ライフサイエンスコーパス: PHI

1 PHI and VIP inhibited proliferation at concentrations as

2 PHI appeared infrequently within the corpus of reports s

3 PHI could change according to the application time, beca

4 PHI manifested with typical ARS in 202 (70%) and with at

5 PHI scores were measured in men undergoing re-biopsy wit

6 PHI-base () is devoted to the identification and present

7 PHI-base also curates literature describing specific gen

8 PHI-base contains expertly curated molecular and biologi

9 PHI-base data is disseminated to UniProtKB, FungiDB and

10 PHI-base is the first on-line resource devoted to the id

11 PHI-base is therefore an invaluable resource for the dis

12 PHI-base phenotypes were mapped via their associated gen

13 PHI-base provides phenotypic annotation and genotypic in

14 PHI-base version 4.17 is freely available at and PHI-bas

15 PHI-base will migrate to a new gene-centric version (ver

16 PHI-BLAST is applied to the analysis of CED4-like cell d

17 PHI-BLAST searches a protein database for other instance

18 epeat (NHR) that is exposed within the HIV-1 PHI and toward CD4, the HIV-1 receptor on T cells.

19 ), which is transiently exposed in the HIV-1 PHI, exhibit enhanced broad neutralization in cells expr

20 In the review, we applied the tool to 26 PHIs that included 163 components.

21 At a threshold of >/=35, PHI + mpMRI demonstrated a NPV of 0.97 for excluding sig

22 Samples from 14 healthy donors (HDs), 40 PHI patients, 17 Chronics, and 13 Elite controllers (ECs

23 C-PS and (12)C-PS were also analyzed using a PHI TRIFT I time-of-flight mass spectrometer, with 15-ke

24 Using a PHI>/=35, only 1/21 significant cancers was missed and 3

25 identification of diet and physical activity PHIs; (2) coding of intervention actors and actions; (3)

26 In this study adding PHI to mpMRI improved overall and significant cancer pre

27 After PHI implementation, compared with the clinics with the l

28 The mean outpatient use was higher among PHI recipients compared with non-PHI recipients (mean [S

29 Discovery of PHI-1 and PHI-2 opens new possibilities for regulation of PP1 via

30 base version 4.17 is freely available at and PHI-base version 5.0 is freely available at phi5.phi-bas

31 ferring sites, bivalent VIP/PACAP sites, and PHI-binding sites that did not interact with VIP.

32 ented databases include Enterobase, VFDB and PHI-base.

33 Genes with associated PHI-base data can be easily identified across all plant

34 ere assessed for those who initiated cART at PHI diagnosis.

35 Because PHIs are able to increase erythroblast production at ver

36 se efforts, the pattern-hit initiated BLAST (PHI-BLAST) program described here takes as input both a

37 Tracking of individual FGF2 by PHI in the pericellular matrix of living cells demonstra

38 Furthermore, the calculated PHI values, according to the maximum residue levels set

39 discovery of a new inhibitor protein called PHI-1 that is specific for type-1 protein phosphatase (P

40 ll lines, and a second larger protein called PHI-2 was present in different muscles, especially cardi

41 action in ambient conditions on metal-capped PHI and even with TiO(2)-based systems, rather than the

42 The number of fields that characterize PHI-base entries has almost doubled.

43 The study population comprised PHI patients enrolled in the ANRS-PRIMO-cohort.

44 that contain radiologic images often contain PHI, and this may violate laws, including the U.S. Healt

45 with images, image links, or notes contained PHI.

46 diologic images; 34 (40%) of these contained PHI, and 19 (22%) showed the patient's name.

47 diologic images; 51 (40%) of these contained PHI, and 31 (24%) showed the patient's name.

48 s, or notes, and 52 (36%) of these contained PHI.

49 ipsite zeolite with a Si/Al ratio of 2.5 (Cs-PHI-2.5) are characterized by a rectilinear step shape:

50 nd large size of Cs(+) ions in dehydrated Cs-PHI-2.5.

