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1                                              PPK associated with PC is extremely painful and compromi
2                                              PPK is specifically expressed in nociceptive, class IV m
3                                              PPK-1 is posteriorly enriched in the one-celled embryo t
4                                              PPK-1 is strongly expressed in the nervous system, and c
5                                              PPKs phosphorylate light-signaling proteins and histones
6 arily synthesized by Polyphosphate Kinase-1 (PPK-1) and regulates numerous cellular processes, includ
7                      Tryptic digests of [32P]PPK contain a predominant 32P-labeled peptide that inclu
8                          Our data identify a PPK-mediated phospho-code on HY5 that integrates the mol
9 scoideum, the social slime mold, possesses a PPK activity (DdPPK1) with sequence similarity to bacter
10 ned spontaneous skin lesions and accelerated PPK development in footpad skin.
11    These data demonstrate that tPA activates PPK in plasma and PKal inhibition reduces cerebral compl
12                                     Although PPK did not form channels on its own, it associated with
13 y detect in vivo physical interactions among PPK and Balboa subunits.
14               The requirement for Balboa and PPK in mechanical nociception behaviors and their specif
15                          Remarkably, another PPK in Dictyostelium discoideum (PPK2) is an actin-relat
16  consistently causes oral lesions as well as PPK-like hyperkeratotic calluses on Krt16(-/-) front and
17 ssion as additional drivers of PC-associated PPK and highlight restoration of KRT9 expression as a wo
18       The defining features of PC-associated PPK are reproduced in mice null for keratin 16 (Krt16),
19 lop footpad lesions that mimic PC-associated PPK, providing an opportunity to decipher its pathophysi
20  - 2) (Equation 4); and autophosphorylation, PPK + ATP --> PPK-P + ADP (Equation 5).
21 dPPK1) with sequence similarity to bacterial PPKs.
22 t for antibiotics, with low toxicity because PPK is not found in higher eukaryotes.
23 pose that asymmetric generation of PIP(2) by PPK-1 directs the posterior enrichment of GPR-1/2 and LI
24 phosphate and for the regeneration of ATP by PPK in the degradosome.
25  of a phosphate from polyphosphate to GDP by PPK to produce GTP was the predominant reaction, the enz
26  However, the molecular pathways impacted by PPK activity and polyP accumulation remain poorly charac
27 terested in the diverse pathways impacted by PPK.
28 tion to identify novel pathways regulated by PPK.
29              Chemical modification of RNA by PPK, for example the addition or removal of 3' or 5' ter
30 brane domain (TMD), G557R and G562R, causing PPK (DSG1(PPK-TMD)) and SAM syndrome (DSG1(SAM-TMD)), re
31 mon mechanism whereby Cx26 mutations causing PPK and deafness transdominantly influence multiple func
32                                 In contrast, PPK was found in sensory dendrites of a subset of periph
33 turnover relative to wildtype DSG1, but DSG1(PPK-TMD) lacked stability, leading to increased turnover
34 in (TMD), G557R and G562R, causing PPK (DSG1(PPK-TMD)) and SAM syndrome (DSG1(SAM-TMD)), respectively
35 -TMD) acts dominant negatively, whereas DSG1(PPK-TMD) is a loss-of-function mutation causing the mild
36                  The gene (ppk) that encodes PPK is highly conserved among many bacterial pathogens,
37 he polyphosphate kinase (ppk) gene, encoding PPK responsible for the synthesis of inorganic polyphosp
38  gamma CSNK-1 and a PIP(2) synthesis enzyme (PPK-1) transduce PAR polarity to asymmetric Galpha regul
39                Once neurons are established, PPK-1 overexpression results in progressive membrane ove
40   Among deletion mutants, some lost all five PPK activities, but others retained partial activity for
41 hich mutations have been identified in focal PPK families who show no increased cancer risk.
42                                 In PC, focal PPK (FPPK) is the most painful and debilitating phenotyp
43              Overall, we show a new role for PPK in lipid A modification during starvation and provid
44       The order of substrate specificity for PPK was: ADP > GDP > UDP, CDP; activity with ADP was 2-6
45 n 4); and autophosphorylation, PPK + ATP --> PPK-P + ADP (Equation 5).
46              By comparison, other hereditary PPKs such as pachyonychia congenita and Olmsted syndrome
47 hanical nociception function for heteromeric PPK and Balboa channels in vivo.
48         Loss of CSNK-1 causes uniformly high PPK-1 levels, high symmetric cortical levels of GPR-1/2
49 ncipal functional unit of the homotetrameric PPK is a dimer.
50 e adverse effects of tPA were ameliorated in PPK (Klkb1)-deficient and FXII-deficient mice and in wil
51 atterns of corneal paraprotein deposition in PPK.
52 imaging feature not previously documented in PPK.
