ライフサイエンスコーパス: PNA

1 PNA has a much lower helical twist than RNA and the resu

2 PNA is a promising molecule for antisense therapy of tri

3 PNA may be a better choice in situations where mesenchym

4 PNA monomers carrying the modified nucleobases were synt

5 PNA probes are an attractive alternative to DNA and RNA

6 PNA retains its overall conformation while locally there

7 PNA, via insula activity, may relate to arousal in ways

8 PNA-binding proteins may also participate in the pattern

9 PNA/VD3/CpG-laden PLD-MNA was safe and required only 6 t

10 PNAs conjugated to either triantennary GalNAc at the N-t

11 PNAs were designed to inhibit the pathways identified in

12 Among four PNA microcapsule products (PNA-0, PNA-10, PNA-30, and PNA-50 with size 489 +/- 31 um, 480

13 ur PNA microcapsule products (PNA-0, PNA-10, PNA-30, and PNA-50 with size 489 +/- 31 um, 480 +/- 40 u

14 r metabolic activity, indicating that the 3D PNA-10 microcapsule could be suitable to maintain better

15 RNA polymerase alpha subunit (rpoA) using a PNA that was covalently conjugated to five different CPP

16 Probe (CP) and a second hybridization with a PNA Signalling Probe (SP), with a complementary sequence

17 Poly(A) DNA, RNA and peptide nucleic acid (PNA) all form these assemblies.

18 eplacement of dsDNA by peptide nucleic acid (PNA) and the in situ growth of electroactive polymers th

19 creased sensitivity of Peptide Nucleic Acid (PNA) and Xenonucleic Acid (XNA) clamp PCR, enabling dete

20 in vivo application of peptide nucleic acid (PNA) anti-microRNA therapeutics.

21 el and highly specific peptide nucleic acid (PNA) as the recognition element.

22 second one starts from peptide nucleic acid (PNA) building blocks in which nucleobases are already li

23 arbonyl (Fmoc)-guanine peptide nucleic acid (PNA) conjugate with diverse morphology and photoluminesc

24 f pseudo-complementary peptide nucleic acid (PNA) has been evaluated.

25 ockdown, we employed a peptide-nucleic acid (PNA) hybridization assay.

26 RNA analysis utilizing peptide nucleic acid (PNA) hybridization probes.

27 ize using pyrrolidinyl peptide nucleic acid (PNA) immobilized on a magnetic solid support as a captur

28 g blocking primers and peptide-nucleic acid (PNA) oligonucleotide blockers.

29 omplementing (CCCTAA)3 peptide nucleic acid (PNA) probe coupled with cardiac-specific antibody staini

30 equences into a single peptide nucleic acid (PNA) scaffold to enable tunable storage and retrieval of

31 ecular probes based on peptide nucleic acid (PNA) scaffolds for the detection of single-stranded olig

32 nucleic acid (TNA) and peptide nucleic acid (PNA) scaffolds.

33 c platform, exploiting peptide nucleic acid (PNA) sequences as probes.

34 the polymer by using a peptide nucleic acid (PNA) targeting compound.

35 y, mercapto-terminated peptide nucleic acid (PNA) was firstly immobilized onto gold electrode and use

36 The modification of peptide nucleic acid (PNA) with unnatural nucleobases enables the formation of

37 this issue, we tested peptide nucleic acid (PNA), chemically modified RNA and their hybrids with DNA

38 ilding block for a new peptide nucleic acid (PNA), which exhibits excellent DNA binding affinity with

39 exible, self-assembled peptide nucleic acid (PNA).DNA complexes uncovered a well-defined and, surpris

40 imprinted polymers and Peptide nucleic acid (PNAs) were developed as an attractive receptor with appl

41 e neutral backbone of peptide nucleic acids (PNA), our method is based on the design of low electroph

42 ch applications using peptide nucleic acids (PNA), we herein report the chemical synthesis of fluorin

43 study, we describe a peptide nucleic acids (PNA)-based approach to block the ability of HOTAIR to in

