ライフサイエンスコーパス: PGF2alpha

1 eir endogenous ligand prostaglandin F2alpha (PGF2alpha).

2 classes of isomers of prostaglandin F2alpha (PGF2alpha).

3 produced, 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha).

4 -8-iso-PGF2alpha, and prostaglandin-F2alpha (PGF2alpha).

5 pid mediators such as prostaglandin F2alpha (PGF2alpha).

6 ct's baseline urinary concentration of 8-iso-PGF2alpha.

7 iated cell rounding following treatment with PGF2alpha.

8 9220 on the intraocular pressure response to PGF2alpha.

9 contained F-type prostane rings analogous to PGF2alpha.

10 n synthesis and bFGF-2 expression induced by PGF2alpha.

11 effect on the ocular hypotensive response to PGF2alpha.

12 nsignificant effect on the pupil response to PGF2alpha.

13 s mediate hypertrophic growth in response to PGF2alpha.

14 , in addition to the cyclooxygenase product, PGF2alpha.

15 tion, PGHS-2, and the production of PGE2 and PGF2alpha.

16 GF2alpha, in addition to its cognate ligand, PGF2alpha.

17 the plaque were markedly positive for 8-epi PGF2alpha.

18 ng infusion of 500 microg of unlabeled 8-iso-PGF2alpha.

19 tural specificity versus 8-epi PGF3alpha and PGF2alpha.

20 so-PGF2alpha, 2,3-dinor-8-iso-PGF2alpha, and PGF2alpha.

21 apamycin, implicating mTOR in the actions of PGF2alpha.

22 he expression of which is also stimulated by PGF2alpha.

23 quartile of baseline concentrations of 8-iso-PGF2alpha.

24 Much higher concentrations of 8-epi-PGF2alpha (10-20 microM) alone induce weak, reversible a

25 in monolayer cultures and were treated with PGF2alpha, 11-deoxy-PGE1, or PhXA85 (the nonesterified a

26 Twenty-four-hour treatment with 20 nM PGF2alpha, 11-deoxy-PGE1, or PhXA85 reduced the amount o

27 When the concentration of PGF2alpha, 11-deoxy-PGE1, or PhXA85 was increased to 200

28 Prostaglandin (15R-PGF2alpha, 11B-dhk-PGF2alpha) and linoleic acid derivati

29 d 8-isoprostane-prostaglandin-F2alpha (8-iso-PGF2alpha), 2,3-dinor-5,6-dihydro-8-iso-PGF2alpha, 2,3-d

30 PBDEs were associated with increasing 8-iso-PGF2alpha, 2,3-dinor-8-iso-PGF2alpha, and PGF2alpha.

31 -iso-PGF2alpha), 2,3-dinor-5,6-dihydro-8-iso-PGF2alpha, 2,3-dinor-8-iso-PGF2alpha, and prostaglandin-

32 ma concentrations of F(2)-isoprostane (8-iso-PGF2alpha), 9-hydroxyoctadecadieneoic acid (9-HODE), and

33 PGF2alpha also activates the extracellular signal-regula

34 8-Iso-PGF2alpha also had no effect on HMEC surface expression

35 PGF2alpha also induced eIF4E and 4E-BP1 phosphorylation,

36 the isoprostane 8-iso-prostaglandin F (8-iso-PGF2alpha), among other ligands examined, to activate G1

37 iPF2alpha-III (previously 8-iso-PGF2alpha), an isoprostane from Class III (previously kn

38 Microalbuminuria and urinary 8-iso-PGF2alpha, an index of in vivo oxidative stress, indepen

39 Recently, PGF2alpha analogs have been hypothesized to reduce intra

40 Consistent with these observations, only PGF2alpha and 12-iso-PGF2alpha caused rapid homologous d

41 ntraocular pressure, indicating that in cats PGF2alpha and 17-phenyl trinor PGE2 act on the same rece

42 In the dose ranges used, PGF2alpha and 17-phenyl trinor PGE2 decreased intraocula

43 ent administration of 12.5 microg of each of PGF2alpha and 17-phenyl trinor PGE2 did not produce an a

44 ed the intraocular pressure response to both PGF2alpha and 17-phenyl trinor PGE2.

