ライフサイエンスコーパス: PP1

1 PP1 also associates with NCX1; however, the molecular ba

2 PP1 binds multiple motifs of DNA-PKcs, regulates DNA-PKc

3 PP1 dephosphorylates an Spt5 carboxy-terminal repeat (CT

4 PP1 dephosphorylates key CDC7 and CDK2 kinase substrates

5 PP1 first reactivates PP2A-B55; this enables PP2A-B55 in

6 PP1 inhibition involves metal center oxidation rather th

7 PP1 is delivered by the evolutionarily conserved tail of

8 PP1 pharmacological inhibitors would thus not be able to

9 PP1 plays critical roles in many essential physiological

10 PP1 recruitment to human, mitotic PP2A-B56 holoenzymes a

11 PP1 therefore facilitates the metaphase-to-anaphase tran

12 PP1-mediated dephosphorylation of Mps1 occurs at kinetoc

13 ow are underpinned by protein phosphatase 1 (PP1) activity, the inhibition of which extends readthrou

14 interactions between protein phosphatase 1 (PP1) and its regulator CPI-17, resulted in a reversible

15 vidence suggests that protein phosphatase 1 (PP1) and other protein phosphatases modulate NCC phospho

16 sal in budding yeast, protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) activities have e

17 kinase (PKA) and the protein phosphatase 1 (PP1) and/or PP2A.

18 F1 mutants that block Protein Phosphatase 1 (PP1) binding activated telomeric origins but did not elo

19 domain important for protein phosphatase 1 (PP1) binding.

20 The serine-threonine protein phosphatase 1 (PP1) deactivates this pathway whereas prolonging eIF2alp

21 induced activation of protein phosphatase 1 (PP1) in CRMP2 regulation.

22 nd in Drosophila that Protein Phosphatase 1 (PP1) inactivates Mps1 by dephosphorylating its T-loop.

23 tment of GCs with the protein phosphatase 1 (PP1) inhibitor tautomycin increased phosphorylation of Y

24 (PPP1R1A) is a potent protein phosphatase 1 (PP1) inhibitor; however, its role in tumor development i

25 In particular, protein phosphatase 1 (PP1) is recruited to a DSB-mimicking substrate in Xenopu

26 Protein phosphatase 1 (PP1) limits steady-state phosphorylation of both RyR2 an

27 genetic inhibition of protein phosphatase 1 (PP1) prevented HTTex1 aggregation in both human cells an

28 ly phosphorylates the protein phosphatase 1 (PP1) regulatory subunit myosin phosphatase targeting sub

29 omprising a catalytic protein phosphatase 1 (PP1) subunit in complex with a PPP1R15-type regulatory s

30 Repo-Man is a protein phosphatase 1 (PP1) targeting subunit that regulates mitotic progressio

31 protein that recruits protein phosphatase 1 (PP1) to certain phosphoprotein substrates.

32 eriphery and recruits protein phosphatase 1 (PP1) to chromatin at anaphase onset, in a similar manner

33 cally, Dok3 recruited protein phosphatase 1 (PP1) to dephosphorylate Card9, an essential player in in

34 ting serine/threonine protein phosphatase 1 (PP1) to dephosphorylate eIF2alpha.

35 domain (CTD) recruits protein phosphatase 1 (PP1) to kinetochores to promote timely anaphase onset [1

36 ature localization of protein phosphatase 1 (PP1) to kinetochores, which antagonizes Ipl1-mediated ph

37 Ska complex recruits protein phosphatase 1 (PP1) to kinetochores.

38 IGF-1R by activating protein phosphatase 1 (PP1) to promote dephosphorylation of inhibitory Ser/Thr

39 ed the interaction of protein phosphatase 1 (PP1) with the SR protein splicing factor (SRSF1) to unde

40 tor, whereas purified protein phosphatase 1 (PP1), dephosphorylated Thr-450 in vitro.

41 t Gwl associates with protein phosphatase 1 (PP1), particularly PP1gamma, which mediates the dephosph

42 d) and the associated protein phosphatase 1 (PP1), requiring NMDARcd movement, and persistently reduc

43 The metalloenzyme protein phosphatase 1 (PP1), which is responsible for >=50% of all dephosphoryl

44 are both regulated by protein phosphatase 1 (PP1), which silences the SAC and stabilizes kinetochore-

45 se in the activity of protein phosphatase 1 (PP1).