44 s functionalized with peptide nucleic acids (PNAs) (templating strand and catalyst-functionalized str

45 pared to DNA and RNA, peptide nucleic acids (PNAs) are chemically stable and have a neutral peptide-l

46 Peptide nucleic acids (PNAs) are DNA analogs that bind with high affinity to DN

47 Peptide nucleic acids (PNAs) are engineered uncharged oligonucleotide analogues

48 Peptide nucleic acids (PNAs) are linear equivalents of DNA with a neutral acycl

49 this problem by using peptide nucleic acids (PNAs) modified with extended nucleobases that form three

50 Peptide nucleic acids (PNAs) present a novel method to target intracellular pat

51 that triplex-forming peptide nucleic acids (PNAs) substituted at the gamma position plus stimulation

52 m to create antisense peptide nucleic acids (PNAs), gene-specific molecules designed to inhibit prote

53 ing oligonucleotides, peptide nucleic acids (PNAs), minor groove binding polyamides, and--more recent

54 plore the assembly of peptide nucleic acids (PNAs), which are short DNA mimics that have an amide bac

55 oposed RNA precursor, peptide nucleic acids (PNAs).

56 e development of peripheral nodal addressin (PNAd)-expressing high endothelial venules and enriched i

57 ukocytes and with peripheral node addressin (PNAd) on high endothelial venules.

58 stability compared to that of unmodified aeg PNA, perhaps due to electronic effects.

59 f 10 base pair long homoduplexes of DNA, aeg-PNA, gamma-PNA, and a heteroduplex of DNA/aeg-PNA with i

60 NA, gamma-PNA, and a heteroduplex of DNA/aeg-PNA with identical nucleobase sequence were measured.

61 ductance value, 0.06G0, was measured for aeg-PNA duplexes with a base stack linker.

62 bilized compared to duplexes of standard aeg-PNA.

63 l nucleobases at Calpha or Cgamma on the aeg-PNA backbone and open up ways to design programmed supra

64 fect (GNA) and pain-related negative affect (PNA).

65 and found that UEA-I and Peanut agglutinin (PNA) have a specific affinity for acinar cells in the mo

66 in from Arachis hypogaea (peanut agglutinin, PNA) as the recognition element.

67 circulating platelet-neutrophil aggregates (PNAs) were found in CypDplt+/+ mice.

68 dy, polymeric nanofibre-integrated alginate (PNA) hydrogel microcapsules were designed using NIM tech

69 majority of the pairwise network alignment (PNA) algorithms do not have MNA counterparts.

70 The results showed that all PNA/DNA, dsRNA and PNA/RNA exhibited strong resistance t

71 with a mixture of powdered peanut allergen (PNA), 1,25-dihydroxyvitamin D(3) (VD3), and CpG.

72 Peanut allergy (PNA) has been reported to be transferred to tolerant rec

73 Prognostication of peanut allergy (PNA) is relevant for early interventions.

74 herapeutic efficacy were evaluated alongside PNA-specific forkhead box P3-positive regulatory T cells

75 with the springtime Pacific/North American (PNA) index.

76 eratures through the Pacific-North American (PNA) teleconnection pattern.

77 ng the doping of N-phenylnaphthalen-2-amine (PNA) or its derivatives into a crystalline 4,4'-dibromob

78 g characterized by protein network analysis (PNA).

79 capsule products (PNA-0, PNA-10, PNA-30, and PNA-50 with size 489 +/- 31 um, 480 +/- 40 um, 473 +/- 5

80 e results showed that all PNA/DNA, dsRNA and PNA/RNA exhibited strong resistance to both soluble DNas

81 In conclusion, GNA and PNA have distinct neural signatures and uniquely contrib

82 While elevated GNA and PNA were both indicative of depression and anxiety disor

83 Thus, UEA-I and PNA appear to be excellent lectins for pancreatic acinar

84 ion, suggesting the influence of the PDO and PNA teleconnections.

