ライフサイエンスコーパス: PUFA

1 PUFA-PIs were identified using spatial lipidomics and de

2 PUFAs and specifically AA trigger a cytokine response of

3 to those from feeding rape (+43% MUFA, +10% PUFA, +40% CLA), combining to produce milk 16% lower SFA

4 , randomized clinical trial adding 1.8 g n-3 PUFA (930 mg eicosapentaenoic acid and 660 mg docosohexa

5 0.66-0.99] for current asthma), and the n-3 PUFA alpha-linolenic acid (OR, 0.78 [95% CI, 0.64-0.95]

6 nderutilized tool that can track dietary n-3 PUFA and elucidate complex metabolic questions.

7 hich enables the endogenous synthesis of n-3 PUFA and increased valvular n-3 PUFA content, exhibited

8 results indicate that dietary long-chain n-3 PUFA and nonfried fish intake are associated with lower

9 rred in 54 (10.7%) and 56 (11.0%) in the n-3 PUFA and placebo groups, respectively (P=0.87).

10 However, the effects of n-3 PUFA and specialized proresolving mediators on AVS have

11 with clinical observations showing that n-3 PUFA and SSRI have antidepressant affects, which may be

12 Associations of n-3 PUFA biomarkers (alpha-linolenic acid, eicosapentaenoic

13 n peak corresponding to the encapsulated n-3 PUFA concentrate.

14 hesis of n-3 PUFA and increased valvular n-3 PUFA content, exhibited reduced valve calcification, low

15 in rapid increases in leukocyte membrane n-3 PUFA content.

16 this process suggests a manner in which n-3 PUFA could augment antidepressant effects.

17 cAMP antagonist, RP-cAMPs did not block n-3 PUFA CREB activation.

18 Our results show that maternal dietary n-3 PUFA deficiency increases microglia-mediated phagocytosi

19 tive epoxy-PUFAs increased linearly with n-3 PUFA dose and showed low interindividual variance (r2 >

20 label use of a perioperative intravenous n-3 PUFA emulsion as a standalone infusion in the time seque

21 nts with infectious complications in the n-3 PUFA group (8 compared with 3, P = 0.036).

22 In the n-3 PUFA group a clear relation with serum and LPS-stimulate

23 mulation was significantly higher in the n-3 PUFA group at the first day after surgery (P = 0.014), b

24 White blood cell count was higher in the n-3 PUFA group at the fourth day after surgery (P = 0.029).

25 delta13C of n-3 PUFA in humans is a powerful and underutilized tool that

26 We found that n-3 PUFA incorporation into human stenotic aortic valves was

27 ween child sex, maternal asthma, and n-6/n-3 PUFA indicated that male children born to women with ast

28 for detrimental effects of low maternal n-3 PUFA intake on hippocampal development in mice.

29 We demonstrate here that low maternal n-3 PUFA intake worsens MIA-induced early gut dysfunction, i

30 esponse of oxylipin concentrations after n-3 PUFA intake.

31 By modeling genome-wide n-3 PUFA interactions, we identified a novel DPP10 SNP assoc

32 a13C]) of n-3 PUFA supplements to assess n-3 PUFA metabolism following DHA or EPA supplementation in

33 en resection (saline n = 5 compared with n-3 PUFA n = 0, P = 0.056).

34 f contrasting sources of dietary n-6 and n-3 PUFA on expression of genes related to lipid metabolism

35 were randomly assigned to 2 intravenous n-3 PUFA or saline control infusions the night before and th

36 bon-13 isotopic abundance [delta13C]) of n-3 PUFA supplements to assess n-3 PUFA metabolism following

37 pothesis was that daily addition of 1.8g n-3 PUFA to standard of care secondary prophylaxis in elderl

38 ations made in neuronal and glial cells, n-3 PUFA treatment attenuated cAMP accumulation in LCLs.

39 ytes derived from patients subsequent to n-3 PUFA treatment.

40 osahexaenoic acid were +87% and +16% for n-3 PUFA versus -13% and -8% for placebo.

41 oint occurred in 108 (21.4%) patients on n-3 PUFA versus 102 (20.0%) on placebo (hazard ratio, 1.08 [

42 dpoint occurred in 28 (7.2%) patients on n-3 PUFA versus 15 (4.0%) on placebo (1.84 [0.98-3.45]; P=0.

