ライフサイエンスコーパス: Polycomb

1 nd suggest a functional intersection between Polycomb and AR signaling in CRPC.

2 ow that 3D regulation occurs upstream of the polycomb and DNA methylation pathways.

3 harmacologic susceptibility to inhibition of polycomb and glucose transporters.

4 omplex, regulates the genome-wide binding of polycomb and polycomb H3K27me3 repressive marks to pluri

5 We find that TERRAs are enriched at polycomb and stem cell genes in pluripotent cells and th

6 Polycomb and Trithorax group proteins maintain stable ep

7 DNA methylation and Polycomb are key factors in the establishment of vertebr

8 Despite their importance, studies on Polycomb are often restricted to classical model systems

9 Polycomb-associated DNA methylation valleys, hypomethyla

10 te the interplay between DNA methylation and Polycomb at key developmental regulators as a determinan

11 to reside in membraneless organelles called Polycomb bodies, leading to speculation that canonical P

12 ne promoters and associate with COMPASS- and Polycomb-bound chromatin.

13 we demonstrate that catalysis by PRC1 drives Polycomb chromatin domain formation and long-range chrom

14 associated with repressive marks made by the Polycomb complex and are diminished upon EZH2 inhibitor

15 most up-regulated genes in diapause include Polycomb complex members.

16 y repressing alternative cell fates, and the Polycomb complex plays a crucial role in this process.

17 reas CRGs that reduce accessibility, such as Polycomb complex proteins, were associated with decrease

18 second class in which genes are premarked by Polycomb complexes and tend to rely on the B repeat in X

19 peat in Xist for silencing, known to recruit Polycomb complexes during XCI.

20 ned differential dependencies of SWI/SNF and Polycomb complexes in regulation of diverse gene sets in

21 Gene silencing by Polycomb complexes is central to eukaryotic development.

22 pmental regulator genes are repressed by the Polycomb complexes PRC1 and PRC2.

23 Therefore, Xist and Polycomb complexes require each other to propagate along

24 1 can trigger transcriptional repression and Polycomb-dependent chromatin modifications.

25 han 50 loci regulated by DNA methylation and Polycomb-dependent histone methylation.

26 lleles, as defined by differential levels of Polycomb-dependent trimethylation of histone H3 Lys27 (f

27 study identifies a novel mechanism by which Polycomb directs the developmental process by activating

28 blish precedence for H2AK119u1 in initiating Polycomb domain formation in a physiological context.

29 somatic cells, silence genes in traditional Polycomb domains and in generally inactive chromatin.

30 specific NPC sub-complexes, and a subset of Polycomb domains is stabilized by interactions with Nup9

31 cm concentrates PRC2 activity on traditional Polycomb domains.

32 ycomb target genes and in spatial folding of Polycomb domains.

33 ion, as well as discovering novel details of Polycomb-driven interactions.

34 al deletion of the enhancer of trithorax and polycomb (ETP) gene, Asxl2, prevents weight gain.

35 mity assay, we find that BAF directly evicts Polycomb factors within minutes of its occupancy, thereb

36 stable epigenetic silencing through separate Polycomb factors, which spread across the locus after co

37 Importantly, we show that this novel Polycomb feed-forward loop is also active in human GIC a

38 The Polycomb Group (PcG) and Trithorax Group (TrxG) proteins

39 estion of how noncoding RNAs are involved in Polycomb group (PcG) and Trithorax group (TrxG) regulati

40 The polycomb group (PcG) of proteins are epigenetic represso

41 The Polycomb group (PcG) protein family is a well-known grou

42 Polycomb group (PcG) proteins are a group of evolutionar

43 Among the distinct factors, Polycomb group (PcG) proteins are major negative regulat

44 Polycomb group (PcG) proteins are transcriptional repres

45 sheds light on how nuclear organization and Polycomb group (PcG) proteins contribute to epigenetical

