ライフサイエンスコーパス: Ph

1 Ph SAM forms helical head to tail polymers, and SAM-SAM

2 Ph SAM-dependent condensates can recruit PRC1 from extra

3 Ph(+) acute lymphoblastic leukemia (ALL) is characterize

4 Ph-AH(+)-Np@CB[7] is formed by reactions with free CB[7]

5 Ph-like ALL is driven by genetic alterations that activa

6 Ph-negative myeloproliferative neoplasms (MPNs) are hema

7 Ph. argentipes males produce acoustic signals during cop

8 Phd presented an antioxidant protective effect toward O(

9 Phd substrates showed properties as antioxidant additive

10 R,R)-((iPr) DuPhos)Co(CO)(2) C(O)CH(2) CH(2) Ph, which upon hydrogenolysis under 4 atm H(2) produced

11 ) (mu(4) -S)(dppa)(4) ](2+) (1, dppa=mu(2) -(Ph(2) P)(2) NH) has N(2) O reductase activity in methano

12 ducts: {[Cu(hfac)(2)](py-CH(2)NH(2)CH(2)CH(2)Ph)[Cr(7)NiF(8)(O(2)C(t)Bu)(16)]}, {[Cu(hfac)(2)][py-CH(

13 served for compounds with OCH(3) (3b), OCH(2)Ph (3d), or Ph(3)P(+) (3i) as leaving groups than those

14 a (L = OAc), 3b (L = OMe), and 3d (L = OCH(2)Ph) showed a similar photoreactivity toward dGs and dAs.

15 sulfonate ligand PPh(2-SO(3)(-)-4,5-(OMe)(2)-Ph)(2) (OPO(2-), 2) are described.

16 f an ortho-substituted closo-carborane (1,2-(Ph(2)PO)(2)-1,2-C(2)B(10)H(10)) cluster molecule can lea

17 [CuX(CAArC)] (X = Br (1), Cbz (2), acac (3), Ph(2)acac (4), Cp (5), and Cp* (6)) with known Cu(I) com

18 (1) = R(2) = Me or R(1) = H, R(2) = SiMe(3), Ph; Tp' = kappa(3)-N,N',N"-hydridotris(3,5-dimethylpyraz

19 -Im->AlPorF(5)-Ph-C(60), BTMPA-Im->AlPorF(3)-Ph-C(60), and BTMPA-Im->AlPor-Ph-C(60), respectively.

20 u(hfac)(2)]([py-C(6)H(4)-CH(2)NH(2)(CH(2))(4)Ph][Cr(7)NiF(8)(O(2)C(t)Bu)(16)])(2)}, and {[Cu(hfac)(2)

21 tion to give diazametallocyclobutene 8 (Ar=4-Ph-2,6-iPr2 C6 H2 ).

22 y of TEMPO to catalyze H. transfer from (C(5)Ph(5))Cr(CO)(3)H to a trityl radical (tris( p- tert-buty

23 the catalytic process: H. transfer from (C(5)Ph(5))Cr(CO)(3)H to TEMPO and H. transfer from TEMPO-H t

24 1240, 740, and 56 ns for BTMPA-Im->AlPorF(5)-Ph-C(60), BTMPA-Im->AlPorF(3)-Ph-C(60), and BTMPA-Im->Al

25 in the oxidation state V [R/X = t-Bu/O (6), Ph/S, (7), t-Bu/S (8), t-Bu/Se (9)] or III [R/X = Ph/BH(

26 of ((Ar)L)CoBr ((Ar)L = 5-mesityl-1,9-(2,4,6-Ph(3)C(6)H(2))dipyrrin) with a stoichiometric amount of

27 (Ar)L)Co(II)Br ((Ar)L = 5-mesityl-1,9-(2,4,6-Ph(3)C(6)H(2))dipyrrin) with potassium graphite afforded

28 ((Ar)L)Co(NR) ((Ar)L = 5-mesityl-1,9-(2,4,6-Ph(3)C(6)H(2))dipyrrin), ((Tr)L)Co(NR) displays enhanced

29 The dynamics of the capped Na(+).CB[7]@Ph-AH(+)-Np 1:1 complex is slower than in the absence of

30 of the smaller phenyl moiety in CB[7] (CB[7]@Ph-AH(+)-Np) is transient.

31 +) leads to the formation of the Na(+).CB[7]@Ph-AH(+)-Np@CB[7] 2:1 host-guest complex, where each moi

32 lver nanoparticles (Ag(210) ((i) PrPhS)(71) (Ph(3) P)(5) Cl and Ag(211) ((i) PrPhS)(71) (Ph(3) P)(6)

33 (Ph(3) P)(5) Cl and Ag(211) ((i) PrPhS)(71) (Ph(3) P)(6) Cl labeled as SD/Ag210 and SD/Ag211 (SD=SunD

34 navian languages and literature from UCLA, a Ph.D. in biochemistry from Uppsala University, and an M.

