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1                                              PGH(2) fits well into the IMN binding site by placing th
2                                              PGH(2)-G produced by macrophages is a substrate for cell
3                                              PGH2-like endoperoxides are intermediates in this pathwa
4 to prostaglandin (PG) G2 (catalytic step 1), PGH2 (catalytic step 2), and PGI2 (catalytic step 3).
5 cal sensing platform for prostaglandin H(2) (PGH(2)) as the basis for quantitation of pain.
6                          Prostaglandin H(2) (PGH(2)) formed from arachidonic acid is an unstable inte
7                          Prostaglandin H(2) (PGH(2)) formed from arachidonic acid is an unstable inte
8 arachidonic acid (AA) to prostaglandin H(2) (PGH(2)) in the committed step of prostaglandin biosynthe
9    The product of COX-2, prostaglandin H(2) (PGH(2)), can undergo spontaneous rearrangement and nonen
10                     Prostaglandin (PG) H(2) (PGH(2)), formed from arachidonic acid, is an unstable in
11 vert arachidonic acid to prostaglandin H(2) (PGH(2)), the committed step in prostaglandin and thrombo
12 ic acid (AA) to generate Prostaglandin H(2) (PGH(2)), the precursor to prostaglandins, prostacyclin,
13 vert the same substrate, prostaglandin H(2) (PGH(2)), to thromboxane A(2) and prostaglandin I(2), whi
14 ndin H synthases (PGHS), prostaglandin H(2) (PGH(2)), undergoes rearrangement to the highly reactive
15 nic acid to prostaglandin endoperoxide H(2) (PGH(2)).
16 lectrons to prostaglandin endoperoxide H(2) (PGH(2)).
17 achidonic acid (AA) into prostaglandin H(2) (PGH(2)).
18 ic TXA(2), TXA(2) mimetic (U-46619), TXB(2), PGH(2) mimetic (U-51605), PGD(2,) PGJ(2), and PGF(2alpha
19 f the crystal structure and mutation data, a PGH(2)-bound model structure was built.
20 landin (PG) I(2) (PGI(2), prostacyclin) is a PGH(2) metabolite with anti-inflammatory, antiproliferat
21 sozymes and terminal enzymes by developing a PGH2-divided model.
22                                    U46619, a PGH2/TxA2 mimetic, induced specific phosphorylation of b
23 ce between the heme and the protein, where a PGH2 might be able to bind.
24 reflect, in part, rediversion of accumulated PGH(2) to augment formation of PGI(2).
25 s, reflecting rediversion of the accumulated PGH(2) substrate in the double knockouts.
26 recursors, arachidonic acid (AA), PGG(2) and PGH(2).
27 uctures of PGFS containing PGF(2)(alpha) and PGH(2) were built.
28  or SQ 29,548 (10(-4) M), cyclooxygenase and PGH(2)/TXA(2) receptor antagonists, partially restored a
29 the intermediate endoperoxides, PGH(2)-G and PGH(2)-EA, to the corresponding prostacyclin derivatives
30 abinoid-derived COX-2 products, PGH(2)-G and PGH(2)-EA.
31 nhibits both the PGD(2) 11-ketoreductase and PGH(2) 9,11-endoperoxide reductase activities of PGFS.
32 ediate PGH2 by cyclooxygenase-2 (COX-2), and PGH2 undergoes an isomerization reaction to generate PGE
33            Further metabolism of PGH2-EA and PGH2-G by prostaglandin synthases produces a variety of
34 c parameters of TXAS-catalyzed reaction are: PGH2 bound TXAS at a rate of 1.2-2.0 x 10(7) M(-1) s(-1)
35       Using N(alpha)-acetylarginine and both PGH(2) and synthetic LGE(2), we discovered a novel serie
36 ngs question mechanisms of catalysis in both PGH2 synthases.
37 ynthase was far more efficient at catalyzing PGH(2) isomerization than at catalyzing the isomerizatio
38                      Given that the cellular PGH2 concentration is quite low, we concluded that under
39 rize the contribution of mPGES-1 to cellular PGH2 metabolism in murine macrophages by studying the sy
40 te kinetic study revealed that TXAS consumed PGH2 at a rate of 3,800 min(-1) and that the k(cat)/K(m)
41 ating the levels of a synthase that converts PGH(2) to PGD(2), the intracellular signaling proteins t
42 (mPGES1), which converts COX-1/COX-2-derived PGH(2) to PGE(2).
