ライフサイエンスコーパス: PVN

1 PVN class 1 compared to classes 2 and 3 was diagnosed ea

2 PVN inhibition did not affect the amplitude of the inspi

3 PVN LepR are not expressed in astroglia and rarely in mi

4 PVN neurons labeled with retrograde tracer from rVLM wer

5 idate the PVN classification, that is, the 3 PVN disease classes predicted clinical presentation, all

6 rostral (71 +/- 3%) than caudal (33 +/- 8%) PVN.

7 ely maintained in anaesthetized DH rats by a PVN-driven component of sSNA that is neither respiratory

8 While the location of a PVN-homologous region has been described in adult fish a

9 elevated blood pressure responses through a PVN opioid mechanism.

10 a circuit whereby brainstem GLP-1 activates PVN signaling to mount an appropriate whole-organism res

11 bilaterally vagotomized and underwent acute PVN inhibition by bilateral injection of the GABA-A rece

12 g a lack of tolerance to acute ethanol among PVN neurons.

13 verity of PV replication, tissue injury, and PVN disease grades.

14 al cells, but only at a low level in SON and PVN neurons, whereas robust upregulation in AVP neurons

15 s levels in the cortex, dorsal striatum, and PVN were significantly greater in Pitx3-/- than +/+ mice

16 und that ArcN NPY/AgRP fibers closely appose PVN and DMH presympathetic neurons.

17 ncluding calcium-permeable AMPA receptors at PVN postsynaptic sites.

18 ked activity of cardiovascular barosensitive PVN neurons that also project directly to the rVLM.

19 Aside from the direct anatomic link between PVN and RAIC, our findings provide evidence about the ro

20 analysis to examine the relationship between PVN NMDA receptors and the blood pressure increase induc

21 NR1 subunit trafficking in ERbeta-containing PVN neurons.

22 s of social buffering and reduced STP in CRH(PVN) neurons from females but not males.

23 hologic classification scheme for definitive PVN from the Banff Working Group on Polyomavirus Nephrop

24 ted morphologic classification of definitive PVN that groups histologic changes, reflects clinical pr

25 he largest systematic analysis of definitive PVN undertaken thus far.

26 from patients with biopsy-proven definitive PVN.

27 dy that included 99 patients with definitive PVN transplanted post January 1, 2009 and followed the o

28 , noninvasive urinary PV-Haufen test detects PVN in kidney transplant recipients with greater than 95

29 aufen numbers strongly correlated with early PVN grade 1 and minimal intrarenal expression of SV40-T

30 emales, NR1 density is upregulated in ERbeta-PVN dendrites and ultimately leads to the neurohumoral d

31 By contrast, in females, PVN BIBO3304 increased LSNA similarly in OP, OR and CON

32 on, we validate the 2018 Banff Working Group PVN classification that provides significant clinical in

33 However, the true burden of post-HCT PVN is unknown because kidney biopsies are avoided due t

34 V-Haufen was correlated with both histologic PVN disease grades 1 to 3 and the number of SV40-T-expre

35 However, PVN NPY injection decreased LSNA similarly in obesity pr

36 lation activates neurons in the hypothalamic PVN.

37 paraventricular nucleus of the hypothalamus (PVN) and median preoptic nucleus (MnPO), but not in the

38 paraventricular nucleus of the hypothalamus (PVN) by alpha-MSH and AgRP can be mediated independently

39 paraventricular nucleus of the hypothalamus (PVN) dose-dependently suppressed lumbar SNA (LSNA) and i

40 paraventricular nucleus of the hypothalamus (PVN) found no significant changes in synaptic function t

41 paraventricular nucleus of the hypothalamus (PVN) of male and female adolescent Hom rats.

42 paraventricular nucleus of the hypothalamus (PVN) that appear to synapse onto vasopressin-synthesizin

43 paraventricular nucleus of the hypothalamus (PVN) to RAIC.

