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1 tic properties of human DNA polymerase iota (pol iota).
2 ly, 8-oxoguanine significantly blocked human Pol iota.
3 s earlier in mice concomitantly deficient in pol iota.
4 d for bypass ability and fidelity with human pol iota.
5 is consistent with Hoogsteen base pairing by pol iota.
6 e incorporation opposite template purines by Pol iota.
7          However, human DNA polymerase iota (Pol iota), a member of the Y family of DNA polymerases,
8  is rotated into the syn conformation in the pol iota active site and that dTTP misincorporation by p
9 late purines adopt a syn conformation in the Pol iota active site, enabling the formation of a Hoogst
10  and incoming dCTP have revealed that in the Pol iota active site, the templating purine adopts a syn
11                          We next examined if Pol iota affected tandem mutations generated by another
12 e kinetic assay, herein we showed that human Pol iota and a two-subunit yeast Pol zeta complex (REV3/
13 on structures of the C-terminal UBM of human pol iota and its complex with ubiquitin.
14                       Mouse Pol kappa, Rev7, Pol iota and Pol eta each bind to the same approximately
15 ta) and with two other Y-family polymerases, Pol iota and Pol eta.
16  replicated through N(2),3-epsilonG, whereas pol iota and REV1 yielded only 1-base incorporation.
17 ro results also suggested the involvement of pol iota and/or REV1 in inserting correct dCMP opposite
18  of pol kappa > REV1 > pol eta approximately pol iota, and dTTP misincorporation is the major miscodi
19 o4, RB69, KlenTaq, yeast pol iota, human (h) pol iota, and human pol beta.
20 mice with negligible expression of truncated Pol iota, and knock-in mice that express full-length Pol
21 eract with the Y-family polymerases Pol eta, Pol iota, and Pol kappa, and the Rev1 C terminus mediate
22                       Additionally, Pol eta, Pol iota, and Pol zeta, but not Pol kappa, had important
23  focus on the interaction between RAD23A and Pol iota, and through a series of biochemical, cell-base
24 eins in vitro demonstrate that both forms of Pol iota are active but that they may differ in substrat
25  and IgM crosslinking-dependent induction of pol iota at 12 h may indicate an SHM "triggering" event
26 hat the constricted active site of wild-type pol iota becomes more spacious in the Y39A variant.
27 t Mn(2+) increases the catalytic activity of pol iota by approximately 30-60,000-fold through a drama
28 re, mapping of the domain structure of human pol iota by controlled proteolysis revealed that the enz
29 imidinic (AP) endonuclease and DNA ligase I, pol iota can use its dRP lyase and polymerase activities
30 d S-cdG in human cells, where Pol eta and/or Pol iota carries out nucleotide insertion opposite the l
31 BA2) interact with separate sites within the Pol iota catalytic domain.
32 mics simulations to examine the mechanism of pol iota-catalyzed nucleotide incorporation.
33                  To test the hypothesis that Pol iota causes the high frequency and abnormal spectrum
34 0 mutations from both strains indicated that Pol iota-compromised mice lost the tandem signature, whe
35                                        Human pol iota contains two functional UBMs, both contributing
36                                     Although pol iota deficiency alone had no effect, UV-induced skin
37                                              Pol iota deficiency unleashes PrimPol-dependent reprimin
38 pe cells that was diminished in pol eta- and pol iota-deficient mouse cells and abolished in cells de
39 be "at risk" for elevated mutagenesis during pol iota-dependent TLS.
40                                           In Pol iota-depleted cells, the excess participation of Pri
41  both USP7 domains is required for efficient Pol iota deubiquitination.
42 the variable region, indicating that loss of Pol iota did not change overall mutagenesis.