43 onic acid-derived prostaglandin endoperoxide PGH(2).
44 donic acid to the prostaglandin endoperoxide PGH2, from which all other prostaglandins are formed.
45 w a cell processes the unstable endoperoxide PGH2 during the inactivation of a major metabolic outlet
46 enase metabolite prostaglandin endoperoxide (PGH(2)).
47 he conversion of prostaglandin endoperoxide (PGH2) into thromboxane A2 (TxA2) which plays a crucial r
48 erization of the intermediate endoperoxides, PGH(2)-G and PGH(2)-EA, to the corresponding prostacycli
49 el lipid, prostaglandin H(2) glycerol ester (PGH(2)-G), in vitro and in cultured macrophages.
50 -ethanolamide (PGH2-EA) and -glycerol ester (PGH2-G), respectively.
51 ol (2-AG), to prostaglandin-H2-ethanolamide (PGH2-EA) and -glycerol ester (PGH2-G), respectively.
52 lipase A(2), which was restored by exogenous PGH(2), implying that the effects of COX-1 required its
53 ES-2h has significant catalytic activity for PGH2 degradation.
54 f 3,800 min(-1) and that the k(cat)/K(m) for PGH2 consumption was 3 x 10(6) M(-1) s(-1).
55  the 15-hydroperoxyl group of PGG(2) to form PGH(2) catalyzed by the peroxidase activity.
56                                 Once formed, PGH(2) is converted, again depending on the context, to
57 (S)-1 catalyzes the formation of PGE(2) from PGH(2), a cyclooxygenase product that is derived from ar
58  activities: formation of PGF(2)(alpha) from PGH(2) by the PGH(2) 9,11-endoperoxide reductase activit
59 ta-PGF(2) from PGD(2) and PGF(2)(alpha) from PGH(2) in the presence of NADPH.
60              Formation of PGF(2)(alpha) from PGH(2) most likely involves a direct hydride transfer fr
61       Prostaglandin (PG) E(2) is formed from PGH(2) by a series of PGE synthase (PGES) enzymes.
62 ly all of the LG predicted to be formed from PGH2 can be accounted for as adducts of the PGH-synthase
63 tadecatrienoic acid and malondialdehyde from PGH2, but not formation of PGE2.
64     The first COX product, prostaglandin H2 (PGH2) is also a command substrate for other prostanoid e
65 in E synthases involved in prostaglandin H2 (PGH2) metabolism.
66 d peroxidase activities of prostaglandin H2 (PGH2) synthase I and II were monitored by stopped-flow s
67  molecular oxygen, it uses prostaglandin H2 (PGH2) to catalyze either an isomerization reaction to fo
68         TBXAS1 metabolizes prostaglandin H2 (PGH2), a cyclooxygenase (COX) product of arachidonic aci
69 arachidonic acid (AA) into prostaglandin H2 (PGH2).
70 ostaglandin E2 (PGE2) from prostaglandin H2 (PGH2).
71 und I and compound II observed with EtOOH in PGH2 synthase II suggest that peroxidative cleavage is n
72  mutations in TBXAS result in an increase in PGH2 availability for other PG synthases.
73 bit the enzyme, and that diclofenac inhibits PGH(2) but not 15-hydroperoxyeicosatraenoic acid formati
74 ently converted to the unstable intermediate PGH2 by cyclooxygenase-2 (COX-2), and PGH2 undergoes an
75 e nonacetylated partner monomer forms mainly PGH(2) but only at 15 to 20% of the rate of native huPGH
76 n the presence of an enzyme that metabolizes PGH(2).
77 athways leading to LTB(4) and LTC(4) but not PGH(2) biosynthesis.
78 trated their formation after coincubation of PGH(2) with synthetic peptides and proteins.
79 and specifically catalyzes the conversion of PGH(2) to PGE(2).
80  from the bound NADPH to the endoperoxide of PGH(2) without the participation of specific amino acid
81 , respectively, of the rates of formation of PGH(2) by native PGHS-2.
