ライフサイエンスコーパス: PIR

1 PIR also maintains NREF, a non-redundant reference datab

2 PIR can strongly influence the timing of spikes on rebou

3 PIR clones could form DNA-damage-induced RAD51 nuclear f

4 PIR cross-linkers are designed to contain chemical bonds

5 PIR maintains the Protein Sequence Database (PSD), an an

6 PIR technology enabled our team to precisely describe th

7 PIR-1 also regulates the CSR-1 22G-RNA pathway and has c

8 PIR-A and PIR-B are activating and inhibitory Ig-like re

9 PIR-A and PIR-B, paired immunoglobulin-like receptors en

10 PIR-ALN includes 529 alignments that can be used to deve

11 PIR-ALN is currently being distributed as a single ASCII

12 PIR-B coligation with the IgE receptor (FcepsilonRI) inh

13 PIR-B contains four ITIM motifs and is thought to be an

14 PIR-B negatively regulates macrophage functions in respo

15 PIR-B(-/-) BMMphi also produced more nitrite and TNF-alp

16 PIR-B(-/-) bone marrow-derived macrophages (BMMphi) fail

17 PIR-B(-/-) mice have more inflammatory cells in the live

18 PIR-B(-/-) mice were found to be more susceptible to Sal

19 PIR-B-deficient bone marrow eosinophils underwent compar

20 PIR-LAESI offers a 20-30 mum vertical resolution ( appro

21 PIR-LAESI was further used to image the distribution ins

22 PIR-LAESI was used to map the distribution of endogenous

23 PIR-NREF provides a timely and comprehensive collection

24 MBL proteins organized with more than 36 000 PIR superfamilies, 145 000 families, 4000 domains, 1300

25 In 2002, persons with ARED and a PIR of less than 1.50 were significantly less likely tha

26 late innate lung responses to P. murina in a PIR-B-independent manner.

27 e structure of the extracellular domain of a PIR from Plasmodium chabaudi We use structure-guided seq

28 significantly less likely than those with a PIR of at least 5 to report visiting an eye care provide

29 10.4 is shown to recognize an allelic PIR-A/PIR-B determinant on cells from BALB/c but not C57BL/6 m

30 ession could differentially affect the PIR-A/PIR-B equilibrium in different cell lineages.

31 eling to show that this fold is found across PIR proteins from mouse- and human-infective malaria par

32 e receptors (PIRs) that serve as activating (PIR-A) and inhibitory (PIR-B) receptors on B lymphocytes

33 Paired Ig-like receptors of activating (PIR-A) and inhibitory (PIR-B) isoforms are expressed by

34 the paired Ig-like receptors of activating (PIR-A) and inhibitory (PIR-B) types for modifying an IgE

35 rine paired Ig-like receptors of activating (PIR-A) and inhibitory (PIR-B) types, we isolated PIR hom

36 tibody 10.4 is shown to recognize an allelic PIR-A/PIR-B determinant on cells from BALB/c but not C57

37 Although PIR-B's inhibitory pathway has been described, it is unk

38 000 person-years were 1052 (547, 2022) among PIR versus 261 (166, 409) among immune responders; rate

39 In multivariable analysis, PIR was associated with older age and worse immunologica

40 educational attainment (25.2; P = .049) and PIR (21.8; P = .01).

41 phages, two inhibitory receptors, SHPS-1 and PIR-B, are the major proteins binding to the tyrosine ph

42 PIR-A and PIR-B are activating and inhibitory Ig-like receptors on

43 ngs suggest that the disruption of PIR-A and PIR-B balance affects their regulatory roles in host def

44 determine the functional roles of PIR-A and PIR-B in primary bacterial infection, PIR-B-deficient (P

45 PIR allotype are expressed whereas PIR-A and PIR-B molecules bearing the maternal allotype are not.

46 elic expression of the polymorphic PIR-A and PIR-B molecules, and possibly of their human Ig-like tra

47 PIR-A and PIR-B, paired immunoglobulin-like receptors encoded, res

48 Although mast cells produced both PIR-A and PIR-B, PIR-B was found to be preferentially expressed on

49 ired immunoglobulin-like receptors PIR-A and PIR-B.