46 s dephosphorylated by protein phosphatase 1 (PP1).

47 regulatory subunit of protein phosphatase 1 (PP1).

48 activator (PP2A) and protein phosphatase 1 (PP1).

49 is sufficient to bind protein phosphatase 1 (PP1)alpha, a ubiquitously expressed phosphatase in the p

50 ive for a single PPP, protein phosphatase 1 (PP1/PPP1C).

51 mechanism mediated by protein phosphatase-1 (PP1) and dual specificity phosphatase-1 (DUSP1).

52 leasable version of a protein phosphatase-1 (PP1)-disrupting peptide (PDP-Nal) that triggers protein

53 Serine/threonine protein phosphatase type-1 (PP1), a major phosphatase in the heart, consists of a ca

54 1NA-PP1 failed to effectively dock within WT PKCdelta.

55 yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (1NA-PP1) and 1-(tert-butyl)-3-(2-methylbenzyl)-1H-pyrazolo[3

56 onor and for its selective inhibition by 1NA-PP1 and 2MB-PP1.

57 The adenine rings of 1NA-PP1 and 2MB-PP1 matched the adenine ring of ATP when doc

58 highly specific pharmacologic inhibitor (1NM-PP1) of Ret also caused a substantial reduction in pulpa

59 ld be blocked by a protein phosphatase 1/2A (PP1/PP2A) inhibitor and was partly blocked by a NMDA rec

60 yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (2MB-PP1) but not by other 4-amino-5-(4-methylphenyl)-7-(t-bu

61 The adenine rings of 1NA-PP1 and 2MB-PP1 matched the adenine ring of ATP when docked in AS PK

62 its selective inhibition by 1NA-PP1 and 2MB-PP1.

63 erapeutics that selectively target the Ki-67:PP1 and RepoMan:PP1 holoenzymes.

64 nase activity by administration of 1NMPP1, a PP1 derivative, and 2) smooth muscle-specific BDNF knock

65 defined by a covalent bond between TTN and a PP1-specific cysteine residue, Cys127.

66 st that I-2, despite its assumed action as a PP1 inhibitor, is a positive regulator of PP1 function i

67 Our results identify robenidine as a PP1:PPP1R15A-independent cytoprotective compound that ho

68 rse functions, surprisingly acting as both a PP1 inhibitor and as an activator.

69 th a metabolic labeling method, we defined a PP1/2A-sensitive phosphorylation site at Thr-48 in human

70 ctivation of PP2A-B56 by dephosphorylating a PP1-docking site in PP2A-B56, thereby promoting the recr

71 T cells from mice that expressed a PP1 analog-sensitive form of CSK (CskAS) corroborated th

72 horylation through selective disruption of a PP1-PPP1R15A holophosphatase complex.

73 he waning of stress responses and requires a PP1 catalytic subunit and a regulatory subunit, PPP1R15A

74 Ska1 lacking its CTD fused to a PP1-binding peptide or fused directly to PP1 rescues mit

75 4) is induced downstream of ATF4, binds to a PP1-targeting subunit GADD34 at the endoplasmic reticulu

76 reases upon PP1 depletion, consistent with a PP1 function in termination first uncovered in yeast.

77 cal, yet novel mechanism, interacting with a PP1 pocket that is engaged only by these two PP1 regulat

78 C phosphorylation, but little is known about PP1's role and the mechanism regulating its function in

79 tase targeting subunit 1 (MYPT1) to activate PP1 associated with the IGF1R-IRS1 complex.

80 Activated PP1 is sufficient to dephosphorylate at least four IRS1

81 we demonstrate that Rif1 is a high-affinity PP1 adaptor, able to out-compete the well-established PP

82 , whereas WT PKCdelta was insensitive to all PP1 analogs.

83 ed regulation between CaMKII (activator) and PP1 (inhibitor) and then the model performance was valid

84 urning assays with inhibitions of CaMKII and PP1.

85 ugh the interactions of Ng, CaM, CaMKII, and PP1, providing a mechanism to precisely control the sens

86 versal of anomalous changes in circuitry and PP1 gene methylation.