46 Polycomb Group (PcG) proteins form memory of transient t

47 Polycomb Group (PcG) proteins organize chromatin at mult

48 Polycomb group (PcG) proteins play critical roles in the

49 Polycomb group (PcG) proteins play vital roles in plant

50 Polycomb group (PcG) proteins repress master regulators

51 Polycomb group (PcG) proteins silence gene expression by

52 ation at both TSS regions and gene bodies of Polycomb group (PcG) target developmental genes, while D

53 latory genes require stable silencing by the polycomb group (PcG) to prevent misexpression during dif

54 ene expression programmes established by the Polycomb group of proteins and to promote and maintain a

55 Here, we analyzed Polycomb group protein (PcG) complex integrity in respon

56 The polycomb group protein CBX2 is an important epigenetic r

57 n of alternative fate genes by retaining the Polycomb Group protein Pleiohomeotic at Ubx targeted gen

58 3 and is essential for proper recruitment of Polycomb group protein Rnf2.

59 CBX7 is a polycomb group protein, and despite being implicated in

60 generation of ChIP-seq data for SWI/SNF and Polycomb group proteins and the transcriptional represso

61 Polycomb group proteins are essential regulators of deve

62 Polycomb group proteins are important for maintaining ge

63 MUC1-C regulated nuclear localization of the polycomb group proteins BMI1 and EZH2, which formed comp

64 uces dorsal mesoderm by releasing repressive polycomb group proteins from chromatin, bound to the Sta

65 miR-16 levels down-regulated BMI1 and other polycomb group proteins like RING1A, RING1B, EZH2 and al

66 ubtypes and multiple myeloma, linked several polycomb group proteins that could be targeted by small

67 keletal or chromatin tethers as well as with polycomb group proteins.

68 rs and epigenetic gene silencing mediated by Polycomb group proteins.

69 homolog 1/scm-like with 4 mbt domains 2 and polycomb group ring finger (Pcgf) 2/ Pcgf5, displayed an

70 We show that the expansion of the Polycomb Group RING Finger (PCGF) protein family, an ess

71 tion in euchromatic regions and overlap with Polycomb Group transcriptional silencing loci.

72 Polycomb-group (PcG) complexes are multiprotein, evoluti

73 with facultative heterochromatin mediated by Polycomb-group (PcG) proteins has been reported as well.

74 -binding of histone deacetylases (HDACs) and Polycomb-group (PcG) proteins.

75 tion-sequencing (RIP-seq), we identified the Polycomb-group histone methyltransferase EZH2 as a p53 m

76 strate that p53 influences expression of the Polycomb-group protein PHC1, which functions as a transc

77 ingle-cell genome-wide interaction data on a polycomb-group protein, RING1B, and the associated trans

78 Polycomb-group proteins control many fundamental biologi

79 HSI2 and HSL1 recruit components of polycomb-group proteins, including CURLY LEAF (CLF) and

80 basis of epigenetic maintenance mediated by Polycomb-group proteins.

81 We also extensively discuss polycomb-group repressive complexes (PRCs), which freque

82 Arabidopsis polycomb-group repressor complex2 (PRC2) protein MEDEA (

83 in NBs, unlike NSC differentiation, requires Polycomb-group-mediated repression.

84 ates the genome-wide binding of polycomb and polycomb H3K27me3 repressive marks to pluripotency genes

85 The chromatin mark regulated by Polycomb, H3K27me3, is maintained at key developmental g

86 sive histone mark H3K27me3 (mediated via the polycomb histone methyltransferase, enhancer of zeste ho

87 cers and its depletion from regions bound by Polycomb, Histone H1, and heterochromatin Protein 1.

88 re we propose that SMCHD1 acts downstream of polycomb imprints to mediate its function.

89 Deletion of Polycomb-independent borders led to ectopic enhancer-pro

90 e and Polycomb-repressed DNA, and unexpected Polycomb-independent borders.