35 nd cleavage, affording 2-pyridinyl acetates, Ph(3)P-catalyzed [4 + 2] annulation leads to functionali

36 lic Ge(I) compound [(ADC(Ph))Ge](2) (4) (ADC(Ph) = {CN(Dipp)}(2)CPh, Dipp = 2,6-iPr(2)C(6)H(3)) conta

37 The cyclic Ge(I) compound [(ADC(Ph))Ge](2) (4) (ADC(Ph) = {CN(Dipp)}(2)CPh, Dipp = 2,6-i

38 yield the elusive bis-hydridogermylene [(ADC(Ph))GeH](2) (5).

39 MYB and CDK6 were highly correlated in adult Ph(+) ALL (P = 0.00008).

40 silver-organic Ag(89) ((i) PrPhS)(71) Cl[Ag(Ph(3) P)](n) outermost shell.

41 The number (n) of Ag(Ph(3) P) is five for SD/Ag210 and six for SD/Ag211.

42 -Im->AlPorF(3)-Ph-C(60), and BTMPA-Im->AlPor-Ph-C(60), respectively.

43 Although Ph(+) ALL is defined by BCR-ABL1 fusion, Ph-like ALL cas

44 ), platelet count (HR, 7.437; P = .005), and Ph-like ALL (HR, 1.818; P = .03).

45 ds to a high activity in catalytic CO(2) and Ph(2) CO reduction by Et(3) SiH and hydrogenation of 1,1

46 ng reaction employing secondary alcohols and Ph* (Me5C6) ketones to give beta-branched carbonyl produ

47 C(sp)-C(sp2) coupled products RC=C-C=CAr and Ph-C=CAr with concomitant generation of [Cu(I)](solvent)

48 ypes of reaction products with carbazole and Ph-BIM.

49 ed by an unusual migration of the H, Me, and Ph groups from germanium to the carbene ligand.

50 nt with the linear arrangements Ph-B-N-N and Ph-B-C-O obtained by density functional theory computati

51 e Markovnikov products, Ph(Me)C(H)SiH2Ph and Ph(Me)C(H)Bpin, and (ii) hydroboration of carbodiimides

52 nucleophiles R'C=C-Li (R' = aryl, silyl) and Ph-Li to [Cu(II)]-C=CAr affords the corresponding C(sp)-

53 0.5, 0.6 and 0.8microM were obtained for AP, Ph, and NP, respectively.

54 ytic activity toward electrooxidation of AP, Ph, and NP to three well-separated peaks in the potentia

55 -ate species of the form [U(Ar)(6) ](2-) (Ar=Ph, p-tolyl, p-Cl-Ph).

56 re in agreement with the linear arrangements Ph-B-N-N and Ph-B-C-O obtained by density functional the

57 s that include alkyl (C(5)H(11)), (het)aryl (Ph, 2-thienyl, ferrocenyl), ArC=C, amine (NHPh and morph

58 t on the regioselective binding of auxiliary Ph(3) P on the surface of silver nanoparticles.

59 e from values for SAMs of oligophenyls (beta(Ph)n = 0.28 +/- 0.03 A(-1)), and significantly lower tha

60 a potential synergistic interaction between Phd and antioxidants used in food industry were investig

61 the rapid construction of both biradicaloid (Ph(2)- s-IDPL, 1) and radical [10(OTf)] bisphenalenyls i

62 SAM-SAM interactions between chromatin-bound Ph/PRC1 are believed to compact chromatin and mediate lo

63 ansfer is revealed in the Re(I)(CO)3(py)(bpy-Ph)-perylenediimide radical anion (Re(I)-bpy-PDI(-*)) dy

64 )H(3)-5-R'-(C(O)PMe)}(2) (R' = I, Me, (t)Bu, Ph, and p-NCC(6)H(4)); the analogues m-{-C(O)-C(5)H(3)N-

65 nterception of the released benzoate ions by Ph(C(6)F(5))I(+) ions.

66 s to the intermediate, (eta(5)-C5Me5)[N(Et)C(Ph)N(Et)]Mo(Cl)(NHSiMe3) (V), and XOSiMe3 as a co-produc

67 erminal imido complex, (eta(5)-C5Me5)[N(Et)C(Ph)N(Et)]Mo(NSiMe3) (3), with a 1:2 mixture of iPrOH and

68 the Mo(IV) dichloride, (eta(5)-C5Me5)[N(Et)C(Ph)N(Et)]MoCl2 (1), and the generation of 1 equiv each o

69 hilic character of the phosphinidene {(NHC)C(Ph)}P moiety.