43 nd concentrations and delta13C of plasma n-3 PUFA were determined.

44 unts of n-3 polyunsaturated fatty acids (n-3 PUFA).

45 shed BDNF and GDNF production induced by n-3 PUFA, suggesting CREB dependence.

46 DHA) increase systemic concentrations of n-3 PUFA-derived oxylipins and moderately decrease arachidon

47 n-3 PUFA-derived resolvin E1 and its receptor ChemR23 emerge

48 mediator lipidomics identified that the n-3 PUFA-derived specialized proresolving mediator resolvin

49 f this study was to identify the role of n-3 PUFA-derived specialized proresolving mediators in relat

50 ne standard deviation increase in LC omega-3 PUFA (380 mg/day) was associated with an MDD decrease of

51 bo and periodontal debridement (CG), omega-3 PUFA + ASA (3 g of fish oil/d + 100 mg ASA/d for 2 month

52 l debridement (test group [TG]1), or omega-3 PUFA + ASA (3 g of fish oil/d + 100 mg ASA/d for 2 month

53 r placebo for TG1 and CG (t1), after omega-3 PUFA + ASA (before periodontal debridement) for TG2 (t1)

54 hs after periodontal debridement and omega-3 PUFA + ASA or placebo for TG1 and CG (t1), after omega-3

55 d FA, including rumenic acid and the omega-3 PUFA alpha-linolenic, eicosapentaenoic and docosapentaen

56 ogical impact of orally administered omega-3 PUFA and ASA as adjuncts to periodontal debridement for

57 dings indicate that low intake of LC omega-3 PUFA and its precursors may be elevating MDD and PTB rat

58 We then estimated the LC omega-3 PUFA levels that these intakes produce by accounting for

59 rganic and rape feeding provide less omega-3 PUFA than the conventional and control diets, yet contra

60 omega-3 polyunsaturated fatty acids (omega-3 PUFA) and low-dose aspirin (ASA) have been proposed as a

61 ga-3 polyunsaturated fatty acids (LC omega-3 PUFA) have been linked to major depressive disorder (MDD

62 entation significantly increased the omega-3 PUFA, particularly ALA, EPA, DPA, and DHA of broiler chi

63 ecreased linearly with increasing LC omega-3 PUFA, up to ~ 1000 mg/day for MDD and up to ~ 550 mg/day

64 Generally, omega (n)-3 PUFAs are considered proresolving whereas n-6 PUFAs are

65 Long-chain n-3 PUFAs (n-3 LCPUFAs) accrete in the brain during childhoo

66 Here we showed that n-3 PUFAs and escitalopram (selective serotonin reuptake inh

67 tandard deviation (SD) increase in total n-3 PUFAs and individual n-3 DPA was associated with a 36% (

68 Women with high (>=median) n-3 PUFAs and low (<median) n-6 PUFAs levels had a 64% (95%

69 h recent AMI who were treated with 1.8 g n-3 PUFAs daily for 2 years.

70 However, the n-3 PUFAs deficiency-mediated mechanisms affecting the devel

71 developmental defects caused by maternal n-3 PUFAs dietary deficiency.

72 ] for allergic rhinitis), the sum of the n-3 PUFAs eicosapentaenoic acid and docosahexaenoic acid (OR

73 Together, these results suggested that n-3 PUFAs facilitate astrocyte differentiation, and may mimi

74 Low maternal intake of n-3 PUFAs has been linked to neurodevelopmental diseases in

75 rmore, these data validate usefulness of n-3 PUFAs in treatment for depression.

76 astrocyte differentiation, we found that n-3 PUFAs increased GFAP expression and GFAP positive cell f

77 the effects of perioperative intravenous n-3 PUFAs on inflammatory cytokines in colon cancer surgery.