87 cell cycle-dependent association of Gwl and PP1, Gwl and PPP1R3B dissociate in M phase.

88 between kinetochore localization of Ipl1 and PP1, a balance that is essential for accurate meiotic ch

89 ernary complex comprised of SHOC2, MRAS, and PP1 (SHOC2 complex) functions as a RAF S259 holophosphat

90 in-of-function mutations in SHOC2, MRAS, and PP1 that promote complex formation are found in Noonan s

91 uggest that PKA-mediated phosphorylation and PP1/PP2A-dependent dephosphorylation of the alpha2 subun

92 Thus, PNUTS and PP1 together fine-tune the dynamic phosphorylation of DN

93 key target of CTD, independently of PP2A and PP1 activities.

94 main cardiac protein phosphatases, PP2A and PP1.

95 d stabilizes an interaction between RIF1 and PP1 in replicating cells.

96 ich disrupts an interaction between RIF1 and PP1 phosphatase.

97 vity towards its substrates, compared to apo-PP1 or other PP1 holoenzymes.

98 PPP-family phosphatases such as PP1 have little intrinsic specificity.

99 Serine/threonine phosphatases such as PP1 lack substrate specificity and associate with a larg

100 lve the crystal structure of the human ASPP2/PP1 complex and show that ASPP2 recruits PP1 using both

101 ubR1-associated PP2A, unlike KNL1-associated PP1, plays a significant role in end-on conversion.

102 Thus, Astrin-PP1 mediates a dynamic 'lock' that selectively and rapid

103 Abrogating Astrin:PP1-delivery disrupts attachment stability, which is not

104 Constitutive Astrin:PP1-delivery disrupts chromosome congression and segrega

105 itated with PP1-alpha but not with PP1-beta, PP1-gamma1, or PP2A.

106 he ASPP2 SH3 domain can discriminate between PP1 isoforms using an acidic specificity pocket in the n

107 data also reveal that Ki-67 and RepoMan bind PP1 using an identical, yet novel mechanism, interacting

108 NA recognition motif 1 (RRM1) in SRSF1 binds PP1 and represses its catalytic function through an allo

109 cruitment requires the Ska1 CTD, which binds PP1 in vitro and in human HeLa cells.

110 Tautomycetin blocked PP1 activity and abrogated PTH-sensitive phosphate trans

111 lex to kinetochores where Ska1 can bind both PP1 and microtubules to promote anaphase onset.

112 We find that Spc105-bound PP1 is critical for SAC silencing but dispensable for er

113 PPP1R3B bridges PP1 and Gwl association and promotes Gwl Ser-883 dephosp

114 ndirectly by Aurora B, and is antagonized by PP1-mediated dephosphorylation.

115 n of HTTex1 single phosphorylation events by PP1 could constitute an efficient and direct molecular t

116 ibutor to suppression of memory formation by PP1 may provide a novel therapeutic target for memory-re

117 enzymes and the sequences of these conserved PP1-docking motifs suggest that PP1 regulates PP2A-B55 a

118 regulated by CDK1-cyclin B and counteracting PP1 and PP2A family phosphatases through modulation of b

119 Ska1 fusion to catalytically dead PP1 mutant does not rescue and shows dominant negative e

120 The R658C mutation decreases PP1 binding and eIF2alpha dephosphorylation and results

121 1R3B) as a targeting subunit that can direct PP1 activity toward Gwl.

122 remains to be determined how GADD34 directs PP1 to specifically dephosphorylate eIF2alpha.

123 The PNUTS W401A mutation, which disrupts PP1 binding, causes genome-wide acceleration of transcri

124 g PP1, how they distinguish between distinct PP1 isoforms and how the assembly of these two holoenzym

125 -microtubule attachments, how these distinct PP1 functions are coordinated remains unclear.

126 the interaction between PPP1R15A and either PP1 or eIF2alpha in intact cells.

127 s Ser(290) Mutating (257)VPF(259) eliminated PP1 binding and blunted dephosphorylation.

128 hat in anaphase, when the spindle elongates, PP1/Repo-Man promotes the accumulation of NuMA at the co

129 l regulator Phactr1 is a neuronally enriched PP1 cofactor that is controlled by G-actin.

130 vel probes targeting single PPPs, especially PP1.