51 The pathogen-host interaction database (PHI-base) is a web-accessible database that catalogues e

52 sing the Pathogen-Host Interaction database (PHI-base), our previous RNA-seq data and RT-PCR of Pc co

53 for the Pathogen-Host Interactions database (PHI-base) as a case study.

54 The Pathogen-Host Interactions database (PHI-base) catalogues experimentally verified pathogenici

55 05, the Pathogen-Host Interactions Database (PHI-base) has manually curated experimentally verified p

56 The Pathogen-Host Interactions Database (PHI-base) has, since 2005, provided manually curated gen

57 hen performing dissipation studies to define PHI.

58 We report on this framework and describe PHI-Canto, a community curation tool for use by publicat

59 to trigger host responses, we have developed PHI-base.

60 tively enrolled 290 patients with documented PHI in the Zurich Primary HIV Infection Study.

61 reservoir in patients initiating cART during PHI and to assess the impact of the timing of cART initi

62 -lymphocyte (CTL) responses developed during PHI in comparison to CTL responses in chronic infection

63 We included patients enrolled during PHI in the Agence Nationale de Recherche sur le Sida PRI

64 Diagnosing HIV during PHI can markedly reduce transmission by changing transmi

65 known whether temporary ART initiated during PHI has a long-term effect on viral persistence.

66 ths of high-dose zidovudine initiated during PHI results in higher CD4 cell counts and lower PBMC cul

67 voir size) after treatment initiation during PHI.

68 tors that could be associated with RC during PHI.

69 CTL responses during PHI followed clear hierarchical immunodominance patterns

70 ntacts may overestimate transmissions during PHI for real, dynamic sexual partnerships with varying (

71 The fraction of transmissions during PHI has a U-shaped relationship with respect to the rate

72 participants who had been pre-treated during PHI, indicating a long-term suppressive effect of tempor

73 ART initiation in individuals treated during PHI.

74 eks of temporary ART vs. no treatment during PHI, who subsequently (re)initiated ART during chronic H

75 ion of gp41-induced membrane fusion by early PHI conformation and fusion arrest after folding to the

76 P may therefore be associated with the early PHI conformation and FP withdrawal with the final hairpi

77 Okra samples harvested after the estimated PHIs were found safe for human consumption.

78 between level of cognitive decline following PHI and the possession of certain genetic markers that h

79 The breakpoints for PHI and PRHI were 2012.6 (95% confidence interval [CI],

80 Future plans for PHI-base include development of tools facilitating commu

81 of manually curated effector sequences from PHI-Base and used these to train a range of model archit

82 lect, evaluate, and synthesise evidence from PHIs has the potential to advance our understanding of h

83 Disease-Pollution and Health Initiative (GBD-PHI), which aims to work with IHME and the GBD study to

84 very low concentrations of glucocorticoids, PHI-induced stimulation of BFU-E progenitors thus repres

85 wed in the Dat'AIDS cohort; 2027 (10.0%) had PHI and 7314 (36.1%) had PRHI.

86 HIF PHIs represent a novel class of molecules with broad pot

87 11.5 g per deciliter to receive an oral HIF-PHI (daprodustat) or an injectable ESA (epoetin alfa if

88 le factor prolyl hydroxylase inhibitors (HIF-PHIs) are currently under clinical development for treat

89 le factor-prolyl hydroxylase inhibitors (HIF-PHIs).

90 m clinical trials studying the safety of HIF-PHIs.

91 Low vs high PHI use was stratified at the facility level to measure

92 Higher PHI values were found to be due to the polyester present

93 If PHI lasts for 3 months and testing is performed monthly,

94 roscopy and photothermal heterodyne imaging (PHI) show that the spatial distribution of the HS-bindin

95 talytic properties of poly(heptazine imide) (PHI), the microswimmers are activated by both visible an

96 We also describe the unification of data in PHI-base 4 with the data curated from a new curation wor

97 A decrease in PHI (-35.1%) and PRHI (-25.4%) was observed starting in

98 Each entry in PHI-base is curated by domain experts and supported by s

99 Finally, in PHI patients the VL set point was a significant predicto

100 Each gene in PHI-base is presented with its nucleotide and deduced am

101 alysis of the conserved orthologous genes in PHI-base, and the increasing variety of research studies

102 We welcome new data for inclusion in PHI-base, which is freely accessed at www4.rothamsted.bb

103 sample, mean +/- standard deviation) than in PHI patients (0.066 +/- 0.09/VL sample).