78 We corroborated beneficial effects of n-3 PUFAs on pulmonary function.

79 The mechanisms underlying n-3 PUFAs potential therapeutic properties remain unknown.

80 d to receive capsules providing doses of n-3 PUFAs reflecting 3 patterns of consumption of oily fish

81 The administration of n-3 PUFAs resulted in rapid increases in leukocyte membrane

82 In addition, n-3 PUFAs serve as the substrate for the synthesis of specia

83 Long-chain n-3 PUFAs were associated with a 20% decreased HNC and EA ri

84 CI, 1.07-2.71) diagnosed asthma, whereas n-3 PUFAs were associated with lower risk (RR Q4 vs Q1, 0.59

85 PFT-associated n-3 PUFAs were carried forward to genome-wide interaction an

86 Serum concentrations of n-3 PUFAs were significantly higher in the DE and DP groups

87 Omega-3 fatty acids (n-3 PUFAs) are essential for the functional maturation of th

88 ate omega-3 polyunsaturated fatty acids (n-3 PUFAs) at mild, non-oxidative conditions.

89 on, omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been reported to act as both antidepressants

90 of omega-3 polyunsaturated fatty acids (n-3 PUFAs) in cardiovascular prevention have recently been d

91 ective prenatal nutrients (vitamin D and n-3 PUFAs), as well as adverse prenatal pro-oxidant exposure

92 ologically active oxylipins derived from n-3 PUFAs, including epoxy-PUFAs and SPM-precursors, increas

93 when these astrocytes were treated with n-3 PUFAs, the cAMP antagonist, RP-cAMPs did not block n-3 P

94 ogressive reduction in dietary intake of n-3 PUFAs.

95 associations and their interactions with n-3 PUFAs.

96 higher linoleic acid (18:2n-6) and total n-3 PUFAs.

97 received saline and 21 patients received n-3 PUFAs.

98 Emerging evidence suggests that omega-3 PUFAs can also modulate gut microbiota impacting WAT fun

99 ability assays demonstrated that the omega-3 PUFAs concentrates entrapped in SDNLs was protected agai

100 nce the physicochemical stability of omega-3 PUFAs concentrates from fish oil, biopolymer coating bas

101 ted nanoliposomes (SDNLs) containing omega-3 PUFAs concentrates was found to be in the range of 209.5

102 oxidation in comparison to the free omega-3 PUFAs concentrates.

103 tal omega-3 and total marine-derived omega-3 PUFAs with less decline in DSST.

104 Omega-3 polyunsaturated fatty acids (omega-3 PUFAs), which have known hypotriglyceridemic and cardiop

105 -3 (n-3) PUFAs, total marine-derived omega-3 PUFAs, total omega-6 PUFAs].

106 total SFAs, total MUFAs, total omega-3 (n-3) PUFAs, total marine-derived omega-3 PUFAs, total omega-6

107 n-3 (omega-3) PUFAs modulate inflammatory responses and may help to pr

108 ical composition of the cells (vitamin D(3), PUFAs and carotenoids) was evaluated.

109 eat at least three portions/week of omega-3-PUFA enriched (or control) chicken-meat, and to eat at l

110 cken-meat, and to eat at least three omega-3-PUFA enriched (or control) eggs/week, for 6 months.

111 We show that regular consumption of omega-3-PUFA enriched chicken-meat and eggs significantly increa

112 monly eaten, relatively inexpensive, omega-3-PUFA enriched foods.

113 aturally enriched with algae-sourced omega-3-PUFAs, may serve as alternative dietary sources of these

114 ic rather than conventional management (+39% PUFA, +24% long chain omega-3 and +12% conjugated linole

115 and unsaturated fatty acids (~27% MUFA, ~39% PUFA).

116 milk 16% lower SFA and higher in MUFA (43%), PUFA (55%) and CLA (59%).

117 d fatty acids (PUFA) but lower levels of n-6 PUFA in the Montanera pigs than in the Pienso pigs.

118 A very favorable n-3/n-6 PUFA ratio was found in all studied species, and PUFA/SF

119 of adrenic acid (AdA), a poorly studied n-6 PUFA.