131 or, able to out-compete the well-established PP1-inhibitor I2 in vitro.

132 During mitotic exit, PP1-dependent dephosphorylation of Gwl Ser-883 occurs pr

133 lso partially in agreement with the extended PP1-binding motif K(V/I)FF-X5-8Phi1Phi2-X8-9-R.

134 M1 metal loading and loss are essential for PP1 regulation in cells, which has broad implications fo

135 n in cells, which has broad implications for PP1 maturation, activity, and holoenzyme subunit exchang

136 This requirement for PP1 is lost in cells expressing CDK1 phosphorylation-def

137 a adaptation pathway by inhibition of Gadd34-PP1 phosphatase with guanabenz protects oligodendrocytes

138 o signalling triggers assembly of the GADD34/PP1 complex in a negative feedback loop to inhibit Yap a

139 tion of the eIF2alpha holophosphatase GADD34:PP1, increases the phosphorylation of eIF2alpha in Schwa

140 However, how PP1 might be regulated in memory is still not clear.

141 2, HR37, and HR46) that in addition to HR40 (PP1) from our previous study, have been determined to ha

142 Together, these results identified PP1-alpha as a regulator of AS160 Thr(642) and Ser(588)

143 Moreover, we identified PP1 regulatory subunit 3B (PPP1R3B) as a targeting subun

144 Reduced PPP1R3A levels impair PP1 targeting and increase phosphorylation of both RyR2

145 in PP1c-R-subunit interactions, which impair PP1 targeting to proteins involved in electrical and Ca(

146 Subcellular heterogeneity in PP1 activity and downstream protein phosphorylation in A

147 , i.e., SDS22 traps metal-deficient inactive PP1.

148 that the major effect of RSK-2 is to inhibit PP1 rather than to directly phosphorylate YB-1 on Ser(10

149 rupting Dok3-Card9 interaction or inhibiting PP1 activity represents therapeutic opportunities to dev

150 erived from the promiscuous kinase inhibitor PP1 to search for analogs that could potentially target

151 We show that a potent Src inhibitor, PP1, regulates expression of genes involved in the G1 to

152 4 at the endoplasmic reticulum, and inhibits PP1 activity to increase eIF2alpha phosphorylation and A

153 (low dose inhibits PP2A; high dose inhibits PP1) delayed AS160 Ser(588) (both doses) and Thr(642) (h

154 e identified PPP1R11, whose product inhibits PP1, as a target of MIR34A.

155 ied by a second metal (M1) being loaded into PP1, as free metal cannot dissociate the complex and M1-

156 estruction of cyclin B and was resolved into PP1-dependent categories with unique sequence motifs.

157 Like PP1, G-actin associated with the functional core of PPP1

158 tivities of major protein phosphatases, like PP1 and PP2A, appear directly or indirectly repressed by

159 that Phactr1 regulates the Slack by linking PP1 to the channel.

160 ortex at mid anaphase, kinetochore-localized PP1-Sds22 helps to break cortical symmetry by inducing t

161 Repo-Man/PP1 regulates the formation of heterochromatin, dephosph

162 After mitosis, Repo-Man/PP1 remains associated with chromatin but its function i

163 Meanwhile PP1, which functions as a phosphatase, is found to media

164 ex that has been previously shown to mediate PP1 targeting to PLN.

165 Moreover, PP1 dephosphorylated NCC in vitro, and the PP1 inhibitor

166 at Drosophila ASPP is part of a multiprotein PP1 complex and that PP1 association is necessary for se

167 stasis by activating Yap through a RhoA/MYPT-PP1 pathway.

168 ther show that platelets activate RhoA-MYPT1-PP1-mediated YAP1 dephosphorylation and promote its nucl

169 pothesized that a direct and functional NCX1-PP1 interaction is a prerequisite for pSer-68-PLM dephos

170 Blockade of TrkA by 1-NM-PP1 enhanced eosinophil spreading on VCAM-1 but inhibite

171 cally inhibit TrkA kinase activity with 1-NM-PP1 in TrkA(F592A)-knock-in (TrkA-KI) eosinophils.