91 Here we define the Xist RNA Polycomb Interaction Domain (XR-PID), a 600 nt sequence

92 PHD finger protein 19 (PHF19; also known as polycomb-like 3), as a crucial mediator of tumorigenicit

93 The Polycomb-like protein PHF19/PCL3 associates with PRC2 an

94 somes, underlying the selective targeting to polycomb-marked genomic regions and synovial sarcoma-spe

95 H3K36me3 normally limits DNA methylation of Polycomb-marked regions.

96 chromatin changes include initial repressive polycomb marking of genes, later manifesting abnormal DN

97 to find that actively transcribed genes with Polycomb marks have greater cell-to-cell variation in ex

98 this work defines an additional phase in the Polycomb mechanism instrumental in natural variation of

99 mics to discover the central determinants of Polycomb-mediated gene repression in mouse embryonic ste

100 together, our results in zebrafish show that Polycomb-mediated gene repression is important immediate

101 Finally, we discover that Polycomb-mediated gene repression requires PRC1 catalyti

102 eveal a new variant PRC1-dependent logic for Polycomb-mediated gene repression.

103 orial chromatin states, including incomplete Polycomb-mediated gene silencing.

104 ation, CpG hypermethylation and depletion of Polycomb-mediated H3K27me3.

105 nes sensitive to SMCHD1 is their reliance on polycomb-mediated methylation as germline or secondary i

106 r that becomes progressively inactivated via Polycomb-mediated silencing as discs mature (Harris et a

107 and found icu11 disrupted the cold-induced, Polycomb-mediated silencing underlying vernalization.

108 and present a unified view of Xist's role in Polycomb-mediated silencing.

109 key developmental genes in diapause, and the Polycomb member CBX7 mediates repression of metabolism a

110 ZBTB16 locus encoding PLZF, is repressed by Polycomb (PcG) and H3K27me3 in naive hMSCs.

111 ically, VEC exerts this effect by inhibiting polycomb protein activity on the specific gene promoters

112 he components and mechanisms that define how Polycomb protein complexes achieve this remain enigmatic

113 in and analysis offered further insight into polycomb protein distribution in differentiated cells.

114 erating cells via SCML2, a germline-specific Polycomb protein required for spermatogenesis-specific g

115 cally, an interaction between B2 RNA and the Polycomb protein, EZH2, results in cleavage of B2 RNA, r

116 Polycomb proteins are involved in specific transcription

117 Strategies to manipulate Polycomb proteins might be used to improve hepatocyte de

118 tion according to which, in the naive state, polycomb recessive complex 2 repressed the IRAK-M promot

119 Polycomb, recruited through the Xist B/C-repeat, also pl

120 Our findings overturn existing models for Polycomb recruitment by Xist RNA and establish precedenc

121 Our findings define a key pathway for Polycomb recruitment by Xist RNA, providing important in

122 Polycomb recruitment is initiated by the PCGF3/5-PRC1 co

123 1-dependent changes in TERRA levels modulate polycomb recruitment to pluripotency and differentiation

124 t repeats A and B play in gene silencing and Polycomb recruitment.

125 -promoters (E-P) and bundle contacts between Polycomb regions.

126 ubunit EZH2, and genome-wide deregulation of polycomb-regulated genes.

127 delling and deacetylation complex (NuRD) and polycomb-related complex 2 (PRC2) through the invariant

128 solve longstanding questions about the EBNA3-polycomb relationship.

129 h as super-enhancers, bivalent promoters and Polycomb repressed regions, and identify additional patt

130 specific physical borders between active and Polycomb-repressed DNA, and unexpected Polycomb-independ

131 gions for PRC2 recruitment, diluting PRC2 at Polycomb-repressed genes.

132 Several of the DEGs are components of the Polycomb Repressing Complex 2 (PRC2), and they are expre

133 (PHD)-containing protein, EPR-1 (effector of polycomb repression 1; NCU07505).