53 a genome-wide analysis of gene expression in PPK-like lesions of Krt16-null mice.
54  and Olmsted syndrome show prevalent pain in PPK lesions.
55              Of the 16 histidine residues in PPK of E. coli, 4 are conserved among several bacterial
56 Follow-up studies reveal a temporal shift in PPK onset in Krt16(-/-) females, coinciding with sex-spe
57 ter tracheal tube formation, with individual PPK genes showing distinct temporal and spatial expressi
58  non-epidermolytic palmoplantar keratoderma (PPK or palmoplantar ectodermal dysplasia type III) is as
59 x26-S183F, causing palmoplantar keratoderma (PPK) and deafness.
60  the skin diseases palmoplantar keratoderma (PPK) and severe dermatitis, multiple allergies, and meta
61                    Palmoplantar keratoderma (PPK) are debilitating lesions that arise in individuals
62  in SLURP1 cause a palmoplantar keratoderma (PPK) known as mal de Meleda.
63 eratin 5), striate palmoplantar keratoderma (PPK), and ichthyosis hystrix Curth-Macklin (different fr
64 utosomal recessive palmoplantar keratoderma (PPK), Mal de Meleda (MdM), which is characterized by dif
65 use, transgradient palmoplantar keratoderma (PPK).
66  de Meleda, a rare palmoplantar keratoderma (PPK).
67 eukokeratosis, and palmoplantar keratoderma (PPK).
68          Painful palmar-plantar keratoderma (PPK) severely impairs mobility in pachyonychia congenita
69                   Palmoplantar keratodermas (PPKs) are a group of disorders that are diagnostically a
70               The palmoplantar keratodermas (PPKs) are a large group of clinically and genetically he
71                 Paraproteinemic keratopathy (PPK) is a rare ocular manifestation of monoclonal gammop
72 nderwent pediatric penetrating keratoplasty (PPK) for herpes simplex virus (HSV) keratitis.
73 ic polyphosphate (poly P) and poly P kinase (PPK), the enzyme principally responsible for its synthes
74                               Poly P kinase (PPK), the enzyme that synthesizes poly P from ATP, is en
75 bolism of poly-P, namely, (i) poly-P kinase (PPK), which synthesizes poly-P reversibly from ATP, (ii)
76 TP is catalyzed reversibly by poly P kinase (PPK, now designated PPK1) initially isolated from Escher
77 coli, polyP is produced by the polyP kinase (PPK) and is thought to play a protective role during the
78  to assess the role of polyphosphate kinase (PPK) in the physiology of Porphyromonas gingivalis, a pp
79 ty of Escherichia coli polyphosphate kinase (PPK) that can convert poly P and ADP to ATP and of a yea
80 ity in the capacity of polyphosphate kinase (PPK) to use inorganic polyphosphate as the donor in plac
81                        Polyphosphate kinase (PPK), encoded by the ppk gene, is the principal enzyme i
82   The ppk gene encodes polyphosphate kinase (PPK), the principal enzyme in many bacteria responsible
83                        Polyphosphate kinase (PPK), the principal enzyme required for the synthesis of
84 nt of the degradosome, polyphosphate kinase (PPK), which catalyses the reversible polymerization of t
85 te (polyP) from ATP by polyphosphate kinase (PPK; EC 2.7.4.1) of Escherichia coli, an N-P-linked phos
86 discovery of at least four distinct kinases (PPKs, CK2, BIN2, and phytochrome itself) and four famili
87                      The ppk mutant, lacking PPK and thus severely deficient in poly P, also fails to
88 ngenita, develop pachyonychia congenita-like PPK.
89             The gene defects underlying many PPKs still need to be resolved to facilitate definitive
90 loss-of-function mutation causing the milder PPK disease phenotype.
91                       In developing neurons, PPK-1 overexpression leads to growth cones that become s
92 amily with severe, diffuse, nonepidermolytic PPK and verrucous hyperkeratotic plaques over the joints
93 rameric state for the autophosphorylation of PPK (Equation 5) at low ATP concentrations.
94                          We report a case of PPK where anterior segment optical coherence tomography
95                          The conservation of PPK among many bacterial pathogens and its absence in eu
96 t with publicly available microarray data of PPK lesions from individuals with PC revealed significan
97 f Krt16-/- mice prevented the development of PPK and normalized redox balance via regeneration of GSH
98             The highly conserved homology of PPK among 18 microorganisms was used to determine import
99  Western blot analysis to quantify levels of PPK and PPX and found that these enzymes differentially
100  hemichannel activity in the pathogenesis of PPK and further highlight an emerging role for Cx43 in g
101  of virulence on poly P and the potential of PPK as a target for antimicrobial drugs.
102 ion of glutathione levels, and prevention of PPK in female Krt16(-/-) mice.
