and is the only PAT predicted to bind Type-I PDZ domain-containing proteins.

128 ), which encodes an evolutionarily conserved PDZ domain-containing putative tumor suppressor, is requ

129 G protein signaling (RGS)-homology-RhoGEFs (PDZ domain-containing RhoGEF and leukemia-associated Rho

130 rge/ZO-1 (PDZ) domains; via interaction with PDZ domain-containing scaffold proteins, this allows for

131 pe CFTR because of reduced interactions with PDZ domain-containing scaffold proteins.

132 MDA-9/Syntenin, a highly conserved double-PDZ domain-containing scaffolding protein, is robustly e

133 tween the C-terminus of the Dscams and multi-PDZ domain-containing scaffolding proteins in mouse.

134 t the long isoform of whirlin (L-whirlin), a PDZ domain-containing submembrane scaffold protein, is p

135 5 kilodaltons, disc large, zona occludens-1 (PDZ) domain-containing proteins appear most abundant and

136 pes target a select group of PSD95/DLG1/ZO1 (PDZ) domain-containing proteins by using a C-terminal PD

137 tions with PSD-95/disc large/zona occludens (PDZ) domain-containing proteins.

138 tion of PSD-95/Discs Large/Zona Occludens 1 (PDZ) domain-containing proteins.

139 found that one candidate, the tail-anchored, PDZ-domain-containing OMM protein SYNJ2BP, dramatically

140 Harmonin is a PDZ-domain-containing protein that interacts with the C-

141 Here we show that expression of MPP1, a PDZ-domain-containing protein, highly correlated with AB

142 However, PDZ-domain-containing proteins have diverse functions an

143 engage the transport mechanism, but with the PDZ domains deleted, basolateral displacement still occu

144 A PDZ domain-deleted nNOS gene (DeltaPDZ nNOS) was package

145 gand severely affected the affinity with the PDZ domain, demonstrating that hydrogen bonds contribute

146 Taken together, these results suggest that PDZ domain-dependent ephrinB2 reverse signaling protects

147 erful tools for acute perturbation of native PDZ domain-dependent interactions in live cells.

148 regulates trafficking of cargo proteins in a PDZ domain-dependent manner.

149 -dependent signaling, with a lesser input of PDZ domain-dependent signaling.

150 mong them; and stimulates ENaC function in a PDZ domain-dependent, aldosterone-induced manner.

151 To better understand how Scribble PDZ domains direct cell polarity signaling, we investiga

152 ses the fundamental question as to how these PDZ domains discriminate ligands and exert specificities

153 al that an exposed beta-hairpin in the SNX27 PDZ domain engages a groove in the arrestin-like structu

154 r protein-protein interactions, those of the PDZ domain family involve formation of intermolecular hy

155 earch and is perhaps best exemplified by the PDZ domain family of proteins.

156 alysis provides a structural portrait of the PDZ domain family, which serves as a guide in understand

157 ble for the diverse specificities across the PDZ domain family.

158 cluding at conserved functional sites in the PDZ domain family.

159 of synaptic transmission that contain three PDZ domains followed by an SH3-GK domain tandem.

160 binding increases the affinity of the SNX27 PDZ domain for PDZ- binding motifs by an order of magnit

161 DZ domains by several fold, which would free PDZ domains for occupancy by other proteins.

162 ferentiate the binding affinities of the two PDZ domains, for the type 1 PDZ-binding motif (QDTRL) in

163 how that cholesterol specifically binds many PDZ domains found in scaffold proteins, including the N-

164 BAI1 C terminus interacts with a variety of PDZ domains from synaptic proteins, including MAGI-3.

165 ch exhibits a K(D) value of 6 nM for the CAL PDZ domain, >= 130-fold selectivity over closely related

166 In particular, PDZ domains have represented a paradigm for these studie

167 We have identified 16 structures of PDZ domains in complex with high-affinity ligands and ha

168 Comparison of the structures of these two PDZ domains in complex with ligands containing P(0) Leu

169 ssociates with the N-terminal tandem pair of PDZ domains in PSD-95, suggesting that PSD-95 may be inv

170 nteracting with scaffold proteins containing PDZ domains, in the subcellular localization of CaV1.2 i

171 Here we show that the Bazooka PDZ domains interact with the negatively charged phospho

172 oP-PD libraries are useful tools for probing PDZ domain interactions.