134 umor development is accompanied by increased Polycomb repression and EZH2-mediated redistribution of

135 Furthermore, the Polycomb repression complex is not active at most of the

136 Our results highlight that Polycomb repression does not occur via one mechanism but

137 We posit that interplay between RNAi and Polycomb repression is a widely conserved phenomenon, wh

138 how reduced levels of H3K27me3 and defective Polycomb repression of HOX genes.

139 cestral EPR-1 was a component of a primitive Polycomb repression pathway.

140 d in mutants deficient in the RNAi-dependent Polycomb repression pathway.

141 RNAi and Polycomb repression play evolutionarily conserved and of

142 es, and we investigate their contribution to Polycomb repression.

143 anscriptional processing as well as RNAi and Polycomb repression.

144 ile hyper-methylated regions are enriched in polycomb repressive complex (EZH2/SUZ12) recognizing reg

145 d hits are two interacting components of the polycomb repressive complex (L3MBTL2 [L(3)Mbt-Like 2] an

146 Deeper analysis of central Polycomb repressive complex (PRC) 1 and 2 components ind

147 Upon HS, various Polycomb Repressive Complex (PRC)1 and PRC2 subunits, in

148 The roles of polycomb repressive complex (PRC)2 subunit SUZ12 and of

149 The dependency on the polycomb repressive complex (PRC2) and EZH2 represents o

150 Here we focus on Polycomb Repressive Complex 1 (PRC1) and trace the evolu

151 egration site 1 (BMI1) is a component of the polycomb repressive complex 1 (PRC1) complex that is ove

152 Polycomb repressive complex 1 (PRC1) is critical for med

153 demonstrate that epigenetic reprogramming by Polycomb Repressive Complex 1 (PRC1) promotes an inflamm

154 ence live-cell imaging, we observed that the Polycomb repressive complex 1 (PRC1) protein chromobox 2

155 A conserved Sterile Alpha Motif (SAM) in the Polycomb Repressive Complex 1 (PRC1) subunit Polyhomeoti

156 repressor (BCOR) is a component of a variant Polycomb repressive complex 1 (PRC1) that is essential f

157 Chromobox 6 (CBX6) is a subunit of Polycomb Repressive Complex 1 (PRC1) that mediates epige

158 CBX2, a component of the mammalian Polycomb repressive complex 1 (PRC1), contains a compact

159 We identified UbE2E1 as a novel component of Polycomb repressive complex 1 (PRC1), the E3 ligase comp

160 We demonstrate that canonical Polycomb repressive complex 1 (PRC1), which mediates hig

161 terochromatin Protein 1b (SlLHP1b), a tomato Polycomb Repressive Complex 1 (PRC1)-like protein with a

162 NA drives their formation via recruitment of Polycomb repressive complex 1 (PRC1).

163 ery can be divided into two major complexes: Polycomb repressive complex 1 and 2 (PRC1 and PRC2).

164 Furthermore, ChIP-seq analysis of the polycomb repressive complex 1 component RING1B indicated

165 eriments, we find that two components of the Polycomb repressive complex 1.1 (PRC1.1), BCL6 corepress

166 We found that Polycomb repressive complex 2 (PRC2) and its associated

167 of genes transcriptionally regulated by the polycomb repressive complex 2 (PRC2) and others previous

168 The Polycomb repressive complex 2 (PRC2) catalyzes H3K27 met

169 Polycomb repressive complex 2 (PRC2) catalyzes methylati

170 Polycomb Repressive Complex 2 (PRC2) catalyzes mono-, di

171 In addition, LINC00313 bound to polycomb repressive complex 2 (PRC2) complex components,

172 referential dependency on genes encoding the polycomb repressive complex 2 (PRC2) components EZH2, EE

