ライフサイエンスコーパス: PZ

1 PZ accelerates the inhibition reaction approximately 200

2 PZ ADCs show significant interpatient variation, which h

3 PZ cells from GFP+ donor mouse embryos were transplanted

4 PZ effectively clears SCs and rejuvenates tissue stem an

5 PZ is administered prophylactically for respiratory sync

6 PZ is given as prophylaxis against infection with respir

7 PZ mice developed the highest concentrations of interleu

8 PZ neurons monosynaptically innervated and released syna

9 PZ production is regulated in part by the PhzR/PhzI quor

10 PZ-128 is a cell-penetrating pepducin inhibitor of PAR1

11 PZ-235 significantly inhibited PAR2-mediated expression

12 PZ-235 significantly reduced itching caused by wasp veno

13 PZ-235 significantly suppressed liver fibrosis, collagen

14 PZ-235 was distributed to liver and other mouse tissues

15 These results suggest that: (1) PZ(Vgat) neurons actively maintain, as oppose to simply

16 ion for a system operated with a 25% AMP/15% PZ solvent, but only 0.73 muM for a 35% MEA solvent.

17 e-promoting medial parabrachial nucleus; (2) PZ neurons express c-Fos after sleep but not after wakef

18 te with PZ was studied in 0.1 to 5 mol/dm(3) PZ with 0.001 to 0.8 mol CO2/mol PZ at 50 to 135 degrees

19 ecular basis for mechanism of action; and 4) PZ(Vgat) neurons represent a key cell population for SWS

20 A PZ-dependent protease inhibitor (ZPI) has been isolated

21 on when the inhibitor was neutralized with a PZ-specific antibody and decreased thrombin generation w

22 he intact constituents of a model ADC (Ab095-PZ) and a commercial ADC (brentuximab vedotin) under the

23 Compared to ABT263, PZ is less toxic to platelets, but equally or slightly m

24 mal ridge; ZPA, zone of polarizing activity; PZ, progress zone; SHH, sonic hedgehog; OSX, osterix tra

25 ial of RSV to resist prophylaxis, additional PZ-resistant viruses were selected in cell culture and w

26 ppressed with cyclophosphamide, administered PZ, and inoculated intranasally with RSV.

27 The binding assay indicated that all PZ derivatives interact with ZPI with a similar dissocia

28 ers with a Gleason score of at least 7 among PZ lesions at 3 T in data from two manufacturers.

29 d an observed 6-fold loss in PZ affinity and PZ catalytic action.

30 cantly different between prostate cancer and PZ (P < .012).

31 Parameters in prostate cancer and PZ were compared by using paired Student t tests.

32 by maintaining a boundary between the CZ and PZ.

33 uman prostate epithelial cell lines EP12 and PZ-HPV-7, respectively, and in human prostatic epitheliu

34 22Rnu1 than in human prostate epithelial and PZ-HPV-7 (virally transformed cells derived from normal

35 xpression of S100A2 was observed in NHPE and PZ-HPV-7 cells, whereas its complete absence was observe

36 n all carcinoma cells compared with NHPE and PZ-HPV-7 cells.

37 tor Xa in a calcium ion-, phospholipid-, and PZ-dependent fashion, but also directly inhibits coagula

38 flow cell analyses demonstrated that QS and PZs are involved in biofilm formation in P. chlororaphis

39 ryl group (i.e., Fab-SH), and whole antibody PZs regarding sensitivity and specificity.

