ライフサイエンスコーパス: PG

1 PG biosynthesis is tightly coordinated with cell wall gr

2 PG decreased cell viability compared to that of BG, but

3 PG derivatives were synthesized and immobilized on the s

4 PG is also constantly synthesized and turned over; the l

5 PG is difficult to diagnose as several differential diag

6 PG is essential for structural maintenance of bacterial

7 PG is often associated with a variety of other immune-me

8 PG treatment resulted in robust inhibition of viral repl

9 PG-CAT treated mice showed amelioration in airway obstru

10 PGs hydrolyze the cell wall polysaccharide pectin and ar

11 Protegrin-1 (PG-1) is a potent antimicrobial peptide (AMP).

12 opylene glycol and vegetable glycerol (50:50 PG/VG vehicle), or to PG/VG with 16 mg/mL nicotine ( + N

13 Taken together, PSL1 functions as a PG that modifies cell wall biosynthesis, plant developme

14 he site of stalk PG synthesis, but SpmX is a PG hydrolase.

15 FtsQLB-FtsWI complexes but fail to activate PG synthesis.

16 We also identified an adaptive PG assembly that is present in smaller amounts and fluct

17 Biofilm-derived adaptive PG exhibited significant changes compared with planktoni

18 In addition, PG-CAT greatly reduced the concentration of inflammatory

19 Additionally, PG protected against HSV-1 infection and disease progres

20 Here, the AdRGD-PG-hIFNbeta vector encoding the human interferon-beta cD

21 The AdRGD-PG-hIFNbeta vector provides extensive killing of human m

22 53, we developed an adenoviral vector, AdRGD-PG, which provides robust transduction and transgene exp

23 Finally, we discover aminoacyl-PGs not only in Gram-positive bacteria but also in Gram-

24 Conventional methods for analyzing PG composition are complex and time-consuming.

25 may reduce the loss of notochordal cells and PG in the IVD.

26 genicity and regulation of cell division and PG synthesis.

27 ly higher than those of gallic acid (GA) and PG.

28 e of this study was to examine ATP level and PG production of porcine IVD cells under prolonged expos

29 ld focus on PG-specific outcome measures and PG quality-of-life studies.

30 the only covalent tether between the OM and PG and is crucial for cell envelope stability(4); howeve

31 The OM and PG are load-bearing, selectively permeable structures th

32 nt attachments occur between OM proteins and PG, with tethering of the beta-barrel OM protein BbpA be

33 this study, we performed simultaneous TG and PG analysis in blood plasma samples from humans and 6 sp

34 The collective impact of abnormal TG and PG in HFD-fed mice produced normal fibrin formation kine

35 Integrating TG and PG measurements may define a prothrombotic risk factor i

36 TG and PG parameters from baboon and rhesus macaque plasma appr

37 TG and PG parameters from Guinea pig samples were extremely low

38 TG and PG were investigated in male and female donor platelet-p

39 teraction between a plant PGIP and an animal PG.

40 ource for cell survival and function such as PG biosynthesis.

41 As PGs regulate the actin bundler Fascin, and Fascin is req

42 In Gram-negative bacteria, PG is assembled in the cytoplasm and exported into the p

43 he glycan strands of Gram positive bacterial PG and degrades the PG peptide chains, leading to cell d

44 lting in four different solutions (free-base/PG, free-base/VG, protonated/PG, and protonated/VG).

45 lethal deficits in either aPBP or SEDS/bPBP PG synthase activity.

46 The cause of PG is not well understood, but PG is generally considered an autoinflammatory disorder.

47 ll elongation requires crosslink cleavage by PG endopeptidases to make space for the incorporation of

48 line extraction and enzymatic deamidation by PG have great potential to produce edible EPSC protein w

49 Pseudoalterin synthesis is induced by PG degradation products such as glycine and glycine-rich

50 rned over; the latter process is mediated by PG cleavage enzymes, for example, the endopeptidases (EP

51 of polyethylene glycol-conjugated catalase (PG-CAT) for RSV-infected mice.

52 Programming for a postgraduate certificate (PG Cert) in Clinical Bioinformatics with a more technica

53 Unlike other lipid classes, chloroplast PG in nearly all plants contains a substantial fraction

54 Although most of chloroplast PG assembly occurs at the inner envelope membrane, FAD4

55 for both classes of PG synthases by cleaving PG glycans as they are being actively synthesized.