173 Polycomb repressive complex 2 (PRC2) installs and spread

174 The polycomb repressive complex 2 (PRC2) is a chromatin-asso

175 The Polycomb repressive complex 2 (PRC2) is a crucial chroma

176 Polycomb repressive complex 2 (PRC2) is a histone methyl

177 Polycomb repressive complex 2 (PRC2) is a histone methyl

178 Polycomb repressive complex 2 (PRC2) is a key chromatin

179 The polycomb repressive complex 2 (PRC2) is composed of thre

180 Polycomb repressive complex 2 (PRC2) is responsible for

181 K27M and EZHIP are competitive inhibitors of Polycomb Repressive Complex 2 (PRC2) lysine methyltransf

182 The Polycomb repressive complex 2 (PRC2) mainly mediates tra

183 Polycomb repressive complex 2 (PRC2) maintains repressio

184 Polycomb repressive complex 2 (PRC2) places H3K27me3 at

185 Dysregulation of polycomb repressive complex 2 (PRC2) promotes oncogenesi

186 Coherently, binding of the Polycomb Repressive Complex 2 (PRC2) protein SUZ12 and d

187 Polycomb repressive complex 2 (PRC2) silences expression

188 Consistent with this view, we show that Polycomb Repressive Complex 2 (PRC2) silencing is geneti

189 NG LOCUS C (FLC) involves distinct phases of Polycomb repressive complex 2 (PRC2) silencing.

190 histone methyltransferase is a member of the polycomb repressive complex 2 (PRC2) that is highly expr

191 fied an evolutionarily conserved function of polycomb repressive complex 2 (PRC2) that mediates coord

192 tion of EZH2, the catalytic component of the Polycomb Repressive complex 2 (PRC2) that methylates H3K

193 stically, we show that lamin B1 recruits the polycomb repressive complex 2 (PRC2) to alter the H3K27m

194 subunits are involved in the recruitment of polycomb repressive complex 2 (PRC2) to CpG island (CGI)

195 JARID2 is a noncatalytic member of the polycomb repressive complex 2 (PRC2) which methylates of

196 performed chromatin interaction analyses of Polycomb repressive complex 2 (PRC2), a key inducer of t

197 Inhibition of the Polycomb Repressive Complex 2 (PRC2), an H3K27 tri-methy

198 One of these, Polycomb repressive complex 2 (PRC2), deposits the H3K27

199 VRN2), an angiosperm-specific subunit of the polycomb repressive complex 2 (PRC2), is an oxygen (O(2)

200 e H3 trimethylation on lysine 27, induced by polycomb repressive complex 2 (PRC2), is responsible for

201 Zeste 2 (EZH2), the catalytic subunit of the Polycomb Repressive Complex 2 (PRC2), of unknown functio

202 expression of EZH2, the enzymatic subunit of polycomb repressive complex 2 (PRC2), often occurs in ca

203 er of zeste homolog 2 (EZH2), a component of polycomb repressive complex 2 (PRC2), to inhibit c-Met e

204 Polycomb repressive complex 2 (PRC2), which contains cor

205 Homolog 2 (EZH2) is the catalytic subunit of Polycomb Repressive Complex 2 (PRC2), which minimally re

206 ant peripheral nerve sheath tumors (MPNSTs), Polycomb repressive complex 2 (PRC2), which plays a cruc

207 homolog 2 (EZH2) is the catalytic subunit of polycomb repressive complex 2 (PRC2), which silences tra

208 e homolog 2 (EZH2), the catalytic subunit of polycomb repressive complex 2 (PRC2), with a focus on EZ

209 2) negatively regulated CBX6 expression in a Polycomb Repressive Complex 2 (PRC2)-dependent manner.

210 Developmentally controlled expression of two Polycomb repressive complex 2 (PRC2)-interacting protein

211 accompanied by a reduction in the levels of polycomb repressive complex 2 (PRC2)-mediated H3K27 trim

212 ions of the genome and in recruitment of the polycomb repressive complex 2 (PRC2).

213 enzymes, which are the catalytic subunits of Polycomb Repressive Complex 2 (PRC2).

214 tion of Arabidopsis INCURVATA11 (ICU11) as a Polycomb Repressive Complex 2 accessory protein.

