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1                                              PI4K-IIIalpha co-localized with NS5A and double-stranded
2 y, Vps74 (the orthologue of human GOLPH3), a PI4K effector required to maintain residence of a subset
3                                     Although PI4K-IIIalpha siRNAs decreased HCV replication and virus
4 onist-induced phospholipase C activation and PI4K inhibition, but not isolated PtdIns(4,5)P(2) deplet
5 dent of phosphoinositide kinase 3 (PI3K) and PI4K.
6 rum (Pf) phosphatidylinositol-4-kinase beta (PI4K), identified 1,5-naphthyridines with basic groups a
7 versely, lowering PIP2 synthesis by blocking PI4K or using the PIP2 scavengers polylysine or bovine s
8 e-III phosphatidylinositol 4-kinase enzymes (PI4Ks).
9 er-studied phosphoinositide kinase families, PI4K and PIPK, focusing on their functions and relevance
10 l 4-kinase beta (PI4KB) is one of four human PI4K enzymes that generate phosphatidylinositol 4-phosph
11 soform of the recently characterized type II PI4K (PI4KII) family.
12 annel indirectly as a substrate for type III PI4Ks.
13 t of subtype-specific inhibitors of type-III PI4Ks and help to better understand the significance of
14                       Inhibition of type-III PI4Ks with 10 microM wortmannin (Wm) significantly reduc
15 ibits phosphatidylinositol 4-kinase IIIbeta (PI4K) in the human malaria parasite Plasmodium, demonstr
16  chemically distinct agents known to inhibit PI4K, resulted in both an inhibition of agonist-induced
17 , neither LIS1 nor phosphoinositol-4 kinase (PI4K) were detected in any of the purified tagged 3A sam
18 7 cells during manipulations of PI 4-kinase (PI4K) activities.
19 that type III phosphatidylinositol-4-kinase (PI4K) activity is required.
20           We report here that a PI 4-kinase (PI4K) activity previously reported on synaptic vesicles
21 osely related phosphatidylinositol 4-kinase (PI4K) PI4Kbeta1 and PI4Kbeta2 lipid kinases.
22 wo classes of phosphatidylinositol 4-kinase (PI4K), designated as Types II and III, that phosphorylat
23  patches in a phosphatidylinositol 4-kinase (PI4K)-dependent manner.
24       Because phosphatidylinositol 4-kinase (PI4K)-mediated phosphatidylinositol 4-phosphate (PI(4)P)
25 e activity of phosphatidylinositol-4-kinase (PI4K).
26 Plasmodium phosphatidylinositol-4-OH kinase (PI4K)-specific inhibitor KDU691.
27              Phosphatidylinositol 4-kinases (PI4K) catalyze the first step in the synthesis of phosph
28 nlike PI3Ks, phosphatidylinositol 4-kinases (PI4Ks) and phosphatidylinositol phosphate kinases (PIPKs
29              Phosphatidylinositol 4-kinases (PI4Ks) and small guanosine triphosphatases (GTPases) are
30          Two phosphatidylinositol 4-kinases (PI4Ks) have been localized to the Golgi complex in mamma
31 hat distinct phosphatidylinositol 4-kinases (PI4Ks) play important roles at multiple steps in the tra
32  vesicles by phosphatidylinositol 4-kinases (PI4Ks) that produce phosphatidylinositol 4-phosphate (Pt
33 bit type III phosphatidylinositol 4-kinases (PI4Ks).
34 egulation of phosphatidylinositol 4-kinases (PI4Ks).
35 parison of type II and type III PI4-kinases, PI4Ks were not required for HCV entry, and only PI4K-III
36 respect to the kinetic effects of modulating PI4K activity on polarized biosynthetic traffic in MDCK
37 IIalpha, which also accounts for the bulk of PI4K activity in brain extracts, is concentrated at syna
38 er, the structural basis for coordination of PI4K, GTPases, and their effectors is unknown.
39                             Determination of PI4K activity in subcellular fractions of SH-SY5Y cells
40  that the activity of a WT-sensitive form of PI4K, such as PI4Kbeta, is required.
41 ailed study of novel selective inhibitors of PI4K IIIbeta, which exert antiviral activity against a p
42  distribution of the 110-kDa beta isoform of PI4K, as determined by Western blot analysis.
43 zyme results in the arrest of replication of PI4K IIIbeta-dependent viruses.
44                             Dysregulation of PI4Ks and PIPKs has been associated with various maligna
45 dosomal compartments, a process dependent on PI4K activity.
46 Ks were not required for HCV entry, and only PI4K-IIIalpha was required for HCV replication.
47 confirmed that phospholipase C activation or PI4K inhibition greatly reduced I(CRAC) currents.
48 tidylinositol 4-kinases (PtdIns 4-kinases or PI4Ks) are at the apex of the phosphoinsitide cascade.
49 , a type I PITP that stimulates phospholipid PI4K activity for PI(4)P production.
50 and toxicity compared to previous Plasmodium PI4K inhibitors.
51 ups at 8-position, which retained Plasmodium PI4K inhibitory activity but switched primary mode of ac
52 nt firing by proBDNF relies on a p75NTR-Rac1-PI4K pathway.
53           To convert their lipid substrates, PI4Ks must be recruited to the correct membrane compartm
54                              We propose that PI4K-IIIalpha plays an essential role in membrane altera
55 initial HCV RNA translation, suggesting that PI4K-IIIalpha functions at a posttranslational stage.
56 l binding protein (Osbp) or knockdown of the PI4K four wheel drive (fwd) exacerbates the Vps54KO/KO p
57                   We previously reported the PI4K inhibitor PIK93, and this compound has defined key
58            Therefore, the inhibition of this PI4K isoform leads to the arrest of viral replication.
59 ts under dynamic conditions and that various PI4Ks regulate PI(4)P synthesis in distinct cellular com
60 localized PtdIns4P production by the various PI4Ks isoforms in specific cellular compartments.
61                            Pretreatment with PI4K-IIIalpha siRNAs greatly reduced the accumulation of