56 BrPGIP3_GPI inhibited several P. cochleariae PGs in vitro, providing the first direct evidence of an

57 otation approaches to quantitatively compare PGs produced in planktonic- and biofilm-cultured Pseudom

58 skeletal protein, SpmX, define and constrain PG synthesis to form stalks?

59 bovine tracheal AMP gene promoter-controlled PG-1 transgene.

60 pulation and gene-level information (DeepSAV+PG) has similar predictive power as some of the best ava

61 ice fed a high-fat diet (HFD) showed delayed PG and reduced PG velocity.

62 d proteomic analyses determined that delayed PG in HFD-fed mice was not due to altered levels of plas

63 ant changes compared with planktonic-derived PG, including amino acid substitutions of the stem pepti

64 oducible workflow for accurately determining PG composition in samples that can be used to assess glo

65 , (iii) distinguishing healthy from diseased PGs, and (iv) minimizing postoperative hypocalcemia afte

66 ealthy PGs or inability to localize diseased PGs, resulting in postsurgical complications.

67 ) or chemomechanical agents - Papacarie Duo (PG) and Brix 3000 (BG).

68 Brix 3000 (BG) than that for Papacarie Duo (PG), showing mean values of 85.0 and 110.5 seconds, resp

69 thus effectively reducing levels of effector PGs (including PGE(2)).

70 establishes rod shape de novo by elongating PG at nonpolar regions.

71 ae (Spn), septal and peripheral (elongation) PG synthesis occur simultaneously at midcell.

72 ex of FtsW and FtsI (FtsWI) as the essential PG synthase within the divisome; however, how PG polymer

73 nd the combination further decreased fasting PG.

74 n and LY2409021 individually lowered fasting PG compared with placebo, and the combination further de

75 However, only a few PG biosynthetic enzymes are direct kinase substrates.

76 ested one peptide to bind primarily per five PG molecules with a K(d) ~ 0.2 muM for PC/PG 1:1 and 0.6

77 3 +/- 13.26 KHN, and 47.63 +/- 22.40 KHN for PG, BG, and CBG, respectively.

78 s a stalk-specific topological organizer for PG synthesis activity, including its recruiter SpmX, at

79 ental differences in binding preferences for PG by innate immune receptors and reveals unique recogni

80 rotein NlpI as a general adaptor protein for PG hydrolases.

81 ss well understood, with only regulators for PG amidases having been described.

82 cell division, the machinery responsible for PG synthesis localizes mid-cell, at the septum, under th

83 a cyclooxygenase-like enzyme responsible for PG synthesis.

84 t to this review of NIRAF as a technique for PG identification.

85 was identified as a potential terminase for PG synthesis in Escherichia coli.

86 glycosyl hydrolase that cleaves peptide-free PG glycans.

87 matic transesterification of propyl gallate (PG) and tripalmitin under solvent-free condition.

88 he enzymatic glycerolysis of propyl gallate (PG) using a food-grade lipase (Lipozyme(R) 435).

89 Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that presents with

90 Pyoderma gangrenosum (PG) is an inflammatory condition characterized by chroni

91 thema nodosum (EN) and pyoderma gangrenosum (PG), LCV requires biopsy for diagnosis.

92 ght gelator (LMWG) with the polymer gelator (PG) calcium alginate in a hybrid hydrogel.

93 ubstrate, we developed a plasmin generation (PG) assay for mouse plasma that is sensitive to tissue p

94 ntity which can lead to pigmentary glaucoma (PG).

95 in samples that can be used to assess global PG fluctuations in response to changing growth condition

96 s (SGLT2i) effectively lower plasma glucose (PG) concentration in patients with type 2 diabetes, but

97 Higher maternal plasma glucose (PG) concentrations, even below gestational diabetes mell

98 nzymatic deamidation by protein-glutaminase (PG) on evening primrose seed cake (EPSC) protein and its

99 hicle consisting of either propylene glycol (PG) or vegetable glycerin (VG), resulting in four differ

100 pared with a pre-specified performance goal (PG).

101 r or not with genetic regulation, may govern PG production in the IVD under restricted nutrient suppl

102 these with proteomic data of pollen grains (PGs) and PTs.

