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1                                              PTPN1 haploinsufficiency causes a type 1 IFN-driven auto
2                                              PTPN1 is located in 20q13, a genomic region linked to ty
3 ein tyrosine phosphatase nonreceptor type 1 (PTPN1) and PTPN2, whose expression is significantly high
4  show that these perturbations, as well as a PTPN1/PTPN2 inhibitor, sensitize ovarian cancer cells to
5 ators, including SOCS3 (6%), SOCS1 (3%), and PTPN1 (3%).
6   KRAS, GRB2, PCK2, BCL2L1, INSL3, DOK3, and PTPN1 were among the most significantly upregulated gene
7 class, orally bioavailable, potent PTPN2 and PTPN1 active-site inhibitor.
8  The protein tyrosine phosphatases PTPN2 and PTPN1 are central regulators of inflammation, and their
9   We find that constitutive deletion of both PTPN1 and PTPN2 leads to bone marrow hypoplasia and leth
10        Dephosphorylation of the substrate by PTPN1 and PTPN2 obeyed Michaelis-Menten kinetics, with K
11  phosphatase nonreceptor type 1, also called PTPN1) was also identified as a potential proximity fact
12  We replicated the ADO-EGR2, IRF8, and CEBPB-PTPN1 loci by genotyping 969 Iranian cases and 826 contr
13 ee new risk loci, IL1A-IL1B, IRF8, and CEBPB-PTPN1, with genome-wide significance (P < 5 x 10(-8)) by
14 t clusters driven by PRKCB, HLA, SNAI1/CEBPB/PTPN1 and VEGFA/XPO5/POLH hubs.
15                               Loss of either PTPN1 or PTPN2 induced resistance to ALK TKIs in vitro a
16                           Our data establish PTPN1 mutations as new drivers in lymphomagenesis.
17 nes (DEGs), KLF9, AMPK, FOXO3, PTX3, GADD45, PTPN1, CASP7, MAPK4, HSPA12A, and JAK-STAT were probably
18  the first intron of the PTP1B encoding gene PTPN1, correlating with an AR-mediated increase in RNA p
19 erase reporter assay revealed that the genes PTPN1, HOXA1, and TP53I11 were miR-210 target genes regu
20                          Thus, we identified PTPN1 and PTPN2 as ALK phosphatases that control sensiti
21 omic loss-of-function screens, we identified PTPN1 and PTPN2 phosphatases as consistent top hits driv
22 of individuals heterozygous for mutations in PTPN1, encoding the protein-tyrosine phosphatase 1B (PTP
23 ilies who were heterozygous for mutations in PTPN1.
24 ee single nucleotide polymorphisms (SNPs) in PTPN1 were genotyped and assessed for association with I
25  We found ten novel or very rare variants in PTPN1 (frequency on gnomAD version 4.1.0 of <1.25 x 10:s
26                                  Variants in PTPN1 were identified by exome and directed Sanger seque
27                         Genetic variation in PTPN1, a diabetes susceptibility gene, was investigated
28                        This led to increased PTPN1 (PTP1b)-mediated dephosphorylation of VEGFR2 at Y(
29 xample, a genome-wide significant locus near PTPN1 (dog-directed aggression) overlapped with human me
30 with SNPs spanning the 3' end of intron 1 of PTPN1 through intron 8 (P values ranging from 0.043 to 0
31       This comprehensive genetic analysis of PTPN1 reveals significant association with metabolic tra
32 ast, there is no evidence for association of PTPN1 polymorphisms with acute insulin response (a measu
33                  The genetic contribution of PTPN1 to measures of glucose homeostasis has been assess
34 m signaling analysis showed that deletion of PTPN1 or PTPN2 induces resistance to crizotinib by hyper
35 istance to ALK TKIs showed downregulation of PTPN1 and PTPN2 associated with upregulation of SHP2 exp
36  genetic perturbations-including knockout of PTPN1 and ACTR8-that trigger this malignant cell state.
37 sted PTPN1 variants led to reduced levels of PTPN1 mRNA and PTP1B protein, and in-vitro assays demons
38 hed the AR as a transcriptional regulator of PTPN1 transcription and implicated PTP1B in a tumor-prom
39 ilibrium encompassing the coding sequence of PTPN1 were significantly associated with CorCP (P values
40                       Moreover, silencing of PTPN1 by RNA interference in Hodgkin lymphoma cell line
41  effects of miR-210, coordinate silencing of PTPN1, HOXA1, and TP53I11 dramatically decreased tumor c
42 tically inhibited the growth of wild-type or PTPN1/PTPN2 knock-out ALCL, where it reverted TKI resist
43  the EGFR phosphatase PTPN2 (and potentially PTPN1)-via ligation to the PTPN2 active site cysteine si
44  phosphatases, five of which - DUSP6, PPTC7, PTPN1, PTPN13 and PPP3CA - promote differentiation by ne
45 ylated SRC and its regulators CSK and PTP1B (PTPN1) was conducted in 30 synovial sarcomas.
46  The protein-tyrosine phosphatase 1B (PTP1B; PTPN1) is an important regulator of mammalian metabolism
47 S1, CD44, GET4, IL4R, KIAA0226L, MID1, RCC1, PTPN1 and segments of the immunoglobulin loci.
48     In turn, oncogenic ALK and STAT3 repress PTPN1 transcription.
49 ent blood and fibroblasts showed that tested PTPN1 variants led to reduced levels of PTPN1 mRNA and P
50 re coamplified in metastatic tumors and that PTPN1 amplification was associated with a subset of high
51  genes in distinct in vivo contexts and that PTPN1 and PTPN2 have some functional redundancy importan
52                          We demonstrate that PTPN1 mutations lead to reduced phosphatase activity and
53        Mechanistically, we demonstrated that PTPN1 and PTPN2 are phosphatases that bind to and regula
54                                We found that PTPN1 and AR genes were coamplified in metastatic tumors
55                                We found that PTPN1 is also a phosphatase for SHP2, a key mediator of
56                   These results suggest that PTPN1 is a significant contributor to type 2 diabetes su
57                                          The PTPN1 gene codes for protein tyrosine phosphatase 1B (PT
58                                          The PTPN1 gene encodes protein tyrosine phosphatase-1B, whic
59 yrosine phosphatase (PTP)-1B, encoded by the PTPN1 gene, catalyzes the dephosphorylation of proteins
60 ms (SNPs) spanning 161 kb and containing the PTPN1 gene were genotyped and tested for association.
61 0.1 in a single haplotype block covering the PTPN1 genomic sequence show significant association with
62  100-kb haplotype block that encompasses the PTPN1 gene.
63  DNA arrays to genotype 6 SNP markers in the PTPN1 gene and 10 mutations in the cystic fibrosis trans
64 ent somatic coding-sequence mutations in the PTPN1 gene.
65 he 161-kb genomic region, which includes the PTPN1 gene.
66                     We demonstrated that the PTPN1 gene, which encodes PTP1B, was a target of MECP2 a
67 ease in RNA polymerase II recruitment to the PTPN1 transcriptional start site.
68 response of CML cells to imatinib treatment: PTPN1, NF1, SMARCB1, and SMARCE1, and 5 regulators of th