70 (IMe(4)) to yield the Lewis adduct [{(NHC)C(Ph)}P(IMe(4))]Fe(CO)(4) (5) [IMe(4) = C(NMeCMe)(2)].

71 st terminal phosphinidene complexes [{(NHC)C(Ph)}P]Fe(CO)(4) [NHC = IPr = C{(NDipp)CH}(2) for 3; Me-I

72 s of 1-phenyl-1-X-1-silacyclohexanes C5H10Si(Ph,X) (X = F (3), Cl (4)) were studied by gas-phase elec

73 ic guest N-phenyl-2-naphthylammonium cation (Ph-AH(+)-Np) to cucurbit[7]uril (CB[7]) by facilitating,

74 CCA/Ph(-) occurred in 58 patients (10%); the most common wer

75 We further categorized CCA/Ph(-) into those in which -Y was the only clonal abnorma

76 ies in Philadelphia chromosome-negative (CCA/Ph(-)) metaphases emerge as patients with chronic phase

77 In conclusion, non -Y CCA/Ph(-) are associated with decreased survival when emergi

78 We found that patients with non -Y CCA/Ph(-) had worse failure-free survival (FFS), event-free

79 Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL), also referr

80 Philadelphia chromosome (Ph)-like B-cell acute lymphoblastic leukemia (Ph-like AL

81 described in adult Philadelphia chromosome (Ph)-negative B-cell precursor (BCP) acute lymphoblastic

82 py in patients with Philadelphia chromosome (Ph)-negative CD20-positive B-cell acute lymphoblastic le

83 es in patients with Philadelphia chromosome (Ph)-positive acute lymphoblastic leukemia (ALL) have imp

84 ory, CD22-positive, Philadelphia chromosome (Ph)-positive or Ph-negative B-cell acute lymphoblastic l

85 e form [U(Ar)(6) ](2-) (Ar=Ph, p-tolyl, p-Cl-Ph).

86 Platinum complex (Ph(3)P)(2)Pt(eta(2)- (t)BuPS) (4, 47%) is also accessed

87 ization of the dimeric iron hydride complex [Ph(2)B((t)BuIm)(2)FeH](2) reveals an unusual structure i

88 1,n- bis-diphenylphosphinoalkane complexes [Ph(2)P-(CH(2)) (n)-PPh(2)]CoX(2); n = 1-5) or from (2-ox

89 Conclusion Ph-like ALL is a highly prevalent subtype of ALL in adul

90 ib therapy seems to be beneficial to control Ph+ leukemia resistance and the quantitative model can d

91 ed the interactions of phenolic derivatives (Phd), tyrosol and tyrosol derived isomers, with O(2)((1)

92 transplantation models using patient-derived Ph(+) ALL cells.

93 -line therapy in adults with newly diagnosed Ph-positive ALL (with no upper age limit).

94 Patients with newly diagnosed, Ph-negative B-cell acute lymphoblastic leukaemia or lymp

95 in swings the aromatic rings from downstream Phes in the cavity of the channel, which blocks ion flux

96 platform with anti-IL7R antibody eliminates Ph(+) ALL cells including those with resistance to commo

97 ng catalyst; its substrate scope encompasses Ph(H)C=N tBu, Ph(2)C=CH(2), and anthracene.

98 The CF3 analogue participates in fast Ph-CF3 coupling (<5 min at 80 degrees C).

99 derivative (OEP)Fe(PhNO)(5-MeIm) and (OEP)Fe(Ph).

100 hosphido nucleophiles LiPHR (R = ferrocenyl, Ph, Cy, t-Bu, Mes* (Mes* = 2,4,6-(t-Bu)(3)C(6)H(2))), fo

101 nimization with the definition LA(I) = 0 for Ph(2)I(+) and s(I) = 1.00 for the benzoate ion provides

102 val and overall survival were determined for Ph-like ALL versus non-Ph-like ALL patients.

103 s), endowed with antileukemia activity, from Ph(+) ALL patients and healthy donors.

104 ubstituted stereo-defined cyclopentanes from Ph* methyl ketone and cyclopropyl alcohols.

105 ugh Ph(+) ALL is defined by BCR-ABL1 fusion, Ph-like ALL cases contain a variety of genomic alteratio

106 captures the trityl radical Ph(3)C. to give Ph(3)C-C=CAr.