45 dural values by 24 hours (122+/-18 for 8-epi-PGF2alpha and 457+/-102 for IPF2alpha-I).

46 Both PGF2alpha and 8,12-iso-iPF2alpha-III activate the p70S6

47 Thus, both PGF2alpha and 8,12-iso-iPF2alpha-III induce myocyte hype

48 Thus, PGF2alpha and 8,12-iso-iPF2alpha-III stimulate inositol

49 sted, including 8-iso-prostaglandin F (8-iso-PGF2alpha and a purported antagonist (pinane thromboxane

50 se relationship exists between the levels of PGF2alpha and a steroid-inducible anti-inflammatory prot

51 Therefore, PGF2alpha and Bimatoprost appear to interact with differ

52 Both PGF2alpha and Bimatoprost up-regulated Cyr61 mRNA expres

53 , induced mkp1 mRNA to a greater extent than PGF2alpha and fluprostenol, which activate PKC signaling

54 atosus had higher urinary excretion of 8-epi-PGF2alpha and IPF2alpha -I than controls; urinary excret

55 urinary excretion of two isoprostanes, 8-epi-PGF2alpha and IPF2alpha -I, free radical catalyzed oxida

56 8-epi PGF2alpha and IPF2alpha-I are F2-isoprostanes produced i

57 (r=.68, P<.0001; n=33) between urinary 8-epi-PGF2alpha and IPF2alpha-I levels in patients receiving t

58 Our results indicate that 8-epi PGF2alpha and IPF2alpha-I, two distinct F2-isoprostanes

59 structurally distinct F2 isoprostanes, 8-epi-PGF2alpha and IPF2alpha-I.

60 er and a strong association of urinary 8-iso-PGF2alpha and of serum soluble NOX2-derived peptide with

61 her (p < 0.001) mean values of urinary 8-iso-PGF2alpha and of serum soluble NOX2-derived peptide, ala

62 The potency of the natural prostaglandins PGF2alpha and PGD2 was not enhanced by the mutations.

63 triggers the synthesis of the prostaglandins PGF2alpha and PGE2, but not PGD2, in rat cerebral cortic

64 Urinary 8-iso-PGF2alpha and serum soluble NOX2-derived peptide levels

65 igate any possible correlation between 8-iso-PGF2alpha and the consumption of the two drugs.

66 PGF2alpha and the PG mixture at 25 muM concentration sig

67 Levels of PGF2alpha and thromboxane B2 (TXB2 ) were quantified by

68 ar sex differences in PVAT function in which PGF2alpha and TXA2 antagonists can inhibit the PVAT-indu

69 n (NPV) stimulated by prostaglandin F2alpha (PGF2alpha ) and by the drug LY83583, which causes contra

70 Prostaglandin (15R-PGF2alpha, 11B-dhk-PGF2alpha) and linoleic acid derivatives (12,13 EpOME) a

71 se using progesterone, prostaglandin F2alpha(PGF2alpha) and pregnant mare serum gonadotrophin (PMSG).

72 1alpha (PGF1alpha), prostaglandin F(2alpha) (PGF2alpha), and prostaglandin D2 (PGD2).

73 sed the ability of 8-isoPGF2alpha, 5iPF2 VI, PGF2alpha, and a mixture containing these PGs in a 0.5/0

74 d decreased myometrial NF-kappaB activation, PGF2alpha, and expression of contraction-associated gene

75 However, the TP receptor agonists U-46,619, PGF2alpha, and PGD2 were more potent than PGE2.

76 increasing 8-iso-PGF2alpha, 2,3-dinor-8-iso-PGF2alpha, and PGF2alpha.

77 ertrophic agonists in culture, endothelin-1, PGF2alpha, and phorbol 12-myristate 13-acetate, also ind

78 5,6-dihydro-8-iso-PGF2alpha, 2,3-dinor-8-iso-PGF2alpha, and prostaglandin-F2alpha (PGF2alpha).