50 ctivating receptors referred to as PIR-B and PIR-A, respectively.

51 BIT and PIR-B bind preferentially to substrate-trapping mutants

52 1 dephosphorylates specific sites on BIT and PIR-B while protecting other sites from dephosphorylatio

53 membrane potential, endogenous bursting, and PIR properties could be observed in the intact nervous s

54 ession of 2 known ITAM antagonists, CD22 and PIR-B, was suppressed.

55 itory receptors (ILT3 and ILT4 in humans and PIR-B in rodents) and low levels of costimulatory and ad

56 ess with conjugate excitation-inhibition and PIR provides a reinforcing and evolutionarily advantageo

57 omprehensive fragmentation of these PIRs and PIR-labeled cross-linked peptides with low-energy collis

58 ession of PIR-B, an inhibitory receptor, and PIR-A, an activating receptor; demonstrate the requireme

59 When combined, most BVM resistance and PIR mutations acted additively to impair viral replicati

60 f of the inhibitory receptors SIRP1alpha and PIR-B, which in turn recruit the phosphatase SHP-1.

61 onal information, the Swiss-Prot, TrEMBL and PIR protein database activities have united to form the

62 niProt Knowledgebase (Swiss-Prot, TrEMBL and PIR-PSD) using the standardized vocabulary of the Gene O

63 at NBRF.Georgetown.edu, directory [ANONYMOUS.PIR.ALIGNMENT].

64 erived macrophages, masking of PIR-B by anti-PIR mAb or genetic deletion of PIR-B shows significantly

65 The monoclonal anti-PIR antibody 10.4 is shown to recognize an allelic PIR-A

66 Inhibitory receptors such as PIR-B might be used as therapeutic targets for treatment

67 putative activating receptors referred to as PIR-B and PIR-A, respectively.

68 tation-tagged literature corpus developed at PIR was used to evaluate the system for finding phosphor

69 ch as paired immunoglobulin-like receptor B (PIR-B) and their function regulating eosinophil accumula

70 eptor paired immunoglobulin-like receptor B (PIR-B) in the regulation of macrophage function in innat

71 on of paired immunoglobulin-like receptor B (PIR-B), also known as leukocyte immunoglobulin-like rece

72 ficient in paired immunoglobulin receptor B (PIR-B), an inhibitory receptor activated by SFKs, did no

73 gh mast cells produced both PIR-A and PIR-B, PIR-B was found to be preferentially expressed on the ce

74 tatistically significant association between PIR and BMI z score among preterm boys (betaPIR + beta P

75 deleting PIR-A in the recipient or blocking PIR-A binding to donor MHC-I molecules blocks memory and

76 cells were much more likely to display both PIR and autapse-induced firing than GAD2(+) cells, suppo

77 155 000 sequence entries retrieved from both PIR-International and SWISS-PROT databases.

78 Although mast cells produced both PIR-A and PIR-B, PIR-B was found to be preferentially ex

79 death on suppressive ART were calculated by PIR status.

80 abase has been maintained collaboratively by PIR-International, an international association of data

81 ntries into families defined collectively by PIR superfamilies and PROSITE patterns.

82 ine signaling, whereas in hck-/-fgr-/- cells PIR-B was unphosphorylated.

83 Correspondingly, PIR-B was normally expressed on the cell surface of sple

84 zation (MALDI) were performed to corroborate PIR-LAESI images of the exogenous agent.

85 triatum (DMS) and olfactory piriform cortex (PIR).

86 a non-redundant reference protein database, PIR-NREF.