104 mpanied by a reduction of about one-third in PHI and PRHI between 2013 and 2017.

105 To identify changes in trends in PHI and PRHI, we used single breakpoint linear segmented

106 he study also found significant variation in PHI uptake, with higher uptake associated with clinics w

107 ad Index (PLI) and the Polymer Hazard Index (PHI).

108 k calculator, and the Prostate Health Index (PHI) as well as derived multiplex 2-gene and 3-gene mode

109 c MRI (mpMRI) and the Prostate Health Index (PHI) have shown promise in predicting a positive biopsy

110 serum biomarker, the Prostate Health Index (PHI), before MRI or biopsy.

111 herapy (ART) during primary HIV-1 infection (PHI) has been proposed to limit the formation of HIV-1 r

112 Primary HIV-1 infection (PHI) is marked by a flu-like syndrome and high levels of

113 an immunodeficiency virus (HIV)-1 infection (PHI) to receive zidovudine, 1000 mg daily, or placebo fo

114 ng acute and recent primary HIV-1 infection (PHI) were determined using a novel high-throughput infec

115 y infected cells in primary HIV-1 infection (PHI) would predict clinical progression and viral replic

116 man immunodeficiency virus type 1 infection (PHI), diagnosed in France (1996-2010).

117 ges of HIV infection: primary HIV infection (PHI) and chronic stage.

118 during (acute/early) primary HIV infection (PHI) and up to one year post-infection (p.i).

119 e the epidemiology of primary HIV infection (PHI) and/or recent HIV infection (patients with CD4 cell

120 within the CNS during primary HIV infection (PHI) has not been characterized.

121 who began ART during primary HIV infection (PHI) investigates which pre- and posttherapy factors bes

122 itiating HAART during primary HIV infection (PHI) or chronic HIV infection (CHI) using flow cytometry

123 jects enrolled during primary HIV infection (PHI), 10 chronically infected subjects (chronic), and 7

124 ing highly infectious primary HIV infection (PHI), we developed a stochastic individual-based model t

125 uman immunodeficiency virus (HIV) infection (PHI) have not been published.

126 uman immunodeficiency virus (HIV) infection (PHI) yields a larger decrease in cell-associated HIV-DNA

127 ly infected patients (primary HIV infection [PHI] group) who started therapy within 6 months of the o

128 categories of protected health information (PHI) in 2503 radiology reports were annotated from a lar

129 oncerns around Protected Health Information (PHI), genetic information is restrictively protected by

130 se or disclose protected health information (PHI).

131 ctivation by a prolyl hydroxylase inhibitor (PHI) synergizes with glucocorticoids and enhances produc

132 exposure to a small molecule PHD inhibitor (PHI) (2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido) a

133 Unlike any other known inhibitor, PHI-1 inhibited the myosin- and glycogen-associated holo

134 Prolyl hydroxylase inhibitors (PHI) promote stabilization of hypoxia-inducible factor-1

135 factor (HIF) prolyl hydroxylase inhibitors (PHIs) are as effective as erythropoiesis-stimulating age

136 Several HIF-prolyl hydroxylase inhibitors (PHIs) induced erythropoietin (epo) expression in vitro a

137 with predominantly penetrating head injury (PHI) suffered more than 30 years ago.

138 s include an early pre-hairpin intermediate (PHI) characterized by extended coiled-coil structure in

139 (NHR) of the HIV-1 prehairpin intermediate (PHI) is highly conserved (>90%) and is inhibited by the

140 he highly conserved prehairpin intermediate (PHI) of class I viral membrane-fusion proteins are gener

141 gnize the conserved prehairpin intermediate (PHI) of class I viral membrane-fusion proteins typically

142 e accessible in the prehairpin intermediate (PHI) state and block the formation of the six-helix bund

143 refusion state to a prehairpin intermediate (PHI), while the second phase is marked by transition fro

144 mation known as the prehairpin intermediate (PHI).

