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1                                              Pol gamma also exhibited approximately 2-fold lower rate
2                                              Pol gamma B shows high similarity to glycyl-tRNA synthet
3                                              Pol gamma comprises a catalytic core in a heterodimeric
4                                              Pol gamma is a high fidelity polymerase with polymerase
5                                              Pol gamma is particularly susceptible to inhibition by d
6                                              Pol gamma is responsible for the replication and repair
7                                              Pol gamma is the only DNA polymerase found in mitochondr
8                                              Pol gamma is vulnerable to nonselective antiretroviral d
9                                              Pol gamma was detected as one of the major oxidized mito
10 ructural and mechanistic differences between Pol gamma and RT in response to NRTIs will provide inval
11 ably due to unfavorable interactions between Pol gamma and certain 5' labels.
12  (-)-3TC] are both potent RT inhibitors, but Pol gamma discriminates against (-)-FTC-TP by two orders
13 d the kinetics of incorporation catalyzed by Pol gamma for each Food and Drug Administration-approved
14 trate dCTP, providing a structural basis for Pol gamma-mediated drug toxicity.
15 ol gamma B dimer contains distinct sites for Pol gamma A binding, dimerization, and DNA binding.
16               When compared to the apo form, Pol gamma undergoes intra- and inter-subunit conformatio
17 binant human mitochondrial polymerase gamma (Pol gamma) holoenzyme.
18 y of the mitochondrial DNA polymerase gamma (Pol gamma) in vitro, providing a potential means to favo
19 eplication accuracy of DNA polymerase gamma (Pol gamma) is essential for mitochondrial genome integri
20              The human DNA polymerase gamma (Pol gamma) is responsible for DNA replication in mitocho
21 tochondrial replicase, DNA polymerase gamma (Pol gamma) is stimulated by another key component of the
22  mitochondrial DNA (mtDNA) polymerase gamma (Pol gamma) is the only polymerase known to replicate the
23  mitochondrial polymerase (polymerase-gamma (Pol-gamma)) are associated with various mitochondrial di
24 omosome 15, encodes the DNA polymerase gamma(Pol gamma).
25 ystal structures of the human heterotrimeric Pol gamma holoenzyme and, separately, a variant of its p
26  (mtDNA) is replicated by the heterotrimeric Pol gamma comprised of a single catalytic subunit, encod
27                                      A human Pol gamma B mutant lacking the four-helix bundle failed
28 mer (+)-FTC-TP, it is discriminated by human Pol gamma four orders of magnitude more efficiently than
29                            Mutation of human Pol gamma arginine-853 has been linked to neurological d
30  exonuclease activities of recombinant human Pol gamma.
31 lease-deficient (E200A), reconstituted human Pol gamma holoenzyme in single turnover kinetic studies
32         Additionally, we observed that human Pol gamma preferentially utilizes compacted templates, w
33 the yeast mtDNA polymerase (MIP1) with human Pol-gamma.
34  and P587L substitutions functionally impair Pol gamma, with greater pathogenicity predicted for the
35 le defects resulting from point mutations in Pol-gamma with their physiological consequences, we crea
36 e of template DNA organization in modulating Pol gamma activity and the variation among systems.
37 We determined the crystal structure of mouse Pol gamma B, a core component of the mitochondrial repli
38  primer by the 3'-5'-exonuclease activity of Pol gamma were similar (0.01 s(-)1) for both 3TC analogs
39 y subunit (POLG2), which enhances binding of Pol gamma to DNA and promotes processivity of the holoen
40 for understanding the deleterious effects of Pol gamma mutations in human disease.
41 tions, we studied the effect of oxidation of Pol gamma on replication errors.
42 or factor contributing to the stimulation of Pol gamma activity.
43        We compared a series of structures of Pol gamma, complexed with primer/template DNA, and eithe
44           The stimulatory effect of mtSSB on Pol gamma on these ssDNA templates is not species-specif
45                                 The oxidized Pol gamma becomes editing-deficient, displaying a 20-fol
46 ide or its analogues being bound in the pol, Pol gamma residue stability varied across the protein, p
47 fidelity human mitochondrial DNA polymerase (Pol gamma) contains two active sites, a DNA polymerizati
48          Human mitochondrial DNA polymerase (Pol gamma) is the sole replicase in mitochondria.
49  inhibit human mitochondrial DNA polymerase (Pol gamma), causing unwanted mitochondrial toxicity.
50 ities of human mitochondrial DNA polymerase (Pol gamma), including reverse transcription, RNA-directe
51 s on the human mitochondrial DNA polymerase (Pol gamma), the polymerase responsible for mitochondrial
52 ne the role of the mitochondrial polymerase (Pol gamma) in clinically observed toxicity of nucleoside
53 own of the nuclear-encoded mtDNA polymerase (Pol gamma-alpha), Tamas, produces a more complete block
54 uctures of the mitochondrial DNA polymerase, Pol gamma, in complex with substrate or antiviral inhibi
55  by two known mitochondrial DNA polymerases (Pol gamma, PrimPol) in vitro was strongly blocked by rep
56  + P587L double variant forms of recombinant Pol gamma.
57                                  Remarkably, Pol gamma catalyzes reverse transcription with a slightl
58       To understand how the mtDNA replicase, Pol gamma, can give rise to elevated mutations, we studi
59 report crystal structures of the replicating Pol gamma-DNA complex bound to either substrate or zalci
60            Although not a catalytic residue, Pol gamma arginine-853 mutants are void of polymerase ac
61 lution or to stimulate the catalytic subunit Pol gamma A, but retained the ability to bind with Pol g
62                             Our finding that Pol gamma also incorporates ribonucleotide triphosphates
63 of mtDNA replication, and we have found that Pol gamma holoenzyme is capable of performing this react
64                              We propose that Pol gamma and other dual-function polymerases exploit an
65      Mass spectrometry analysis reveals that Pol gamma exo domain is a hotspot for oxidation.
66                   This analysis reveals that Pol gamma incorporates (-)3TC-triphosphate 16-fold less
67                                 We show that Pol gamma exo domain is far more sensitive to oxidation
68                                          The Pol gamma holoenzyme consists of the p140 catalytic subu
69                                          The Pol gamma structure also provides a context for interpre
70 se, we determined a crystal structure of the Pol gamma mutant ternary complex with correct incoming n
71  and repairs mitochondrial DNA, requires the Pol gamma B subunit for processivity.
72               These results suggest that the Pol gamma B dimer contains distinct sites for Pol gamma
73 uctures reveal that zalcitabine binds to the Pol gamma active site almost identically to the substrat
74                          The severity of the Pol-gamma mutant phenotype in heterozygous diploid human
75  that the functional holoenzyme contains two Pol gamma B molecules.
76     In heterozygous diploid cells, wild-type Pol-gamma suppresses mutation-associated growth defects,
77 alcitabine provide a basis for understanding Pol gamma-mediated drug toxicity.
78 mma A, but retained the ability to bind with Pol gamma A to a primer-template construct, indicating t