173 complex with nectin-1 and nectin-3, and its PDZ domain interacts directly with the PDZ-binding motif

174 We also subdivided lipid-binding PDZ domains into three classes based on the interplay be

175 ne depletion also reduced the affinity for a PDZ domain involved in synaptic trafficking and affected

176 c density 95/discs large/zonula occludens 1 (PDZ) domain, involved in scaffolding and signaling and e

177 he margin of thermodynamic stability for the PDZ domain is modest ( approximately 3 kcal/mol) and fur

178 unconventional myosin MYO18A that contains a PDZ domain is required for muscle integrity during zebra

179 at distinguishes CAL from other CFTR-binding PDZ domains is the accommodation of an isoleucine residu

180 ast, SynGAP-beta, which does not bind PSD-95 PDZ domains, is less synaptically targeted and promotes

181 these proteins, which consists of two tandem PDZ domains, is required to tether the Golgi membranes.

182 nds to the PDZ3 domain of PSD-95 through the PDZ domain ligand at its C terminus.

183 phosphorylation-dependent modulation of the PDZ domain-ligand interaction involving the water channe

184 phosphorylation-dependent alteration in the PDZ domain-ligand interaction was explained by 3D struct

185 Using a human PDZ domain (LNX2(PDZ2)) as a model system, we show that

186 (E6peptide) immobilized on the sensor and a PDZ domain (MAGI-1 PDZ1) in the mobile phase.

187 (peptide binding-independent) capacities of PDZ domains may be employed by a single such adaptor for

188 ant cytosolic polarization of Yap1 through a PDZ domain-mediated interaction with the scaffold Scribb

189 is an adapter protein containing two tandem PDZ domains mediating cell adhesion.

190 We use PDZ domain microarrays to identify candidate interaction

191 onstitution experiments with wild type and a PDZ domain mutant (GYGF --> GAGA) of SNX27 demonstrate t

192 an oncogenic signaling pathway, in which two PDZ domains (NHERF-2 PDZ2-N2P2 and MAGI-3 PDZ6-M3P6) com

193 Importantly, full active nNOS lacking PDZ domain (nNOSbeta) does not localize in nuclei and fa

194 ependent on its tail region but modulated by PDZ domain occupancy, which is not the case for E3KARP.

195 he PDZ motif, suggesting that binding to the PDZ domain of CAL is required for MARCH2-mediated degrad

196 terminal cytoplasmic region of RNF43 and the PDZ domain of dishevelled is essential for this suppress

197 facilitating the membrane recruitment of the PDZ domain of Dvl and its interaction with other protein

198 ith protein-protein interactions between the PDZ domain of MAST2 and the C-terminal moieties of its c

199 a conserved asparagine residue in the second PDZ domain of Mint2 that binds to neurexin-1alpha (Nrxn1

200 scaffold proteins, including the N-terminal PDZ domain of NHERF1/EBP50.

201 ion, it has been recently suggested that the PDZ domain of nNOS binds with very low affinity to the C

202 teractions are poorly understood because the PDZ domain of nNOS can apparently exhibit class I, class

203 We describe herein that the PDZ domain of nNOS can behave as a bona fide class III P

204 rmeable peptide that competes for the unique PDZ domain of nNOS that interacts with NOS1AP.

205 nalyzed the high affinity association of the PDZ domain of nNOS to claudin-3 and claudin-14, two tigh

206 asmic region of PlexinB2 in complex with the PDZ domain of PDZ-RhoGEF.

207 ree structural mechanisms explaining why the PDZ domain of PICK1 selectively binds >30 receptors, tra

208 ic CRIPT-derived PDZ(3) ligands to the third PDZ domain of PSD-95 induces functional changes in the i

209 -derived PDZ(3) ligands binding to the third PDZ domain of PSD-95, unraveling a hierarchical binding

210 We solved the crystal structure of the PDZ domain of PTPN4 bound to the p38gamma C terminus.

211 n between the C terminus of p38gamma and the PDZ domain of PTPN4.

212 e that the kinesin KIF14 associates with the PDZ domain of Radil and negatively regulates Rap1-mediat

213 d in part by a novel interaction between the PDZ domain of SNX27 and sequences in a central portion o

214 GYGF --> GAGA) of SNX27 demonstrate that the PDZ domain of SNX27 is required to maintain basal NHE3 a

215 ssociates with the cargo-binding site in the PDZ domain of SNX27.