107 mes from studies of the archeal homologs Glt(Ph) from Pyrococcus horikoshii and Glt(Tk) from Thermoco

108 al model glutamate transporter homologue Glt(Ph) from Pyrococcus horikoshii suggested that the slow c

109 Using bioinformatics, we identified Glt(Ph) gain-of-function mutations in the flexible helical h

110 ritical aspect of the transport cycle in Glt(Ph) is the coupled binding of sodium and aspartate.

111 al amino acid, p-cyanophenylalanine into Glt(Ph) We use the HP2 assays to show that HP2 opening with

112 The crystal structures of Glt(Ph) from archaea have been used in computational studies

113 We report Cryo-EM structures of Glt(Ph) reconstituted into nanodiscs, including those struct

114 e of the high-energy transition state of Glt(Ph) that limits the rate of the substrate translocation

115 mics of unlabeled membrane-reconstituted Glt(Ph), a prokaryotic EAAT homologue, with millisecond temp

116 r the trimeric Na(+)-aspartate symporter Glt(Ph), a homolog of an important class of neurotransmitter

117 homolog, sodium, and aspartate symporter Glt(Ph).

118 The sodium-coupled Asp symporter, Glt(Ph) is an archaeal homolog of glutamate transporters and

119 We find that Glt(Ph) transporters can operate much faster than previously

120 upled binding of sodium and aspartate to Glt(Ph) In this study, we develop a fluorescence assay for m

121 upled binding of sodium and aspartate to Glt(Ph).

122 sm(Pr(i)Benz)]MgX [X = F, Cl, Br, I, SH, N(H)Ph, CH(Me)Ph, O2CMe, S2CMe].

123 hinoboranes, [RR'PBH(2)](n) (R = Ph; R' = H, Ph or Et), or are trapped in the form of CAAC-phosphinob

124 f 148 patients, 33.1% had Ph-like, 31.1% had Ph(+), and 35.8% had other B-ALL subtypes (B-other).

125 Of 148 patients, 33.1% had Ph-like, 31.1% had Ph(+), and 35.8% had other B-ALL subt

126 Nine (27%) of 33 patients had Ph-like acute lymphoblastic leukaemia.

127 with length-matched SAMs of oligophenyls (HS(Ph)nH) and n-alkanethiols (HS(CH2)nH) demonstrates that

128 l of MDSPCs derived from prolyl hydroxylase (Phd) 3-knockout (Phd3(-/-)) mice, which displayed higher

129 mplexes of general structure (P(t)Bu3)Pd(II)(Ph)(RF).

130 Additional genomic alterations in Ph-like ALL activate other kinases, including BLNK, DGKH

131 se range of kinase-activating alterations in Ph-like ALL has important therapeutic implications.

132 referential degradation of CDK6 over CDK4 in Ph+ ALL cells, and markedly suppress S-phase cells conco

133 otherapeutic approaches with BCR-ABL CTLs in Ph(+) ALL.

134 were consistent with previous experience in Ph(-) ALL.

135 kinase-like gene (PITG_04584) by 60-fold in Ph. infestans.

136 t germination, and appressorium formation in Ph. infestans.

137 cyst formation, or appressorium formation in Ph. infestans.

138 of CDK6 are, in part, kinase-independent in Ph+ ALL.

139 testing combinations of kinase inhibitors in Ph-like ALL patients are indicated.

140 hibitors have been minimally investigated in Ph-like ALL.

141 on and suppression of resistant outgrowth in Ph(+) clinical isolates and cell lines.

142 enes previously reported to be rearranged in Ph-like ALL.

143 nal essential signaling pathways required in Ph-like leukemogenesis for improved therapeutic targetin

144 Consistent with their essential role in Ph(+) ALL, pharmacologic inhibition of CDK6 and BCL2 mar

145 covery of this copulation courtship songs in Ph. argentipes supports the possibility that acoustic co

146 han 700 extracts, one consistently inhibited Ph. infestans cyst germination.

147 roethanol than the parent benzhydrylium ion (Ph)2CH(+), even though in solvolysis reactions (80% aque

148 enide nanopropeller Fe(3)Co(6)Se(8)L(6) (L = Ph(2)PNTol) featuring three Fe edge sites, and its ensui

149 ene dication in [(L(Ph)Si)(4)](BPh(4))(2) (L(Ph) = PhC(NtBu)(2)) has been obtained in a simple and st

150 Complexes [L(Ph)(Ni(II)-H)(2)](-) (3) are prone to intramolecular red

151 imple and straightforward synthesis, from [L(Ph)SiCl], [L(Ph)SiSiL(Ph)] and NaBPh(4), and fully chara

152 tron tetrasilacyclobutadiene dication in [(L(Ph)Si)(4)](BPh(4))(2) (L(Ph) = PhC(NtBu)(2)) has been ob

153 addition to the dinickel(I) intermediate [L(Ph)Ni(I)(2)](-) (4).