103 n = 20) and periodontitis/gingivitis group (PG, n = 70) according to their periodontal status.

104 d the highest scavenging capacity (GG > GA > PG).

105 eater scavenging capacity than PG (GG = GA > PG).

106 ead to accidental damage/excision of healthy PGs or inability to localize diseased PGs, resulting in

107 ile the second, TP-DES9*, contained <10% HMP-PG, similar to the wild type.

108 except that one, ER-FAT5, contained high HMP-PG, similar to the fab1 parent, while the second, TP-DES

109 t 2 degrees C, demonstrating the role of HMP-PG in low-temperature damage and death in fab1, and in c

110 To test the relevance of HMP-PG to the fab1 phenotype, we used transgenic 16:0 desatu

111 0% high-melting-point molecular species (HMP-PG; molecules that contain only 16:0, 16:1-trans, and 18

112 G synthase within the divisome; however, how PG polymerization by this synthase is regulated and coor

113 ere significant with the exceptions of human PG, baboon TG, rat TG and Guinea pig PG.

114 of alpha-helix 30 results in hyperacetylated PG, suggesting this LtgA variant affects the function of

115 ntial of NIRAF detection for (i) identifying PG tissues intraoperatively, (ii) locating PGs before or

116 new avenues for intraoperatively identifying PGs with high accuracy in real-time.

117 Concurrent to impaired PG, HFD also enhanced thrombin generation (TG).

118 Changes in PG were also not explained by elevated PAI-1 because act

119 which catalyses the first committed step in PG biosynthesis.

120 Metabolic activities (including PG production) of IVD cells are restricted under the in-

121 The released nutrients, including PG-derived D-amino acids, can then be utilized by strain

122 nt functions in diverse processes, including PG turnover, cell elongation/division, and antibiotic re

123 n after exposure to antibiotics that inhibit PG synthases (e.g., beta-lactams).

124 e question whether PGIPs also inhibit insect PGs and protect plants from herbivores.

125 praisal of this technique for intraoperative PG detection.

126 Spertus JA, Jones PG, Maron DJ, et al.

127 ereas aggrecan, a structurally-similar large PG, has different and often opposing effects on collagen

128 At each power level, PG-based liquids resulted in approximately double the ni

129 lori serum IgG and serum pepsinogens levels (PGs) as markers of gastric inflammation and the immune r

130 explored, and the synthesis of cross-linked PG fragments, carrying biologically relevant amino acid

131 anionic diacyl phosphatidylglycerol lipids (PG); however, the ITC data could not properly be fitted

132 g PG tissues intraoperatively, (ii) locating PGs before or after dissection, (iii) distinguishing hea

133 that (E)FtsN binds specifically to the major PG synthase PBP1b and is sufficient to stimulate its bio

134 this study, we showed that different matrix PGs have distinct roles in regulating collagen behaviors

135 d organization, the function of large matrix PGs in collagen matrices is less well known.

136 fibrosis and cancer, and suggest that matrix PGs are potential therapeutic targets.

137 The different ways in which matrix PGs interact with collagen have important implications f

138 responsible for recruitment of a morphogenic PG remodeling complex, SpmX, is distinct from the protei

139 he localized synthesis and remodeling of new PG at midcell by the divisome.

140 s to make space for the incorporation of new PG material throughout the cell cylinder.

141 ble fibrinolysis inhibitor (TAFI) normalized PG, revealing a thrombomodulin- and TAFI-dependent antif

142 ly coordinating the spatiotemporal action of PG synthases and hydrolases.

143 rved FtsQLB complex is a direct activator of PG polymerization by the FtsWI synthase and thereby defi

144 om the direct bacteria-killing activities of PG-1, and the immunomodulatory effects of PG-1 via stimu

145 The addition of PG (PGE(2)) further diminished IFN-gamma levels in PBMCs

146 cal studies indicate that the average age of PG onset is in the mid-40s, with an incidence of a few c

147 We used a glycoproteomic analysis of PG to show that beta-barrel OM proteins are covalently a

148 aeruginosa We identified a core assembly of PG that is present in high abundance and that does not s

149 biochemical evidence for the association of PG fragments to NOD2 and NLRP1 with nanomolar affinity i

150 The cause of PG is not well understood, but PG is generally considere

151 functions as a terminase for both classes of PG synthases by cleaving PG glycans as they are being ac

152 Optimal conditions of PG deamidation based on reaching a high degree of deamid

153 etition with one another and that control of PG endopeptidase activity represents an important point

154 subsites for binding the saccharide core of PG using computational docking experiments, and multiang

155 two PG experts agreed in their diagnosis of PG on the basis of clinical descriptions, photographs, a

156 of PG-1, and the immunomodulatory effects of PG-1 via stimulating interleukin 1 beta secretion.