44 paraventricular nucleus of the hypothalamus (PVN), in both Pitx3+/+ and -/- mice.

45 paraventricular nucleus of the hypothalamus (PVN), OXT-induced anxiolysis is mediated, at least in pa

46 paraventricular nucleus of the hypothalamus (PVN), to block alpha-melanocyte-stimulating hormone (alp

47 paraventricular nucleus of the hypothalamus (PVN), which is involved in the regulation of food intake

48 paraventricular nucleus of the hypothalamus (PVN).

49 paraventricular nucleus of the hypothalamus (PVN).

50 paraventricular nucleus of the hypothalamus (PVN).

51 paraventricular nucleus of the hypothalamus (PVN).

52 n reduced anxiety-like behavior, implicating PVN GLP-1 signaling in behavioral stress reactivity.

53 In PVN slices from mice expressing GCaMP6, leptin excites g

54 /adapter NOX p47(phox) subunit is altered in PVN dendrites following AngII administered (14 days) dur

55 However, dual PRV-labeled cells in PVN only occasionally expressed OX or CRH but not CART.

56 ude of NMDAR-EPSCs and puff NMDA currents in PVN neurons in WKY rats but not in SHRs.

57 trated by the finding that GluN1 deletion in PVN neurons attenuated the Ang II-induced increases in b

58 ntified prominent NPS receptor expression in PVN-OXT neurons.

59 NK3Rs have been localized in PVN neurons and have showed nuclear translocation follow

60 In the present study, densities of NK3Rs in PVN AVP- or OC-labeled somatodendritic profiles were mea

61 ) and a decrease in cytoplasmic p47(phox) in PVN AVP dendrites.

62 ts indicate that NMDA receptor plasticity in PVN neurons significantly contributes to the elevated bl

63 ogen receptors beta (ERbetas) are present in PVN neurons.

64 how that local vasopressin (VP) signaling in PVN buffers the short-term potentiation (STP) at glutama

65 euronal mechanism of RLN3/RXFP3 signaling in PVN in male and female rats and characterized sex differ

66 ion augments excitatory synaptic strength in PVN corticotropin-releasing hormone (CRH) neurons, with

67 ating that endogenous NPY tonically inhibits PVN presympathetic neurons.

68 s from index biopsies at the time of initial PVN diagnosis.

69 After insulin, PVN BIBO3304 failed to increase LSNA in CON/OR females b

70 r an NPY receptor Y1 (NPY1R) antagonist into PVN or DMH decreased or increased SSNA, respectively.

71 tic effect of NPS seen after i.c.v. or intra-PVN infusion requires responsive OXT neurons of the PVN

72 ograde tracing experiments showed that intra-PVN or intra-BNST red fluorobead unilateral injection la

73 MDAR-EPSCs and puff NMDA currents in labeled PVN neurons in SHRs but had no effect in WKY rats.

74 d puff NMDA currents in retrogradely labeled PVN neurons were significantly higher in SHRs than in WK

75 on mEPSCs or puff NMDA currents in labelled PVN neurons in Wistar-Kyoto (WKY) rats.

76 on mEPSCs and puff NMDA currents of labelled PVN neurons in SHRs.

77 llular cells interspersed with magnocellular PVN neurons expressing secretagogin.

78 brafish neuropeptides found in the mammalian PVN (CCK, CRH, ENK, NTS, SS, VIP, OXT, AVP), we provide

79 was significantly decreased by manipulating PVN CRF neuronal activity.

80 on with ERbeta-ir (48 +/- 16%) in the middle PVN.

81 Moreover, PVN injection of Y1 and Y5 receptor antagonists in other

82 We recommend using this morphologic PVN classification scheme for diagnostic communication,

83 d striking differences between rat and mouse PVN cytochemistry, but careful exploration of PVN ERbeta

84 l differences in ERbeta neurons of the mouse PVN that are different from that previously described fo

85 polymer electret (poly(2-vinyl naphthalene) (PVN)) and metal nanoparticles (Copper).