215 Polycomb repressive complex 2 and the epigenetic mark th

216 on the chromatin compaction the roles of the Polycomb repressive complex 2 histone methyltransferases

217 the potential roles of the immune system and polycomb repressive complex 2 in pathological AD.

218 stinal and blood cells, sustained absence of polycomb repressive complex 2 indirectly reactivates mos

219 The Polycomb repressive complex 2 proteins EZH1 and EZH2 reg

220 Enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2), a core com

221 nin co-localization with enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2).

222 yrimidine biosynthesis and downregulation of polycomb repressive complex 2 targets.

223 IN3)(5-7), a PHD protein that functions with Polycomb repressive complex 2 to epigenetically silence

224 a single Pax5-binding site by recruiting the polycomb repressive complex 2 to induce bivalent chromat

225 acilitates nitrogen-dependent recruitment of polycomb repressive complex 2 to repress branching-inhib

226 of H3K27 methyltransferases or of the PRC2 (Polycomb Repressive Complex 2) by pharmaceutical inhibit

227 The polycomb repressive complex 2, with core components EZH2

228 Polycomb repressive complex I exerted a further layer of

229 Interestingly, targets of polycomb repressive complex in stem cells were mostly af

230 It is likely that the role of Polycomb repressive complex is to dampen expression of t

231 al transcription factor Yin Yang 1 (YY1) and Polycomb repressive complex member enhancer of zeste hom

232 s, enhancers, and gene bodies, as well as in polycomb repressive complex occupancy and CTCF binding s

233 Polycomb repressive complex-2 (PRC2) is a group of prote

234 EZH2, which encodes a core component of the Polycomb repressive complex-2 (PRC2).

235 Polycomb Repressive Complexes (PRC1 and PRC2) regulate d

236 e of repressed chromatin and the function of polycomb repressive complexes (PRC1/2).

237 The opposition between Polycomb repressive complexes (PRCs) and BAF (mSWI/SNF)

238 Polycomb repressive complexes (PRCs) are important histo

239 Long noncoding RNAs (lncRNAs) cause Polycomb repressive complexes (PRCs) to spread over broa

240 s crucial for spreading Xist and maintaining Polycomb repressive complexes 1 and 2 (PRC1/PRC2) along

241 Involvement of Polycomb repressive complexes 1 and 2 in XCI has been in

242 omplex 2 subunit (EZH2), a core component of polycomb repressive complexes 2, possesses histone methy

243 unctions of the Trithorax-COMPASS complexes, Polycomb repressive complexes and Clr4/Suv39 histone-mod

244 r regulation of pluripotency and development.Polycomb repressive complexes modify histones but it is

245 The Polycomb Repressive Complexes PRC1 and PRC2 catalyse dis

246 ions between Firre RNA and components of the Polycomb repressive complexes.

247 deubiquitinase and ASXL1, a component of the Polycomb repressive deubiquitinase (PR-DUB) complex, bot

248 The mammalian Polycomb repressive deubiquitinase (PR-DUB) complexes ca

249 The Polycomb repressive system is an essential chromatin-bas

250 Polycomb-repressive complex 1 (PRC1) and PRC2 are critic

251 Here we show that Polycomb-repressive complex 1 (PRC1) directs timely acti

252 The Polycomb-repressive complex 1 (PRC1) family complexes ar

253 55-60) studied the function of Polycomb-repressive complex 1 (PRC1) in mouse skin devel

254 Here we examine the role of Polycomb-repressive complex 1 (PRC1) in shaping 3D genom

255 inhibition of BMI1, an integral component of polycomb-repressive complex 1 (PRC1) that catalyzes H2Au

256 Polycomb-repressive complex 2 (PRC2) is a histone methyl

257 2) is the enzymatic catalytic subunit of the polycomb-repressive complex 2 (PRC2) that can alter gene

258 opment, the stage is set for the activity of Polycomb-repressive complex 2 (PRC2) to maintain these r

259 th recurrent loss-of-function alterations in polycomb-repressive complex 2 (PRC2), a histone-modifyin

260 omolog 2 (EZH2), an enzymatic subunit of the polycomb-repressive complex 2 and the main writer of chr

261 th tumors (MPNST) harboring loss-of-function polycomb-repressive complex 2 mutations.