120 sis in human cells, pinpointing this omega-6 PUFA as a conserved metabolic instigator of this lethal

121 Mounting evidence points to omega-6 PUFA excess limiting metabolic and cognitive processes t

122 common complications of intrauterine omega-6 PUFA excess, cellular underpinnings of life-long modific

123 Here, we show that nutritional omega-6 PUFA-derived endocannabinoids desensitize CB(1) cannabin

124 When chosen during pregnancy, omega-6 PUFA-enriched 'Western' diets can reprogram maternal bod

125 Associations between total n-6 PUFAs and GDM were null, whereas associations with indiv

126 FAs) for cardiometabolic health, n-3 and n-6 PUFAs and their interplay in relation to diabetes risk r

127 UFAs are considered proresolving whereas n-6 PUFAs are classified as proinflammatory.

128 d individual plasma phospholipid n-3 and n-6 PUFAs in early to midpregnancy in relation to subsequent

129 SFAs in the cheese diet was replaced by n-6 PUFAs in the other diets.

130 genously metabolized plasma phospholipid n-6 PUFAs including GLA, DGLA, and DTA in early to midpregna

131 h (>=median) n-3 PUFAs and low (<median) n-6 PUFAs levels had a 64% (95% CI 0.14-0.95; P value = 0.03

132 , individual plasma phospholipid n-3 and n-6 PUFAs levels were measured at gestational weeks (GWs) 10

133 gly, dietary supplementation of selected n-6 PUFAs rescued the embryonic lethality and defective perm

134 idual and total SFAs, MUFAs, and n-3 and n-6 PUFAs were analyzed using SD scores and principal compon

135 Higher n-6 PUFAs were associated with a higher risk of all respirat

136 In quartile (Q) analyses, higher n-6 PUFAs were associated with increased risk of ever (risk

137 ll, whereas associations with individual n-6 PUFAs were differential.

138 f GDM versus women with low n-3 and high n-6 PUFAs.

139 mouse fetuses are exposed to excess omega-6 PUFAs in utero.

140 Conversion of omega-6 PUFAs into endocannabinoids disrupted the temporal preci

141 reater decline in DWRT; higher total omega-6 PUFAs with less decline in DWRT; and higher total omega-

142 marine (20:5n-3+22:6n-3+22:5n-3) and omega-6 PUFAs, SFAs, MUFAs, and trans FAs were 4.7 +/- 1.2, 38.0

143 ent with 'Western' diets enriched in omega-6 PUFAs.

144 marine-derived omega-3 PUFAs, total omega-6 PUFAs].

145 74537, to metabolize 18-carbon omega-6 (n-6) PUFAs in borage oil (BO) and soybean oil (SO) to GLA, DG

146 d dyads with omega-3 (n-3) and omega-3 (n-6) PUFAs measured in second-trimester plasma; n-6/n-3 ratio

147 from voxel volume (rho = 0.125, p = 0.632), PUFA content (rho = 0.256, p = 0.320) or water/fat ratio

148 A PUFA-enriched Western diet triggers focal granuloma-like

149 In addition, a PUFA analogue selective for the cardiac I(Ks) channel (K

150 mol/L; obese 4.4 +/- 0.8 mmol/L) to either a PUFA diet enriched with oil-based margarine ( n = 42) or

151 potato chips exposed to DBRDFEs when using a PUFA-laden sunflower oil frying medium: these contents i

152 linoleic acid (C18:2) was the most abundant PUFA in terrestrial origin lecithins (HL and SL), wherea

153 with the omega-6 polyunsaturated fatty acid (PUFA) arachidonic acid (AA), which entails risk for deve

154 ase in the total polyunsaturated fatty acid (PUFA) content were observed for both UAE-E:W insect extr

155 eferences toward polyunsaturated fatty acid (PUFA) content with 'Western' diets enriched in omega-6 P

156 trongly with the polyunsaturated fatty acid (PUFA) content.

157 the activity of polyunsaturated fatty acid (PUFA) desaturation and the lipid composition in human bl

158 ingestion of the polyunsaturated fatty acid (PUFA) dihomogamma-linolenic acid (DGLA; 20:3n-6) can tri

159 ings on prenatal polyunsaturated fatty acid (PUFA) intake and child wheeze and asthma have been incon

160 tion and low n-3 polyunsaturated fatty acid (PUFA) intake on neurodevelopment with long-lasting conse

161 with n-3 and n-6 polyunsaturated fatty acid (PUFA) subtypes remain unclear.

162 long chain (LC-) polyunsaturated fatty acid (PUFA)-containing lipids.