82                                 Formation of PGH(2) involves an initial oxygenation of arachidonate t
83  PGI synthases catalyze the isomerization of PGH(2)-G at rates approaching those observed with PGH(2)
84 tion than at catalyzing the isomerization of PGH(2)-G.
85 tion data, a putative catalytic mechanism of PGH(2) 9,11-endoperoxide reductase of PGFS is proposed.
86        To examine the catalytic mechanism of PGH(2) 9,11-endoperoxide reductase, a crystal structure
87 y that these functions include metabolism of PGH(2) to PGE(2).
88  this study, we assessed whether reaction of PGH(2) with arginine yielded covalent adducts.
89 quivalent to the enzymatic transformation of PGH(2) to PGD(2).
90 hat specifically catalyzes the conversion of PGH2 to PGE2.
91 ) s(-1); the rate of catalytic conversion of PGH2 to TXA2 or MDA was at least 15,000 s(-1) and the lo
92 ting the prostaglandin pathway downstream of PGH2 synthesis and avoiding suppression of antithromboti
93           An important structural feature of PGH2 formed by COX is the trans-configuration of side ch
94  PGE synthases catalyze the isomerization of PGH2 into PGE2.
95 nthase (PGES) catalyzes the isomerization of PGH2 to PGE2.
96 tic function of PGIS in the isomerization of PGH2 to prostacyclin.
97                        Further metabolism of PGH2-EA and PGH2-G by prostaglandin synthases produces a
98                          During reactions of PGH2 synthase I with arachidonic acid (AA) and ethyl hyd
99                 However, during reactions of PGH2 synthase II with EtOOH, compound I and compound II
100 ter reaction of levuglandin E(2) (LGE(2)) or PGH(2) with lysine.
101  that recombinant Lac1 does not modify AA or PGH(2), but does have a marked activity toward PGG(2) co
102 gation response stimulated by thromboxane or PGH2 analogs.
103  of arachidonic acid to the PGI(2) precursor PGH(2) or other eicosanoids likely results in TP recepto
104 g that Cyp2c44 metabolized the PG precursor, PGH(2) to 12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid
105  isomerization of the cyclooxygenase product PGH(2) into PGE(2).
106  the endocannabinoid-derived COX-2 products, PGH(2)-G and PGH(2)-EA.
107 ynthase catalyzes an isomerization reaction, PGH(2) to PGE(2).
108 ironment, was used to interact with a stable PGH(2) analog,.
109 impact to facilitate their common substrate, PGH(2), across the membrane into their active sites from
110 ure of the unstable TXAS and PGIS substrate, PGH(2).
111 ormation of PGF(2)(alpha) from PGH(2) by the PGH(2) 9,11-endoperoxide reductase activity and 9alpha,1
112 Data Bank suggests that IMN can fit into the PGH(2) binding site in various proteins.
113 the E(cat) subunit actively oxygenates AA to PGH(2).
114 PGHS)-1 and -2 oxygenate arachidonic acid to PGH(2), the precursor to PGs and thromboxane.
115 ses (COXs), convert arachidonic acid (AA) to PGH2.
116 nase-2 (COX-2), converts arachidonic acid to PGH2 PGHS-2 is a conformational heterodimer composed of
117 talyze the conversion of arachidonic acid to PGH2.
118 ey step in the conversion of arachidonate to PGH2, the immediate substrate for a series of cell speci
119 HS peroxidase (POX) activity reduces PGG2 to PGH2.
120 en and a peroxidase that reduces the PGG2 to PGH2.
121                              Aspirin-treated PGH2 synthase II was found to produce 15-HETE, and the a
122                However, when aspirin-treated PGH2 synthase II was reacted with AA, a unique spectral
123                         When aspirin-treated PGH2 synthase II was reacted with EtOOH, a normal peroxi
124 btained for the bicycloendoperoxides U44069, PGH2, and U46619 (Ki = 29-39 nM).
125 )-G at rates approaching those observed with PGH(2).
126  with heme ligands in binding study and with PGH2 in enzymatic study.
127        Incubations of cells carried out with PGH2 demonstrated that PGE2 synthase activity was increa
128                        During reactions with PGH2 synthase II with AA, compound I and compound II wer
129 nal absorbance changes upon mixing TXAS with PGH2, indicating minimal accumulation of any heme-derive

 
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