154 olate-based bis(beta-diketiminato) ligand [L(Ph)](3-) with bulky m-terphenyl substituents that can ho

155 ws for the unmasking of a highly reactive [L(Ph)Ni(I)(2)](-) intermediate 4 either via elimination of

156 aightforward synthesis, from [L(Ph)SiCl], [L(Ph)SiSiL(Ph)] and NaBPh(4), and fully characterized.

157 osome-positive acute lymphoblastic leukemia (Ph(+) ALL) is currently treated with BCR-ABL1 tyrosine k

158 osome-positive acute lymphoblastic leukemia (Ph(+) ALL) undergoing maintenance tyrosine-kinase inhibi

159 h)-like B-cell acute lymphoblastic leukemia (Ph-like ALL) is associated with activated JAK/STAT, Abel

160 me-like B cell acute lymphoblastic leukemia (Ph-like B-ALL) experience high relapse rates despite bes

161 Philadelphia chromosome-like (Ph-like) acute lymphoblastic leukemia (ALL) is a high-ri

162 oxo atom donor adduct, Fe-O horizontal lineI-Ph, or an Fe(V) horizontal lineO remains to be determine

163 nz)]MgX [X = F, Cl, Br, I, SH, N(H)Ph, CH(Me)Ph, O2CMe, S2CMe].

164 ereoisomeric alcoholato complexes [Fe(OCH(Me)Ph)(CNCEt(3))(1)]BF(4) (10R and 10S).

165 ibed to prepare compounds R(2)P(X)C(S)SCH(Me)Ph with the P atom either in the oxidation state V [R/X

166 protonated to yield the [t-Bu(2)PHC(S)SCH(Me)Ph](+) cation (10-H(+)), which was isolated as a BF(4)(-

167 ated the nucleophilic addition product [(Me)(Ph)(CCHC){Au(IPr)}(2)(SOMe(2))]NTf(2) with DMSO.

168 Moreover, Ph(+) ALL cells exhibited a specific requirement for CDK

169 lized magnesium silicates (MSil-C16 and MSil-Ph) were confirmed by X-ray diffraction (XRD), Fourier t

170 ort describes the use of [Cp*Ru(P(tBu) (2) N(Ph) (2) )((15) NH(3) )][BAr(F) (4) ], (P(tBu) (2) N(Ph)

171 )((15) NH(3) )][BAr(F) (4) ], (P(tBu) (2) N(Ph) (2) =1,5-di(phenylaza)-3,7-di(tert-butylphospha)cycl

172 The triads, BTMPA-Im->AlPorF(n)-Ph-C(60) (n = 0, 3, 5), were constructed by linking the

173 the lifetime of the BTMPA(*+)-Im->AlPorF(n)-Ph-C(60)(*-) radical pair was found to be very different

174 rge separated state, BTMPA(*+)-Im->AlPorF(n)-Ph-C(60)(*-), which lies energetically 1.50 eV above the

175 ed faster via the isomer (C(6)H(4), O)(C, N, Ph) formed by P-stereomutation involving a M(B2) permuta

176 ate shows that compared to N-Me, N-iPr and N-Ph variants, the N-o-tolyl variant of the rhodium enolat

177 This may explain why N-Ph and N-Bu imines are not hydrogenated.

178 SiO)(2) ](PF(6) ) (2) and [Dy(III) (L(N6) )(Ph(3) SiO)(2) ](BPh(4) ) (3) hexagonal bipyramidal dyspr

179 Bu-PhO)(2) ](PF(6) ) (1), [Dy(III) (L(N6) )(Ph(3) SiO)(2) ](PF(6) ) (2) and [Dy(III) (L(N6) )(Ph(3)

180 l were determined for Ph-like ALL versus non-Ph-like ALL patients.