87 rimary bacterial infection, PIR-B-deficient (PIR-B(-/-)) and wild-type (WT) control mice were injecte

88 We demonstrate that deleting PIR-A in the recipient or blocking PIR-A binding to dono

89 We also demonstrate PIR-A3 interaction with the endogenous FcepsilonRIgamma

90 Rigorously designed PIR promotes global learning and local accountability.

91 mplitude or duration of IPSCs desynchronizes PIR activity in a population of TC cells.

92 Here, we show that C. elegans PIR-1 dephosphorylates ppp-RNAs made by cellular RNA-dep

93 e systematic detection of annotation errors, PIR has extended its superfamily concept and developed t

94 The expanded PIR WWW site allows sequence similarity and text searchi

95 in eight children in our cohort experienced PIR despite sustained VS.

96 Consistent with these findings, PIR-B negatively regulated eotaxin-dependent eosinophil

97 indicated that MDSCs genetically ablated for PIR-B (Lilrb3(-/-)) underwent a specific transition to M

98 earched expressed sequence tag databases for PIR relatives to identify chicken expressed sequence tag

99 veral in vitro studies, in vivo evidence for PIR remains scarce.

100 nsight supports a likely shared function for PIR-1 in C. elegans Furthermore, we show that DUSP11 mod

101 uence within this domain of IkappaBalpha for PIR degradation.

102 paBbeta, contained information necessary for PIR degradation, thereby explaining IkappaBalpha selecti

103 bservations point to a nonredundant role for PIR-B in the regulation of leukocyte integrin signaling.

104 suggest a physiological inhibitory role for PIR-B that is regulated by endogenous MHC class I-like l

105 sts of about 800 000 proteins collected from PIR-PSD, SWISS-PROT, TrEMBL, GenPept, RefSeq and PDB, wi

106 nsisting of more than 1 000 000 entries from PIR-PSD, SWISS-PROT, TrEMBL, RefSeq, GenPept, and PDB.

107 any multiple sequence alignment source (e.g. PIR and CLUSTAL formats), and is valuable for revealing

108 At 1 year of VS, 12% had PIR.

109 The criterion with the highest PIR was deemed the one with best performance.

110 The highest PIR was obtained with the progression criterion requirin

111 actor, the conserved RNA-phosphatase homolog PIR-1, is required for the processing of a putative ampl

112 Among girls, an increase in PIR was associated with a statistically significant decr

113 h greater national and global investments in PIR capacity will be required to enable the scaling of e

114 on: diffuse spreading along the sinusoids in PIR-B(-/-) mice vs nodular restricted localization in WT

115 The association between increased PIR and change in BMI z score varied by sex but not by r

116 -A and PIR-B in primary bacterial infection, PIR-B-deficient (PIR-B(-/-)) and wild-type (WT) control

117 urons were either presynaptically inhibited (PIR; 11%) or excited (PER; 8%) when extracellular glucos

118 eptors of activating (PIR-A) and inhibitory (PIR-B) isoforms are expressed by many hematopoietic cell

119 serve as activating (PIR-A) and inhibitory (PIR-B) receptors on B lymphocytes, dendritic cells, and

120 eptors of activating (PIR-A) and inhibitory (PIR-B) types for modifying an IgE antibody-mediated alle

121 eptors of activating (PIR-A) and inhibitory (PIR-B) types, we isolated PIR homologues from a rat sple

122 s, a protein family database that integrates PIR superfamilies and PROSITE motifs.