85 Prometryn and PNA concentrations were significantly higher at the P-si

86 A (dsDNA), PNA/DNA, dsRNA (modified RNA) and PNA/RNA, were tested and evaluated in terms of DNase res

87 n tons of carbon were lost from both ITs and PNAs (-434 MtC and -423 MtC, respectively), with degrada

88 We find that ITs and PNAs stored more than one-half (58%; 41,991 MtC) of the

89 eficient platelets had fewer neutrophils and PNAs recruited to their brain following stroke relative

90 induced in mice following prenatal androgen (PNA) exposure.

91 is is a potent tool for designing antibiotic PNA.

92 we evaluated a novel MYCN-specific antigene PNA oligonucleotide (BGA002) in MYCN-amplified (MNA) or

93 opropylglycine (apg) backbone (gamma-CF2-apg PNA) have been synthesized and evaluated for biophysical

94 igher compared to that of nonfluorinated apg PNA, with NIH 3T3 cells showing better permeability comp

95 ular uptake of the fluorinated gamma-CF2-apg PNAs in NIH 3T3 and HeLa cells was 2-3-fold higher compa

96 al peptide nucleic acids (bm-Calpha-PNA) are PNAs with two faces and are designed homologues of PNAs

97 rritories (ITs) and protected natural areas (PNAs).

98 in recognition and complex formation between PNA and glycoproteins containing T antigen.

99 a activity mediated the relationship between PNA and task-specific anxious reactivity.

100 gether, these properties establish bilingual PNA as a powerful biopolymer that combines two informati

101 Cgamma-bimodal PNA oligomers that have two nucleobases per aeg unit are

102 A new type of PNA termed bimodal PNA [Cgamma(S/R)-bm-PNA] is designed to have a second nu

103 Bimodal PNAs are first examples of PNA analogues that can form D

104 urrent multiple complex formation by bimodal PNAs with additional nucleobases at Calpha or Cgamma on

105 The conjoined duplexes of Cgamma-bimodal PNAs can be used to generate novel higher-level assembli

106 developed nucleobase-modified dsRNA-binding PNAs (dbPNAs) to facilitate structure-specific and selec

107 A duplexes are more stable than Cgamma(R)-bm-PNA duplexes.

108 The ternary DNA 1:Cgamma(S/R)-bm-PNA:DNA 2 complexes exhibit better thermal stability tha

109 pe of PNA termed bimodal PNA [Cgamma(S/R)-bm-PNA] is designed to have a second nucleobase attached vi

110 the isolated duplexes, and the Cgamma(S)-bm-PNA duplexes are more stable than Cgamma(R)-bm-PNA duple

111 Due to the strand replacement of dsDNA by PNA, dsDNA can be directly detected without sequence-pre

112 e and the somites that is normally formed by PNA-binding proteins that block entry to medial pathways

113 ogistic regression, using data stratified by PNA status and randomly assigned to development and vali

114 NAs dA(8) and dG(6) at neutral pH, bm-Calpha-PNA 1 forms a higher order pentameric double duplex of a

115 The synthesis of bm-Calpha-PNA with homothymine (T(7)) on the t-amide face and homo

116 Such bm-Calpha-PNA with mixed sequences can form double duplexes by sim

117 pha-bimodal peptide nucleic acids (bm-Calpha-PNA) are PNAs with two faces and are designed homologues

118 uplex of a triplex composed of two bm-Calpha-PNA-C(5):dG(5) duplexes built on a core (bm-Calpha-PNA-T

119 5):dG(5) duplexes built on a core (bm-Calpha-PNA-T(7))(2):dA(8) triplex.

120 al as a mimic of nucleosides, carbohydrates, PNA, amino acids, and steroid analogs.

121 ution, compared to conventional non-cationic PNA probes.

122 r-neutral PNA with highly negatively charged PNA-miRNA hybrids.

123 with uncharged PNA and/or negatively charged PNA/miRNA-492 duplex by differential pulse voltammetry.

124 y complexes, the two duplexes share a common PNA backbone.

