ライフサイエンスコーパス: PP2B

1 PP2B binds immediately downstream of residue 1971.

2 PP2B expression in NG108-15 cells was altered by transfe

3 PP2B independent dephosphorylation contributes to degrad

4 rs and activation of protein phosphatase 2B (PP2B or calcineurin).

5 estingly, disrupting protein phosphatase 2B (PP2B) anchoring to AKAP79/150, known to elevate basal PK

6 nicotinic receptor, protein phosphatase 2B (PP2B) and the tyrosine phosphatase STEP.

7 between calcineurin (protein phosphatase 2B (PP2B) and voltage-operated Ca2+ channels (VOCCs) in NG10

8 in phosphatase 1 and protein phosphatase 2B (PP2B) do not affect pigment movement.

9 was prevented by the protein phosphatase 2B (PP2B) inhibitor cyclosporin A.

10 phosphorylation and protein phosphatase 2B (PP2B)-mediated dephosphorylation of AMPA receptors can d

11 SH1) and calcineurin/protein phosphatase 2B (PP2B).

12 ease in calcineurin [protein phosphatase 2B (PP2B)] and MAP kinase phosphatase-1 (MKP-1) in the VTA.

13 t enzymes, including protein phosphatase 2B (PP2B, also called calcineurin).

14 calcium/calmodulin-dependent phosphatase 2B (PP2B, calcineurin) focuses and insulates termination of

15 MICT1 interacts with protein phosphatase 2B (PP2B, calcineurin) through the docking motif PNIIIT, the

16 rotein kinase C, and protein phosphatase-2B (PP2B/calcineurin) at the postsynaptic membrane of excita

17 bly of greater complexity comprising AKAP79, PP2B, a type II regulatory subunit fragment (RII 1-45) o

18 y (EM) reveals an ensemble of dormant AKAP79-PP2B configurations varying in particle length from 160

19 -360 are necessary and sufficient for AKAP79-PP2B anchoring in cells.

20 that the structural features of this AKAP79-PP2B-binding domain may share similarities with other pr

21 ells that is mediated by casein kinase 2 and PP2B.

22 We identified GSK-3beta and PP2B as effectors of abnormal tau phosphorylation in viv

23 on of Ser845 but also confers a calcium- and PP2B-mediated downregulation to GluR1 receptor currents.

24 ats, PP2A from Saccharomyces cerevisiae, and PP2B from humans.

25 -mediated signaling and attenuates GPCR- and PP2B-mediated signaling, RCS synergistically increases t

26 easing RCS phosphorylation blocked GPCR- and PP2B-mediated suppression of L-type Ca2+ currents in str

27 The phenotypes of GSK3alpha and PP2B knockout mice are similar, prompting us to examine

28 sults suggest that the regulation by PKA and PP2B of phosphorylation of a substrate on mGlu5 and/or o

29 hose phosphorylation is regulated by PKA and PP2B.

30 orylates Bcl2 in vitro compared with PP1 and PP2B; 5) reciprocal immunoprecipitation studies indicate

31 yclosporin A to selectively inhibit PP2A and PP2B activities, respectively, in metabolically competen

32 The protein phosphatases PP2A and PP2B are part of this complex.

33 tases protein phosphatase 1 (PP1), PP2A, and PP2B did not prevent the inhibitory effect of NMDA.

34 ate prevented the decrease in PP1, PP2A, and PP2B levels.

35 d a 50% decrease in levels of PP1, PP2A, and PP2B protein, whereas coadministration of 17beta-estradi

36 t a phosphatase distinct from PP1, PP2A, and PP2B was responsible.

37 the 315-360 region of AKAP79 can antagonize PP2B anchoring in vitro and targeting in transfected cel

38 assing residues 330-357 of AKAP79 attenuates PP2B-dependent down-regulation of GluR1 receptor current

39 der control conditions, are downregulated by PP2B upon stimulation, with the major effect on N-type V

40 both phosphorylation sites was unaltered by PP2B or PP2C inhibitors.

41 Calcineurin (PP2B) is a calcium/calmodulin-activated, serine-threonin

42 PKA) and protein phosphatase 2B/calcineurin (PP2B/CaN) to AMPA receptors to regulate GluR1 phosphoryl

43 naptic calcium accumulation and calcineurin (PP2B) activity.

44 factors attenuate cardiomyocyte calcineurin (PP2B) activity.

45 he Ca2+-dependent activation of calcineurin (PP2B).

46 protein phosphatase-1 (PP1) or calcineurin (PP2B) resulted in elevation of basal Ca(2+) levels in MS

47 e calcium-activated phosphatase calcineurin (PP2B) and the family of transcription factors known as N

48 m-regulated protein phosphatase calcineurin (PP2B) functions as a regulator of gene expression in div

49 almodulin-regulated phosphatase calcineurin (PP2B) is sufficient to induce cardiac hypertrophy that t

50 n-activated protein phosphatase calcineurin (PP2B) plays in modulating cardiac apoptosis after acute

51 on of the tyrosine phosphatase, calcineurin (PP2B).

52 ale mice lacking sperm-specific calcineurin (PP2B), a calcium regulated phosphatase, in testis and sp

53 at was blocked by inhibitors of calcineurin [PP2B (protein phosphatase 2B)], a Ca2+-activated protein

54 ndent phosphoprotein phosphatase calcineurin/PP2B.

55 tau phosphatases, we found that calcineurin/PP2B was downregulated by 30% in pre-symptomatic and 50%

56 ficiently inhibit CpA binding to calcineurin/PP2B phosphatase.