123 phosphorylated insulin receptor interacting (PIR) domain between the PH (pleckstrin homology) and SH2

124 85-kD molecules exclusively intracellularly; PIR-A and FcRgammac cotransfectants expressed the PIR-A/

125 PIRL ablation with electrospray ionization (PIR-LAESI) mass spectrometry is demonstrated and charact

126 A) and inhibitory (PIR-B) types, we isolated PIR homologues from a rat splenocyte cDNA library.

127 l surface molecules of approximately 120 kD, PIR-A transfectants expressed the approximately 85-kD mo

128 way, an RNA silencing role for the mammalian PIR-1 homolog (dual specificity phosphatase 11 [DUSP11])

129 The Ig-like receptor family member, PIR-B, has been shown to play an inhibitory role in rece

130 In Lyn-deficient mice, PIR-B tyrosine phosphorylation was greatly reduced.

131 beta(2)-microglobulin (beta(2)M) molecules, PIR-B served as a permissive checkpoint for IL-5-induced

132 proximately 25% amino acid identity to mouse PIR.

133 nsmembrane and cytoplasmic domains of murine PIR-A3 showed the ability of PIR-A3 to physically intera

134 The new PIR search systems have proved very useful in providing

135 s, our findings suggest that nonconventional PIR degradation of IkappaBalpha may play a physiological

136 otation databases: Swiss-Prot, TrEMBL, NREF, PIR, Gene Ontology, KEGG, Entrez Gene, GenBank, GenPept,

137 mains of murine PIR-A3 showed the ability of PIR-A3 to physically interact with the FcepsilonRIgamma

138 y suppressing the proapoptotic activities of PIR-A, which were mediated by the Grb2-Erk-Bim pathway.

139 Surprisingly, the inhibitory activity of PIR-B was unimpaired in SHP-1-deficient mast cells.

140 phism data and search tools, the addition of PIR gene superfamily classifications, phenotype data for

141 Applications of PIR technology in host-pathogen interactions will enable

142 PIR-B by anti-PIR mAb or genetic deletion of PIR-B shows significantly impaired recognition of S. aur

143 ld account for the brain state dependence of PIR.

144 d not explain this brain state dependence of PIR.

145 In wild-type (wt) cells dephosphorylation of PIR-B was associated with maximal chemokine signaling, w

146 hese findings suggest that the disruption of PIR-A and PIR-B balance affects their regulatory roles i

147 in rats and mice, yet suggest divergence of PIR regulatory elements during rodent speciation.

148 e findings offer insights into the effect of PIR mutations on the evolution of BVM resistance in PI-e

149 crophage-rich region (MRR) at the expense of PIR DCs.

150 We also assessed expression of PIR-B human homologues (immunoglobulin-like transcript [

151 define the coordinate cellular expression of PIR-B, an inhibitory receptor, and PIR-A, an activating

152 However, the function of PIR-1 in RNAi has remained unclear.

153 The inhibitory function of PIR-B is mediated via its cytoplasmic immunoreceptor tyr

154 Cell surface levels of PIR molecules on myeloid and B lineage cells increased w

155 Eosinophils expressed high levels of PIR-B, and Pirb(-/-) mice displayed increased gastrointe

156 bone marrow-derived macrophages, masking of PIR-B by anti-PIR mAb or genetic deletion of PIR-B shows

157 Here, we examined the mechanisms of PIR degradation by comparing it to the canonical pathway

158 meric receptors to address the mechanisms of PIR-A signaling.

159 ved constitutive tyrosine phosphorylation of PIR-B molecules on macrophages and B lymphocytes, irresp

160 Unexpectedly, tyrosine phosphorylation of PIR-B was not observed in most myeloid and B cell lines

161 by maintaining the tonic phosphorylation of PIR-B.

162 Pearson) version of the annotated portion of PIR 39.

163 data are the first to show the potential of PIR-A3 to deliver activation signals to macrophages and

164 The prevalence of PIR (defined as World Health Organization advanced/sever

165 riments were performed to define the role of PIR-B in the negative regulation of macrophage function

166 To determine the functional roles of PIR-A and PIR-B in primary bacterial infection, PIR-B-de

167 Finally, the phosphorylation status of PIR-B was significantly reduced in MHC class I-deficient

168 Surprisingly, we found that the strength of PIR increased slowly over multiple cycles of synaptic in

169 matically alters the timing and synchrony of PIR.