172 cells by the ATP-competitive inhibitor 1-NM-PP1 reproduced the splicing defects and proved that it i

173 d eosinophil migration, additively with 1-NM-PP1, indicating a role for matrix metalloproteases in Tr

174 Furthermore, knockdown of PP1-alpha but not PP1-beta or PP1-gamma1 by small interfering RNA caused g

175 Proteomic analysis uncovered a novel PP1-regulatory subunit (PPP1R3A [PP1 regulatory subunit

176 PPP1R3A is a novel PP1-regulatory subunit within the RyR2 channel complex.

177 ed and enter into anaphase in the absence of PP1 activity.

178 itions even when the levels or activities of PP1 and PP2A are strongly inhibited at kinetochores.

179 Phactr1 mutant that disrupts the binding of PP1 but not that of actin fails to alter Slack currents.

180 ation of Ppp1r3a in mice impaired binding of PP1 to both RyR2 and PLN.

181 2 selectively binds a unique conformation of PP1 that contains a single metal (M2) at its active site

182 Here, we investigate the contribution of PP1, docked on its conserved kinetochore receptor Spc105

183 abilised by spatially-restricted delivery of PP1 near the C-terminus of Ndc80, a core kinetochore-mic

184 Depletion of PP1 impairs NHEJ in both Xenopus egg extracts and human

185 e, p37 negatively regulates this function of PP1, resulting in lower cortical NuMA levels and correct

186 However, identification of PP1 inhibitor-2 as a critical contributor to suppression

187 Depletion or chemical inhibition of PP1 stabilizes cyclin B and results in a pronounced dela

188 orylation of I1 and subsequent inhibition of PP1.

189 to test whether a DCT-enriched inhibitor of PP1, protein phosphatase 1 inhibitor-1 (I1), mediates cA

190 Furthermore, knockdown of PP1-alpha but not PP1-beta or PP1-gamma1 by small interf

191 study, we aimed to analyze the mechanisms of PP1 targeting to the NCX1-pSer-68-PLM complex and hypoth

192 Perturbations of PP1 activity and optogenetic manipulations of cortical a

193 EFb) catalyzes inhibitory phosphorylation of PP1 and PP4 complexes that localize to 3' and 5' ends of

194 The staged recruitment of PP1 (the Dis2 isoform) to the regulatory subunits of the

195 tions lead us to propose that recruitment of PP1 to Spc105/Knl1 is carefully regulated to ensure that

196 2A-B56, thereby promoting the recruitment of PP1.

197 igned to impede MYPT1-mediated regulation of PP1, also decreased TEER in a reversible and non-toxic m

198 a PP1 inhibitor, is a positive regulator of PP1 function in memory formation.

199 ibitor-2 (I-2) is an endogenous regulator of PP1 in hippocampal and cortical neurons.

200 subunit (PNUTS), an inhibitory regulator of PP1, is also recruited to DNA damage sites to promote NH

201 Our findings expand the repertoire of PP1 functions during mitosis and indicate that spatiotem

202 es and microtubules and, instead, depends on PP1 phosphatase and its regulatory subunit Sds22.

203 taining the K(I/V)FF motif, had no effect on PP1 activity in an in vitro assay.

204 Among them, we focus here on PP1.

205 ow they might confer sequence-specificity on PP1.

206 , knockdown of PP1-alpha but not PP1-beta or PP1-gamma1 by small interfering RNA caused greater AS160

207 t switches comprising Cdk9 and either PP4 or PP1 govern pause release and the elongation-termination

208 Other PP1 analogs failed to interact with either AS PKCdelta o

209 Other PP1 targets distant from the endoplasmic reticulum are u

210 its substrates, compared to apo-PP1 or other PP1 holoenzymes.

211 intimate contacts with the composite Phactr1/PP1 surface, which are required for efficient dephosphor

212 tified mouse fibroblast and neuronal Phactr1/PP1 substrates, which include cytoskeletal components an

213 rmined high-resolution structures of Phactr1/PP1 bound to the dephosphorylated forms of its substrate

214 Sequence specificity explains why Phactr1/PP1 exhibits orders-of-magnitude enhanced reactivity tow

215 d spread through the activity of phosphatase PP1 to generate cortical myosin II gradients.