40 he initial assembly of a membrane-associated PZ-ZPI-FXa Michaelis complex (K(M) 53+/-5 nM) followed b

41 spinocerebellar mossy fibers in the mouse AZ/PZ, whereas in rat CART immunoreactive mossy fibers term

42 Within the rat AZ/PZ, climbing fibers terminated selectively within the de

43 ntrast between cancerous sextants and benign PZ was significantly greater for D or K than ADC (0.25+/

44 ficantly different (P < .001) between benign PZ (23.7 and 7.7, 8.83, and 1.58 x 10(-3) mm(2)/sec, res

45 fferentiating cancerous sextants from benign PZ than ADC or D (93.3% vs 78.5% and 83.5%, respectively

46 greater in cancerous sextants than in benign PZ (0.96+/-0.24 vs 0.57+/-0.07, P<.001), as well as in c

47 n-related factors VII, IX, and X and PC, but PZ differs from these other proteins in that it is not t

48 omote the inactivation of factor Xa (fXa) by PZ-dependent protease inhibitor (ZPI) by three orders of

49 terminants of catalytic activation of ZPI by PZ and suggest novel strategies for ameliorating hemophi

50 ulation factor Xa by a plasma protein called PZ-dependent protease inhibitor (ZPI).

51 te tissues including peripheral zone cancer (PZ-C); peripheral zone noncancer; and benign tissue from

52 rally transformed prostate epithelial cells (PZ-HPV-7); several human prostate carcinoma cells (22Rv1

53 ng differentiation of peripheral zone cells (PZ), which surround the CZ, into CZ cells and restricts

54 glutamic acid domain (GD-PZ), and a chimeric PZ mutant in which both Gla and EGF-like domains of the

55 However, the apparent K(D) for the chimeric PZ-mediated ZPI inhibition of fXa was elevated 6-fold on

56 esponse in human plasma and that concomitant PZ deficiency dramatically increases the severity of the

57 Daily PZ-235 treatment of filaggrin-deficient mice exposed to

58 tor deficient (ZPI) and protein Z deficient (PZ) mice, as well as their wild-type littermates (ZPI, P

59 eliminated PZ binding and membrane-dependent PZ acceleration of fXa inhibition.

60 s of oxazolone- and DNFB-induced dermatitis, PZ-235 significantly attenuated skin thickening by 43%-1

61 rmined the x-ray structure of Gla-domainless PZ (PZ(DeltaGD)) complexed with protein Z-dependent prot

62 tion of four ZPI contact residues eliminated PZ binding and membrane-dependent PZ acceleration of fXa

63 For PZ and TZ lesions, the AUCs were 0.92 and 0.87, respecti

64 For PZ lesions, less-experienced observers increased their A

65 Here, we evaluated the potential for PZ-resistant RSV mutants to arise in vivo.

66 significantly with tumor-muscle SI ratio for PZ tumors on corrected and uncorrected images (P = .006

67 and Asp293 of ZPI are crucial hot spots for PZ binding.

68 rupt GABA/glycinergic neurotransmission from PZ neurons.

69 d conformational change in ZPI resulted from PZ binding, which contributed only approximately 2-fold

70 a circuit substrate through which GABAergic PZ neurons can potently trigger SWS and modulate the cor

71 ng the gamma-carboxyglutamic acid domain (GD-PZ), and a chimeric PZ mutant in which both Gla and EGF-

72 The cofactor activity of GD-PZ was dramatically impaired; however, the deletion muta

73 To understand how PZ acts catalytically, we analyzed the interaction of re

74 ilar mixtures containing factor Va, however, PZ and ZPI do not inhibit thrombin generation.

75 The studies in mice suggest that human PZ and ZPI deficiency would be associated with a modest

76 It remains, however, to be determined if PZ(Vgat) neurons actively maintain, as oppose to simply

77 Importantly, PZ-128 had no effect on bleeding or coagulation paramete

78 In PZ, reproducibility was moderate to substantial for feat

79 ns per type I HC range from 19 in CZ to 3 in PZ.

80 The median value of pPSA was 3% in PZ-C and 0% (undetectable) in TZ (P < 0.0026).

81 pectroscopic imaging had similar accuracy in PZ cancer localization (AUC, 0.60 vs 0.58, respectively;

82 Agreement tended to be better in PZ than TZ, although was weak for DCE in PZ.

83 re many more ribbons and afferent boutons in PZ than in CZ, whereas efferent innervation is relativel

84 Eleven parameters were calculated in PZ lesions: normalized T2-weighted signal intensity, ske

85 in PZ than TZ, although was weak for DCE in PZ.