103                      Effective prevention of PPK-like lesions in Krt16-null paw skin (via topical del
104 ity suggests a crucial and essential role of PPK or polyP in bacterial pathogenesis.
105         The predicted amino acid sequence of PPK is 701 residues (81.6 kDa), with 64% identity to tha
106 imaging insights to the clinical spectrum of PPK and underscoring the importance of ophthalmic findin
107 on of dasatinib and extended the survival of PPK tumor-bearing mice (mutant TP53, mutant PDGFRA, H3K2
108 nside a host, the dependence for motility on PPK reveals important roles for poly P in diverse proces
109  shares similar clinical features with other PPKs caused by protease overactivity, including erythema
110 rosophila DEG/ENaC genes, called pickpocket (PPK) genes, we found 9 expressed in the tracheal system.
111 l Drosophila DEG/ ENaC proteins, Pickpocket (PPK) and Ripped Pocket (RPK).
112 Thus, Slurp knock-out mice exhibit polymodal PPK-associated pain that is associated with both immune
113  2 (NRF2)-dependent gene expression precedes PPK onset, which can be prevented by topical sulforaphan
114  the effects of tPA on plasma prekallikrein (PPK) activation and the role of PKal on cerebral outcome
115 treatment fails to activate NRF2 and prevent PPK in female Krt16(-/-) mice despite a similar set of m
116 18 families with autosomal dominant punctate PPK, we report heterozygous loss-of-function mutations i
117                                     Punctate PPKs are characterized by circumscribed hyperkeratotic l
118 onas aeruginosa as well as with the purified PPK from E. coli; the activity was absent from the membr
119  call into question the view that PC-related PPK arises exclusively as a gain-of-function on account
120 ck-out and Slurp2X knock-out, exhibit robust PPK in all four paws.
121                        Promoters for several PPK genes drove reporter gene expression in the larval a
122            Slurp1(-/-) mice developed severe PPK characterized by increased keratinocyte proliferatio
123 raloxifene hydrochloride as a broad-spectrum PPK-1 inhibitor.
124                                     As such, PPKs regulate not only the binding of HY5 to its target
125                          Purified His-tagged PPK was shown to bind RNA, and RNA binding was prevented
126 vation and provide a rationale for targeting PPK to sensitize bacteria towards polymyxin treatment.
127                                 We show that PPK-1 purified from C. elegans can generate PIP(2)in vit
128                     Here, we have shown that PPK onset is preceded by oxidative stress in footpad ski
129                   These results suggest that PPK may be a channel subunit involved in mechanosensatio
130                   These results suggest that PPK may be important for incorporation of these organism
131 s and its absence in eukaryotes suggest that PPK might be an attractive target for antimicrobial drug
132 l microRNA-expressing lines demonstrate that PPKs catalyse blue light-dependent CRY2 phosphorylation
133 analyses of these mutant lines indicate that PPKs may have additional substrates, including those inv
134                       In these families, the PPK is inherited as autosomal dominant and has a late on
135 ced to <5% of the WT; in the ppx mutant, the PPK activity is elevated 10-fold, and the accumulation o
136           The high degree of homology of the PPK sequence in many bacteria, including some of the maj
137 uded 9 eyes; median age at the moment of the PPK was 14 years.
138  in the Drosophila tracheal system where the PPK proteins likely play a role in Na(+) absorption.
139          This reaction was observed with the PPK activity present in crude membrane fractions from Es
140 xpand the genetic testing repertoire for the PPKs.
141        Genetic analyses demonstrate that the PPKs are collectively necessary for the normal light-ind
142                These data establish that the PPKs are directly involved in catalysing the photoactiva
143                                         Thus PPK may prove, as it has with P. aeruginosa, to be an at
144                                        Thus, PPK in the degradosome appears to maintain an appropriat
145 d neuromuscular abnormalities in addition to PPK.
146 ss and dysfunctional NRF2 as contributors to PPK pathogenesis, identify K16 as a regulator of NRF2 ac
147 nit highly similar in amino acid sequence to PPK.
148 entification of therapeutic targets to treat PPK-associated pain.
149    Other sensory-related genes such as TRPs, PPKs and mechanoreceptors had consistent levels of expre
150 have discovered a previously uncharacterized PPK activity (designated PPK2) distinguished from PPK1 b
151 with history of HSV keratitis that underwent PPK and were followed in a single institution.
152       We find here a previously unrecognized PPK (DdPPK2) in D. discoideum with the sequences and pro
153 codependent as balboa-RNAi eliminates Venus::PPK from the sensory dendrites of nociceptors.
154 ly expressed in other neuron subtypes (where PPK is not expressed).
155                  The long-term outcomes with PPK for HSV keratitis in children provide improvement in
156 ribosome biogenesis, suggesting that without PPK, cells remain inappropriately primed for growth even

 
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