163 e (P < 0.05) in polyunsaturated fatty acids (PUFA) as well as in the tyrosol and hydroxytyrosol deriv

164 t of long-chain polyunsaturated fatty acids (PUFA) as well as lysophosphatidylcholine (LysoPC) and ly

165 r levels of n-3 polyunsaturated fatty acids (PUFA) but lower levels of n-6 PUFA in the Montanera pigs

166 wice as much as polyunsaturated fatty acids (PUFA) concentration found in the polar lipid fraction (8

167 e of marine n-3 polyunsaturated fatty acids (PUFA) has been associated with reduced risk of cardiovas

168 ration, whereas polyunsaturated fatty acids (PUFA) increased in both varieties.

169 ts of their n-3 polyunsaturated fatty acids (PUFA) on the bacterial community.

170 Long-chain n-3 polyunsaturated fatty acids (PUFA) such as EPA and DHA exert beneficial effects on in

171 cious source of polyunsaturated fatty acids (PUFA), however extraction is difficult due to the peculi

172 enriched in n-3 polyunsaturated fatty acids (PUFA), known to enhance nutritional quality, but to decr

173 mega-3 (omega3) polyunsaturated fatty acids (PUFA).

174 20% oil rich in polyunsaturated fatty acids (PUFA, 82.22%), particularly linoleic acid (C18:2).

175 Polyunsaturated fatty acids (PUFAs) and their metabolites are potent regulators of in

176 seafood omega-3 polyunsaturated fatty acids (PUFAs) are very prevalent.

177 ommendations of polyunsaturated fatty acids (PUFAs) for cardiometabolic health, n-3 and n-6 PUFAs and

178 ituting dietary polyunsaturated fatty acids (PUFAs) for saturated fatty acids are well known.

179 Polyunsaturated fatty acids (PUFAs) form cellular, mitochondrial, retinal, and other

180 r omega-3 (n-3) polyunsaturated fatty acids (PUFAs) has potential benefits for skin inflammation.

181 Polyunsaturated fatty acids (PUFAs) have emerged as potential therapeutics for LQTS b

182 a major flux of polyunsaturated fatty acids (PUFAs) in oil synthesis.

183 ed the ratio of polyunsaturated fatty acids (PUFAs) in their embryonic fatty acid pool.

184 as the fall in polyunsaturated fatty acids (PUFAs) level and the active serine-glycine-one-carbon (S

185 tation with n-3 polyunsaturated fatty acids (PUFAs) may be efficacious for treatment of major depress

186 and long chain polyunsaturated fatty acids (PUFAs) omega-3 and omega-6 has also been confirmed.

187 Polyunsaturated fatty acids (PUFAs) such as alpha-linolenic acid (ALA, 18:3Delta(9) (

188 or oxidation of polyunsaturated fatty acids (PUFAs), as robustly overexpressed in PCa tissues and ass

189 t the levels of polyunsaturated fatty acids (PUFAs), especially linoleic acid (LA) and eicosapentaeno

190 activation and polyunsaturated fatty acids (PUFAs), present in fish oils, modulate channel inactivat

191 mpounds such as Polyunsaturated Fatty Acids (PUFAs).

192 onvert n6 to n3 polyunsaturated fatty acids [PUFAs]) to identify novel genes and pathways involved in

193 yolk in experimental groups, as well as all PUFA (polyunsaturated fatty acids) proportions.

194 sing varieties with higher phytochemical and PUFA contents and a second group, with higher linolenic

195 in SFA and ~4 E% in PUFA between the SFA and PUFA groups.

196 ighest concentration (30-55 DAF) and SFA and PUFA reached their lowest.

197 two and 21 DAF characterized by high SFA and PUFA, which decreased 21 DAF.

198 ratio was found in all studied species, and PUFA/SFA ratios ranged between 0.94 and 1.72, which is d

199 m parenteral nutrition with both choline and PUFAs.

200 A small increased intake of beneficial PUFA may be expected by consuming ORG milk but human hea

201 ic lethality as well and could be rescued by PUFA supplementation.

202 d metabolites and depleted in esterified C18-PUFA-derived diols.

203 tage of genotypes enabling active long-chain PUFA synthesis when the introduction of agriculture prov

204 ulating concentrations of any n-6 long-chain PUFAs.

205 ous and endogenous influences on circulating PUFA levels and the lack of causality inherent in observ

206 portance of assessing individual circulating PUFAs to investigate their distinct pathophysiologic rol

207 ere likely attributable to the corresponding PUFA epoxides generated in tumor cells and/or host, sinc

208 In oilseed crops, PUFAs are synthesized on phosphatidylcholine (PC) and ac

209 ight the potential of the deuterated-PUFA (D-PUFA) drug candidates currently in development.