157 eria-inducible tissue-specific expression of PG-1 transgene.

158 Outer-leaflet and total fractions of PG were determined via zeta-potential (zeta) measurement

159 sed devices for label-free identification of PG by the Food and Drug Administration, it becomes cruci

160 Because NIRAF-based identification of PG is noninvasive and label-free, the popularity of this

161 ement with exclusive outside localization of PG.

162 evidence exists regarding the mechanisms of PG recognition.

163 tion from elongation to the division mode of PG biogenesis.

164 ulate transitions between these two modes of PG biogenesis.

165 activities that carry out these two modes of PG synthesis, we examined Spn cells vertically oriented

166 doglycan regulators and adaptors are part of PG biosynthetic multi-enzyme complexes, regulating and p

167 case report presents a rare presentation of PG with bilateral dense pigment deposits of the posterio

168 indings reveal novel antiviral properties of PG, suggesting its high potential as an alternative trea

169 rgeted methods of testing to reduce rates of PG misdiagnosis and patient misclassification in clinica

170 However, the regulation of PG hydrolases is less well understood, with only regulat

171 protease activity in response to signals of PG homeostasis imbalance.

172 rms a cluster that responds to the status of PG growth and stabilizes at one future cell pole.

173 data imply that the first committed step of PG biosynthesis is activated through control of ClpCP pr

174 Although the enzymatic steps of PG synthesis are well characterized, the steps involved

175 ns capable of cleaving the glycan strands of PG.

176 n the SPR surface influenced the strength of PG recognition by both NLRs.

177 Treatment of PG typically starts with fast-acting immunosuppressive d

178 re, this study enhances our understanding of PG O-acetyltransferases, which could guide the developme

179 Future research should focus on PG-specific outcome measures and PG quality-of-life stud

180 nst C. albicans by platelets is dependent on PGs.

181 One PG group, bipotential pregranulosa (BPG) cells, derives

182 rted, is a possible important sign of PDS or PG.

183 ults reveal new aspects of spatially ordered PG synthesis in ovococcal bacteria during cell division.

184 d that herbivorous insects express their own PG multi-gene families, raising the question whether PGI

185 ve PG molecules with a K(d) ~ 0.2 muM for PC/PG 1:1 and 0.6 muM for PC/PG 7:3 liposomes.

186 ) ~ 0.2 muM for PC/PG 1:1 and 0.6 muM for PC/PG 7:3 liposomes.

187 Peptidoglycan (PG) is a critical component of the bacterial cell wall a

188 Peptidoglycan (PG) is an essential constituent of the bacterial cell wa

189 Peptidoglycan (PG) is the core structural motif of the bacterial cell w

190 Peptidoglycan (PG) is the main component of bacterial cell walls and th

191 A peptidoglycan (PG) cell wall composed of glycans crosslinked by short p

192 A peptidoglycan (PG) cell wall is an essential component of nearly all ba

193 ial cells are surrounded by a peptidoglycan (PG) cell wall.

194 ses an outer membrane (OM), a peptidoglycan (PG) layer and an inner membrane (IM)(1).

195 of the polymerized aminosugar peptidoglycan (PG).

196 terium Myxococcus xanthus are peptidoglycan (PG)-deficient.

197 Bacterial peptidoglycan (PG) is recognized by the human innate immune system to g

198 Bacterial peptidoglycan (PG) synthesis requires strict spatiotemporal organizatio

199 -positive bacteria of diverse peptidoglycan (PG) chemotypes by secreting the metalloprotease pseudoal

200 (LT) are enzymes involved in peptidoglycan (PG) remodeling.

201 composed of a thick layer of peptidoglycan (PG) modified by the attachment of wall teichoic acid (WT

202 by an incompletely processed peptidoglycan (PG) layer.