86 Polyomavirus nephropathy (PVN) is a common viral infection of renal allografts, wi

87 e urinary test for polyomavirus nephropathy (PVN) is the PV-Haufen test.

88 Polyomavirus nephropathy (PVN) remained inadequately classified until 2018 when th

89 itis and also with polyomavirus nephropathy (PVN).

90 We examined neuroendocrine, PVN CRH neurons and report that social isolation alters

91 esistant DTCs occupy the perivascular niche (PVN) of distant tissues, where they are protected from t

92 nctional, and behavioral features of a novel PVN -> NAc circuit.

93 otp, arx, dlx5a, isl1) in and around the NPO/PVN together with neuropeptide expression within it.

94 In the paraventricular nuclei (PVN) of the hypothalamus, DOC pretreatment diminished bo

95 in the paraventricular hypothalamic nucleus (PVN), a critical neuroregulator of cardiovascular functi

96 projections to the paraventricular nucleus (PVN) and dorsomedial hypothalamus (DMH).

97 of the hypothalamic paraventricular nucleus (PVN) and released into the portal circulation at the med

98 sacrificed, and the paraventricular nucleus (PVN) and rostral ventrolateral medulla (RVLM) were micro

99 in the hypothalamic paraventricular nucleus (PVN) are mediated via actions on local OXT neurons in ma

100 in the hypothalamic paraventricular nucleus (PVN) in a nutritional state-dependent manner by activati

101 The paraventricular nucleus (PVN) in mammals is the main hypothalamic nucleus control

102 n, the hypothalamic paraventricular nucleus (PVN) is activated and drives SNA in support of arterial

103 pression within the paraventricular nucleus (PVN) is critically linked to the increased sympathoexcit

104 in the hypothalamic paraventricular nucleus (PVN) is crucial for the sympathoexcitation driving AngII

105 in the hypothalamic paraventricular nucleus (PVN) is increased and critically involved in heightened

106 in the hypothalamic paraventricular nucleus (PVN) is necessary for the expression of binge-eating beh

107 ressin-synthesizing paraventricular nucleus (PVN) magnocellular neurosecretory cells.

108 essing hypothalamic paraventricular nucleus (PVN) neurons in "menopausal" female mice.

109 s released from the paraventricular nucleus (PVN) of the hypothalamus is essential for mediating stre

110 AR) activity in the paraventricular nucleus (PVN) of the hypothalamus is involved in elevated sympath

111 omic neurons in the paraventricular nucleus (PVN) of the hypothalamus play a large role in the regula

112 ia derived from the paraventricular nucleus (PVN) of the hypothalamus, where loss of OGT was associat

113 ly expressed in the paraventricular nucleus (PVN) of the hypothalamus.

114 mone (CRH) from the paraventricular nucleus (PVN) of the hypothalamus.

115 to the hypothalamic paraventricular nucleus (PVN) or into the bed nucleus of the stria terminalis (BN

116 ctions, activity in paraventricular nucleus (PVN) OXT neurons increased.

117 in the hypothalamic paraventricular nucleus (PVN) plays a major role in elevated sympathetic output i

118 The paraventricular nucleus (PVN) regulates sympathetic outflow and blood pressure.

119 leptin acts in the paraventricular nucleus (PVN) to increase sympathetic nerve activity (SNA) is unc

120 murine hypothalamic paraventricular nucleus (PVN) was altered by changes in nutritional state.

121 nd the hypothalamic paraventricular nucleus (PVN) were evaluated in male rhesus monkeys.

122 in the hypothalamic paraventricular nucleus (PVN), a key central coordinator of blood pressure contro

123 egions, such as the paraventricular nucleus (PVN), in addition to blood pressure, in part through the

124 of the hypothalamic paraventricular nucleus (PVN).

125 mone neurons in the paraventricular nucleus (PVN).