210 Lipid metabolism in pregnancy delivers PUFAs from maternal liver to the developing fetus.

211 ploring the mechanisms that route PC-derived PUFA to TAG is essential for understanding and improving

212 ls highlight the potential of the deuterated-PUFA (D-PUFA) drug candidates currently in development.

213 sion depending on the composition of dietary PUFA, particularly in females.

214 son of bovine and ovine responses to dietary PUFA.

215 Our study identifies dietary PUFAs as a trigger of GPX4-restricted mucosal inflammati

216 Each PUFA indicator and outcome was analyzed in separate mode

217 pins, mostly hydroxy-, dihydroxy-, and epoxy-PUFAs, were quantified in the plasma samples.

218 anti-inflammatory and cardioprotective epoxy-PUFAs increased linearly with n-3 PUFA dose and showed l

219 pins derived from n-3 PUFAs, including epoxy-PUFAs and SPM-precursors, increase linearly with elevate

220 ggest that KSO will be a suitable source for PUFA and nutraceuticals potential.

221 Manzanilla showed higher PUFA content, whereas Picual had higher MUFA concentrati

222 to and evasion from ferroptosis, highlights PUFA-ePL as a distinct functional lipid class that is dy

223 However, PUFAs are susceptible to the noxious lipid peroxidation

224 5, 12-, and 15-lipoxygenase-derived hydroxy-PUFAs as well as those formed autoxidatively increased l

225 These findings implicate PUFA oxidation via DECR1 as an unexplored facet of FAO t

226 is essential for understanding and improving PUFA production.

227 f ~9 energy percent (E%) in SFA and ~4 E% in PUFA between the SFA and PUFA groups.

228 ransition at birth to diets less enriched in PUFA is especially challenging for immature, extremely p

229 The highest yields in PUFA were obtained with Nannochloropsis sp. (207.9 mg/g

230 replace SFAs with unsaturated fat, including PUFAs and MUFAs.

231 The lipid indices (PUFA/SFA ratio, atherogenic and thrombogenic indices) fo

232 However, the impact of individual PUFA has barely been examined, and it is uncertain which

233 the enrichment of food products with n-3 LC-PUFA and their oxidative stability has never been descri

234 Reduced salt intake, omega-3 LC-PUFA use, and folate supplementation could reduce risk f

235 oil and analyzed for their amount of n-3 LC-PUFA, lipid oxidation products, antioxidants and free fa

236 gly associated (p < 1.2 x 10(-8)) with 52 LC-PUFA-containing lipids and signaling molecules, includin

237 -3 long-chain polyunsaturated fatty acid (LC-PUFA) was associated with reduced risk for myocardial in

238 lating levels of physiologically critical LC-PUFA-containing lipids that participate in innate immuni

239 abolites (including four major classes of LC-PUFA-containing molecules and signaling molecules) with

240 d long-chain polyunsaturated fatty acids (LC-PUFAs), especially eicosapentaenoic acid (EPA), as downs

241 f long-chain polyunsaturated fatty acids (LC-PUFAs), while in the center region marine species had th

242 High levels of beneficial LC-PUFAs and micro-nutrients would be taken up (up to 80% o

243 Peruvian marine species are rich in LC-PUFAs and micro-nutrients (Cu, Fe, Mn, Zn), including sp

244 M1 PUFA containing triglycerides (TG) and phospholipids wer

245 valuable omega-3 fatty acid, were the major PUFAs in aquatic origin lecithins (RL and WL).

246 Preconception marine PUFA concentration was associated with higher methylatio

247 l studies on the connection between membrane PUFA levels and GPCR signaling.

248 es CYP1 family enzymes, which can metabolize PUFA to epoxides.

249 These two cultivars also had low MUFA/PUFA (6.0-4.0 and 4.9-3.2 respectively), suggesting that

250 d gut pathology and discern the impact of n3 PUFA enrichment.

251 y contribute to the beneficial effects of n3 PUFAs on EtOH-induced intestinal pathology.