125 portion of the target DNA by a complementary PNA Capture Probe (CP) and a second hybridization with a

126 an oligomer and its binding to complementary PNA evaluated.

127 ncluding ionic strength, AgNP concentration, PNA concentration, and DNA strand mismatches.

128 er cells and indicate that GalNAc-conjugated PNAs have possible therapeutic applications.

129 scently labeled analogs of GalNAc-conjugated PNAs were internalized by HepG2 cells that express the A

130 es anchored at C(gamma) of three consecutive PNA monomers of N-(2-aminoethyl)glycine (aeg) scaffolds

131 uccessful synthesis of thiouracil-containing PNA.

132 monomers and biophysical studies of derived PNA oligomers containing fluorine in in the acetyl side

133 es a foundation for improving and developing PNAs conjugated to CPPs to better target intracellular p

134 The X-ray crystal structure of the GC di-PNA showed the occurrence of both stacking interactions

135 Only three guanine-containing di-PNAs-CG, GC and GG-could form ordered assemblies, as obs

136 bserved by electron microscopy, and these di-PNAs efficiently assembled into discrete architectures w

137 A-antibiotic interaction with five different PNAs across six combinations.

138 biased nanopore, polyarginine-conjugated DNA-PNA duplexes dehybridize faster than their DNA-PNA count

139 s on DNA-PNA and polyarginine-conjugated DNA-PNA duplexes unzipping inside the alpha-hemolysin nanopo

140 le-stranded overhang, and studied A-form DNA-PNA duplexes to provide additional support for the propo

141 study identifies key particularities of DNA-PNA duplex unzipping as it takes place inside the nanopo

142 In this work, comparative studies on DNA-PNA and polyarginine-conjugated DNA-PNA duplexes unzippi

143 A duplexes dehybridize faster than their DNA-PNA counterparts and proposed a model to describe the du

144 conjugates and (ii) rigid self-assembled DNA.PNA complexes.

145 examples of PNA analogues that can form DNA2:PNA:DNA1 double duplexes via recognition through natural

146 Four duplexes: double-stranded DNA (dsDNA), PNA/DNA, dsRNA (modified RNA) and PNA/RNA, were tested a

147 spondences between networks (obtained during PNA or MNA) are not lost as new networks are added.

148 ied in our transcriptomic analysis, and each PNA was then tested in combination with each carbapenem

149 rk demonstrates the feasibility of employing PNA to selectively recognize the T epitope in glycoprote

150 ilability through endosomal escape, enabling PNA to inhibit miR-122 in vivo.

151 plication for determining MNAs from existing PNAs that addresses all the aforementioned challenges.

152 rm of nonassociative long-term facilitation (PNA-LTF) of the sensorimotor synapses in Aplysia califor

153 We also report the first PNA-PNA duplex containing mismatches.

154 cancer with an aqueous solution of CCAT1 FIT-PNA results in bright fluorescence in a matter of minute

155 In addition, a non-targeted FIT-PNA shows no fluorescent signal after spraying this FIT-

156 o fluorescent signal after spraying this FIT-PNA on fresh tumor tissue emphasizing the specificity of

157 Herein, we have designed FIT-PNAs (forced-intercalation-peptide nucleic acids) to det

158 To these FIT-PNAs, we have introduced the bis-quinoline (BisQ) cyanin

159 report the chemical synthesis of fluorinated PNA monomers and biophysical studies of derived PNA olig

160 LC show higher hydrophobicity of fluorinated PNA oligomers, dependent on the number and site of the f

161 The backbone fluorinated PNAs, which are first in this class, when combined with

162 terminus, it is evident that the fluorinated PNAs have potential to emerge as a new class of PNA anal

163 Fluorous PNA analogues possessing fluorine as inherent part of am

164 ficantly enhanced for prometryn, but not for PNA and TBT, confirming site-specific effects on local p

165 Shorter courses of antibiotic treatment for PNA, UTI, and ABSSSI with bacteremia were not associated

166 ission electron microscopy of ex vivo-formed PNAs revealed a propensity of necrotic platelets to inte

167 The triplex-forming PNAs are unique and potent compounds that hold promise a

168 Among four PNA microcapsule products (PNA-0, PNA-10, PNA-30, and PN

169 Furthermore, PNA-inhibition of bacterial protein synthesis was select

170 modifications may have potential for future PNA-based antisense agents.