126 of the hypothalamic paraventricular nucleus (PVN).

127 tide Y (NPY) in the paraventricular nucleus (PVN).

128 ce (ARC-ME) and the paraventricular nucleus (PVN).

129 The activation of PVN neurons in both fasted Nckx4 knock-out and glucose-i

130 luR1 had no effect on the firing activity of PVN neurons in either group.

131 ) similarly increased the firing activity of PVN neurons in WKY rats and SHRs.

132 ity mediates the augmented NMDAR activity of PVN presympathetic neurons in hypertension is unclear.

133 le of CaMKII in regulating NMDAR activity of PVN presympathetic neurons in male spontaneously hyperte

134 duced the spontaneous and evoked activity of PVN.

135 GFP) to examine the chemical architecture of PVN ERbeta cells.

136 The sympathoexcitation following blockade of PVN NPY inhibition was eliminated by prior PVN nanoinjec

137 In males, blockade of PVN NPY Y1 receptors with BIBO3304 increased LSNA in CON

138 rtant basis for cross-species comparisons of PVN/NPO structure and function.

139 ine samples, with histologic confirmation of PVN in 1 autopsy specimen.

140 , we sought to determine the contribution of PVN to support of rhythmic bursting of SNA during dehydr

141 DHPG-induced increases in NMDAR currents of PVN neurons in SHRs.

142 ion in plasma membrane GluN1 in dendrites of PVN neurons in adult male mice.

143 equency of NMDAR-mediated miniature EPSCs of PVN neurons in SHRs.

144 AR-dependent increase in the excitability of PVN neurons only in WKY rats.

145 VN cytochemistry, but careful exploration of PVN ERbeta neurons in mice has been hindered by a lack o

146 ptic and postsynaptic NMDAR hyperactivity of PVN presympathetic neurons and for the augmented sympath

147 and their relevance to the hyperactivity of PVN presympathetic neurons in hypertension remain unclea

148 sion and contributes to the hyperactivity of PVN presympathetic neurons through PKC- and SNAP-25-medi

149 Optogenetic activation or inhibition of PVN CRF neurons was sufficient to induce a conditioned p

150 Conversely, inhibition of PVN OXT axon terminals in the VTA decreased social inter

151 nagement for the diagnosis and prediction of PVN disease grades and monitoring of disease course duri

152 Here, our recordings of PVN CRF neuronal activity in freely behaving mice reveal

153 uggest that the rapid, biphasic responses of PVN CRF neurons encode the positive and negative valence

154 The selective shift of PVN frequency tuning should render pup odor-induced disi

155 This enhanced local recruitment depends on PVN-mediated reciprocal inhibition and results from both

156 physical stress has sex-specific effects on PVN CRH neurons.

157 ) bilaterally into either the ARC-ME area or PVN of Zucker Diabetic Fatty rats, a model of T2D, and m

158 Confirming this assumption, intra-BNST or PVN Hcrt-1/Ox-A injection enhanced alcohol seeking simil

159 dissected arcuate (ARC) and paraventricular (PVN) hypothalamic nuclei.

160 nclude the lateral (LH) and paraventricular (PVN) nuclei of the hypothalamus, parasubthalamic nucleus

161 borated by the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei.

162 Cells in the paraventricular (PVN) and parabrachial (PBN) nuclei and brainstem showed

163 neurons are present in the paraventricular (PVN), dorsomedial (DMH), and ventromedial (VMH) hypothal

164 Parvocellular PVN neurons project to sympathoexcitatory cardiovascular

165 ynaptic glutamate release onto parvocellular PVN neurons in both controls and abstinent drinkers, sug

166 PVN -> NAc has origins in the parvocellular PVN, and that PVN -> NAc neurons express VGLUT1, a marke

167 Notably, higher intra- and peri-PVN RLN3 fiber densities were observed in females, which

168 Persistent PVN was associated with an increased risk for graft fail

169 a-EGFP neurons predominated in the posterior PVN.