86 ound that pPSA is differentially elevated in PZ-C, but is largely undetectable in TZ.

87 that rationalized an observed 6-fold loss in PZ affinity and PZ catalytic action.

88 e PZ and TZ and 60% for cancers occurring in PZ alone.

89 n PZ and TZ and 63% for cancers occurring in PZ alone.

90 (3 + 3) vs. GS >/=7 for cancers occurring in PZ and TZ and 63% for cancers occurring in PZ alone.

91 e of 4 or modified DCE score of positive; in PZ or TZ, upgrading category 4 to 5 based on size of 10-

92 Ionic current remodeling in PZ was also included.

93 edominantly from ionic current remodeling in PZ.

94 or-muscle SI ratios were lower in TZ than in PZ tumors (P < .001).

95 A single prophylactic dose of 15 mg/kg PZ protected cotton rats from infection with F212 but no

96 osine 387 has been changed to alanine, lacks PZ-dependent factor Xa inhibitory activity.

97 Five hundred and ten different lethal PZ element insertions were screened to identify those in

98 pecificity of ADCs for identifying malignant PZ voxels were calculated.

99 and 0.77 (mean, 1.08 +/- 0.20) in malignant PZ voxels (P = .027).

100 In murine gene-deletion models, PZ and ZPI deficiency enhances thrombosis following arte

101 5 mol/dm(3) PZ with 0.001 to 0.8 mol CO2/mol PZ at 50 to 135 degrees C.

102 Our results suggest that C. muridarum PZ genes are transcribed--and some may produce functiona

103 d and characterized a series of C. muridarum PZ nonsense mutants.

104 previously unidentified plasma protein named PZ-dependent protease inhibitor.

105 of regions of interest on tumors and normal PZ.

106 cancer cell line DU-145 (but not for normal PZ-HPV-7 prostate cells) and for the pancreatic cancer c

107 Incorporating normal PZ ADC significantly improved the AUC to 0.96 (P=.0401).

108 used to assess whether incorporating normal PZ ADCs improves the prediction of cancer aggressiveness

109 nochemical procedure was developed to obtain PZ-1361, a potent and selective 5-HT(7) receptor antagon

110 orter (Vgat)-GFP], we then show that >50% of PZ sleep-active neurons are inhibitory (GABAergic/glycin

111 The ability of PZ-235 to effectively suppress fibrosis, hepatocellular

112 studies in both the presence and absence of PZ revealed that Arg-143, Lys-147, and Arg-154 of the au

113 I also inhibits factor XIa in the absence of PZ, phospholipids, and Ca(++).

114 educed more than 1000-fold in the absence of PZ.

115 The onset of action of PZ-128 was rapid and suppressed PAR1 aggregation and art

116 We found that activation of PZ(Vgat) neurons completely blocked the behavioral and e

117 nowledge gap, we asked whether activation of PZ(Vgat) neurons could attenuate or block the wake-promo

118 In some contrast, activation of PZ(Vgat) neurons inhibited the behavioral, but not elect

119 her with native PAGE and kinetic analyses of PZ binding to ZPI, that Tyr240 and Asp293 of ZPI are cru

120 The combination of PZ and ZPI dramatically delays the initiation and reduce

121 The unique combination of PZ ionic current remodeling and different degrees of Mfb

122 s have an important role in the detection of PZ prostate cancer.

123 Disruption of PZ GABAergic/glycinergic neurotransmission resulted in s

124 cific interaction between the Gla domains of PZ and fXa contributes approximately 6-fold to the accel

125 of both pseudocatalytic and EGF2 domains of PZ for the critical ZPI interactions.

126 Thus, the major effect of PZ and ZPI is to dampen the coagulation response prior t

127 hus overcoming the arrhythmogenic effects of PZ ionic current remodeling.

128 ce to PZ did not always result in failure of PZ prophylaxis.

129 determined that an uncharacterized family of PZ genes encoding orthologs of eukaryotic and prokaryoti

130 Two groups of PZ-encoded proteins, the membrane attack complex/perfori

131 roscopic imaging for sextant localization of PZ prostate cancer is equal to that of MR imaging alone.