79 We show that NFAT is activated by PGF2alpha, and the isoform NFATC2 is required for PGF2al

80 because unreactive lipids, e.g. PGB1, PGE2, PGF2alpha, and TxB2, did not inhibit LKB1 activity (p >

81 catalyzed the transport of PGE1, PGE2, PGD2, PGF2alpha, and, to a lesser degree, TXB2.

82 ontraction in arteries from females, whereas PGF2alpha appears to mediate the contraction in arteries

83 The rank order substrate profile was PGF2alpha approximately PGE2 > TXB2 >> 6 keto-PGF1alpha.

84 The biological effects of PGF2alpha are mediated via the G protein-coupled recepto

85 the cyclooxygenase products thromboxane and PGF2alpha are released from coronary artery PVAT from pi

86 a (TNFalpha) and prostaglandin (PG) F2alpha (PGF2alpha) are involved in the control of ovulation but

87 intraocular pressure and pupil responses to PGF2alpha, are mediated by EP1 and FP receptors, respect

88 present study shows the potential for 8-iso-PGF2alpha as a wastewater biomarker for the assessment o

89 c-fos and identify the diffusable messenger PGF2alpha as obligatory for NMDA receptor-mediated trans

90 cosanoids analyzed, tetranor-PGEM and 11beta-PGF2alpha as well as 11-dehydro-TXB2 showed a significan

91 , urinary 8-iso prostaglandin F2alpha (8-iso PGF2alpha) as a marker of oxidative stress, and gastric

92 We demonstrate that prostaglandin F2alpha (PGF2alpha) as well as two analogues augment muscle cell

93 identified as 8-isoPGF2alpha, 5iPF2 VI, and PGF2alpha based on their retention times and MS/MS spect

94 roxylamine (HA, 100 mum), altered the NPV to PGF2alpha (BCA increased, HA inhibited) and/or LY83583 (

95 iently quantified by this method, with 8-iso-PGF2alpha being identified as a major isomer.

96 It is established that PGF2alpha binds to a G-proteincoupled receptor (GPCR) to

97 ocytes resulted in marked formation of 8-epi-PGF2alpha, but not of PGE2 or TxB2.

98 We further demonstrate that PGF2alpha, but not PGE2 or PGD2, is necessary but not su

99 istent with the enzymatic formation of 8-epi PGF2alpha by cyclooxygenases.

100 ro-15-F2t-IsoP (2,3-dinor-5, 6-dihydro-8-iso-PGF2alpha), by gas chromotography/negative ion chemical

101 The data show that 8-iso-PGF2alpha can suppress the attachment of monocytes to HM

102 Although 12-iso-PGF2alpha caused a dose-dependent activation of the FP,

103 hese observations, only PGF2alpha and 12-iso-PGF2alpha caused rapid homologous desensitization of FP

104 Moreover, PGF2alpha causes a robust activation ( approximately 50-

105 Similarly, PGF2alpha causes translocation of cytosolic phospholipas

106 For example, prostaglandin F2alpha (PGF2alpha) causes hypertrophy of neonatal rat ventricula

107 idly metabolized to inactive products, 8-epi PGF2alpha circulates in plasma.

108 indings are consistent with a model in which PGF2alpha communicates fertility status via Ptgfr to cir

109 as associated with a 4.50% decrease in 8-iso-PGF2alpha concentrations (95% CI: -6.32%, -2.65%) and a

110 The run-in diet reduced 8-iso-PGF2alpha concentrations by 33% (P < 0.0001).

111 endent relaxations in prostaglandin F2alpha (PGF2alpha)-contracted strips of porcine coronary artery.

112 induced endothelium-dependent relaxations in PGF2alpha-contracted porcine coronary arteries.