170 V-Haufen shed per milliliter urine, predicts PVN disease grades and the severity of intrarenal PV rep

171 f PVN NPY inhibition was eliminated by prior PVN nanoinjection of the melanocortin 3/4 receptor inhib

172 urrents were recorded in spinally projecting PVN neurons in SHRs and male Wistar-Kyoto (WKY) rats.

173 urrents were recorded in spinally projecting PVN neurons in spontaneously hypertensive rats (SHRs) an

174 basal firing activity of spinally projecting PVN neurons in spontaneously hypertensive rats (SHRs), b

175 of retrogradely labelled spinally projecting PVN neurons in spontaneously hypertensive rats (SHRs).

176 inputs may facilitate rapid and proportional PVN recruitment in regulating local circuit operations.

177 esults of this study suggest that in the rat PVN 1) NK3R distribution is conducive to modulation of s

178 ings demonstrate plasticity of liver-related PVN neurons and a shift toward excitation in a diabetic

179 s were silent, indicating that liver-related PVN neurons are more active in db/db mice.

180 In db/db mice, the majority of liver-related PVN neurons fired spontaneously; whereas, in lean mice t

181 urotransmission was reduced in liver-related PVN neurons of db/db mice.

182 Liver-related PVN neurons were identified with a retrograde, trans-syn

183 , in lean mice the majority of liver-related PVN neurons were silent, indicating that liver-related P

184 vidence of overall activity of liver-related PVN neurons.

185 inate from altered activity of liver-related PVN neurons.

186 c inhibition was identified in liver-related PVN neurons; although, the magnitude of tonic inhibitory

187 CRF-releasing PVN neurons receive inputs from multiple brain regions t

188 ha-MSH) inhibit and stimulate, respectively, PVN-RVLM neurons.

189 tion of fluorogold revealed that the rostral PVN ERbeta-EGFP cells are neuroendocrine neurons whereas

190 RFRP-3 fibers are found in the POA, SCN, PVN, DMH, VMH, and ARC.

191 us hypothalamic areas, notably the POA, SCN, PVN, DMH, VMH, supraoptic nucleus, and the ventral and d

192 Finally, silencing PVN TNFR1 prevented the increase in systolic blood press

193 hetic nerve activity (SNA) is unclear, since PVN leptin receptors (LepR) are sparse.

194 NAb, NTS, and RVLM) and two forebrain sites (PVN and SFO) were examined.

195 Next, we pharmacogenetically stimulated PVN -> NAc neurons and quantified both gamma-aminobutyri

196 Finally, we pharmacogenetically stimulated PVN -> NAc which decreased intake of highly palatable fo

197 ed excitatory currents in sympathoexcitatory PVN neurons following AngII infusion.

198 s origins in the parvocellular PVN, and that PVN -> NAc neurons express VGLUT1, a marker of glutamate

199 viral tracing techniques, we determined that PVN -> NAc has origins in the parvocellular PVN, and tha

200 Given that PVN neurones project to brainstem cardio-respiratory reg

201 irst evidence supporting the hypothesis that PVN Sirt1 activates the hypothalamic-pituitary-adrenal a

202 We show in rats that PVN leptin slowly increases SNA to muscle and brown adip

203 Here, we show that PVN-specific loss of G(q)alpha and G11alpha, which stimu

204 Collectively, these data suggest that PVN NPY inputs converge with alpha-MSH to influence pres

205 The PVN also harbors parvocellular OT cells that project to

206 The PVN classes 1-3 as described here can easily be recogniz

207 n-mediated interactions between DTCs and the PVN, driven partly by endothelial-derived von Willebrand

208 ly involved in stress regulation such as the PVN and the BNST.

209 diated sympathoexcitatory responses from the PVN in CHF.

210 n signal, possibly relayed directly from the PVN to the OVLT.