181 The bis-NQIM-Ph was implemented in a real-time electrochemical qLAMP,

182 tives olefinated through the isolated (N, O)(Ph, C(6)H(4), C) oxaphosphetanes (Channel A), whereas Mo

183 de to afford [((o-(Ph(2) P)C(6) H(4) )(2) (o-Ph(2) PO)C(6) H(4) )SbAuCl(2) ](+) ([2 a](+) ) which was

184 onic complex [((o-(Ph(2) P)C(6) H(4) )(2) (o-Ph(2) PO)C(6) H(4) )SbAuCl](2+) ([3](2+) ) by treatment

185 o as [4](2+) [((o-(Ph(2) P)C(6) H(4) )(2) (o-Ph(2) PO)C(6) H(4) )SbAuNTf(2) ](2+) readily catalyzes b

186 ([3](+) ; Acr=9-N-methylacridinium) and [(o-Ph(2) P(C(6) H(4) )Xan)AuCl](+) ([4](+) ; Xan=9-xanthyli

187 we describe the phosphine gold complexes [(o-Ph(2) P(C(6) H(4) )Acr)AuCl](+) ([3](+) ; Acr=9-N-methyl

188 ivated complex, referred to as [4](2+) [((o-(Ph(2) P)C(6) H(4) )(2) (o-Ph(2) PO)C(6) H(4) )SbAuNTf(2)

189 dized with hydrogen peroxide to afford [((o-(Ph(2) P)C(6) H(4) )(2) (o-Ph(2) PO)C(6) H(4) )SbAuCl(2)

190 converted into the dicationic complex [((o-(Ph(2) P)C(6) H(4) )(2) (o-Ph(2) PO)C(6) H(4) )SbAuCl](2+

191 this end, the dangling phosphine arm of ((o-(Ph(2) P)C(6) H(4) )(3) )SbCl(2) AuCl (1) was oxidized wi

192 odel carbohydrate acceptors using the Tf(2)O/Ph(2)SO promoter system.

193 al strategy to target the MYB "addiction" of Ph(+) ALL.Significance: MYB blockade can suppress Philad

194 bs) was not affected by the concentration of Ph(C(6)F(5))I(+) indicating that the benzoate release fr

195 -induced phase separation, in the context of Ph, can mediate large-scale compaction of chromatin into

196 strategy to exploit the "CDK6 dependence" of Ph+ ALL and, perhaps, of other hematologic malignancies.

197 L1-induced transformation and development of Ph(+) ALL.

198 of the latter reaction, the dissociation of Ph-AH(+)-Np@CB[7] is faster at higher Na(+) concentratio

199 ng mechanism, here we analyze the effects of Ph SAM on chromatin in vitro.

200 ike ALL in adults, an increased frequency of Ph-like ALL in adults of Hispanic ethnicity, significant

201 Our findings show high frequency of Ph-like ALL in adults, an increased frequency of Ph-like

202 ve helped to define the genomic landscape of Ph-like ALL and how it varies across the age spectrum, a

203 Binding of the larger naphthyl moiety of Ph-AH(+)-Np forms the Ph-AH(+)-Np@CB[7] 1:1 complex (whe

204 We show that overexpression of Ph with an intact SAM increases ubiquitylated H2A in cel

205 ydroisoquinolines (THIQs) in the presence of Ph(3)CBF(4) as an oxidant to afford 1-substituted THIQs.

206 cting data on the incidence and prognosis of Ph-like ALL in adults.

207 //PCM(MeCN) calculations for the reaction of Ph(2)P(O)H and PhX revealed a favorable energetics only

208 This Communication describes studies of Ph-RF (RF = CF3 or CF2CF3) coupling at Pd complexes of g

209 tly worse outcomes in the CRLF2(+) subset of Ph-like ALL.

210 iferation, colony formation, and survival of Ph(+) ALL cells ex vivo and in mice.

211 that shares significant overlap with that of Ph-positive (Ph(+)) ALL and is suggestive of activated k

212 Moreover, they suggest that treatment of Ph+ ALL with CDK6-selective PROTACs would spare a high p

213 utility of these agents in the treatment of Ph-like ALL.

214 Treatment of [Ph(3) EMe][I] with [Na{N(SiMe(3) )(2) }] affords the yli

215 ompounds with OCH(3) (3b), OCH(2)Ph (3d), or Ph(3)P(+) (3i) as leaving groups than those containing O

216 H(3) )(2) CF(3) CO, CH(3) (CF(3) )(2) CO, or Ph(CF(3) )(2) CO] prepared in situ significantly increas

217 and MeO cap substituents and beta-Me, Et, or Ph arm substituents are obtained, and a modified condens

218 de (PI) oligomers (Xn-R, n = 2-4, R = Hex or Ph) linked together by single C-C bonds between their be

219 ve, Philadelphia chromosome (Ph)-positive or Ph-negative B-cell acute lymphoblastic leukaemia who wer

220 e synthesis and characterization of new P2(P'Ph) Fe(N2 )(H)x systems that are active for catalytic N2

221 n imino-phosphanamide ligand, [NHI(iPr2Me2)P(Ph)NH-2,6-(i)Pr(2)C(6)H(3)] (LH), containing two differe

222 Zr((Mes)PDP(Ph))(2) engages in numerous photoredox catalytic process

223 bsorbing Zr(IV) photosensitizer, Zr((Mes)PDP(Ph))(2), where [(Mes)PDP(Ph)](2-) is the doubly deproton

224 itizer, Zr((Mes)PDP(Ph))(2), where [(Mes)PDP(Ph)](2-) is the doubly deprotonated form of [2,6-bis(5-(

225 etermination of 4-Amino Phenol (AP), Phenol (Ph) and 4-Nitro Phenol (NP).