113 It was also found that PGF2alpha-could activate T-cell factor (Tcf)/beta-cateni

114 c ring contraction experiments revealed that PGF2alpha-dependent activation of FP potentiated angiote

115 Treatment with PGF2alpha did not increase AKT phosphorylation but incre

116 Urinary CC16 and 8-iso-PGF2alpha did not increase.

117 e blockade by thromboxane antagonists, 8-epi PGF2alpha does not activate either of the thromboxane re

118 Thus, 8-epi-PGF2alpha does not compete for binding at the stably exp

119 ne chip technology, we first identified that PGF2alpha dramatically up-regulated Cyr61 and CTGF mRNA

120 PGF2alpha-G and PGD2-EA, but not PGE2-EA or PGF2alpha-EA, also increased the frequency of mIPSCs.

121 alpha was less potent (EC50 = 5 microM) than PGF2alpha (EC50 = 10 nM) in generating inositol phosphat

122 on, human monocytes may form bioactive 8-epi-PGF2alpha either via free radical- or enzyme-catalyzed p

123 tor of activated T cells (NFAT) in mediating PGF2alpha-enhanced cell growth was examined.

124 This increased myotube size is not due to PGF2alpha-enhancing cell fusion that initially forms myo

125 Urinary 8-iso PGF2alpha excretion was associated with the risk of gast

126 Median urinary 8-iso PGF2alpha excretion was higher in cases (0.014; IQR: 0.0

127 Furthermore, the response to 8-epi PGF2alpha exhibits structural specificity versus 8-epi P

128 type I (AT1R) and the prostaglandin F2alpha (PGF2alpha) F prostanoid (FP) receptors are both potent r

129 ther cycloxygenase products, PGE2, PGD2, and PGF2alpha, failed to activate p38 kinase in aspirin-trea

130 Exposure of HMEC to 8-iso-PGF2alpha for 1-2 h was sufficient to reduce monocyte ad

131 GE2 has much lower efficacy as compared with PGF2alpha for the activation of Tcf/beta-catenin signali

132 Although serum 8-iso-PGF2alpha formation is substantially depressed by COX in

133 ane B2 (TXB2 ) were quantified by ELISA, and PGF2alpha (FP) and thromboxane A2 (TP) receptor expressi

134 the four Gq/Gi-coupled receptors [EP1, EP3, PGF2alpha (FP), thromboxane A2 (TP)] suggests that prost

135 Thus, prostaglandin F2alpha (PGF2alpha) (FP receptor agonist), Butaprost (EP2 recepto

136 in the following order of activity: PGE2-G > PGF2alpha-G > PGD2-G; LYPLA2 hydrolyzed 1- but not 2-ara

137 PGD2-G, PGF2alpha-G and PGD2-EA, but not PGE2-EA or PGF2alpha-EA

138 The primary outcomes 2,3-dinor-11-beta-PGF2alpha, GETE score, and standard clinical biomarkers

139 In monocyte adhesion assays, 8-iso-PGF2alpha (>10(-8) M) suppressed both basal and TNF-alph

140 taglandin profile: TxB2>6-keto PGF1alpha and PGF2alpha>PGE2, despite the comparable release of total

141 8-Iso-PGF2alpha had no effect on the viability (Trypan Blue ex

142 Thus, the ratio of endogenous PGE2 and PGF2alpha has the potential to selectively regulate one

143 One F-ring IsoP, 15-F2t-IsoP (8-iso-PGF2alpha) has been shown to be formed in abundance in v

144 Bs in biosynthesis of prostaglandin F2alpha (PGF2alpha) has not been investigated.

145 COX) enzyme product, prostaglandin F2alpha (PGF2alpha), has exhibited promise as an index of oxidant

146 Elevated serum and urine levels of 8-iso-PGF2alpha have been reported in a variety of diseases, m

147 Following the removal of PGF2alpha, however, FPA-expressing cells return to their

148 poral trends observed in the levels of 8-iso-PGF2alpha, however, spatial differences were found at th

149 8-epi PGF2alpha immunoreactivity was also detected in cells po

150 oportion of the ocular hypotensive action of PGF2alpha in cats is mediated by EP1 but not by FP recep

151 of inositol phosphates to the same extent as PGF2alpha in cells expressing either the FPA or FPB isof

152 y isoprostanes may complement the actions of PGF2alpha in clinical syndromes where oxidant stress and

153 we investigated the potential role of 8-iso-PGF2alpha in inflammation, focusing on its effects on ad

154 Given this novel role for PGF2alpha in skeletal muscle cell growth, these studies

155 he estimated per capita daily loads of 8-iso-PGF2alpha in the 11 cities ranged between 2.5 and 9.9 mg

156 novel functions for parasite-derived LBs and PGF2alpha in the cellular metabolism of Leishmania and i

157 potential anti-inflammatory effect of 8-iso-PGF2alpha in the microvasculature.