145 ce of fluopyram at the pre-harvest interval (PHI) of 7-21 d was between 0.0108 and 0.1603 mg/kg, and

146 degradation rates, the pre-harvest interval (PHI) values and the half-life values of the three pestic

147 The estimated pre-harvest intervals (PHI) for fipronil and difenoconazole were 15 and 19.5day

148 Estimated pre-harvest intervals (PHI) for fipronil were 20.3-27.0 days in sugarcane plant

149 were studied and the pre-harvest intervals (PHIs) were calculated.

150 sidues dissipated with preharvest intervals (PHIs) of 33.5, 12 and 32 days at recommended dose with n

151 c demand of population health interventions (PHIs) might influence how interventions work.

152 irectly curate their own published data into PHI-base.

153 Additional data types included into PHI-base 4 are the direct targets of pathogen effector p

154 implemented the Preventive Health Inventory (PHI) initiative, a multicomponent care management interv

155 A) launched the Preventive Health Inventory (PHI) program-a multicomponent care management interventi

156 (VHA) used the Preventive Health Inventory (PHI), a multicomponent care management intervention, to

157 IR-PHI has a spatial resolution of ~300 nm and can determin

158 Crucially, IR-PHI images show structure that reflects the spatial dist

159 In road dust, IR-PHI analysis reveals the presence of numerous aggregate

160 infrared photothermal heterodyne imaging (IR-PHI) to interrogate single, high aspect ratio Au nanowir

161 infrared photothermal heterodyne imaging (IR-PHI) to simultaneously analyze the chemical and morpholo

162 infrared photothermal heterodyne imaging (IR-PHI).

163 le by the superresolution capabilities of IR-PHI.

164 r near-field optical scanning techniques, IR-PHI experiments are performed under ambient conditions,

165 peptide (VIP), peptide histidine isoleucine (PHI) and gastrin-releasing peptide (GRP).

166 d the level of peptide histidine isoleucine (PHI), a peptide coded for by the same mRNA that encodes

167 peptide (VIP), peptide histidine isoleucine (PHI), and pituitary adenylate cyclase-activating peptide

168 e neuroleukin (NLK)/phosphohexose isomerase (PHI)/maturation factor (MF) polypeptide.

169 The interaction between He atoms and K-PHI is partially originating from charge transfer, as di

170 The potassium salt of polyheptazine imide (K-PHI) is a promising photocatalyst for various chemical r

171 tion data an idealized structural model of K-PHI has been derived.

172 odel we defined an energetically optimized K-PHI structure, in which the K ions are present in the po

173 ly after removal of plasma IgA from 12-month PHI samples: the magnitude of ADCC not only increased af

174 The cDNA sequences of AMF/NLK/PHI/MF found in both human cancer and normal cells were

175 sion, secretion, and distribution of AMF/NLK/PHI/MF in neoplastic and their normal counterpart cells.

176 ochemical visualization has depicted AMF/NLK/PHI/MF to be localized into tubular-like vesicles, diffu

177 No PHI of imidacloprid is required, while for oxamyl it was

178 , 12 and 32 days at recommended dose with no PHI applicable for GA3.

179 igher among PHI recipients compared with non-PHI recipients (mean [SD], 18.4 [27.8] vs 15.1 [24.1] vi

180 80% of PHI enrollment samples and in 100% of PHI 12-month, chronic, and EC samples; it peaked after a

181 ADCC was documented in 80% of PHI enrollment samples and in 100% of PHI 12-month, chro

182 he intrinsic solar energy storage ability of PHI, we establish the concept of photocapacitive Janus m

183 oach was used to evaluate the association of PHI receipt with diabetes and hypertension clinical qual

184 f recall and precision) for each category of PHI.