216 ivities of SRPK1 and the protein phosphatase PP1, thereby regulating the phosphoryl content of the RS

217 of the serine/threonine-protein phosphatase PP1-alpha catalytic subunit or protein kinase A activati

218 llosterically inhibiting protein phosphatase PP1:PPP1R15A.

219 ols cortical NuMA levels via the phosphatase PP1 and its regulatory subunit Repo-Man, but it acts ind

220 ional molecule that recruits the phosphatase PP1 to promote the dephosphorylation of pAKT to give AKT

221 Type I protein phosphatase (PP1), in particular, has been shown to constrain learnin

222 nal influence on type I protein phosphatase (PP1), likely resulting in negative regulation of cAMP/ca

223 romatin at anaphase)-associated phosphatases PP1/PP2A.

224 ition of the CDK1-counteracting phosphatases PP1 and PP2A-B55, allowing wide-spread dephosphorylation

225 eletal muscle serine/threonine phosphatases (PP1, PP2A, PP2B, and PP2C) on AS160 dephosphorylation.

226 heckpoint involves two protein phosphatases, PP1 and PP2A-B56, that are thought to extinguish checkpo

227 site-dependent deceleration caused by PNUTS-PP1 and Spt5 dephosphorylation is required to convert Po

228 We report that PNUTS-PP1 phosphatase is a negative regulator of RNA polymeras

229 quire poly(A) site recognition and the PNUTS-PP1 complex, which is in turn necessary for transcriptio

230 te or purified G-actin, which joined PPP1R15-PP1 to form a stable ternary complex.

231 Surprisingly, PPP1R15-PP1 binary complexes reconstituted in vitro lacked subst

232 The abundance of the ternary PPP1R15-PP1-G-actin complex was responsive to global changes in

233 ditional conserved components of the PPP1R15-PP1 phosphatase identified monomeric G-actin.

234 nolide, destabilised the endogenous PPP1R15A-PP1 complex.

235 eutic value of inhibition of the PKA/PPP1R1A/PP1 pathway in the treatment of primary and metastatic E

236 kinase and phosphatase pathway, PKA/PPP1R1A/PP1, in ES pathogenesis.

237 red a novel PP1-regulatory subunit (PPP1R3A [PP1 regulatory subunit type 3A]) in the RyR2 macromolecu

238 MAP) is an endothelial cell (EC)-predominant PP1 regulatory subunit and a member of the myosin phosph

239 A first generation photoproximity probe, PP1, responds to 365 nm light to simultaneously cleave a

240 osome movement, may instead serve to promote PP1 recruitment to kinetochores fully attached to spindl

241 henyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP1) analogs tested, whereas WT PKCdelta was insensitive

242 ditionally show that artificially recruiting PP1 to Spc105/Knl1 before, but not after, chromosome bio

243 form mitotic exit phosphatases by recruiting PP1, how they distinguish between distinct PP1 isoforms

244 PP2/PP1 complex and show that ASPP2 recruits PP1 using both its canonical RVxF motif, which binds the

245 complex, specifically the Ska1 CTD, recruits PP1 to kinetochores to oppose spindle checkpoint signali

246 by the Aurora-B kinase and RepoMan (recruits PP1 onto mitotic chromatin at anaphase)-associated phosp

247 Reduced PP1 targeting was associated with increased phosphorylat

248 sable for error correction; in fact, reduced PP1 docking on Spc105 improved chromosome segregation an

249 ls contribute to AF pathogenesis by reducing PP1 binding to both RyR2 and PLN.

250 nalysis showed that Phactr1 binding remodels PP1's hydrophobic groove, creating a new composite surfa

251 selectively target the Ki-67:PP1 and RepoMan:PP1 holoenzymes.

252 tein kinase II (CaMKII), a process requiring PP1 activity.

253 m different systems have suggested that Rif1-PP1 interaction is conserved and has important biologica

254 Disruption of RRM1-PP1 interactions reduces the phosphorylation status of t

255 Recombinant inhibitor-2 protein (a selective PP1 inhibitor) delayed AS160 dephosphorylation on both p

256 The MRAS-SHOC2-PP1 (SHOC2 phosphatase) complex plays a key role in RAF-

257 ncogenic ERK signaling through the RAS-SHOC2-PP1 phosphatase complex.