262 Enhancer of zeste 2 polycomb-repressive complex 2 subunit (Ezh2) also bound

263 Mechanistically, WT HNF-1beta recruits the polycomb-repressive complex 2 that catalyzes H3K27 trime

264 n, CTCF interacts with SUZ12, a component of polycomb-repressive-complex 2 (PRC2), to repress the tra

265 We show that the Polycomb Repressor Complex 1 (PRC1) drives colonization

266 miR-155 enhances Polycomb repressor complex 2 (PRC2) activity indirectly

267 Polycomb repressor complex 2 (PRC2) places the histone m

268 Homolog 2 (EZH2) is the catalytic subunit of Polycomb Repressor Complex 2 (PRC2), the enzyme that cat

269 yltransferase EZH2, the catalytic subunit of Polycomb Repressor Complex 2 (PRC2).

270 ZIC2 interacts with and maintains polycomb repressor complex 2 at the K-Rta promoter.

271 erized by hypermethylation of targets of the polycomb repressor complex 2 components.

272 Fie1, a rice FERTILIZATION-INDEPENDENT SEED-POLYCOMB REPRESSOR COMPLEX2 component, in MADS78 and 79

273 ail of histone H3 and affect the function of polycomb repressor complexes 1 and 2 (PRC1 and PRC2).

274 stically, Mdm4 interacts with members of the Polycomb Repressor Complexes and supports the ubiquitina

275 Repression of genes by Polycomb requires that PRC2 modifies their chromatin by

276 In Drosophila, DNA elements termed Polycomb Response Elements (PREs) recruit PcG proteins.

277 of CDKN2a/p16(INK4a) and BMI1 proto-oncogene polycomb ring finger (BMI1), with the latter limiting ex

278 genes while Nup93 associates primarily with Polycomb-silenced regions.

279 ver, the mechanisms underlying opposition to Polycomb silencing are poorly understood.

280 lysis identifies an additional phase in this Polycomb silencing mechanism downstream from H3K27me3 sp

281 Polycomb silencing represses gene expression and provide

282 Here we demonstrate that ENL overcomes polycomb silencing through recruitment of PAF1 via the c

283 rial 6mA network architecture that preserves Polycomb silencing.

284 GSCs) provide a powerful system for studying Polycomb silencing.

285 Perturbing Xist/Polycomb spreading causes failure of de novo Xi silencin

286 element that integrates interdependent Xist/Polycomb spreading, silencing, and changes in chromosome

287 g evidence that PRC1 catalysis is central to Polycomb system function and gene regulation.

288 e requirement for PRC1 catalytic activity in Polycomb system function.

289 The Polycomb system modifies chromatin and plays an essentia

290 Despite being extensively studied, how the Polycomb system selects its target genes is poorly under

291 d a functional role of Nup93 in silencing of Polycomb target genes and in spatial folding of Polycomb

292 ation that are associated with repression of Polycomb target genes and silencing during X chromosome

293 We find that PRC2.2 occupies polycomb target genes at low levels and that homeobox tr

294 re, we show that R-loops form at a subset of Polycomb target genes, and we investigate their contribu

295 regulating PRC2 localization to a subset of polycomb target genes.

296 activity, providing a putative mechanism for Polycomb target site selection.

297 se regions and alleviates repression of some polycomb telomeric genes.

298 promoter usage, accompanied by a switch from polycomb to DNA methylation occupancy.

299 and thus provides insights into genome-wide Polycomb/Trithorax regulation.

300 We present a mathematical model comprising a Polycomb/Trithorax response element (PRE/TRE) coupled to