185 e, we describe the increased data content of PHI-base, plus new database features and further integra

186 linics with the highest and lowest decile of PHI use as of February 2021.

187 The clinics in the highest decile of PHI use completed a mean (SD) of 32 997.4 (14 019.3) not

188 egies to increase detection and diagnoses of PHI.

189 Discovery of PHI-1 and PHI-2 opens new possibilities for regulation o

190 The random distribution of PHI-BLAST alignment scores is studied analytically and e

191 31-45 to 15-23 events; a shorter duration of PHI and/or a lower testing frequency reduces the number

192 f the high infectivity but short duration of PHI, even short-term behavior change can significantly r

193 The types and frequencies of PHI present within the reports were tallied.

194 al suppression was more effective in GALT of PHI patients than CHI patients during HAART.

195 Dates accounted for the majority of PHI found in the dataset of radiology reports (n = 2755

196 ter HIV transmission, though a proportion of PHI patients demonstrate relatively reduced CSF HIV RNA

197 o analyze factors associated with receipt of PHI.

198 The new release of PHI-base Version 4.2 (October 2016) has an increased dat

199 The release of PHI-base version 4.8 (September 2019) contains 3454 manu

200 ), which forms the first complete release of PHI-base version 5.0.

201 The annotators identified 3528 spans of PHI text within the 2503 reports.

202 variety of research studies that make use of PHI-base.

203 The latest version of PHI-base, 4.17, contains a 19% increase in genes and a 2

204 novel tool to classify the agentic demand of PHIs and demonstrate its feasibility within a systematic

205 ding the rationale for further evaluation of PHIs, in the prevention and treatment of acute GVHD.

206 n in the 3 months after infection depends on PHI duration and testing frequency.

207 One PHI, FG-2216, was further tested in a nonhuman primate m

208 vels of CSF inflammation lower than in other PHI participants but higher than in HIV-seronegative con

209 onstrate potent regulatory actions of PACAP, PHI, and VIP on neuroblastoma cell proliferation which a

210 ding experiments using 125I-labeled PACAP27, PHI, and VIP, demonstrated the presence of PACAP-preferr

211 h stages on the Pre-harvest Interval Period (PHI).

212 st interaction phenotype are also presented. PHI-base is invaluable for comparative analyses and for

213 mediated by CPI-17 and its related proteins, PHI, KEPI, and GBPI, are discussed.

214 ized a NiV heptad repeat peptide to quantify PHI formation and the half-lives (t(1/2)) of the first a

215 largely due to an enhanced dynamic response (PHId), and a more than twofold improvement in glucose to

216 Here we describe a revised PHI-base Version 4 data platform with improved search, f

217 ort study found that implementation of VHA's PHI was associated with improved care quality of care fo

218 In this cohort study of the VHA's PHI, patients with higher CAN scores and more outpatient

219 Furthermore, several PHIs induced fetal hemoglobin (HbF) expression in primar

220 ring the responses of patients treated since PHI and showing a similar virological and immunological

221 As such, PHI-base is a valuable resource for the discovery of can

222 Recombinant tagged PHI-1 was phosphorylated by protein kinase C at two site

223 Immunoblotting showed that PHI-1 was expressed in most animal tissues and several c

224 The PHI can be captured with peptides that mimic F's heptad

225 The PHI participants (median 77 days post transmission) had

226 The PHI was assessed for ability to add value to mpMRI in pr

227 critical loading of CO(2) , which allows the PHI framework to relax to its wide pore form and enables

228 lster efforts to target the gp41 NHR and the PHI for vaccine development.

229 ions are present in the pore and between the PHI-planes.

230 The presentations were examined for the PHI contained on any images, links, or notes pages.

231 econd phase is marked by transition from the PHI to the six-helix-bundle hairpin.

232 imary care clinics that have implemented the PHI.

233 In the PHI cohort, all models were prone to underestimate clini

234 odel demonstrated highest net benefit in the PHI cohort.