170 on network and demonstrate the usefulness of PIR technology for precision mapping of functional host-

171 he inhibitory effect of increased glucose on PIR neurons appears to be mediated by a presynaptic gamm

172 s acquired most frequently with either WT or PIR PR.

173 n in the context of either wild-type (WT) or PIR PR, even at high BVM concentrations.

174 R amino acid sequences in a search for other PIR relatives led to the recognition of mammalian Fc rec

175 ates that PIR molecules bearing the paternal PIR allotype are expressed whereas PIR-A and PIR-B molec

176 otein family databases (Blocks + DOMO, Pfam, PIR-ALN, PRINTS, PROSITE, ProDom, PROTOMAP, SBASE, and S

177 he monoallelic expression of the polymorphic PIR-A and PIR-B molecules, and possibly of their human I

178 The rat (ra) PIR-A and raPIR-B cDNA sequences predict transmembrane p

179 ment), and progression-to-improvement ratio (PIR) for each criterion.

180 ntire distributions of poverty-income ratio (PIR) and educational attainment.

181 sessed by using the poverty to income ratio (PIR), were associated with changes in BMI z score among

182 ool) and lower income (poverty income ratio [PIR] <1.00 vs >/= 4.00) were consistently less likely to

183 verse inhibition and postinhibitory rebound (PIR) excitation of the pFRG and postinspiratory feedback

184 ng IPSCs accelerates postinhibitory rebound (PIR) in TC neurons, and that increasing either the ampli

185 Postinhibitory rebound (PIR) is believed to play an important role in the genesi

186 rease in the size of postinhibitory rebound (PIR) occurred with 5-HT application in all three cell ty

187 s 2 excitability and postinhibitory rebound (PIR), for the integrators that are typically used.

188 Many neurons exhibit postinhibitory rebound (PIR), in which neurons display enhanced excitability fol

189 their effect through the inhibitory receptor PIR-B since neutrophils and DCs from pir-b-/- mice were

190 we identify murine-paired Ig-like receptor (PIR)-B, and its human orthologs Ig-like transcript 2 and

191 ma)RIIB, gp49B1 and paired Ig-like receptor (PIR)-B, have shown that the molecules indeed suppress al

192 ated by paired immunoglobulin-like receptors PIR-A and PIR-B.

193 Paired immunoglobulin-like receptors (PIR) are expressed on B cells and macrophages and includ

194 Paired Ig-like receptors (PIR) that can reciprocally modulate cellular activation

195 urine equivalents, paired Ig-like receptors (PIR), contain two additional immunoglobulin domains, but

196 A-type paired immunoglobulin-like receptors (PIR-As) as the MHC-I receptors necessary for the memory

197 al antibodies produced against a recombinant PIR protein identified cell surface glycoproteins of app

198 consists of more than 200,000 non-redundant PIR and SWISS-PROT proteins organized with more than 28,

199 sion consists of about 830 000 non-redundant PIR-PSD, SWISS-PROT, and TrEMBL proteins organized with

200 The p21's PCNA interacting region (PIR), and not its CDK binding domain, is needed to preve

201 in the LN peripheral interfollicular region (PIR), DCs generate more frequent and stable interactions

202 rallel linear (SAM) and isotonic regression (PIR) methods identified 95 and 53 probe sets as dose-res

203 Members of the closely related PIR-1 (phosphatase that interacts with RNA and ribonucle

204 tous are the Plasmodium-interspersed repeat (PIR) proteins, with more than 1,000 variants in some gen

205 ers, including protein interaction reporter (PIR) technologies, enables XL-MS studies on protein stru

206 We used protein interaction reporter (PIR) technology to illustrate how viruses exploit host p

207 us [PLRV]) and protein interaction reporter (PIR), a revolutionary technology that couples a mass spe

208 nker was named protein interaction reporter (PIR).