132 ntly rated the likelihood of the presence of PZ cancer in each sextant by using a five-point scale-fi

133 Herein, we report that the presence of PZ dampens the coagulation response in human plasma and

134 n cell culture for growth in the presence of PZ develops F gene mutations and can be resistant to PZ

135 monary replication of RSV in the presence of PZ was followed by the appearance of viruses resistant t

136 gulation assay) and requires the presence of PZ, calcium ions, and cephalin.

137 ible to inhibition by ZPI in the presence of PZ.

138 elet inhibition and reversible properties of PZ-128 are well suited to the acute interventional setti

139 To elucidate the role of PZ, we determined the x-ray structure of Gla-domainless

140 In these patients, no signs of PZ cancer were found at all three MR imaging sessions.

141 uggest that: (i) the ZPI interactive site of PZ is located within the C-terminal domain of the cofact

142 The structure of PZ is very similar to that of the coagulation-related fa

143 The structure of PZ-128 closely resembles the predicted off-state of the

144 Intra- and interpatient variation of PZ ADCs was determined by means of repeated measurements

145 examined the effect of altering the ratio of PZs produced by P. chlororaphis on biofilm formation and

146 onal or radiation treatment and at least one PZ lesion (volume, >0.1 cm(3)) at whole-mount pathologic

147 omy for prostate cancer and had at least one PZ tumor larger than 0.1 cm(3) at surgical pathologic ex

148 Palivizumab (PZ) is the only monoclonal antibody currently available

149 Palivizumab (PZ) is the only monoclonal antibody in use against a hum

150 Mice were treated with the pepducin PZ-235 either from onset of the experiment or after fibr

151 the ability of a cell-penetrating pepducin, PZ-235, to mitigate the potentially deleterious effects

152 type II HCs in central (CZ) and peripheral (PZ) zones of monkey cristae.

153 cy for cancers occurring in both peripheral (PZ) and transition (TZ) zones and 92% for cancers occurr

154 The production of phenazines (PZs) by strain 30-84 is the primary mechanism of pathoge

155 oscillating polymer gels to a piezoelectric (PZ) micro-electro-mechanical system (MEMS).

156 The biosensor comprises a piezoimmunosensor (PZ) displaying a specially constructed recombinant antib

157 Piperazine (PZ) is an efficient amine for carbon capture systems, bu

158 e higher for the secondary amine piperazine (PZ) than for the primary amines 2-amino-2-methyl-1-propa

159 Blends of tertiary amines with piperazine (PZ) showed n-nitrosopiperazine (MNPZ) yields close to un

160 nd cephalin also is enhanced in the presence PZ.

161 ownstream circuitry engaged by SWS-promoting PZ neurons, and we found that this circuit uniquely and

162 gnificantly improve the accuracy of prostate PZ tumor volume measurement.

163 ed the x-ray structure of Gla-domainless PZ (PZ(DeltaGD)) complexed with protein Z-dependent proteina

164 of fXa with ZPI, we expressed wild-type PZ, PZ lacking the gamma-carboxyglutamic acid domain (GD-PZ)

165 al inhibitor, by converting it into PZ15227 (PZ), a Bcl-xl PROTAC, which targets Bcl-xl to the cerebl

166 e lung homogenate of a rat that had received PZ.

167 escape mutant, MP4, has been shown to resist PZ prophylaxis in cotton rats.

168 Both in vitro and in vivo, individual RSV PZ escape mutants varied in their susceptibility to PZ.

169 Experimental data show that the scFv SAM PZ is superior to Fab fragment, Fab fragment containing

170 Sixty PZ cancer lesions larger than 0.1 cm(3) were found at pa

171 n experienced radiologist outlined suspected PZ tumors.