43                   Human DNA polymerase iota (Pol iota) differs from other DNA polymerases in that it
44                    A covalently cross-linked pol iota-DNA complex, representing a trapped intermediat
45                                              Pol iota effectively bypassed N2-methyl (Me)G and N2-eth
46        Opposite a template abasic site human Pol iota efficiently incorporated a G, less frequently a
47                                        Human Pol iota encoded by the RAD30B gene is a recently identi
48                                              pol iota exhibited the greatest activity in the presence
49              This implies that the change in pol iota expression is an early event after UV-mediated
50                          We report here that pol iota expression is elevated in breast cancer cells a
51 f breast cancer cells additionally increases pol iota expression with a peak occurring between 30 min
52  families: Pol delta (family B), Pol eta and Pol iota (family Y), and Pol lambda and Pol beta (family
53  experiments revealed a strong preference of pol iota for Mn(2+) even when Mg(2+) is present in a >10
54                                              Pol iota, for example, bypasses minor-groove and exocycl
55                                              Pol iota formed T x G mispairs at a frequency of 10(-2),
56                   Thus, our data support the Pol iota gene as a modifier of lung tumorigenesis by alt
57 nt database updating, we have found that the Pol iota gene, encoding the DNA polymerase iota, contain
58                                              Pol iota had the highest dTTP misincorporation frequency
59                    We report here that human pol iota has an intrinsic 5'-deoxyribose phosphate (dRP)
60                  We found earlier that human pol iota has deoxyribose phosphate (dRP) lyase activity
61 discovered human enzyme DNA polymerase iota (pol iota) has been shown to have an exceptionally high e
62 lymerases kappa (hDinB1), pol eta (hRad30A), pol iota (hRad30B), and yeast pol zeta (Rev3 and Rev7) i
63 ases (pols), e.g. Dpo4, RB69, KlenTaq, yeast pol iota, human (h) pol iota, and human pol beta.
64 a and three distinct catalytic properties of pol iota implicate it in specialized forms of base excis
65 dence that both RAD23 proteins interact with Pol iota in a similar manner, as well as with each of th
66 ollectively, these data reveal functions for pol iota in bypassing UV photoproducts and in delaying t
67 ble body of in vitro evidence for a role for pol iota in DNA lesion bypass, there is no in vivo evide
68       These results suggest a role for human Pol iota in DNA lesion bypass.
69 ur findings unravel an unanticipated role of Pol iota in protecting the genome stability of cells fro
70 ir depletion, we identified a unique role of Pol iota in regulating such a pathway choice.
71  interaction also impair the accumulation of pol iota in replication foci and Rev1-mediated DNA damag
72 lain the slightly favored dCTP insertion for pol iota in steady-state kinetic analysis.
73 uing possibility that the cation utilized by pol iota in vivo may actually be Mn(2+) rather than Mg(2
74 ivity of dTTP opposite O(6)-methylG by human pol iota, in contrast to the mispairing modes observed p
75                                              pol iota incorporates and extends NTPs opposite damaged
76 s, the two DNA polymerases act sequentially: Pol iota incorporates deoxynucleotides opposite DNA lesi
77                            Because wild-type pol iota incorporates NTPs in a template-specific manner
78 re strongly diminished in cells deficient in pol iota, indicating that pol iota participates in the b
79 rporation studies, pol eta inserted C and A, pol iota inserted T, and pol kappa inserted G.
80 leting either UBA domain disrupts the RAD23A-Pol iota interaction, demonstrating that both interactio
81 nvolves the ubiquitin-binding cleft of UBA2, Pol iota interacts with a distinct surface on UBA1.
82 ur results indicate that a single residue in pol iota is able to discriminate between NTPs and dNTPs
83 G compared with N2-EtG by pol eta but not by pol iota is consistent with Hoogsteen base pairing by po
84 he hypothesis that in cells lacking Pol eta, Pol iota is responsible for the high frequency and abnor
85                      Thus, polymerization by pol iota is severely inhibited by a bulky group at G N2
86 g to the A, B, or Y family, DNA synthesis by Pol iota is severely inhibited by these N7-modified base
87 ctive site and that dTTP misincorporation by pol iota is the result of Hoogsteen base pairing with th
88                         DNA polymerase iota (pol iota) is a conserved Y family enzyme that is implica
89                   Human DNA polymerase iota (pol iota) is a member of the Y-family of low fidelity le
90    Here, we report that DNA polymerase iota (Pol iota) is a novel USP7 substrate that interacts with
91                         DNA polymerase iota (Pol iota) is an attractive candidate for somatic hypermu
92                         DNA polymerase iota (pol iota) is one of several recently discovered DNA poly
93 in Pol eta or Pol zeta, but not Pol kappa or Pol iota, led to pronounced drops in bypass efficiencies
94      Overall, our data strongly suggest that pol iota may be involved in the generation of both incre
95 advantageous mode of Hoogsteen base pairing; pol iota may play a limited role in translesion synthesi
96                                         That pol iota may play a role in the higher mutation frequenc
97             An approximately 4-fold increase pol iota mRNA occurs within 12 h when cocultured with T
98                       The Y39A "steric gate" pol iota mutant is considerably more active in the prese
99                                      Neither pol iota nor pol zeta, either alone or in combination, w
100            The results support a model where Pol iota occasionally accesses the replication fork to g
101 tter than did pol kappa and much better than pol iota or delta.