226 CR, where R = nitrophenyl (PhNO(2)), phenyl (Ph), thiophene (Th), bithiophene (biTh), and dimethyl an

227 lkane (Ak), ethylene glycol (EG) and phenyl (Ph).

228 als are tuned by the substitution of phenyl (Ph), 3,4,5-trifluorophenyl (PhF(3)), or 2,3,4,5,6-pentaf

229 ophores carbazole and 2-phenylbenzimidazole (Ph-BIM) with two representative isolable singlet carbene

230 , alkynoate esters and the phosphinoboronate Ph(2) P-Bpin are efficiently converted into the correspo

231 ssive Complex 1 (PRC1) subunit Polyhomeotic (Ph) has been shown to play an important role in chromati

232 th CML and Philadelphia chromosome-positive (Ph(+)) acute lymphoblastic leukaemia.

233 ients with Philadelphia chromosome-positive (Ph(+)) B-precursor acute lymphoblastic leukemia (ALL) wh

234 therapy in Philadelphia chromosome-positive (Ph(+)) leukemia is effectively managed with several appr

235 ignificant overlap with that of Ph-positive (Ph(+)) ALL and is suggestive of activated kinase signali

236 CDK6 is required for Philadelphia-positive (Ph+) acute lymphoblastic leukemia (ALL) cell growth, whe

237 te complex, [KPr(OSiPh(3))(4)(THF)(3)], 1-Pr(Ph), with [N(C(6)H(4)Br)(3)][SbCl(6)], affords the Pr(IV

238 along with the DFT computations of the 2-Pr(Ph) complex unambiguously confirm the presence of Pr(IV)

239 IV) complex [Pr(OSiPh(3))(4)(MeCN)(2)], 2-Pr(Ph), which is stable once isolated.

240 tyrosine kinase inhibitor-resistant primary Ph+ ALL cells, and this effect was comparable or superio

241 styrene to afford the Markovnikov products, Ph(Me)C(H)SiH2Ph and Ph(Me)C(H)Bpin, and (ii) hydroborat

242 mice on highly variant C57BL/6J (B6) and PWD/Ph (PWD) genetic backgrounds.

243 Ru pincer complexes [RuHClPNP (R)(CO)] (R = Ph/ i-Pr/Cy/ t-Bu) for both amine formylation and formam

244 e hydrogenation, only catalyst Ru-Macho (R = Ph) provided a high methanol yield after both steps were

245 ng polyphosphinoboranes, [RR'PBH(2)](n) (R = Ph; R' = H, Ph or Et), or are trapped in the form of CAA

246 -disubstituted polymers, [RR'PBH(2)](n) (R = Ph; R' = Ph or Et).

247 oH(2)}=Si={H(2)Co[BP(3) (iPr)]} species (R = Ph, 2a; R = H, 2b; [BP(2) (iPr)] = kappa(2)-PhB(CH(2)P (

248 roups since an analogous derivative with R = Ph is observable but too unstable for isolation.

249 tuted polymers, [RR'PBH(2)](n) (R = Ph; R' = Ph or Et).

250 The use of a CuCl (R,R)-Ph-Pybox catalyst system effects a simultaneous kinetic

251 OR ethers was observed to range from 50 % (R=Ph) to greater than 90 % (R=n-C4 H9 , cyclohexyl, and Ph

252 (II)]-C=CAr also captures the trityl radical Ph(3)C. to give Ph(3)C-C=CAr.

253 ive signaling plasticity of CRLF2-rearranged Ph-like ALL following selective TKI pressure, which occu

254 ic therapeutic strategy for CRLF2-rearranged Ph-like ALL.

255 -like factor 2-rearranged (CRLF2-rearranged) Ph-like ALL subset.

256 omab in patients with relapsed or refractory Ph(+) ALL.