258 PKA phosphorylation at Thr35, and subsequent PP1 binding and inhibition, was required for PPP1R1A-med

259 Cofactors can target PP1 to substrates or subcellular locations, but it remai

260 an interaction between NCC and the I1-target PP1.

261 microtubule-dependent polarity landmark Tea4-PP1.

262 lude that female mice lacking the C-terminal PP1-binding domain of PPP1R15A show reduced dietary inta

263 r, but is reversed by artificially tethering PP1 near the C-terminus of Ndc80.

264 part of a multiprotein PP1 complex and that PP1 association is necessary for several in vivo functio

265 Our previous work has elucidated that PP1 inhibitor-2 (I-2) is an endogenous regulator of PP1

266 We show here that PP1 and PP2A-B56 phosphatases are primarily required to

267 f this study was to test the hypothesis that PP1 is dysregulated in paroxysmal atrial fibrillation (P

268 Here, we report that PP1 promotes cyclin B destruction at the onset of anapha

269 tructure of the PP1:TTN complex reveals that PP1 selectivity is defined by a covalent bond between TT

270 ariety of molecular techniques, we show that PP1 catalytic subunit (PP1c) co-localized, co-fractionat

271 Previous studies suggest that PP1 is dysregulated in AF, but the mechanisms are unknow

272 Our findings suggest that PP1 modulates HTTex1 aggregation by regulating phosphory

273 se conserved PP1-docking motifs suggest that PP1 regulates PP2A-B55 and PP2A-B56 activities in a vari

274 , PP1 dephosphorylated NCC in vitro, and the PP1 inhibitor calyculin A increased NCC phosphorylation.

275 characterized AGC-family kinase Ypk3 and the PP1 phosphatase Glc7, whereas TORC2 regulates phosphoryl

276 th its canonical RVxF motif, which binds the PP1 catalytic domain, and its SH3 domain, which engages

277 omain, and its SH3 domain, which engages the PP1 C-terminal tail.

278 Proteomics identified the PP1-regulatory subunit PPP1R3A as a novel RyR2-binding p

279 s of fungal viability in the presence of the PP1 inhibitor.

280 and a targeted oxidative inactivation of the PP1 metal center, that sustains eIF2alpha phosphorylatio

281 mage-inducible protein 34), a subunit of the PP1 phosphatase complex that promotes the dephosphorylat

282 in vitro affecting neither stability of the PP1-PPP1R15A complex nor substrate-specific dephosphoryl

283 Our structure of the PP1:TTN complex reveals that PP1 selectivity is defined

284 Whereas the PP1-binding motif on GADD34 has been defined, it remains

285 MYC on the kinase NUAK1, which acts through PP1 and PNUTS to ensure that splicing keeps up with MYC-

286 combinatorially to tune binding affinity to PP1.

287 PDP-Nal is a 23 mer that binds to PP1 through several interactions.

288 o a PP1-binding peptide or fused directly to PP1 rescues mitotic defects caused by Ska1 depletion.

289 PP1 pocket that is engaged only by these two PP1 regulators.

290 enhance gene expression in other cell types, PP1 activation to relieve IRS1 inhibition may be a more

291 yadenylation signal (CPS) and increases upon PP1 depletion, consistent with a PP1 function in termina

292 easing the phosphorylation levels of various PP1 substrates.

293 which binds NHERF1 through a conserved VxF/W PP1 motif, dephosphorylates Ser(290) Mutating (257)VPF(2

294 us of GADD34 in a region distinct from where PP1 binds to GADD34.

295 escribe a mitotic phosphatase relay in which PP1 reactivation is required for the reactivation of bot

296 bined allosteric/torpedo mechanism, in which PP1-dependent slowing down of polymerases over terminati

297 ting protein of p53) proteins associate with PP1 catalytic subunits and are implicated in multiple fu

298 otic activation of Gwl, its association with PP1 is disrupted in mitotic cells and egg extracts.

299 AS160 was coimmunoprecipitated with PP1-alpha but not with PP1-beta, PP1-gamma1, or PP2A.

300 , we demonstrate the association of DAT with PP1 and PP2A in the mouse brain and heterologous cell sy

301 omosome segregation via its interaction with PP1 at the kinetochore.

302 munoprecipitated with PP1-alpha but not with PP1-beta, PP1-gamma1, or PP2A.