203 The peptidoglycan (PG) cell wall is the primary determinant of cell shape.

204 inery is the synthesis of the peptidoglycan (PG) cell wall that caps the daughter poles and prevents

205 The peptidoglycan (PG) sacculus provides bacteria with the mechanical stren

206 s early in division, representing peripheral PG (pPG) synthesis (outer ring) and the leading-edge (in

207 ly exchange of anionic phosphatidylglycerol (PG), mimicking this key asymmetry of bacterial membranes

208 s and the phospholipid phosphatidylglycerol (PG), are essential for normal plant growth and developme

209 previously found that phosphatidylglycerol (PG) derived from soy can inhibit inflammation in a conta

210 f human PG, baboon TG, rat TG and Guinea pig PG.

211 Simultaneous thrombin (TG) and plasmin (PG) generation is useful to assessing coagulation and fi

212 eneration and associate with plastoglobules (PGs).

213 des a cell wall-localised polygalacturonase (PG), a pectin-degrading enzyme.

214 by inhibiting microbial polygalacturonases (PGs).

215 se to a paradoxical increase in postprandial PG excursion, which was annulled by empagliflozin during

216 Empagliflozin reduced postprandial PG through increased urinary glucose excretion.

217 rod-shaped, walled cells without preexisting PG templates.

218 stage by two groups of ovarian pregranulosa (PG) cells.

219 o aid surgeons in identifying and preserving PGs.

220 we have only recently identified the primary PG synthesis complexes that function during cell elongat

221 te a unique antiviral effect of prodigiosin (PG), a natural secondary metabolite produced by Serratia

222 propose a model where CcmA and MreB promote PG synthesis at positive and negative Gaussian curvature

223 There are three proposed PG diagnostic frameworks (Su, PARACELSUS, Delphi); howev

224 Prostaglandin (PG) E(2) exhibits antifibrotic properties and is reduced

225 xample, formation of TxA(2) , prostaglandin (PG) F(2alpha) , 11-hydroxyeicosatraenoic acid (HETE), an

226 n tumors from both genotypes, prostaglandin (PG) levels were higher in the PyMT(Delta2c44) tumors.

227 (Tsk) analysis, assessment of prostaglandin (PG) E(2) levels (the proximal mediator of fever) in the

228 While prostaglandins (PGs), short-range lipid signals, regulate single cell mi

229 cells and progressive loss of proteoglycan (PG).

230 Proteoglycans (PGs) contribute to the heterogeneity of the ECM and play

231 ions (free-base/PG, free-base/VG, protonated/PG, and protonated/VG).

232 ness was also observed in mice that received PG-CAT as a treatment post-viral inoculation.

233 Consistent with such a role, we reconstitute PG multi-enzyme complexes containing NlpI, the PG synthe

234 fat diet (HFD) showed delayed PG and reduced PG velocity.

235 ialized form of zonal growth, which requires PG synthesis in a spatially constrained zone to extend a

236 Biochemical assays revealed PG activity of recombinant PSL1 protein.

237 the bacterial actin homolog MreB and the Rod PG synthesis complexes away from poles.

238 A second PG group, epithelial pregranulosa (EPG) cells, arises in

239 nine protein kinases (PASTA-eSTK) that sense PG fragments.

240 In Escherichia coli, septal PG synthesis and cell constriction rely on the accumulat

241 and the leading-edge (inner ring) of septal PG (sPG) synthesis.

242 , which may contribute to the overall septal PG synthesis and regulation during cell division.

243 n adaptive Pattern Generator Pattern Shaper (PG/PS) architecture that autonomously generates a desire

244 However, at higher concentrations, soy PG alone enhanced the expression of some proinflammatory

245 e found that in epidermal keratinocytes, soy PG inhibited TLR2 and TLR4 activation and inflammatory m

246 Here, we investigated the ability of soy PG to inhibit inflammatory mediator expression in respon

247 The morphogen SpmX defines the site of stalk PG synthesis, but SpmX is a PG hydrolase.

248 These findings suggest PGs act in both the border cells and nurse cells, the su

249 d that versican, a large chondroitin sulfate PG, promotes collagen fibrillogenesis in a turbidity ass

250 o tackle the remaining questions surrounding PG biosynthesis.