171 ue cation-free "basket" formed by the Fmoc-G-PNA conjugate can serve as an attractive component for t

172 plementary gamma-peptide nucleic acid (gamma-PNA) probes conjugated to polystyrene beads have been re

173 air long homoduplexes of DNA, aeg-PNA, gamma-PNA, and a heteroduplex of DNA/aeg-PNA with identical nu

174 of depression and anxiety disorders, greater PNA was more strongly related to task-specific anxious r

175 The uptake of fluorinated homooligomeric PNAs by HeLa cells was as facile as that of nonfluorinat

176 However, PNA/RNA-based tension sensor had low signal-to-noise rat

177 eic acid-fluorescence in situ hybridization (PNA-FISH) probes, P-Ca726 (targeting a novel region of t

178 molecules were introduced to the hybridized PNA/DNA heteroduplexes by employing phosphate-zirconium-

179 lectins, including WGA, Con A, UEA-I, GS-II, PNA and SBA, were monitored in real time and without lab

180 and the Pi electrons of the peptide bonds in PNA.

181 rs apposing GnRH neurons was even greater in PNA mice (56%).

182 ve GABAergic but not glutamatergic inputs in PNA mice.

183 nderscoring the role of platelet necrosis in PNA formation, we observed a significant number of phosp

184 lf-aggregation, which is a common problem in PNA due to its hydrophobic nature.

185 colocalization with progesterone receptor in PNA animals compared with controls.

186 olecular modeling of the modified triples in PNA-dsRNA helix suggested that the modest binding affini

187 ber of phosphatidylserine (PS)+ platelets in PNAs in CypDplt+/+ mice.

188 n contrast, significantly fewer platelets in PNAs were PS+ in CypDplt-/- counterparts.

189 increase in their size, but does not induce PNAd expression.

190 LGA) nanofibres (CPN) were incorporated into PNA hydrogel microcapsule.

191 egg/milk skin prick test (SPT), but no known PNA.

192 an a 6-mer and proceeded fastest for a 5-mer PNA probe.

193 Herein, we demonstrate that a 9-mer PNA forms a sequence-specific PNA-RNA triplex with a dis

194 (pH approximately 6) tumor microenvironment, PNAs were conjugated to pH-low insertion peptide (pHLIP)

195 n the design of low electrophoretic mobility PNA probes, which do not focus under isotachophoresis (I

196 ation (PDO) and Pacific North American mode (PNA).

197 synthesized and incorporated in short model PNA sequences.

198 Moreover, PNA-purified acinar cells were less contaminated with me

199 ellular requirements for transferring murine PNA.

200 t midcontinental climate reflecting negative PNA-like conditions occurred during the Medieval Climate

201 uld retain and concentrate both near-neutral PNA with highly negatively charged PNA-miRNA hybrids.

202 ells was as facile as that of nonfluorinated PNA.

203 Herein, novel PNA-based fluorogenic biosensors have been designed and

204 icant practical and diagnostic advantages of PNA probes over their DNA counterparts for FISH and indi

205 s have potential to emerge as a new class of PNA analogues for applications in functional inhibition

206 leads to the formation of a high density of PNA/DNA heteroduplexes on the electrode surface for the

207 Overall, this novel design of PNA microcapsule and the one-step method of cell encapsu

208 novel role for B cells in the development of PNA and provide evidence that long-lived anti-peanut IgE

209 arameters associated with the development of PNA in 3- to 15-month-olds with likely egg and/or milk a

210 Bimodal PNAs are first examples of PNA analogues that can form DNA2:PNA:DNA1 double duplexe

211 natural nucleobases enables the formation of PNA-RNA triplexes.