235 ghly conserved region of gp41 exposed in the PHI; it is the target of the FDA-approved drug enfuvirti

236 In mpMRI negative men, the PHI again improved prediction of significant cancers; AU

237 ontained the FP and respectively modeled the PHI and hairpin conformations.

238 onstrated clinically relevant utility of the PHI across threshold probabilities of 5-30%.

239 t rejection led us to test the effect of the PHI dimethyl oxalyl glycine (DMOG) in the pathophysiolog

240 Further, 7 day administration of the PHI induced only modest increases in HVR and carotid bod

241 sted by photoelectrochemical analysis of the PHI surface photoreactions, we elucidate the dominantly

242 Use of the PHI varied considerably across clinics.

243 Use of the PHI was associated with increased outpatient care use.

244 with the clinics with the lowest use of the PHI, clinics with the highest use had a larger mean (SD)

245 encountered and the future directions of the PHI-base project are briefly discussed.

246 briefly describe the future direction of the PHI-base project, and some existing problems with the PH

247 ic health record note documenting use of the PHI.

248 o associated with pathogenicity based on the PHI-base database.

249 er caseloads were more likely to receive the PHI (mean [SD], 778 [231] vs 744 [249] patients; SMD, -0

250 revious year were more likely to receive the PHI.

251 Veterans who received the PHI had higher mean Care Assessment Need (CAN) scores, w

252 eparate cohorts of veterans who received the PHI intervention (from 8434 [statin therapy] to 97 695 [

253 dy cohort, of whom 389 757 (9%) received the PHI.

254 ,g)), disrupts the trimer and sequesters the PHI through the formation of heterotrimers.

255 In summary, the PHI adds predictive performance to image-guided detectio

256 pport for vaccine strategies that target the PHI by eliciting antibodies against the gp41 NHR and sup

257 se preventable care use, suggesting that the PHI may serve as a model for population health approache

258 The data obtained indicated that the PHI-inhibitory and PACAP-stimulatory activities were med

259 Veterans who received care using the PHI tool had a lower probability of poor diabetes contro

260 who received or did not receive care via the PHI.

261 project, and some existing problems with the PHI-base curation process.

262 The PHIs successfully minimised residue problems as observed

263 pport for the Frictionless Data framework to PHI-base 4 datasets, new ways of sharing interaction dat

264 ST search function is provided and a link to PHI-Canto, a tool for authors to directly curate their o

265 n this article, we describe major updates to PHI-base.

266 psis, is structurally related to the tobacco PHI-1 gene, which is re-activated in cultured cells foll

267 , 0.66 using the risk calculator, 0.77 using PHI, 0.76 using the derived multiplex 2-gene model, 0.72

268 dentifying members of this superfamily using PHI-BLAST.

269 ement study of the implementation of the VHA PHI suggests that higher use of a multicomponent care ma

270 ection of a peptide cocktail containing VIP, PHI, GRP.

271 , isoproterenol did not alter levels of VIP, PHI, or VIP-PHI mRNA.

272 the actions of exogenous VIP on cAMP and VIP-PHI mRNA in neuron-enriched cultures.

273 significantly inhibited the increase in VIP-PHI mRNA that normally occurs.

274 VIP or forskolin also increased VIP-PHI mRNA.

275 nol did not alter levels of VIP, PHI, or VIP-PHI mRNA.

276 ators should know the conditions under which PHI may be accessed for research purposes (ie, with auth

277 ypertension quality measures associated with PHI implementation.

278 tient use and CAN score were associated with PHI receipt in the final model.

279 titioner, and clinic factors associated with PHI receipt.

280 ed randomised population of individuals with PHI.

281 id (CSF) and blood from 96 participants with PHI and compared them with samples from neuroasymptomati

282 ccurred in a large fraction of patients with PHI and were associated with substantial morbidity.

283 ression procedures, we found that those with PHI demonstrated a greater degree of cognitive decline o

284 decline does occur in Vietnam veterans with PHI and it is apparently unrelated to dementia and is de

285 e data curated from a new curation workflow (PHI-Canto), which forms the first complete release of PH