216 on the PDZ recognition motif in PTHR and the PDZ domain of SNX27.

217 The second PDZ domain of the protein tyrosine phosphatase BL (PDZ2)

218 nduced misfolding pathway of PDZ3, the third PDZ domain of the PSD95 neuronal protein, is populated b

219 terminus of claudins binds to the N-terminal PDZ domain of zonula occludens proteins (PDZ1).

220 Our results show that not all of the PDZ domains of a multi-PDZ domain-containing adaptor pro

221 nvolved protein trafficking through specific PDZ domains of GIRK2c and GIRK3 subunit isoforms.

222 1) endocytosis requires interaction with the PDZ domains of Mint1 and that this interaction facilitat

223 selectivity and binding affinity of the two PDZ domains of NHERF1.

224 RF2/NHERF3 heterodimerization is mediated by PDZ domains of NHERF2 and the C-terminal PDZ domain reco

225 In addition, both PDZ domains of NHERF2 could be simultaneously occupied b

226 , ZL006 and IC87201 do not interact with the PDZ domains of nNOS or PSD-95, nor inhibit the nNOS-PDZ/

227 Our data further indicate that the four PDZ domains of PATJ function, to a large extent, in redu

228 synaptic signaling proteins that bind to the PDZ domains of PSD-95 are present in higher concentratio

229 detailed model for scaffold formation by the PDZ domains of PSD-95.

230 ion of the PSD by restricting binding to the PDZ domains of PSD-95.

231 known putative viral protein ligands for the PDZ domains of Scribble and Erbin were also identified.

232 ein-protein interactions, and confirmed that PDZ domains of Scribble interact with the C terminus of

233 We find that NC mimics the PDZ domains of syntenin, a membrane-binding adaptor invo

234 main that is phylogenetically related to the PDZ domains of the NHERF proteins.

235 synaptic density (PSD) protein that binds to PDZ domains of the scaffold protein PSD-95.

236 raries we screened the nine PSD-95/Dlg/ZO-1 (PDZ) domains of human Densin-180, Erbin, Scribble, and D

237 first two PSD-95/disks large/zona occludens (PDZ) domains of PSD-95 have been shown to be the key com

238 his study, we have found that the C-terminal PDZ-domain of both A2BR and CFTR were crucial for this i

239 Notably, GluA2 and N-cadherin use different PDZ domains on GRIP1 to simultaneously bind the transpor

240 bined to study peptide binding by the second PDZ domain (PDZ1) of MAGI1, which has been identified as

241 d orientation protein-1) and that two MAGI-1 PDZ domains, PDZ1 and PDZ3, regulate CAR(Ex8) levels in

242 ms of the two alternative spliced forms of a PDZ domain (PDZ2 and PDZ2as) that share a nearly identic

243 In this study, allostery in the second PDZ domain (PDZ2) in the human PTP1E protein is examined

244 pectroscopy experiments on a photoswitchable PDZ domain (PDZ2S) have indicated that the allosteric tr

245 e mutations into the context of five related PDZ domain-peptide complexes.

246 first time specifically addresses these for PDZ domain-peptide interactions.

247 f ligand specificity in a PSD95, DLG1, ZO-1 (PDZ) domain preferentially occurs through class-bridging

248 BX-Cter expression caused depletion of PIST (PDZ domain protein interacting specifically with TC10),

249 the Drosophila homolog of whirlin/DFNB31, a PDZ domain protein linked to Usher syndrome, the most co

250 CFTR abundance by phosphorylating Shank2E, a PDZ domain protein that contains two SGK1 phosphorylatio

251 Sorting nexin 27 (SNX27), a brain-enriched PDZ domain protein, regulates endocytic sorting and traf

252 ns exhibited a decrease in the levels of the PDZ-domain protein CASK (a calcium/calmodulin-activated

253 cient neurons, suggesting that no particular PDZ-domain protein is essential for neurexin surface tra

254 -associated tight-junction protein), a multi-PDZ-domain protein that associates with many tight junct

255 motif of NS1 altered its binding to cellular PDZ domain proteins and affected Akt phosphorylation.