172 s a significantly more severe phenotype than PZ deficiency, implying that factor XIa inhibition by ZP

173 ith FXa, and kinetic analyses confirmed that PZ acted catalytically to accelerate the membrane-depend

174 We hypothesized that PZ genes might mediate the greater virulence and gamma i

175 The results indicate that PZ plays a physiologically important role in the regulat

176 We observed that PZ both acts as an ionophore that promotes uptake of tox

177 We have shown recently that PZ forms a calcium ion-dependent complex with activated

178 Native PAGE and immunoblotting showed that PZ dissociated from ZPI once ZPI forms a stable complex

179 ructure of the ZPI-PZ complex has shown that PZ binds to a unique site on ZPI centered on helix G.

180 The PZ pseudocatalytic domain bound ZPI at a novel site thro

181 The PZ-altered derivatives of strain 30-84 also differed in

182 e relative ratios of cells in the CZ and the PZ are maintained, despite a constant displacement of ce

183 d lipids, but the functions of CT153 and the PZ PLDs (pzPLDs) are unknown.

184 later time in the infarction model, and the PZ served to delay propagation in subsequent beats.

185 % accuracy for cancers occurring in both the PZ and TZ and with 93% for cancers occurring in the PZ a

186 es are also susceptible to inhibition by the PZ-ZPI complex.

187 m(-1) s(-1)) that has been observed for the PZ-dependent inhibition of FXa by ZPI.

188 Signals from the PZ maintain the AER until the anlagen for the distal pha

189 ging outperformed T2-weighted imaging in the PZ (OR, 3.49 vs 2.45; P = .008).

190 ) zones and 92% for cancers occurring in the PZ alone.

191 TZ and with 93% for cancers occurring in the PZ alone.

192 S 7(3 + 4) from GS 7(4 + 3) occurring in the PZ and TZ and 60% for cancers occurring in PZ alone.

193 ROIs in the PZ identified by matching pathologic slides with T2-weig

194 maging and as positive at DCE imaging in the PZ showed a higher probability of cancer detection than

195 tabolite ratios in the TZ and of ADCs in the PZ suggest that they have complementary value.

196 addition of DCE imaging to DW imaging in the PZ was beneficial (OR, 2.0; P = .027), with an increase

197 n of DCE imaging to DW imaging scores in the PZ yields meaningful improvements in probability of canc

198 Results A total of 654 lesions (420 in the PZ) were detected.

199 At these thresholds, in the PZ, similar accuracy was achieved with the PI-RADS scale

200 s were modeled: 0%, 10%, and 30% Mfbs in the PZ, with either 80% or 0% Mfbs in the scar.

201 1 domain may not play a dominant role in the PZ-dependent recognition of fXa by the serpin on phospho

202 ing between benign and malignant ROIs in the PZ.

203 ctively suppresses stem cell identity in the PZ.

204 roles to suppress SCN respecification in the PZ.

205 aging outperforms T2-weighted imaging in the PZ; T2-weighted imaging did not show a significant diffe

206 t displacement of cells from the CZ into the PZ, and subsequent allocation of cells within the PZ to

207 Moreover, the PZ antibody enhanced thrombin generation both in the abs

208 sting membrane potential within and near the PZ and action potential duration shortening throughout t

209 rdia, by elevating the responsiveness of the PZ cells to the plant hormone auxin.

210 ZPI binding and the cofactor function of the PZ derivatives were characterized in both binding and ki

211 However, none of the PZ nonsense mutants exhibited increased IFN-gamma sensit

212 e; and (3) cell-body-specific lesions of the PZ result in large and sustained increases (50%) in dail

213 The presence of the PZ was found to be responsible for the increased vulnera

214 e revealed changes in helices A and G of the PZ-binding site relative to native ZPI that rationalized

215 tiating and non-differentiating cells of the PZ.

216 ncreased cell division rates in cells of the PZ; conversely, decreases in WUS level lead to a smaller

217 Here, we show that the PZ PLD (pzPLD) of Chlamydia trachomatis are transcribed

218 and PNF act to restrict organogenesis to the PZ by maintaining a boundary between the CZ and PZ.

219 nd subsequent allocation of cells within the PZ to form organ primordia.