209 s gap is policy and implementation research (PIR) that aims to produce generalizable evidence on what

210 We derived PARP-inhibitor-resistant (PIR) clones from the human CAPAN1 pancreatic cancer cell

211 , we observed that a PR inhibitor-resistant (PIR) HIV-1 mutant is unable to efficiently cleave the gp

212 luated the interplay between a PI-resistant (PIR) PR and the BVM resistance mutations in Gag.

213 ss-references, Protein Information Resource (PIR) and SWISS-PROT protein sequence database feature ta

214 The Protein Information Resource (PIR) has greatly expanded its Web site and developed a s

215 The Protein Information Resource (PIR) is an integrated public resource of protein informa

216 The Protein Information Resource (PIR) is an integrated public resource of protein informa

217 The Protein Information Resource (PIR) maintains a database of annotated and curated align

218 The Protein Information Resource (PIR) produces the largest, most comprehensive, annotated

219 The Protein Information Resource (PIR) serves as an integrated public resource of function

220 (SIB) and the Protein Information Resource (PIR).

221 (SIB) and the Protein Information Resource (PIR).

222 alence and outcomes of poor immune response (PIR) in children receiving suppressive ART.

223 than proposed for Pre-Industrial Revolution (PIR) conditions has important ecological, biogeochemical

224 These results demonstrate that rhythmic PIR activity is an emergent property of interactions bet

225 ceptors which resemble the six domain rodent PIR as well as the four domain LILR found in other speci

226 Splenocyte PIR-B molecules were constitutively associated with the

227 We studied PIR in the lateral pyloric (LP) neuron of the stomatogas

228 d homodimer associated with the cell surface PIR molecules was identified as the Fc receptor common g

229 FcRgammac chain association for cell surface PIR-A expression; and suggest that the level of FcRgamma

230 a proteasome inhibitor-resistant, now termed PIR, pathway.

231 We conclude that PIR is cell type and brain state dependent and propose t

232 Moreover, we found that PIR degradation of IkappaBalpha and constitutive p50/c-R

233 cortical interneurons support the idea that PIR can serve as a network gamma mechanism.

234 This comparative study illustrates that PIR-LAESI is an ion source for ambient mass spectrometry

235 C57BL/6) F1 hybrid offspring indicates that PIR molecules bearing the paternal PIR allotype are expr

236 Here, we report that PIR can be observed in the dorsomedial entorhinal cortex

237 miniphosphoproteomic approach revealed that PIR-B recruits activating kinases after LTB(4) but not e

238 We further show that PIR-LAESI is capable of desorption ionization of protein

239 Our findings suggest that PIR-1 modulates both Dicer-dependent and Dicer-independe

240 The PIR analysis was most sensitive for detecting transcript

241 The PIR databases and other files are also available by FTP

242 The PIR web site connects data analysis tools to underlying

243 The PIR web site features data mining and sequence analysis

244 The PIR web site features search engines that use sequence s

245 The PIR, in collaboration with the Munich Information Center

246 The PIR-International Protein Sequence Database and other fi

247 n expression could differentially affect the PIR-A/PIR-B equilibrium in different cell lineages.

248 off state, the HAMP is more compact, and the PIR samples a greater breadth of conformations.

249 e the amount of experimental annotation, the PIR has developed a bibliography system for literature s

250 f eye care services; SEP was measured by the PIR and educational attainment.

251 results in cleavage of the gp41 tail by the PIR PR.

252 al ensemble but correspondingly, compact the PIR.

253 sequence database in the public domain, the PIR-International Protein Sequence Database, in collabor

254 sequence database in the public domain, the PIR-International Protein Sequence Database.

255 tation was mapped to At5g18410, encoding the PIR/SRA1/KLK subunit of the ArabidopsisSCAR/WAVE complex

256 As expected, the PIR mutations had no effect on inhibition by BVM; howeve

257 es/macrophages, and mast cells expressed the PIR molecules in varying levels, but T cells and NK cell

258 and FcRgammac cotransfectants expressed the PIR-A/ FcRgammac complex on their cell surface.