252 fied the key targets mediating the action of PUFA arachidonic acid (ARA) on meiotic maturation and de

253 ospectively investigated the associations of PUFA subtypes, ratios, and fish with the incidence of he

254 support the potential long-term benefits of PUFA intake in lowering the risk of CVD and premature de

255 erases that may facilitate the channeling of PUFA from PC to TAG in flax and possibly also in other o

256 Further, the characteristics of PUFA-rich oil were validated by Fourier transforms infra

257 ensitive to oxidation due to high content of PUFA.

258 associated with extensive downregulation of PUFA-ePLs.

259 ative abundance of oxygenated metabolites of PUFA, oxylipins, is altered in TGRL postprandially, and

260 ditives, it is suited for the preparation of PUFA supplements.

261 urther find that the pro-ferroptotic role of PUFA-ePLs can be extended beyond neoplastic cells to oth

262 ing of DECR1 caused cellular accumulation of PUFAs, enhanced mitochondrial oxidative stress and lipid

263 In the case of PUFAs, protection against oxidative degradation is chall

264 BMI modifies the effect of PUFAs compared with SFAs, with smaller improvements in a

265 sponsible for hormonally regulated export of PUFAs from adult liver, strongly supports increased supp

266 disorders show drastically lowered levels of PUFAs.

267 down selectively inhibited beta-oxidation of PUFAs, inhibited proliferation and migration of PCa cell

268 forces oxidation-prone, bis-allylic sites of PUFAs is a novel, nonantioxidant treatment modality that

269 microencapsulated oils could be a source of PUFAs.

270 had the opposite effects in mice fed omega6 PUFA.

271 controls, but no alterations in total fat or PUFA intake.

272 esizing polyunsaturated ether phospholipids (PUFA-ePLs), which act as substrates for lipid peroxidati

273 d a series of polyunsaturated phospholipids (PUFA-PLs), specifically phosphatidylinositol (-PI) lipid

274 s were investigated between genotype, plasma PUFAs, fasting glucose, and hsCRP concentrations in the

275 The fatty acid composition of plasma PUFAs and concentrations of plasma fasting glucose, seru

276 ght to examine associations between prenatal PUFA status and child wheeze/asthma and modifying effect

277 Associations between prenatal PUFA status and childhood wheeze/asthma were modified by

278 The effects of specific PUFA analogues range from selective for a specific ion c

279 Here we demonstrate that PUFA analogues vary in their selectivity for human volta

280 Our data suggest that PUFA analogues could potentially be developed as therape

281 Thus, our study shows that PUFAs and p38-MAPK pathway function downstream of DR to

282 naturally occurring peptide linker from the PUFA synthase of Photobacterium profundum.

283 8% (95% CI: -6.3%, -1.2%), P = 0.021, in the PUFA group.

284 Consequently, genes of the PUFA biosynthesis and p38-MAPK pathway are required for

285 e proteins, we show that the presence of the PUFA DHA helps helical multi-pass proteins such as GPCRs

286 In the total study population, the PUFA diet compared with the SFA diet lowered LDL cholest

287 mutant, or by RNA interference, reduced the PUFA content of the oil to 26.6% compared with 32.5% in

288 ola are responsible for less than 20% of the PUFAs that accumulate in the seed oil compared with 40%

289 (EPA), are increased following DR and these PUFAs are able to activate the CyTP genes.

290 e enzymes, previously shown to contribute to PUFA enrichment of TAG, for physical interactions with e

291 long-chain polyunsaturated fatty acids (VLC-PUFAs) in Adipor1(-/-) and Mfrp(rd6) retinas.

292 SFA intake increases LDL cholesterol whereas PUFA intake lowers it.

293 ncreases membrane bending stiffness, whereas PUFAs decrease it.

294 ere linoleic, oleic and palmitic acid, while PUFA was the most abundant fatty acid class.

295 e mechanism is based on hybrid lipids, whose PUFA chains coat the rough protein surface, while the sa

296 ial in poultry nutrition to enrich eggs with PUFA.

297 LDL-cholesterol-lowering effect is seen with PUFA, followed by MUFA, and then total carbohydrate.

298 ne were reduced when SFAs were replaced with PUFAs.

299 domized controlled trial replacing SFAs with PUFAs in healthy subjects with moderate hypercholesterol

300 mononuclear cells after replacing SFAs with PUFAs.