211 est that CaMKII activity is increased in the PVN and contributes to potentiated presynaptic and posts

212 tion of ArcN NPY/AgRP terminal fields in the PVN and DMH decreased SSNA.

213 The mRNA and protein levels of mGluR5 in the PVN and rostral ventrolateral medulla were significantly

214 ut not ETB receptors were upregulated in the PVN and RVLM of E2 treated animals.

215 phic changes in NPY inhibition of SNA in the PVN as one mechanism.

216 neural substrates of oxidative stress in the PVN associated with AngII hypertension in postmenopausal

217 is lost in mice lacking G(q/11)alpha in the PVN but not in animals deficient for G(s)alpha.

218 1 tonically suppresses NMDAR activity in the PVN by reducing the NMDAR phosphorylation level.

219 an increase in NMDA-mediated currents in the PVN following AngII infusion, suggesting a mechanism whe

220 matic remodeling of DNA accessibility in the PVN following pubertal adversity.

221 female PNS offspring in the NTS, and in the PVN in males.

222 Our results show that Sirt1 levels in the PVN increase in rats fed a high fat diet for 12 weeks.

223 ow that postnatal depletion of GLP-1R in the PVN increases food intake and causes obesity.

224 Finally, TNFR1 silencing in the PVN inhibits elevated blood pressure induced by AngII.

225 Our findings suggest that mGluR5 in the PVN is upregulated in hypertension and contributes to th

226 s of ETA receptor were also increased in the PVN of E2 treated animals.

227 emonstrate a direct RLN3/RXFP3 action in the PVN of male and female rats, identify the associated ion

228 y responses to microinjection of NMDA in the PVN of rats with CHF.

229 Selective overexpression of Tmem18 in the PVN of wild-type mice reduced food intake and also incre

230 Direct activation of these neurons in the PVN or their terminals in the VTA enhanced prosocial beh

231 In obese females, NPY inhibition in the PVN was maintained.

232 Also, the CK1epsilon protein level in the PVN was significantly lower in SHRs than in WKY rats.

233 In addition, when action potentials in the PVN were inhibited with intraparenchymal lidocaine, AngI

234 excitatory glutamatergic transmission in the PVN were measured.

235 nd PKC-mediated NMDAR phosphorylation in the PVN were significantly higher in SHRs than in WKY rats.

236 y, MC4R-dependent oxytocin expression in the PVN, a key essential step in satiety, is prevented by bl

237 n level of GluN2B serine 1303 (S1303) in the PVN, but not in the hippocampus and frontal cortex, was

238 be regulated primarily though action in the PVN, is unknown.

239 In the PVN, the frequency of spontaneous excitatory postsynapti

240 In the PVN, TNFR1 expression and plasma membrane localization a

241 ns to exert its anxiolytic properties in the PVN, we performed in vivo and cell culture experiments.

242 I (AngII) can increase NMDAR activity in the PVN, whether endogenous AT1 receptor-protein kinase C (P

243 level of phosphorylated GluN2B S1303 in the PVN.

244 rane affiliation) regulation of TNFR1 in the PVN.

245 estored with opioid receptor blockade in the PVN.

246 nimals lacking G(s)alpha specifically in the PVN.

247 -1 (CK1) in regulating NMDAR activity in the PVN.

248 via an increase in alpha-MSH activity in the PVN.

249 tion of oxytocin, a peptide expressed in the PVN.

250 influenced by local signaling events in the PVN.

251 ition of LSNA by neuropeptide Y (NPY) in the PVN.

252 c neuropeptide Y receptor 5 agonist into the PVN consequently led to decreased anxiety-related behavi

253 In addition, microinjection of AIP into the PVN significantly reduced arterial blood pressure and lu

254 ection of losartan or chelerythrine into the PVN substantially reduced blood pressure and renal sympa

255 oinjection of the same dose of FGF1 into the PVN was without effect on glycemia or other parameters,

256 roinjection of the NMDAR antagonist into the PVN.