158 om female animals and greater sensitivity to PGF2alpha in the porcine coronary artery from males.

159 Concentrations of 8-epi-PGF2alpha in the range 1 nM to 1 microM induce a dose-de

160 o be activated by the F2 isoprostane, 12-iso-PGF2alpha, in addition to its cognate ligand, PGF2alpha.

161 ree radical-catalyzed F2 isoprostane, 12-iso-PGF2alpha, in addition to the cyclooxygenase product, PG

162 In cardiomyocytes, PGF2alpha increases the hydrolysis of inositol phosphate

163 PGF2alpha induced the activities of extracellular signal

164 and the mechanisms of prostaglandin F2alpha (PGF2alpha)-induced protein synthesis in vascular smooth

165 ependent mechanisms appear to be involved in PGF2alpha-induced activation of ERK2; 2) PGF2alpha-induc

166 in PGF2alpha-induced activation of ERK2; 2) PGF2alpha-induced eIF4E and 4E-BP1 phosphorylation appea

167 ty by PD 098059 led to a significant loss of PGF2alpha-induced eIF4E and 4E-BP1 phosphorylation, glob

168 nhibitor of p70(S6k), also failed to prevent PGF2alpha-induced global protein synthesis and bFGF-2 ex

169 ependent p70(S6k) activation correlates with PGF2alpha-induced global protein synthesis and bFGF-2 ex

170 lpha, and the isoform NFATC2 is required for PGF2alpha-induced muscle cell growth and nuclear accreti

171 minant-interfering proteins demonstrate that PGF2alpha-induced myocyte hypertrophy occurs independent

172 PGF2alpha-induced phosphorylation of eIF4E and 4E-BP1 wa

173 mplicated p38 and JNK, but not ERK, in 8-iso-PGF2alpha-induced suppression of monocyte adhesion.

174 PGF2alpha-induced up-regulation of Cyr61 appeared to exc

175 (CM) transfer experiments suggest that 8-iso-PGF2alpha induces a secondary mediator, which also suppr

176 We show that, within minutes, PGF2alpha injection activates a naturalistic pattern of

177 al hydrophobic cavity, thereby preventing FP-PGF2alpha interaction and suppressing the production of

178 n by binding and most likely by sequestering PGF2alpha into its central hydrophobic cavity, thereby p

179 Four additional F2 isoprostanes, 8-iso-PGF2alpha, IPF2alpha-I, IPF2alpha-III, and 9beta,11beta-

180 8-Epi-PGF2alpha is a more abundant product of monocyte PG G/H

181 pha-I, (IPF2alpha-I) a class I isomer (8-iso-PGF2alpha is class IV), using gas chromatography/mass sp

182 n of intraocular pressure in cats induced by PGF2alpha is mediated by FP or other prostaglandin recep

183 receptor by systemic concentrations of 8-epi PGF2alpha is unlikely to occur, even in syndromes of exc

184 Prostaglandin F2alpha (PGF2alpha) is a product of cyclooxygenase-catalyzed meta

185 Prostaglandin F2alpha (PGF2alpha) is an important mediator of corpus luteum (CL

186 compounds, 8-epiprostaglandin F2alpha (8-epi-PGF2alpha), is a mitogen and vasoconstrictor.

187 However, IPF2alpha-I, unlike 8-iso-PGF2alpha, is not formed in a COX-dependent manner by pl

188 There was a slight increase in urinary 8-epi-PGF2alpha levels (64.7+/-9.5 versus 84.9+/-10.6; P=.02)

189 Although there was no difference in PGF2alpha levels in PVAT between females and males, PGF2

190 d PORH and increased TXA2 but did not change PGF2alpha levels.