256 However, the presence of PDZ domain proteins attached to intracellular membranes

257 PDZ domain proteins control multiple cellular functions

258 Z domain that distinguishes TIP-1 from other PDZ domain proteins that more often contain multiple pro

259 ut also the interaction of NS1 with cellular PDZ domain proteins.

260 r (Dlg1), zonula occludens-1 protein (zo-1) (PDZ) domain proteins.

261 by PDZ domains of NHERF2 and the C-terminal PDZ domain recognition motif of NHERF3.

262 7 interacts with these receptors through its PDZ domain, regulating their recycling to the plasma mem

263 PDZ domains represent one group of the major structural

264 sidues, K69 and K285, present on the DIX and PDZ domains respectively, promote nuclear over cytoplasm

265 structure of iCAL36 in complex with the CAL PDZ domain reveals stereochemical interactions distribut

266 Mutations within PDZ domain (S280A and S311A) reduced the ability of Dvl3

267 PDZ domain scaffold proteins are molecular modules orche

268 l avidity for the strong binding between the PDZ domain scaffold proteins, PICK1 and PSD-95, and thei

269 horylation) of EphA2, and recruitment of the PDZ domain scaffolding protein, PATJ, to the cell periph

270 Given the similarities of the Scribble PDZ domain sequences in their binding grooves, it is com

271 The structure establishes how the SNX27 PDZ domain simultaneously binds PDZ-binding motifs and r

272 The AHNAK2 PDZ domain structure contains a bound class III ligand p

273 evealed significant differences in the local PDZ domain structures and in the global conformations co

274 We have analyzed the existing database of PDZ domain structures in the context of a specificity tr

275 ther, these findings suggest that binding to PDZ domains, such as those from USH1C, PDZD7, and Whirli

276 The presence of a PDZ domain suggests that MYO18A may interact with other

277 r YAP1) and Transcriptional Activator with a PDZ domain (TAZ or WW-domain-containing transcriptional

278 tein (TIP)-1 protein is composed of a single PDZ domain that distinguishes TIP-1 from other PDZ domai

279 Sorting nexin 27 (SNX27) contains a PDZ domain that is phylogenetically related to the PDZ d

280 is composed of two structurally-independent PDZ domains that are connected by a flexible, disordered

281 Many S2Ps also contain a PDZ domain, the function of which is poorly understood.

282 ry to the C terminus of proteins that engage PDZ domains, the C-terminal three residues of beta1, per

283 In contrast to other reported PDZ domains, the solution structure previously reported

284 t interacts weakly with the proximal, second PDZ domain to form a dynamically autoinhibited structure

285 osphatase and tension homolog (PTEN) via the PDZ domain to upregulate the phosphorylation and SUMOyla

286 leukemia-associated RhoGEF (LARG), use their PDZ domains to bind class B plexins and play critical ro

287 erminus of BAI1 against a proteomic array of PDZ domains to identify novel interacting partners.

288 density 95, discs large, zonula occludens-1 (PDZ) domains to engage the transport mechanism, but with

289 l ligand motifs for PSD-95/discs large/ZO-1 (PDZ) domains; via interaction with PDZ domain-containing

290 ucture of the OTU domain in complex with the PDZ domain, we demonstrate that a second interface contr

291 scovered that its free C-terminal tail binds PDZ domains (when unphosphorylated) and 14-3-3 proteins

292 ubiquitous recognition modules--for example, PDZ domains, which bind C-terminal sequences of partner

293 ed protein that interacts through its single PDZ domain with a variety of cell surface receptors.

294 the sarcolemma through an interaction of its PDZ domain with dystrophin spectrin-like repeats R16 and

295 nteraction profiles of all isolated Scribble PDZ domains with a beta-PIX peptide.

296 NHERF1 interacts via its PDZ domains with PHLPP1/PHLPP2 and scaffolds heterotrime

297 y all had increased affinities for the MAST2-PDZ domain, with K(d) values decreasing from 1300 to 60

298 sts of a leucine-rich repeat domain and four PDZ domains, with the latter being responsible for most

299 ucture capable of tolerating insertions of a PDZ domain without disruption of the enzyme's binding an

300 ted protein/Transcriptional coactivator with PDZ domain (YAP/TAZ) and myocardin-related transcription