102 n the isogenic cells deficient in Pol kappa, Pol iota or Pol zeta, suggesting the mutual involvement
103 mozolomide efficacy, whereas a deficiency in pol-iota or pol-lambda did not increase temozolomide-med
104 ype mice to mice lacking functional pol eta, pol iota, or both.
105 ype mice to mice lacking functional pol eta, pol iota, or both.
106 synthesis alongside the DNA polymerase iota (Pol iota)/p53 complex.
107 cells deficient in pol iota, indicating that pol iota participates in the bypass of UV photoproducts
108                  To test the hypothesis that pol iota performs TLS in cells, we compared UV-induced m
109                 To investigate whether human Pol iota plays a role in lesion bypass we examined the r
110               The Y-family DNA polymerases - Pol iota, Pol eta, Pol kappa and Rev1 - are most well-kn
111  factor with dRP lyase activity (pol lambda, pol iota, pol theta and Ku70) were found to remove the 5
112                            We also show that pol iota possesses a pyrophosphatase activity that gener
113                       Interestingly, whereas pol iota preferentially misinserts G opposite T by a fac
114                        Altered expression of POL iota protein and an amino acid-changing nucleotide p
115            We find that, whereas Pol eta and Pol iota provide alternate pathways for mutagenic TLS, s
116             This TLS-independent function of Pol iota requires its PCNA-interacting but not its polym
117                               Purified human Pol iota responded to a template TT (6-4) photoproduct b
118  increasing concentrations of purified human Pol iota, resulting in predominant C and less frequent A
119 ndings provide insights into the features of pol iota's active site that allow it to translocate alon
120              In vitro replication studies of Pol iota show that it replicates past 5'T-T3' and 5'T-U3
121 ts for dCTP and dTTP with pol eta and kappa; pol iota showed a strong preference for dTTP.
122                            To bypass damage, Pol iota specifically incorporates deoxynucleotides oppo
123                         To determine whether pol iota status affects cancer susceptibility, we compar
124 e proximity to the templating residue in the Pol iota ternary complex, have indicated that both facto
125 , and knock-in mice that express full-length Pol iota that is catalytically inactive.
126             Here, we evaluate the ability of pol iota to incorporate NTPs during DNA synthesis.
127 ) also dramatically increased the ability of pol iota to traverse a variety of DNA lesions in vitro.
128 senting BER intermediates, and we found that pol iota was able to complement the in vitro single-nucl
129      Opposite an AAF-adducted guanine, human Pol iota was able to incorporate predominantly a C.
130 uction in mutation frequency was found after pol iota was immunodepleted from nuclear extracts of the
131                           In contrast, human Pol iota was largely unresponsive to a template TT cis-s
132                              The fidelity of pol iota was measured at RGYW hot- and non-hot-spot sequ
133                       To identify a role for Pol iota, we analyzed mutations in two strains of mice w
134  and N7 hydrogen bonding to DNA synthesis by Pol iota, we have examined its proficiency for replicati
135    Of interest is human DNA polymerase iota (pol iota), which has been implicated in TLS of oxidative
136 theta, pol eta, Rev1, pol zeta and, perhaps, pol iota, which are error-prone and crucially insert mis
137 an gene, hRAD30B, encodes the DNA polymerase Pol iota, which misincorporates deoxynucleotides at a hi
138  work from this laboratory using full-length pol iota, which showed that dTTP incorporation occurs wi
139 fespan XPV cell line expressing two forms of Pol iota, whose frequency of UV-induced mutations is twi
140                        Crystal structures of pol iota with N(2),3-epsilonG paired to dCTP and dTTP re
141  Crystal structures of the truncated form of pol iota with O(6)-methylG as the template base and inco
142                    The crystal structures of Pol iota with template A and incoming dTTP and with temp
143 biological implications, as that would endow Pol iota with the ability to replicate through lesions w
144                                              Pol iota worked in conjunction with pol kappa, but not w

 
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