191 rogesterone (DHP) and prostaglandin F2alpha (PGF2alpha) levels rise in teleost fish around the time o

192 Cell 16 (CC16) and 15-isoprostane F2t (8-iso-PGF2alpha) levels were used to assess lung injury and ov

193 urition initiation via COX1 and COX2 derived PGF2alpha leveraging epithelial specific Shp2 knockout m

194 The 8-iso-PGF2alpha mass load was found to be strongly associated

195 8-Epi PGF2alpha may amplify the response to platelet agonists

196 Although 8-iso-PGF2alpha may be formed as a minor product of COX, this

197 r second-trimester levels of 2,3-dinor-8-iso-PGF2alpha (mean change per quartile increase = 0.25, 95%

198 vely, whereas neither compound abrogates the PGF2alpha-mediated response.

199 Similarly, PGF2alpha-mediated vasoconstriction was symmetrically re

200 boxane A2 (TXA2 ) and prostaglandin F2alpha (PGF2alpha ), on skin microcirculatory blood flow, as wel

201 2-iP, iPF2alpha-III (previously called 8-iso-PGF2alpha or 8-epi-PGF2alpha), which demonstrated the ut

202 had little or no effect on the NPV caused by PGF2alpha or LY83583.

203 ute MI (105+/-17.8 versus 230+/-66 for 8-epi-PGF2alpha [P=.009] and 466+/-91 versus 833+/-153 for IPF

204 28767, and misoprostol but not with 10(-6) M PGF2alpha, PGD2, PGI2, or butaprost, suggesting a princi

205 sanoids, such as prostaglandin E2 (PGE2) and PGF2alpha, precedes the onset of labor as a result of in

206 anges in c-Jun-dependent gene transcription, PGF2alpha preferentially activates the MEK-Erk2- cytosol

207 ha levels in PVAT between females and males, PGF2alpha produced a larger contraction in arteries from

208 We conclude that the 22-carbon analogue of PGF2alpha, produced from docosahexaenoic acid by a cyclo

209 ence that the Tnfalpha-dependent increase in PGF2alpha production is necessary for the pro-ovulatory

210 med that COX-1 accounted for the majority of PGF2alpha production.

211 lowing luteolysis in the absence of elevated PGF2alpha production.

212 tes mRNA levels of the putative receptor for PGF2alpha (Ptgfr).

213 and is highly correlated with urinary 8-iso-PGF2alpha (r = 0.9; P < 0.001).

214 8-epi PGF2alpha ranged from 1.310-3.450 pmol/micromol phosphol

215 Recombinant trout Tnfalpha (rTnfalpha) and PGF2alpha recapitulate the stimulatory in vitro effects

216 This growth is mediated through the PGF2alpha receptor (FP receptor).

217 To investigate the molecular basis of PGF2alpha receptor (FP) activation in the eye, we cloned

218 We detected PGF2alpha receptor (FP) on the Leishmania PV surface.

219 f neonatal rat ventricular myocytes, via the PGF2alpha receptor (FP).

220 lon to the myocyte membrane, consistent with PGF2alpha receptor coupling to Gq.

221 that initially forms myotubes, but rather to PGF2alpha recruiting the fusion of cells with preexistin

222 d also exhibited cross-desensitization, with PGF2alpha resulting in a maximum of approximately 60% de

223 ted amniotic fluid IL-1beta, IL-6, IL-8, and PGF2alpha, resulting in PTB and marked neonatal mortalit

224 rations of TXB2 (stable TXA2 metabolite) and PGF2alpha , soluble cell adhesion molecules and blood pr

225 In contrast, 8-iso-PGF2alpha stimulated monocyte adhesion to human umbilica

226 e-dependent manner while having no effect on PGF2alpha-stimulated inositol phosphates formation.