257 ry responses to AngII microinjected into the PVN.

258 e conclude that the ARC-ME area (but not the PVN) is a target for sustained remission of diabetic hyp

259 usion requires responsive OXT neurons of the PVN and locally released OXT.

260 lar distribution in AVP or OC neurons of the PVN and plasticity following restraint stress in rats ar

261 -GlcNAcylation in alphaCaMKII neurons of the PVN as an important molecular mechanism that regulates f

262 ify the definitive borders and extent of the PVN homologous region in larval zebrafish and serve as a

263 All NK3-labeled somata of the PVN in control rats showed cytoplasmic but no nuclear im

264 ulation, whereby pubertal programming of the PVN results in aberrant HPA axis responsiveness when exp

265 Inhibition of the PVN with naloxone reversed the EA-inhibition.

266 and descending/pre-autonomic regions of the PVN, and multiple structural divisions of the PBN and br

267 tered autonomic circuits at the level of the PVN, which can contribute to autonomic dysfunction and d

268 Some of the PVN-projecting cells are oxytocinergic and destinate GAB

269 er sparsely distributed in OC neurons of the PVN.

270 x differences in the RLN3 innervation of the PVN.

271 f FGF1 localized to either the ARC-ME or the PVN is capable of mimicking the sustained antidiabetic e

272 We hypothesized that the PVN and its projections to the rVLM participate in the E

273 neuronal tracers was examined throughout the PVN.

274 Thus, the PVN and its projection to rVLM are important in processi

275 ropose that the ArcN NPY neuropathway to the PVN and DMH is pivotal in obesity-induced elevations in

276 nstem locus coeruleus, and projecting to the PVN.

277 Results validate the PVN classification, that is, the 3 PVN disease classes p

278 bservations, HIF-1alpha silencing within the PVN abrogated the increased basal sympathetic tone and s

279 tes the anxiolytic effects of OXT within the PVN and suggests that eEF2 represents a novel target for

280 induction in vasopressin neurons within the PVN and supraoptic nucleus.

281 nt somatodendritic release of OXT within the PVN as assessed by microdialysis in combination with a h

282 Moreover, activation of eEF2 within the PVN conveyed an anxiolytic effect supporting a role of O

283 mulation of GLP-1 afferent fibers within the PVN is sufficient to suppress food intake independent of

284 We conclude that subtle hypoxia within the PVN may act as a metabolic cue to modulate sympathoexcit

285 le factor 1alpha were upregulated within the PVN of left coronary artery-ligated CHF rats.

286 ng in female rats, RXFP3 blockade within the PVN prevented binge-eating behavior.

287 ogenetic silencing of OXT neurons within the PVN prevented the effect of synthetic NPS.

288 e inhibition of protein synthesis within the PVN prevents the anxiolytic effect of OXT in male rats.

289 potent inhibitory neuromodulator within the PVN that may contribute to changes in SNA that occur in

290 Further, within the PVN, selective optogenetic stimulation of afferents that

291 regulation of energy homeostasis within the PVN.

292 ypothalamic cell line and in vivo within the PVN.

293 formed the basis for the definition of three PVN classes that correlated strongest with three clinica

294 systemic and/or central AVP release through PVN inputs to the posterior pituitary and/or the amygdal

295 the ability of an MC4R agonist delivered to PVN to inhibit food intake is lost in mice lacking G(q/1

296 potentiated glutamatergic synaptic input to PVN presympathetic neurons and elevated sympathetic vaso

297 Thus, tonic PVN NPY inhibition of LSNA may be lost in obese males as

298 e detection of PV-Haufen suggests underlying PVN with an increased risk of kidney failure and dialysi

299 Finally, cNTS-projecting neurons within PVN, LH, and Bar express the activation marker cFOS in m

300 Yet, PVN nanoinjections of NPY decreased LSNA similarly betwe