212 The formation of PNA/miRNA-492 adduct was evaluated by monitoring the int

213 6 treatments accompanied by lower levels of PNA-specific IgE and intestinal mucosal mast cells and e

214 Using an optimized ratio of PNA with a spacer molecule (MCH), the lowest limit of de

215 morphology, size, and chemical structure of PNA microcapsules in cell culture media.

216 antibody does not result in the transfer of PNA in NA recipients, demonstrating that anti-CD20 antib

217 al requirements for the adoptive transfer of PNA.

218 A new type of PNA termed bimodal PNA [Cgamma(S/R)-bm-PNA] is designed

219 hain at Cgamma on the repeating aeg units of PNA oligomer.

220 Here, we show that the development of PNAd-expressing high endothelial venules within intragra

221 ow the outstanding recognition efficiency of PNAs can be combined with the unique properties of CNTs

222 ith two faces and are designed homologues of PNAs in which each aminoethylglycine (aeg) repeating uni

223 A novel amperometric genosensor based on PNA probes covalently bound on the surface of Single Wal

224 sensitive label-free DNA biosensor based on PNA probes immobilized on a gold electrode was used to d

225 ent for the design of new materials based on PNA self-assembly for nanotechnology applications.

226 In conjunction with our previous work on PNAs fluorinated in backbone and at N-terminus, it is ev

227 Only PNA/DNA-based tension sensor reported cellular forces wi

228 L-selectin N138G after it engages PSGL-1 or PNAd.

229 lated to the Pacific North American pattern (PNA) using a 2100-year-long multi-proxy lake-sediment re

230 This first report on pHLIP-PNA lncRNA targeting solid tumors in vivo suggests a nov

231 esistant ovarian tumor xenografts with pHLIP-PNA constructs suppressed HOTAIR activity, reduced tumor

232 National guidelines for pneumonia (PNA), urinary tract infection (UTI), and acute bacterial

233 250-1350 CE corresponded with drier positive PNA-like conditions, culminating in the staggered abando

234 idization using peptide nucleic acid probes (PNA-FISH) and matrix-assisted laser desorption ionizatio

235 Among four PNA microcapsule products (PNA-0, PNA-10, PNA-30, and PNA-50 with size 489 +/- 31 u

236 mensional plasmonic nanostructure array (Q3D-PNA) to enable an exceptionally sensitive and reproducib

237 he crystal structures of fluorinated racemic PNA monomers reveal interesting base pairing of enantiom

238 +/- 51 um and 464 +/- 35 um, respectively), PNA-10 showed overall suitability for HepG2 growth with

239 uplex and the PNA-RNA heteroduplexes reveals PNA's intrinsic structural properties, shedding light on

240 present the first crystal structures of RNA-PNA duplexes.

241 ng diagnosis or last classified as serologic PNA (<2 years, >=5 kUA/L, otherwise >=14 kUA/L, peanut I

242 rm distribution of PLGA NPs containing short PNA probes in the cytoplasm.

243 stemic delivery of PLGA NPs containing short PNA probes in the mice.

244 ivery of PLGA nanoparticles containing short PNA probes in vivo in a xenograft mouse model following

245 of PLGA nanoparticles (NPs) containing short PNA probes showed significantly superior loading, releas

246 vestigate novel nanoparticle-delivered short PNA probes containing cationic domains targeting the see

247 y based on PLGA nanoparticle delivered short PNA probes for potential cancer therapy.

248 We observed significant PNA-antibiotic interaction with five different PNAs acro

249 With SMAL, PNAs can be combined rapidly to obtain an MNA.

250 e that a 9-mer PNA forms a sequence-specific PNA-RNA triplex with a dissociation constant of less tha

251 glycine (aeg) repeating unit in the standard PNA backbone hosts a second nucleobase at Calpha through

252 A fluorescent sense strand PNA probe binding to RNAi duplex guide strands was coupl

253 Models using stricter or less strict PNA criteria both found Ara h2 as predictive.

254 In such PNA:DNA ternary complexes, the two duplexes share a comm

255 The new 2-thiothymine ((S)T) PNA monomer has also been prepared and incorporated into

256 For proof of concept, we tested PNAs targeting miRNA-155 and employed poly(lactic-co-gly

257 Serial blood sampling confirmed that PNA elicits increased LH pulse frequency and impaired pr

258 Collectively, we confirmed that PNA/DNA hybrid is an accessible material for the synthes

259 g and neutral atmospheres is suggestive that PNAs could be prebiotically feasible on early Earth.