57 ium-dependent phosphatase calcineurin (CaN) (PP2B), which in turn activates the transcriptional facto

58 endent protein phosphatase calcineurin (CaN, PP2B, and PPP3).

59 otein phosphatases--PP1 and calcineurin (CaN/PP2B) or protein kinase C.

60 localization showed that in wild-type cells, PP2B immunoreactivity is uniformly distributed in undiff

61 e the regulatory network of calcineurin (CN)/PP2B, the Ca(2+)-activated phosphatase that recognizes L

62 with other proteins that serve to coordinate PP2B localization and activity.

63 ase anchoring protein 79 (AKAP79) delineates PP2B access to phosphoproteins.

64 lysates with PP2A, but not calcineurin (i.e. PP2B), resulted in disappearance of c-Fos protein and MG

65 complex by generating a second interface for PP2B.

66 y also implicate a novel regulatory role for PP2B/calcineurin in the control of insulin secretion dow

67 79 coordinates two RII 1-45 homodimers, four PP2B heterodimers, and two CaM molecules.

68 ructs containing a full length cDNA of human PP2B beta(3) in sense (CN-15) and antisense (CN-21) orie

69 nly observed activating mechanisms involving PP2B and emerges as a new finely tuned modulation that i

70 se, CAM-dependent protein kinases II and IV, PP2B, and CAM-sensitive phosphodiesterase had no effect

71 L7-PP2B mice were not ataxic and showed proper basic motor

72 Significantly fewer L7-PP2B mice were able to learn the task at long RWs.

73 Trained wild-type mice, but not L7-PP2B mice, showed a net increase in simple spikes and co

74 parallel fiber-to-Purkinje cell synapses (L7-PP2B), to an object localization task with a time respon

75 Those L7-PP2B mice that eventually learned the task made unstable

76 esidues 1965-1971 and displaced PP2A but not PP2B from endogenous Ca(v)1.2 increased basal and isopro

77 phosphatase inhibitor okadaic acid, but not PP2B inhibiter cypermethrin, extended the time course of

78 PP1, PP2A, and PP2C but not PP2B were detected in lysates from Calu-3 cells by immun

79 tribution of AKAP79/150 and PKA-RII, but not PP2B/CaN, from postsynaptic membranes to the cytoplasm i

80 tracellular calcium levels and activation of PP2B and GSK-3 signaling.

81 A from synapses in addition to activation of PP2B/CaN.

82 FK-506 (2 microM), a specific blocker of PP2B, reduced the inhibition of L- and N-type VOCCs indu

83 rylation, by activation of PP1 downstream of PP2B.

84 H2O2 caused an elevation of PP2B and total phosphatase activity.

85 nhibition of PP2A, and to a lesser extent of PP2B, was found to induce an increased phosphorylation o

86 ising intracellular cAMP or by inhibition of PP2B) selectively prevented LTD at resting membrane pote

87 Inhibitors of PP2B specifically reduced the second, microtubule-depend

88 Loss of PP2B results in impaired epididymal sperm maturation and

89 The inhibition of PP2A but not of PP2B also induced phosphorylation of MAP2 at multiple si

90 his region bind directly to the A subunit of PP2B and inhibit phosphatase activity.

91 of AKAP79) that occupies a binding pocket on PP2B utilized by the immunosuppressive drug cyclosporin.

92 Calcineurin, or PP2B, plays a critical role in mediating Ca2+-dependent

93 ase in rod outer segments, but not by PP1 or PP2B.

94 to inhibit protein phosphatase 2A (PP2A) or PP2B.

95 We find that PP2C, but not PP1, PP2A, or PP2B, dephosphorylates the mGluR3 cytoplasmic tail in vi

96 In CN-15-transfected cells overexpressing PP2B, total high-voltage-activated (HVA) VOCCs were supp

97 the calcium/calmodulin dependent phosphatase PP2B and protein kinase C (PKC) to postsynaptic membrane

98 nd the calcium-dependent protein phosphatase PP2B and is linked to the AMPA receptor GluR1 subunit by

99 otein kinase C (PKC) and protein phosphatase PP2B.

100 modulin (CaM)-dependent protein phosphatase (PP2B), and protein kinase C (PKC) for phosphoregulation

101 ly the Ca(2+)-dependent protein phosphatase, PP2B (calcineurin), whereas dephosphorylation of Thr-75

102 ism are strikingly similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which

103 le serine/threonine phosphatases (PP1, PP2A, PP2B, and PP2C) on AS160 dephosphorylation.

104 and Ser/Thr protein phosphatases (PP1, PP2A, PP2B, PP2C alpha, and lambda PP).

105 ll of the invariant motifs of the PP1, PP2A, PP2B, PP4, PP5, and PP6 gene family.

106 r to LTD, AKAP79/150 redistribution requires PP2B/CaN activation and is accompanied by GluR1 dephosph

107 tween residues 337-343 of AKAP79 is the sole PP2B-anchoring determinant sustaining these diverse topo

108 nterrelated functions of GSK3alpha and sperm PP2B are essential during epididymal sperm maturation an

109 These findings indicate that PP2B activity does not influence the expression of HVA C

110 and deletion mutants as an assay to map the PP2B-binding site on AKAP79.

111 normal phosphorylation by inhibition of the PP2B protein phosphatase, calcineurin.

112 e with a chemical inhibitor that targets the PP2B docking motif of MICT1 enhances thermogenesis.

113 ty by PKA and other protein kinases, whereas PP2B can either augment or decrease Ca(v)1.2 currents in