257 capable of controlling treatment-refractory Ph(+) ALL in vivo, and support the development of adopti

258 ped an in vitro model of Nilotinib-resistant Ph+ leukemia cells to investigate whether low dose radia

259 inato species with the second O of the O(2)S(Ph-NMe2) unit pointing out of the five-membered Ni-O-S-F

260 ino) cyclopropenylidene (BAC), elemental Se, Ph(2)CO, PhCH=CHCOPh, and PhCN at room temperature.

261 ides materials functionalized with either Si-Ph or Si-H groups, versatile entry points for further ch

262 nyl group by a larger polarization of the Si-Ph than of the Si-O bond in the Phax conformer and addit

263 ligand field generated by the Ph(3) SiO(-) (Ph(3) SiO(-) =anion of triphenylsilanol) and the 2,4-di-

264 ard synthesis, from [L(Ph)SiCl], [L(Ph)SiSiL(Ph)] and NaBPh(4), and fully characterized.

265 nt signaling pathways are active in specific Ph-like ALL subsets, and precision medicine trials have

266 feature of the reaction is that the stronger Ph-O bond is cleaved rather than the weaker aliphatic O-

267 CDK4/6 inhibitor palbociclib in suppressing Ph+ ALL in mice, suggesting that the growth-promoting ef

268 Newly developed TKI can target Ph(+) ALL cells with BCR-ABL1-dependent resistance; howe

269 ts substrate scope encompasses Ph(H)C=N tBu, Ph(2)C=CH(2), and anthracene.

270 owly (half-lives 1.15 yrs and 33 days) than (Ph)2CH-Br (half-life 23 s).

271 Interestingly, we observed that Ph-like ALL cells have activated SRC, ERK, and PI3K sign

272 The Ph-like gene expression profile was identified in 341 of

273 trong uniaxial ligand field generated by the Ph(3) SiO(-) (Ph(3) SiO(-) =anion of triphenylsilanol) a

274 bout the Si-CPh bond (axi and axo denote the Ph group lying in or out of the X-Si-CPh plane) contribu

275 ger naphthyl moiety of Ph-AH(+)-Np forms the Ph-AH(+)-Np@CB[7] 1:1 complex (where "@" represents an i

276 es were isolated for the first time from the Ph(3)P-I(2)-mediated reactions of benzo[d]oxazol-2(3H)-o

277 er research on acoustic communication in the Ph. argentipes species complex and other Old World vecto

278 In the presence of the Ph(3)P-I(2) reagent system, the reaction of both acyclic

279 While Fc undergoes one, the Ph-based apFr depends on temperature.

280 By utilizing the Ph* group, the beta-branched products could be straightf

281 tial activation with trimethylaluminum, then Ph(3)C(+)B(C(6)F(5))(4)(-).

282 The change from -OPh to -Ph results in a marked increase in the quantum yield of

283 ubation of chromatin or DNA with a truncated Ph protein containing the SAM results in formation of co

284 ng ortho urea was achieved via unprecedented Ph(3)P-I(2) mediated ring-opening of 1,3-dihydro-1H-benz

285 t-derived xenograft models harboring various Ph-like genomic alterations with 4 discrete PI3K pathway

286 en-label phase II study enrolled adults with Ph(+) ALL who had relapsed after or were refractory to a

287 ofatumumab is safe and active in adults with Ph-negative CD20-positive B-cell acute lymphoblastic leu

288 effects of grade 3 or higher in adults with Ph-positive ALL.

289 We treated 3 patients with Ph(+) ALL with autologous or allogeneic (p190)BCR-ABL-sp

290 Sixty-eight percent of patients with Ph-like ALL were of Hispanic ethnicity.

291 tly inferior outcomes of adult patients with Ph-like ALL, and significantly worse outcomes in the CRL

292 tivating alterations in 88% of patients with Ph-like ALL, including CRLF2 rearrangements (51%), ABL c

293 is was performed on 180 of 194 patients with Ph-like ALL.

294 in a large series of 617 adult patients with Ph-negative BCP-ALL (median age, 38 years), treated in t

295 (7), t-Bu/S (8), t-Bu/Se (9)] or III [R/X = Ph/BH(3) (4), t-Bu/BH(3) (5), t-Bu/lone pair (10)].

296 X-ray crystallography shows that X2-Ph crystallizes into a densely packed superstructure, de

297 ields a new tetrametaphosphate-based ylide ([Ph(3)PCHP(4)O(11)](3-), 94% yield).

298 th [Na{N(SiMe(3) )(2) }] affords the ylides [Ph(3) E=CH(2) ] (E=As, 1As; P, 1P).

299 In our Present Your Ph.D. Thesis to a 12-Year Old outreach project, our nove

300 ctivation toward CumO(*) is observed for Z = Ph, OH, NH2, and NHAc, as evidenced by an increase in kH