259 explaining IkappaBalpha selectivity for the PIR pathway.

260 Sample questions for the PIR research agenda include how to close the gap in the

261 n also be obtained by anonymous FTP from the PIR FTP site at NBRF.Georgetown.edu, directory [ANONYMOU

262 cted with constructs having mutations in the PIR-B cytoplasmic region.

263 ons requiring standardized annotation in the PIR-International Protein Sequence Database was large an

264 nt interrelationships among sequences in the PIR-International Protein Sequence Database, to spread a

265 he standardized annotations appearing in the PIR-International Protein Sequence Database.

266 return with the inverted relationship in the PIR.

267 n and promote database interoperability, the PIR-International employs rule-based and classification-

268 olecular evidence for common ancestry of the PIR and Fc receptor gene families.

269 ing inverted repeats (PIR2), a member of the PIR family of fungal cell wall glycoproteins that protec

270 Stomata of an independent allele of the PIR gene (Atpir-1) showed reduced sensitivity to darknes

271 s. the pFRG and resultant modulations of the PIR in various excited and depressed states, leading to

272 ines but could be induced by ligation of the PIR molecules.

273 resistance was delayed in the context of the PIR PR, and the SP1-A1V mutation was acquired most frequ

274 hway to AME resistance in the context of the PIR PR, we selected for resistance with an HIV-1 isolate

275 The membership of the PIR superfamily, and whether the family includes Plasmod

276 e findings suggest that further study of the PIR-A receptors should be aggressively pursued toward a

277 Release 22.0, (December 1998), of the PIR-ALN database contains a total of 3806 alignments, in

278 ts define the preferential expression of the PIR-B molecules on mast cells and an inhibitory potentia

279 s, we investigated the effect of loss of the PIR-B protein on integrin-mediated signaling in primary

280 Inhibition of the PIR-B signaling pathway promoted MDSC differentiation in

281 n Information Database (JIPID), produces the PIR-International Protein Sequence Database (PSD), the m

282 l system can be used to browse and query the PIR-ALN alignments.

283 dependent RNA polymerase (RdRP) requires the PIR-1 phosphatase.

284 New capabilities for searching the PIR sequence databases include annotation-sorted search,

285 cation in Jurkat T cells associated with the PIR mutations, even in the absence of compound.

286 formationally destabilized compared with the PIR, whereas in the kinase-off state, the HAMP is more c

287 eraction is dependent on Arg(632) within the PIR-A3 transmembrane domain.

288 ped on the basis of their expression of this PIR allelic determinant.

289 y, ANGPTL2 activates dendritic cells through PIR-B-NOTCH signaling and enhances tumor vaccine efficac

290 o the major protein (PDB, SWISS-PROT/TrEMBL, PIR-ALN, NCBI Taxonomy Browser) and literature (PubMed,

291 d in PROSITE and mostly detected from unique PIR sequences.

292 Whereas PIR-B fibroblast transfectants expressed cell surface mo

293 paternal PIR allotype are expressed whereas PIR-A and PIR-B molecules bearing the maternal allotype

294 f splenocytes from FcRgammac-/- mice whereas PIR-A was not.

295 or tyrosine-based inhibitory motifs, whereas PIR-A pairs with the Fc receptor common gamma chain to f

296 ay has been described, it is unknown whether PIR-A receptors can deliver activation signals to macrop

297 ines of evidence supporting a model in which PIR-B displays opposing but potent regulatory functions

298 Factors associated with PIR were assessed using logistic regression.

299 ll rate of AIDS/death was low, children with PIR had a 4-fold increase in risk of event as compared w

300 l education (trend P = .036), and those with PIR 1.00-1.99 (trend P < .001).