260 The PNA method enables pharmacokinetic analysis of RNAi trig

261 The PNA oligomers containing fluorinated bases form hybrids

262 The PNA probe immobilized on the MNP discriminated between n

263 The PNA scaffold and our synthetic system are highly general

264 sequence of amino acid side-chains along the PNA backbone yields amphiphiles having a "protein code"

265 by using immunofluorescent staining and the PNA-Fish assay, respectively.

266 A comparison of the PNA homoduplex and the PNA-RNA heteroduplexes reveals PNA's intrinsic structura

267 ating a high binding specificity between the PNA used and the complementary DNA.

268 the cone-specific glycocalyx stained by the PNA (peanut agglutinin) lectin marker.

269 The self-assembly is mediated by the PNA-DNA complexation, which results in the formation of

270 luorescence and yellowish-green RTP from the PNA-doped DBBP crystals was also confirmed by Commission

271 aration of the unreacted PNA probes from the PNA-miRNA hybrids and facilitate improvement in LOQ by a

272 PPy, a conducting polymer, to immobilize the PNA probes.

273 the hydrophilic tetrahydrofuran ring in the PNA structure reduces nonspecific interactions and self-

274 as used to incorporate living cells into the PNA microcapsules (~500 um diameter).

275 uired only 6 treatments and one fifth of the PNA adjuvant dose, with improved outcomes when compared

276 A comparison of the PNA homoduplex and the PNA-RNA heteroduplexes reveals PN

277 , stability, and chemical composition of the PNA microcapsules were analysed by light microscopy, flu

278 In FCM-based comparisons of the PNA probes, P-Ca726 was found to be highly specific, sho

279 Type I hydrogel is formed via the PNA/DNA double-helix hybridization.

280 These PNA blockers will facilitate taxonomic profiling of the

281 The performance of these PNA probes was compared quantitatively against that of D

282 Thiolated PNA molecules are firstly self-assembled onto gold elect

283 This PNA-functionalized MNP is potentially useful as an effec

284 al crest cells and pigment localized only to PNA-free areas.

285 is induced as the driving force to transport PNA-beads harboring target miRs to the tip of the pore (

286 Two PNA probe lengths were investigated and the longer probe

287 gonucleotide triple-helix that comprises two PNA sequences and one DNA.

288 otide-templated reaction (EOTR), whereby two PNA probes - functionalized with an aniline and a 1,4-ca

289 Of the two, PNA blockers were the only efficient blocking strategy,

290 vity was facilitated by the use of uncharged PNA probes and large 16S rRNA target and investigations

291 rged ruthenium (III) hexamine with uncharged PNA and/or negatively charged PNA/miRNA-492 duplex by di

292 ohort study of inpatients with uncomplicated PNA, UTI, or ABSSSI and associated bacteremia.

293 strand substitution with DNA and unmodified PNA.

294 ith the CE-based separation of the unreacted PNA probes from the PNA-miRNA hybrids and facilitate imp

295 The primary endpoint was PNA [confirmed/convincing diagnosis or last classified a

296 s and middle frontal gyrus activity, whereas PNA was related to increased bilateral anterior insula a

297 Univariate factors associated with PNA (P < 0.01) included increased AD severity, larger eg

298 Key factors associated with PNA in this high-risk population included lack of breast

299 PLD-MNA was successfully laden with PNA/VD3/CpG powder and capable of epidermal delivery of

300 ng ovarian and breast cancer cell lines with PNAs decreased invasion and increased chemotherapy sensi