227 of FPB-expressing cells with PGE2-attenuated PGF2alpha-stimulated Tcf/beta-catenin signaling in a dos

228 Additional studies demonstrate that PGF2alpha stimulates protein tyrosine phosphorylation an

229 eriments were performed to determine whether PGF2alpha stimulates the mammalian target of rapamycin (

230 suggest that GPCR activation in response to PGF2alpha stimulates the mTOR pathway which increases th

231 t metacyclic stage, as did the expression of PGF2alpha synthase (PGFS).

232 Here we show that Lh induces PGF2alpha synthesis through its stimulation of Tnfalpha

233 w strategies for therapeutic intervention in PGF2alpha-target tissues.

234 (TxS), and the receptors for TxA2 (the TP), PGF2alpha (the FP), and PGI2 (the IP) were upregulated a

235 ith L 745,337, suppressed formation of 8-epi-PGF2alpha, thiobarbituric acid-reactive substances, and

236 ated intracellular pathways are required for PGF2alpha to induce morphological and genetic features c

237 We demonstrate that PGF2alpha treatment results in a timeand concentration-d

238 The stimulation of S6K1 in response to PGF2alpha treatment was abolished by the mTOR inhibitor

239 deposition (MMP9), and prostanoids (PGE(2), PGF2alpha, TXA2) were all more effectively reduced by na

240 Only PGF2alpha up-regulated CTGF mRNA expression in the cat i

241 trictor responses to norepinephrine, U46619, PGF2alpha, vasopressin, BAY K8644; biphasic responses to

242 ction of intraocular pressure by 50.0 microg PGF2alpha was 5.0+/-1.4 mm Hg, whereas that by 50 microg

243 re patient on hemodialysis and urinary 8-iso-PGF2alpha was 7.1-fold higher in a cigarette smoker than

244 Urinary 8-epi-PGF2alpha was highly correlated with both aCL titer (Rho

245 nificant reduction in the excretion of 8-iso-PGF2alpha was induced by the run-in diet and the high-VF

246 20 microCi of tritiated 8-iso-PGF2alpha was infused over 1 h into a male volunteer.

247 12-iso-PGF2alpha was less potent (EC50 = 5 microM) than PGF2alp

248 Urine 8-iso PGF2alpha was measured primarily by ELISA, and by gas ch

249 The effect of 8-iso-PGF2alpha was mimicked by a thromboxane receptor (TP) ag

250 No difference of 8-epi-PGF2alpha was observed between patients with and without

251 his work, 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha) was analysed in raw 24 h-composite wastewater

252 ry excretion of 8-isoprostane F2alpha (8-iso-PGF2alpha) was used as an index of whole-body lipid pero

253 assessed by measuring the isoprostane 8-iso-PGF2alpha, was decreased in the lungs of GM-/- mice.

254 the plasma marker of oxidative stress, 8-iso PGF2alpha, was increased in PHF animals (P < 0.01).

255 respectively) on the intraocular response to PGF2alpha were also examined.

256 iet, whereas urinary concentrations of 8-iso-PGF2alpha were further reduced (P < 0.01) by the high-VF

257 In addition, the levels of urinary 8-iso-PGF2alpha were independent predictors of non-alcoholic f

258 The effects of PGF2alpha were mimicked by the PKC activator PMA and inh

259 The amount of parasite LBs and PGF2alpha were modulated by exogenous arachidonic acid.

260 The greatest reductions in 8-iso-PGF2alpha were observed in subjects in the highest quart

261 er PGT nor PG15DH, exogenously added PGE2 or PGF2alpha were rapidly oxidized to the 13, 14-dihydro, 1

262 (previously called 8-iso-PGF2alpha or 8-epi-PGF2alpha), which demonstrated the utility of monitoring

263 Prostaglandin F2alpha (PGF2alpha), which is released from cells of the myocardi

264 The excretion of 8-iso-PGF2alpha with the low-VF diet remained the same as that

265 synthesis of the most complex prostaglandin, PGF2alpha, with high levels of control of relative and a

266 eralfold as abundant in human urine as 8-iso-PGF2alpha, with mean values of 737 +/- 20.6 pg/mg creati