ライフサイエンスコーパス: Pol protein

1 ared exon led to greatly decreased levels of Pol protein.

2 pression, cleavage, and incorporation of the Pol protein.

3 ate a panel of six MAbs directed against HBV Pol protein.

4 ive if they are synthesized as part of a Gag-Pol protein.

5 pparently normal levels of processed Gag and Pol proteins.

6 with similarity to mammalian retroviral Gag-Pol proteins.

7 33 amino acid sequences from the retroviral Pol proteins.

8 ev and simian immunodeficiency virus Gag and Pol proteins.

9 y active response, recognizing gag, env, and pol proteins.

10 ed to be essential for processing of Gag and Pol proteins.

11 ay be exploited to study the function of the Pol proteins.

12 We found that efficient intracellular Gag-Pol protein accumulation required the region between the

13 (HIV) virions have a lattice of Gag and Gag-Pol proteins anchored to the lumen of their envelope.

14 s, among which unspliced RNA encodes Gag and Pol proteins and a singly spliced mRNA encodes Env prote

15 that express the JSRV Env and the MoMLV Gag-Pol proteins and can produce JSRV-pseudotype vectors at

16 rmine the cleavage sites in the WDSV Pro and Pol proteins and to characterize the viral protease (PR)

17 The Pol proteins are expressed in both follicle and nurse ce

18 FV Gag and Pol proteins are expressed independently of one another,

19 5 vector expressing the HIV-derived Gag and Pol proteins at equivalent levels.

20 mice were tolerant to the ENV but not to the POL proteins at the CTL level.

21 velope [ENV]) and nonstructural (polymerase [POL]) proteins at the CD8+ cytotoxic T lymphocyte (CTL)

22 nts determines the ratio of viral Gag to Gag-Pol proteins available for viral particle morphogenesis,

23 Retroviruses express Gag and Pol proteins by translation of unspliced genome-length v

24 e or absence of the spliced Pol, the PFV Gag-Pol proteins can assemble into virus-like particles (VLP

25 In cells, the PEG10 gag-pol protein cleaves itself in a mechanism reminiscent of

26 The reduction in the virion-associated Pol proteins could not be accounted for by differences i

27 cines expressing structurally intact gag and pol proteins drive immunofocused CD8 responses that redu

28 tant role in recruiting or retaining cleaved Pol proteins during virus assembly.

29 ise ratio of structural (Gag) and enzymatic (Pol) proteins during virus assembly.

30 nse-mediated mRNA decay (NMD) did not affect Pol protein expression.

31 60- to 70-fold increase in the levels of Gag-Pol protein expression.

32 f, Vpr, and Vpu), in addition to the Gag and Pol proteins, for particle formation and virus stock pro

33 HIV-1 expresses Gag-Pol protein from the Gag-coding mRNA through -1PRF, and

34 irus system via coexpression of HBV core and Pol proteins from either a single RNA (i.e., in cis) or

35 motif resulted in reduced virion-associated Pol proteins from transfected COS cells.

36 in p6 also drastically reduced the amount of Pol proteins in mutant virions.

37 precursor, drastically reduced the amount of Pol proteins in the mutant virions.

38 ate levels of Gag-Pol precursors and cleaved Pol proteins in the transfected cells were not affected

39 tion, which include the packaging of cleaved Pol proteins in viral particles, a process which may inv

40 Both HFV and HBV express their Pol protein independently of their structural proteins.

41 Both HFV and HBV express their Pol proteins independently from the structural proteins.

42 Viral Pol proteins influenced tRNAlys,3 packaging but had litt

43 ic studies presented here establish how Prim-Pol proteins instigate primer synthesis, revealing the r

44 target dominant negative mutants of the HIV Pol proteins into virions, we fused HIV-2 Vpx with an en

45 We found that the Pol protein is dispensable for production of extracellul

46 y low avidity and the low level at which the POL protein is expressed by the hepatocyte.

47 The Pol protein is not required for capsid assembly, and the

48 Foamy viruses are retroviruses whose Pol protein is synthesized without Gag from a spliced mR

49 l lines in which expression of HIV-1 Gag and Pol proteins is induced.

50 n in trans between murine leukemia virus Gag-Pol proteins lacking polymerase and RNase H activities r

51 showed an approximately 16-fold reduction in Pol protein levels, whereas the levels of Pol proteins w

52 This epitope lies in the p6(Pol) protein, located in the transframe region of the Ga

53 composed of conserved regions of the Gag and Pol proteins matched to at least 80% globally circulatin

54 ions, including dominant negative mutants of Pol proteins, may provide new opportunities for applicat

55 the simian immunodeficiency virus (SIV) Gag-Pol proteins (MVA-gag-pol) was explored in rhesus monkey

56 In contrast, the Pol protein of HFV is translated from a spliced messenge

57 ed and either are used to encode Gag and Gag-Pol proteins or are packaged into virions as genomic RNA

58 e it is either translated to produce Gag and Pol proteins or packaged into viral particles.

59 crease in antibody reactivity to HIV Gag and Pol proteins, patients with advanced HIV-1 infection rem

60 and E(1419)/G(1420)) within the 75.7-kDa Pro-Pol protein previously mapped in bacterial expression st

61 to a dramatic increase in the amount of Gag-Pol proteins produced in these cells.

62 frameshifting event required to express the Pol proteins protease, integrase, and reverse transcript

63 ytic domain is conserved in other PP2Cs, the POL protein represents a unique subclass of plant PP2Cs.

64 characterized SIVs at 40 to 50% of sites in Pol protein sequences.

65 oretroviruses, which synthesize Pol as a Gag-Pol protein that coassembles with Gag.

66 of VSV vectors expressing SHIV Env, Gag, and Pol proteins to that of a protocol consisting of a VSV v

67 er, little of the unmyristylated Gag and Gag-Pol proteins was found in the membrane fraction.

68 core protein, and functional domains of the Pol protein were highly conserved in all of the new isol

69 in Pol protein levels, whereas the levels of Pol proteins were only marginally reduced in mutant viri

70 LPs), in contrast to the orthoretroviral Gag-Pol proteins, which cannot form VLPs.

71 , encodes homologs of retroviral Gag and Gag-Pol proteins, which, together with genomic RNA, assemble

72 f the spliced Pol, coexpression of a PFV Gag-Pol protein with Gag can produce infectious virions.

73 n alter its sequence within both the Gag and Pol proteins with potential functional consequences for

74 ng immunizations of DNA encoding SIV Gag and Pol proteins, with control macaques receiving vector DNA

75 ted CD8+ T-cell epitopes from virion-derived Pol proteins within 2 h of infection.

76 mutants expressing Gag and Pol only as a Gag-Pol protein without the spliced Pol contain protease act