251 und that germinating spores first synthesize PG randomly on spherical surfaces.

252 acterized, the steps involved in terminating PG glycan polymerization remain poorly understood.

253 tic parameters to calculate the metric of TG/PG ratio revealed a quantifiable net shift toward a prot

254 A exhibited greater scavenging capacity than PG (GG = GA > PG).

255 Together these data lead to the model that PG signaling controls Fascin in the border cells to prom

256 We show that PG naturally exerts antiviral activity against HSV-1 and

257 isms of its antiviral activity, we show that PG specifically inhibits NF-kappaB and Akt signaling pat

258 The results of our study show that PG-CAT supplementation was able to increase specific enz

259 The discovery that PGs have NIRAF led to new avenues for intraoperatively i

260 The PG polymerase activity of this complex was found to be g

261 The PG-1 transgene was specifically expressed in the respira

262 hed those of the parent liquids for both the PG and VG conditions.

263 Gram positive bacterial PG and degrades the PG peptide chains, leading to cell death.

264 dence interval was 90.2%, which exceeded the PG of 83.4% (p < 0.0001).

265 dence interval was 89.9%, which exceeded the PG of 84.4% (p < 0.0001).

266 Fragments released from the PG serve as fundamental recognition elements for the imm

267 hing duration was significantly lower in the PG group compared to the H group.

268 ved resistance to bacterial infection in the PG-1 transgenic mice could be resulted from the direct b

269 PAI-1 concentrations required to inhibit the PG assay were 100-fold higher than circulating concentra

270 by the finding that Cyp2c44 metabolized the PG precursor, PGH(2) to 12(S)-hydroxyheptadeca-5Z,8E,10E

271 multi-enzyme complexes containing NlpI, the PG synthesis regulator LpoA, its cognate bifunctional sy

272 his LtgA variant affects the function of the PG de-O-acetylase (Ape 1).

273 The structure of the PG, however, encompasses a variety of chemical modificat

274 roteins, which both recruit and organize the PG synthesis complex.

275 This group was the PG cohort by which we evaluated the performance and conc

276 These PG-1 transgenic mice exhibited enhanced resistance to na

277 Metabolism of this PG meshwork must be spatially and temporally regulated i

278 arrel OM proteins are covalently attached to PG in several Gram-negative species, including Coxiella

279 n addition, NlpI seems to contribute both to PG elongation and division biosynthetic complexes based

280 The transfer of WTA from lipid carriers to PG, catalyzed by the LytR-CpsA-Psr (LCP) enzyme family,

281 reover, male and female offspring exposed to PG/VG with and without nicotine had a 5.2% lower object

282 etable glycerol (50:50 PG/VG vehicle), or to PG/VG with 16 mg/mL nicotine ( + Nic).

283 in covalently attaching surface proteins to PG.

284 eins known to generate an immune response to PG.

285 : 25 substrate molar ratio of tripalmitin to PG, 120 h reaction time, and 25% enzyme load relative to

286 oteomic analyses indicate that A. trichopoda PGs are prepared for germination requiring lipids, energ

287 methods to collect bicellular A. trichopoda PGs, to induce their germination in vitro, and to monito

288 In Escherichia coli, the activity of two PG synthases is driven by lipoproteins anchored in the o

289 assification of Diseases-10 codes, where two PG experts agreed in their diagnosis of PG on the basis

290 stalks" that are the result of unconstrained PG synthesis.

291 ly low, while rabbit plasmas showed variable PG curves demonstrating one or two peaks with low and hi

292 e plasmon resonance (SPR) assay using varied PG surface presentation was developed.

293 can specifically form complexes with various PG endopeptidases.

294 Failure to visualize PGs could lead to accidental damage/excision of healthy

295 d for on-time migration, we assessed whether PGs regulate Fascin to promote border cell migration.

296 as obtained at a yield of 33.0 +/- 2.0% with PG conversion at 44.8 +/- 1.8% when the following condit

297 al role in coordinating OM invagination with PG remodeling at the division site than previously appre

298 fied the highest proportion of patients with PG (89% [42 of 47 patients]), followed by Delphi and Su

299 ed in a well-defined cohort of patients with PG.

300 a single-institution cohort of patients with PG.