220 Using flow cell assays, we found that these PZ-altered derivatives of strain 30-84 differed from the

221 Mutations associated with resistance to PZ did not always result in failure of PZ prophylaxis.

222 gene mutations associated with resistance to PZ.

223 A virus completely resistant to PZ neutralization was recovered from the lung homogenate

224 tially and MS412 was completely resistant to PZ neutralization.

225 ops F gene mutations and can be resistant to PZ prophylaxis in cotton rats.

226 ed by the appearance of viruses resistant to PZ.

227 ulture and were tested for susceptibility to PZ in cotton rats.

228 pe mutants varied in their susceptibility to PZ.

229 orced expression of SIRT1 in non-transformed PZ-HPV-7 prostate epithelial cells disrupts the epitheli

230 x 10(-3) mm(2)/sec, respectively) and tumor PZ tissue (11.4 and 12.5, 5.13, and 1.20 x 10(-3) mm(2)/

231 P. chlororaphis produces mainly two PZs, phenazine-1-carboxylic acid (PCA) and 2-hydroxy-PCA

232 vity of fXa with ZPI, we expressed wild-type PZ, PZ lacking the gamma-carboxyglutamic acid domain (GD

233 specific proteinases is insignificant unless PZ binds and localizes ZPI and fXa on the membrane, wher

234 Na(V)PZ and Na(V)SP share approximately 40% amino acid sequen

235 expressed in mammalian cell lines, both Na(V)PZ and Na(V)SP were Na(+)-selective and voltage-dependen

236 ed as voltage-dependent Na(+) channels (Na(V)PZ from Paracoccus zeaxanthinifaciens and Na(V)SP from S

237 ons varied significantly (TZ, 8.3 +/- 6.6 vs PZ, 4.4 +/- 4.1 microg/g; P = .001).

238 Mean concentrations within the TZ vs PZ prostate regions varied significantly (TZ, 8.3 +/- 6.

239 chronizing, but not behavioral, effects when PZ(Vgat) neurons are activated, inferring a shared and d

240 cannot exert its wake-promoting effects when PZ(Vgat) neurons are activated, intimating a possible sh

241 To understand the mechanism by which PZ improves the reactivity of fXa with ZPI, we expressed

242 relatively heterogeneous when compared with PZ cells.

243 ion of reactive loop-cleaved ZPI (cZPI) with PZ and determined the cZPI X-ray structure.

244 The reaction of nitrite with PZ was studied in 0.1 to 5 mol/dm(3) PZ with 0.001 to 0.

245 ond retrospective cohort of 51 patients with PZ prostate cancer.

246 ccumulation in CO2 capture by scrubbing with PZ or other amines.

247 that involves the actions of factor Xa with PZ and factor XIa.

248 iffusion-limited rate with fXa, even without PZ, and predominantly as substrate, reflecting both rapi

249 lex through either ZPI-PZ-lipid or factor Xa-PZ-lipid intermediates was rate-limiting.

250 ent kinetic analyses of ZPI-PZ and factor Xa-PZ-membrane complex formation suggested that assembly of

251 Human protein Z (PZ) is a 62,000-Mr, vitamin K-dependent plasma protein w

252 Protein Z (PZ) is a multidomain vitamin K-dependent plasma protein

253 Protein Z (PZ) is a plasma vitamin K-dependent protein that functio

254 Protein Z (PZ) is a vitamin K-dependent plasma protein whose functi

255 olipid vesicles and calcium ions, protein Z (PZ) serves as a cofactor for the inhibition of coagulati

256 PI), complexed with its cofactor, protein Z (PZ), functions as a physiologically significant inhibito

257 e show that ZPI and its cofactor, protein Z (PZ), inhibit procoagulant membrane-bound factor Xa by th

258 chimera by ZPI in the presence of protein Z (PZ), negatively charged membrane vesicles, and calcium i

259 actor Xa (fXa) in the presence of protein Z (PZ), negatively charged phospholipids, and Ca2+.

260 n of factor Xa in the presence of protein Z (PZ), procoagulant phospholipids, and Ca(++) (t(1/2) less

261 ically activated by its cofactor, protein Z (PZ), to regulate the function of blood coagulation facto

262 The serpin ZPI is a protein Z (PZ)-dependent specific inhibitor of membrane-associated

263 ds, including the ionophore pyrithione zinc (PZ), that effectively inhibit C. albicans SOD5 but not m

264 agation delay through the peri-infarct zone (PZ) were responsible.

265 ctivation of GABA-releasing parafacial zone (PZ(Vgat)) neurons in behaving mice produces slow-wave-sl

266 ic neurons in the medullary parafacial zone (PZ) are needed for normal SWS, it remains unclear whethe

267 erve-a region we termed the parafacial zone (PZ)-project to the wake-promoting medial parabrachial nu

268 both infarct regions, the periinfarct zone (PZ) and the scar; six scenarios were modeled: 0%, 10%, a

269 f 4 or greater was 0.593 in peripheral zone (PZ) and 0.509 in transition zone (TZ).

270 nd 64 benign regions in the peripheral zone (PZ) and 19 malignant and 56 benign regions in the transi

271 cores was calculated in the peripheral zone (PZ) and transition zone (TZ) by using generalized estima

272 SI ratios in peripheral zone (PZ) and transition zone (TZ) lesions of the same Gleason

273 ced towards the surrounding peripheral zone (PZ) divide at a faster rate and enter into differentiati

274 Cells in the peripheral zone (PZ) divide at a faster rate than in the central zone (CZ

275 are formed in the circular peripheral zone (PZ) from stem cell descendants in which differentiation

276 Z) and organogenesis in the peripheral zone (PZ) is essential for the integrity, function, and mainte

277 n score of at least 7 among peripheral zone (PZ) lesions seen at 3-T multiparametric magnetic resonan

278 on rules was 30.0%-33.3% in peripheral zone (PZ) lesions upgraded from category 3 to 4 based on dynam

279 nign and malignant prostate peripheral zone (PZ) tissue retrospectively by using a commercial magneti

280 nd cytoplasm and stroma for peripheral zone (PZ), transition zone (TZ), and tumor tissue in both zone

281 tile ADC (rho=-0.63) in the peripheral zone (PZ).

282 index tumors and nontumoral peripheral zone (PZ): apparent diffusion coefficient (ADC) obtained with

283 n Chlamydia spp. termed the plasticity zone (PZ) may encode niche-specific virulence determinants tha

284 amydial genomes, termed the plasticity zone (PZ).

285 on of the genome termed the plasticity zone (PZ).

286 ectodermal ridge (AER) to the progress zone (PZ), which in response proliferates and lays down the pa

287 ons of the telencephalic proliferative zone (PZ) to give rise to neurochemically defined interneuron

288 e (transition zone [TZ] and peripheral zone [PZ]) fosfomycin concentrations using liquid chromatograp

289 ently scored 18 regions (12 peripheral zone [PZ], six transition zone [TZ]) using PI-RADS (range, sco

290 e; AZ) and VIII-anterior IX (posterior zone; PZ), whereas the small heat shock protein 25 (HSP25) is

291 as well as their wild-type littermates (ZPI, PZ), kinetics of light/dye-induced thrombus formation an

292 of the Michaelis complex through either ZPI-PZ-lipid or factor Xa-PZ-lipid intermediates was rate-li

293 eased thrombin generation when exogenous ZPI-PZ complex was added whether prothrombin was activated d

294 her with independent kinetic analyses of ZPI-PZ and factor Xa-PZ-membrane complex formation suggested

295 The importance of ZPI-PZ complex anticoagulant regulation of FXa both before a

296 The X-ray structure of the ZPI-PZ complex has shown that PZ binds to a unique site on Z

297 an important anticoagulant role for the ZPI-PZ complex in regulating both free FXa generated in the

298 e rapid rate of inhibition of FXa by the ZPI-PZ complex on procoagulant membrane vesicles (k(a) ((app

299 Nevertheless, the ZPI-PZ complex produced a major inhibition of thrombin gener

300 ic states through drugs that disrupt the ZPI-PZ interaction.